iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000136636.12	ENST00000259154.8	ENSP00000259154.2
ENSG00000136636.12	ENST00000448333.1	ENSP00000396726.1
ENSG00000136636.12	ENST00000452413.1	ENSP00000399962.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
iRefIndex	HINT	Mentha
Disease-associated Variation
ClinVar	GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	9.40e-09	37.2	20	85
E3 adaptor/Cullin RING/DCX/DWD	9.50e-07	30.6	553	572

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 3    vilvvggeeffahkivLaas.SsvFyalflmele.esksklmveikdvqpevfrallkFlYtgklde 67
           v+l+vgg++f++ + +L+    s+F++l+++  +  +++++ + i+ ++p +f  +l+Fl+t++ld+
   Q: 20   VQLNVGGTRFSTSRQTLMWIpDSFFSSLLSGRIStLRDETGAIFID-RDPAAFAPILNFLRTKELDL 85
           89*****************99*************999*********.******************96 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 14   tllvsGsdDgtikvWDlrtg 33
           ++l +G  +g+i++WDl+t 
   Q: 553  RYLFTGHTNGSIQMWDLTTA 572
           6899*************986 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MAGGHCGSFP AAAAGSGEIV QLNVGGTRFS TSRQTLMWIP DSFFSSLLSG RISTLRDETG 60
AIFIDRDPAA FAPILNFLRT KELDLRGVSI NVLRHEAEFY GITPLVRRLL LCEELERSSC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCGGTGGCA GCGGAGCACG GAGAAGAGGC CCGGGCGGCC CGGCGGCCTG GAGGCCGCGA 60
AAGGTGGAGG CCGGGCCGCC CTTGTGCACC GCAGGATTGA CCCGGGAAGG GGCAGAAGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR003131--T1-type_BTB
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50097--BTB
PS00678--WD_REPEATS_1

Pfam

PF02214--BTB_2

SMART

SM00225--BTB
SM00320--WD40

Gene Ontology

GO:0051260--P:protein homooligomerization

KEGG

hsa:51133

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001874	Ailuropoda melanoleuca	95.97	0.00e+00	1431.00
IUUC-Apl-003629	Anas platyrhynchos	86.11	0.00e+00	1288.00
IUUC-Aca-004414	Anolis carolinensis	86.94	0.00e+00	1372.00
IUUC-Ame-011293	Astyanax mexicanus	82.85	0.00e+00	1166.00
IUUC-Bta-013484	Bos taurus	96.50	0.00e+00	1420.00
IUUC-Cel-018212	Caenorhabditis elegans	45.79	8.00e-168	583.00
IUUC-Cja-019022	Callithrix jacchus	98.00	0.00e+00	1467.00
IUUC-Cfa-020536	Canis familiaris	96.92	0.00e+00	1384.00
IUUC-Cpo-022363	Cavia porcellus	90.81	0.00e+00	1290.00
IUUC-Csa-024032	Chlorocebus sabaeus	99.62	0.00e+00	1503.00
IUUC-Cho-024835	Choloepus hoffmanni	92.64	0.00e+00	723.00
IUUC-Cin-025622	Ciona intestinalis	59.24	0.00e+00	724.00
IUUC-Csv-026126	Ciona savignyi	61.17	0.00e+00	726.00
IUUC-Cgl-026736	Colletotrichum gloeosporioides	32.65	8.00e-04	39.30
IUUC-Dre-028109	Danio rerio	81.65	0.00e+00	1103.00
IUUC-Dno-029798	Dasypus novemcinctus	93.52	0.00e+00	1411.00
IUUC-Eca-033358	Equus caballus	96.58	0.00e+00	1436.00
IUUC-Eeu-034793	Erinaceus europaeus	93.53	0.00e+00	1361.00
IUUC-Fca-035973	Felis catus	97.05	0.00e+00	1391.00
IUUC-Fal-036763	Ficedula albicollis	86.19	0.00e+00	1295.00
IUUC-Gmo-038765	Gadus morhua	81.45	0.00e+00	1083.00
IUUC-Gga-040709	Gallus gallus	85.75	0.00e+00	1305.00
IUUC-Gac-042228	Gasterosteus aculeatus	78.92	0.00e+00	1119.00
IUUC-Ggo-045284	Gorilla gorilla	96.73	0.00e+00	1416.00
IUUC-Itr-049032	Ictidomys tridecemlineatus	97.71	0.00e+00	1041.00
IUUC-Lch-050511	Latimeria chalumnae	79.20	0.00e+00	1192.00
IUUC-Loc-052301	Lepisosteus oculatus	78.55	0.00e+00	1204.00
IUUC-Laf-054063	Loxodonta africana	94.56	0.00e+00	1372.00
IUUC-Mcc-054982	Macaca mulatta	99.62	0.00e+00	1503.00
IUUC-Mga-059871	Meleagris gallopavo	85.53	0.00e+00	1273.00
IUUC-Mmr-061404	Microcebus murinus	97.12	0.00e+00	1482.00
IUUC-Mdo-061936	Monodelphis domestica	92.51	0.00e+00	1377.00
IUUC-Mmu-064398	Mus musculus	93.74	0.00e+00	1400.00
IUUC-Mpu-066743	Mustela putorius furo	96.15	0.00e+00	1339.00
IUUC-Mlu-067514	Myotis lucifugus	90.04	0.00e+00	1332.00
IUUC-Nle-069803	Nomascus leucogenys	99.75	0.00e+00	1538.00
IUUC-Ont-071892	Oreochromis niloticus	79.03	0.00e+00	1151.00
IUUC-Oan-073418	Ornithorhynchus anatinus	88.47	0.00e+00	1330.00
IUUC-Ocu-074232	Oryctolagus cuniculus	95.31	0.00e+00	1436.00
IUUC-Ola-086598	Oryzias latipes	74.64	0.00e+00	1165.00
IUUC-Oga-088192	Otolemur garnettii	97.37	0.00e+00	1496.00
IUUC-Oar-089884	Ovis aries	96.46	0.00e+00	1437.00
IUUC-Ptr-090513	Pan troglodytes	100.00	0.00e+00	1543.00
IUUC-Pan-092414	Papio anubis	99.00	0.00e+00	1490.00
IUUC-Psi-093108	Pelodiscus sinensis	88.38	0.00e+00	1306.00
IUUC-Pma-094707	Petromyzon marinus	41.96	2.00e-16	79.30
IUUC-Pfo-097046	Poecilia formosa	83.19	0.00e+00	1132.00
IUUC-Pab-098161	Pongo abelii	99.75	0.00e+00	1538.00
IUUC-Pva-102643	Pteropus vampyrus	89.46	0.00e+00	1343.00
IUUC-Rno-106022	Rattus norvegicus	92.88	0.00e+00	1356.00
IUUC-Sha-106900	Sarcophilus harrisii	92.80	0.00e+00	1359.00
IUUC-Tgu-117043	Taeniopygia guttata	90.07	0.00e+00	1040.00
IUUC-Tru-118664	Takifugu rubripes	80.44	0.00e+00	1139.00
IUUC-Tsy-119048	Tarsius syrichta	92.73	0.00e+00	1345.00
IUUC-Tni-119688	Tetraodon nigroviridis	82.56	0.00e+00	1101.00
IUUC-Tbe-127958	Tupaia belangeri	98.79	2.00e-144	506.00
IUUC-Ttr-128603	Tursiops truncatus	95.91	0.00e+00	1213.00
IUUC-Vpa-130047	Vicugna pacos	96.45	0.00e+00	1396.00
IUUC-Xtr-131947	Xenopus tropicalis	82.56	0.00e+00	1261.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence