iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Spo-108121

Ensembl Protein ID

SPBC25H2.05.1:pep

UniProt Accession

P87147; NACA_SCHPO

Genbank Protein ID

CAB08781.1

Protein Name

Nascent polypeptide-associated complex subunit alpha; Alpha-NAC

Genbank Nucleotide ID

CU329671

Gene Name

egd2; ucp15; SPBC25H2.05

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPBC25H2.05	SPBC25H2.05.1	SPBC25H2.05.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
Mentha
Post-translational Modifications (PTMs)
dbPAF	dbPTM	UniProt
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	12672455

Reviewed

Classification

Family	Identity	E-value	Score	Source Orthology
UBD/Alpha-Helix/UBA	32.37	2.00e-14	73.60	IUUC-Sce-106371

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. Ucp15 may also be involved in transcription regulation (By similarity).

Protein Sequence
(Fasta)

MSVESQPVEK ISELPAGSTT VVHAEKAQKL IQKLGLKRVE GITRVAMRRP KNILLIINEP 60
IVYKSSNNAY IVLGKVTVED MAAQARAFNE SQKQATETKE EAAITEESGD AQPADTAKIE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AACGAATGCG TCAACGATTG AATCACTTCC AACTACAACA ATAGTCTTTT ATTTTGATCC 60
AAAATGTCTG TTGAATCACA ACCTGTAGAG AAAATTTCTG AGCTTCCTGC TGGATCCACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport

Interpro

IPR016641--EGD2/NACA
IPR002715--Nas_poly-pep-assoc_cplx_dom

PROSITE

PS51151--NAC_AB

Pfam

PF01849--NAC

SMART

SM01407--NAC

Gene Ontology

GO:0005829--C:cytosol
GO:0005854--C:nascent polypeptide-associated complex
GO:0005634--C:nucleus
GO:0042788--C:polysomal ribosome
GO:0051082--F:unfolded protein binding
GO:0051083--P:'de novo' cotranslational protein folding
GO:0015031--P:protein transport

KEGG

spo:SPBC25H2.05

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001167	Aegilops tauschii	39.72	1.00e-22	97.40
IUUC-Aml-001719	Ailuropoda melanoleuca	47.33	1.00e-25	110.00
IUUC-Atr-002586	Amborella trichopoda	33.76	1.00e-14	71.20
IUUC-Apl-003190	Anas platyrhynchos	44.08	3.00e-22	95.90
IUUC-Aca-005265	Anolis carolinensis	49.01	9.00e-26	107.00
IUUC-Aly-006488	Arabidopsis lyrata	42.86	2.00e-24	103.00
IUUC-Ath-006809	Arabidopsis thaliana	42.55	7.00e-20	88.60
IUUC-Ago-007936	Ashbya gossypii	40.72	2.00e-26	109.00
IUUC-Acl-008036	Aspergillus clavatus	50.00	1.00e-16	77.80
IUUC-Afl-008462	Aspergillus flavus	46.43	2.00e-30	123.00
IUUC-Afu-008832	Aspergillus fumigatus	58.93	4.00e-15	72.40
IUUC-Ani-009246	Aspergillus nidulans	51.39	5.00e-18	82.00
IUUC-Ang-009808	Aspergillus niger	46.11	8.00e-28	114.00
IUUC-Aor-009972	Aspergillus oryzae	46.43	2.00e-30	123.00
IUUC-Ame-011674	Astyanax mexicanus	48.00	2.00e-26	110.00
IUUC-Bgr-012162	Blumeria graminis	43.75	4.00e-26	108.00
IUUC-Bta-012508	Bos taurus	47.65	2.00e-25	106.00
IUUC-Bci-013643	Botrytis cinerea	46.20	2.00e-27	113.00
IUUC-Bdi-014854	Brachypodium distachyon	39.72	5.00e-18	82.40
IUUC-Bol-015132	Brassica oleracea	44.68	3.00e-23	99.40
IUUC-Bra-017540	Brassica rapa	41.84	8.00e-20	88.20
IUUC-Cel-018111	Caenorhabditis elegans	44.30	1.00e-26	110.00
IUUC-Cja-019846	Callithrix jacchus	42.86	3.00e-29	122.00
IUUC-Cfa-020429	Canis familiaris	47.65	2.00e-25	106.00
IUUC-Cpo-022542	Cavia porcellus	46.58	1.00e-23	100.00
IUUC-Cre-022679	Chlamydomonas reinhardtii	42.67	6.00e-26	107.00
IUUC-Csa-023260	Chlorocebus sabaeus	45.51	4.00e-29	122.00
IUUC-Cho-024869	Choloepus hoffmanni	81.08	3.00e-12	63.20
IUUC-Cin-025166	Ciona intestinalis	47.02	8.00e-25	104.00
IUUC-Csv-026284	Ciona savignyi	42.07	7.00e-22	94.00
IUUC-Cgl-026520	Colletotrichum gloeosporioides	49.40	2.00e-29	119.00
IUUC-Cne-026920	Cryptococcus neoformans	33.33	1.00e-18	84.00
IUUC-Cme-027301	Cyanidioschyzon merolae	40.74	4.00e-21	92.80
IUUC-Dre-028709	Danio rerio	48.00	1.00e-25	110.00
IUUC-Dno-029786	Dasypus novemcinctus	47.33	1.00e-25	110.00
IUUC-Dor-030962	Dipodomys ordii	47.33	3.00e-25	106.00
IUUC-Dme-032061	Drosophila melanogaster	47.33	4.00e-19	85.90
IUUC-Ete-032965	Echinops telfairi	43.64	4.00e-24	102.00
IUUC-Eca-034049	Equus caballus	48.32	1.00e-25	107.00
IUUC-Eeu-034673	Erinaceus europaeus	47.65	2.00e-25	106.00
IUUC-Fca-036369	Felis catus	47.33	1.00e-25	110.00
IUUC-Fal-037006	Ficedula albicollis	45.45	2.00e-25	106.00
IUUC-Fox-037704	Fusarium oxysporum	45.93	1.00e-29	120.00
IUUC-Fso-038247	Fusarium solani	44.32	1.00e-31	127.00
IUUC-Gmo-039002	Gadus morhua	47.33	1.00e-27	114.00
IUUC-Ggr-039888	Gaeumannomyces graminis	45.03	2.00e-28	116.00
IUUC-Gga-040237	Gallus gallus	47.65	2.00e-25	106.00
IUUC-Gac-041800	Gasterosteus aculeatus	48.32	1.00e-25	108.00
IUUC-Gma-043275	Glycine max	40.94	2.00e-23	99.80
IUUC-Ggo-045163	Gorilla gorilla	41.99	9.00e-31	124.00
IUUC-Hsa-045795	Homo sapiens	47.33	2.00e-25	110.00
IUUC-Hvu-047376	Hordeum vulgare	40.43	3.00e-23	99.40
IUUC-Itr-048152	Ictidomys tridecemlineatus	47.65	2.00e-25	106.00
IUUC-Kpa-049166	Komagataella pastoris	35.36	1.00e-20	90.90
IUUC-Lch-050076	Latimeria chalumnae	48.32	5.00e-26	108.00
IUUC-Lpe-051016	Leersia perrieri	42.66	1.00e-26	110.00
IUUC-Loc-052292	Lepisosteus oculatus	47.26	1.00e-24	104.00
IUUC-Lma-053293	Leptosphaeria maculans	52.70	2.00e-19	86.70
IUUC-Laf-054393	Loxodonta africana	44.37	1.00e-29	120.00
IUUC-Mcc-054632	Macaca mulatta	47.33	2.00e-25	110.00
IUUC-Meu-056242	Macropus eugenii	43.31	6.00e-16	75.50
IUUC-Mor-057099	Magnaporthe oryzae	46.99	6.00e-29	118.00
IUUC-Mpo-057543	Magnaporthe poae	38.65	4.00e-20	89.00
IUUC-Mtr-058112	Medicago truncatula	42.95	3.00e-26	109.00
IUUC-Mla-059166	Melampsora laricipopulina	40.14	4.00e-20	88.60
IUUC-Mga-059406	Meleagris gallopavo	47.33	2.00e-25	107.00
IUUC-Mvi-060390	Microbotryum violaceum	38.62	1.00e-17	80.50
IUUC-Mmr-061569	Microcebus murinus	47.33	2.00e-25	106.00
IUUC-Mdo-062077	Monodelphis domestica	47.33	2.00e-25	108.00
IUUC-Mmu-063984	Mus musculus	47.33	2.00e-25	110.00
IUUC-Mac-065175	Musa acuminata	42.55	3.00e-25	105.00
IUUC-Mpu-065793	Mustela putorius furo	46.38	2.00e-21	97.10
IUUC-Mlu-068234	Myotis lucifugus	47.65	2.00e-25	106.00
IUUC-Nfi-068541	Neosartorya fischeri	58.93	4.00e-15	72.40
IUUC-Ncr-068830	Neurospora crassa	50.00	4.00e-29	119.00
IUUC-Nle-069126	Nomascus leucogenys	47.65	3.00e-25	106.00
IUUC-Opr-070742	Ochotona princeps	47.33	2.00e-25	106.00
IUUC-Ont-071828	Oreochromis niloticus	49.67	2.00e-26	110.00
IUUC-Oan-073462	Ornithorhynchus anatinus	46.58	2.00e-23	103.00
IUUC-Ocu-074890	Oryctolagus cuniculus	43.05	8.00e-24	104.00
IUUC-Oba-075995	Oryza barthii	43.26	7.00e-27	111.00
IUUC-Obr-076668	Oryza brachyantha	41.96	3.00e-26	109.00
IUUC-Ogl-077307	Oryza glaberrima	42.66	5.00e-27	112.00
IUUC-Ogu-078289	Oryza glumaepatula	42.66	5.00e-27	112.00
IUUC-Oin-079287	Oryza indica	43.26	7.00e-27	111.00
IUUC-Olo-080686	Oryza longistaminata	37.65	1.00e-23	100.00
IUUC-Ome-081567	Oryza meridionalis	42.66	4.00e-27	111.00
IUUC-Oni-082873	Oryza nivara	43.26	7.00e-27	111.00
IUUC-Opu-083291	Oryza punctata	43.36	2.00e-27	112.00
IUUC-Oru-085045	Oryza rufipogon	42.66	4.00e-27	111.00
IUUC-Osa-086265	Oryza sativa	42.66	5.00e-27	112.00
IUUC-Ola-087531	Oryzias latipes	48.00	4.00e-26	108.00
IUUC-Olu-087895	Ostreococcus lucimarinus	42.36	2.00e-24	102.00
IUUC-Oga-088273	Otolemur garnettii	46.39	1.00e-25	107.00
IUUC-Oar-089723	Ovis aries	47.33	1.00e-25	110.00
IUUC-Ptr-090481	Pan troglodytes	46.67	3.00e-25	109.00
IUUC-Pan-092223	Papio anubis	47.33	2.00e-25	108.00
IUUC-Psi-093588	Pelodiscus sinensis	47.65	2.00e-25	106.00
IUUC-Pma-094702	Petromyzon marinus	48.67	4.00e-25	105.00
IUUC-Pno-094927	Phaeosphaeria nodorum	52.70	2.00e-19	86.70
IUUC-Ppa-095389	Physcomitrella patens	42.95	1.00e-20	90.90
IUUC-Pfo-096744	Poecilia formosa	43.67	1.00e-26	110.00
IUUC-Pab-098044	Pongo abelii	47.65	2.00e-25	106.00
IUUC-Pop-099384	Populus trichocarpa	42.95	5.00e-28	115.00
IUUC-Pca-100355	Procavia capensis	46.00	7.00e-23	101.00
IUUC-Ppe-101786	Prunus persica	41.13	5.00e-25	105.00
IUUC-Pva-102494	Pteropus vampyrus	49.33	9.00e-26	107.00
IUUC-Pgr-103303	Puccinia graminis	37.18	1.00e-17	80.90
IUUC-Ptt-103748	Puccinia triticina	32.86	9.00e-07	44.70
IUUC-Pte-104368	Pyrenophora teres	44.44	6.00e-29	118.00
IUUC-Pyt-104542	Pyrenophora triticirepentis	44.44	3.00e-28	115.00
IUUC-Rno-105387	Rattus norvegicus	47.33	3.00e-25	110.00
IUUC-Sce-106371	Saccharomyces cerevisiae	31.11	1.00e-15	73.90
IUUC-Sha-107189	Sarcophilus harrisii	47.65	2.00e-25	106.00
IUUC-Sja-107942	Schizosaccharomyces japonicus	67.63	3.00e-51	192.00
IUUC-Ssl-108595	Sclerotinia sclerotiorum	46.82	8.00e-29	118.00
IUUC-Smo-108783	Selaginella moellendorffii	43.36	2.00e-25	106.00
IUUC-Sit-109728	Setaria italica	41.84	1.00e-25	107.00
IUUC-Sly-110957	Solanum lycopersicum	41.84	2.00e-23	100.00
IUUC-Stu-112873	Solanum tuberosum	41.13	7.00e-23	98.20
IUUC-Sar-113668	Sorex araneus	81.08	5.00e-12	62.00
IUUC-Sbi-114223	Sorghum bicolor	43.97	4.00e-27	112.00
IUUC-Sre-115220	Sporisorium reilianum	45.89	1.00e-21	94.00
IUUC-Ssc-116119	Sus scrofa	47.65	2.00e-25	106.00
IUUC-Tgu-116528	Taeniopygia guttata	46.58	1.00e-23	100.00
IUUC-Tru-117538	Takifugu rubripes	47.33	4.00e-26	109.00
IUUC-Tsy-118855	Tarsius syrichta	81.08	3.00e-12	62.80
IUUC-Tni-120134	Tetraodon nigroviridis	47.33	2.00e-26	110.00
IUUC-Tca-121524	Theobroma cacao	41.84	1.00e-25	107.00
IUUC-Tre-121915	Trichoderma reesei	58.67	2.00e-18	83.60
IUUC-Tvi-122411	Trichoderma virens	63.08	2.00e-16	76.60
IUUC-Tae-124851	Triticum aestivum	39.72	2.00e-22	97.10
IUUC-Tur-126821	Triticum urartu	39.72	7.00e-23	97.80
IUUC-Tme-126875	Tuber melanosporum	57.81	1.00e-16	77.40
IUUC-Tbe-127759	Tupaia belangeri	45.83	8.00e-21	91.70
IUUC-Ttr-129124	Tursiops truncatus	45.03	2.00e-23	103.00
IUUC-Uma-129551	Ustilago maydis	44.97	1.00e-23	100.00
IUUC-Vda-129992	Verticillium dahliae	45.29	5.00e-31	125.00
IUUC-Vpa-130096	Vicugna pacos	46.31	2.00e-24	103.00
IUUC-Vvi-130940	Vitis vinifera	43.26	4.00e-18	82.40
IUUC-Xtr-132454	Xenopus tropicalis	47.33	2.00e-25	106.00
IUUC-Xma-133842	Xiphophorus maculatus	45.57	1.00e-26	110.00
IUUC-Yli-134485	Yarrowia lipolytica	34.92	6.00e-20	88.60
IUUC-Zma-135748	Zea mays	43.26	2.00e-27	113.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence