iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-004741

UUCD1 version

UUC-AnC-01017

Ensembl Protein ID

ENSACAP00000008999.3

UniProt Accession

H9GEW5; H9GEW5_ANOCA

Protein Name

Uncharacterized protein

Gene Name

USP28

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000009092.3	ENSACAT00000009192.3	ENSACAP00000008999.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	6.20e-61	206.4	164	640

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle....kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs 85
           +GlkN+gNtC++ +v+Q+L+++pe+r+l+l+    + + ++  ++ k+++ +++ +lq lf+ ++ +++k v+p++ l+ l+ + ++  
   Q: 164  VGLKNIGNTCWFSAVIQSLFQLPEFRRLVLSytpdSGSDNCCSRS-KKRNIAFMLELQCLFALMLGTRRKFVDPTAALELLRGAFRS-P 250
           6******************************88875555555443.79999*******************************99887.7 PP
   S: 86   gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlsl 174
           + +qqD++Ef++ lld le+++                   +  a+ + ++k+++++++lF g++ s+ +    ++  s+ e+f +++l
   Q: 251  EEQQQDVSEFTHKLLDWLEDAF-------------------QLAANVNSQNKSENPMVQLFYGTFLSEGIH--EGKAFSKIETFGQYPL 318
           99********************...................224567899*****************9987..5677789********* PP
   S: 175  pvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlsp 263
           +v+g +     +lq+cLe    e+e e       ++  ++++ +++ +++klP+vL+++L+Rf+f+++ +++eki++k+efp+ + +++
   Q: 319  QVNGYK-----DLQECLEGAILEKETEA------SSSSQSVQYRQERWFTKLPPVLTFELSRFEFNQSLGQPEKIHNKLEFPQVVYMDR 396
           ******.....9*****99888888874......5566677788999****************************************** PP
   S: 264  fcts..................................................................................pee 270
           f+ s                                                                                  p  
   Q: 397  FLYSnkgliqakreeikrlkeqitvlqqkleqymrygsgagrfplldmlqyvlefassrpltanteastesqiskppfiqsrvtvtP-- 483
           999977888877777777777777777777777777777777777777777777777777766666665555555555555555550.. PP
   S: 271  kqke..................................................................................... 274
              +                                                                                     
   Q: 484  ---Seggdeasasqaasppeeasgplrsstppvempespaphgiteeevhlvmtclqrwrreveqdindlkdsiallsasvdqmycdpr 569
           ...05555555555666666666666666777777777777777777777777777777777777888888888888888888888888 PP
   S: 275  ..kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg.....staYvlfYkr 337
             ++ Y L+av+vH+G+++ GHY+ay++++ +k Wl+++D +Vte+++ee ++++      ++aY+l+Y +
   Q: 570  lqQVPYHLHAVLVHEGQANAGHYWAYIYHQPRKcWLKYNDVSVTESSWEELERDSFgglrnASAYCLMYIN 640
           88***************************77777*******************8779************75 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MTAARPEGEA ACGGSPAPNS SVLINQLREI TGIQDPLFLH EALKAANGNL VQAVGFLSEA 60
HAKESSQEGT ATEASYGGRS VLVLEQAAVG VTQDDGASLQ EGIPSDVQDF QGAQVTDQDP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGCTGATTG GGCGGCAGGG TCGGGTGGGC GTGGCCGGGC GCGCGGGCGT CCGTTGAAGC 60
GAGTGAAGGG AAGGCAGACG CTGCTGAGGC GCGTCTCCGG GCGGACGGAG CGGGATGACG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR009060--UBA-like
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0016604--C:nuclear body
GO:0043234--C:protein complex
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008283--P:cell proliferation
GO:0034644--P:cellular response to UV
GO:0000077--P:DNA damage checkpoint
GO:0042771--P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0016579--P:protein deubiquitination
GO:0007265--P:Ras protein signal transduction
GO:0031647--P:regulation of protein stability
GO:0010212--P:response to ionizing radiation
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

acs:100558297

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001836	Ailuropoda melanoleuca	58.66	0.00e+00	853.00
IUUC-Apl-004010	Anas platyrhynchos	61.23	0.00e+00	893.00
IUUC-Ani-009503	Aspergillus nidulans	35.80	6.00e-10	60.10
IUUC-Ame-011910	Astyanax mexicanus	46.67	4.00e-175	609.00
IUUC-Bta-013377	Bos taurus	58.33	0.00e+00	837.00
IUUC-Cel-018346	Caenorhabditis elegans	29.52	2.00e-28	122.00
IUUC-Cfa-020378	Canis familiaris	61.99	0.00e+00	1360.00
IUUC-Cpo-021817	Cavia porcellus	59.19	0.00e+00	831.00
IUUC-Csa-023446	Chlorocebus sabaeus	61.93	0.00e+00	1368.00
IUUC-Cho-024717	Choloepus hoffmanni	51.01	3.00e-116	412.00
IUUC-Cin-025302	Ciona intestinalis	36.69	9.00e-94	337.00
IUUC-Csv-025911	Ciona savignyi	39.72	5.00e-99	355.00
IUUC-Cme-027167	Cyanidioschyzon merolae	31.43	2.00e-13	71.60
IUUC-Dre-028016	Danio rerio	44.81	0.00e+00	925.00
IUUC-Dor-030955	Dipodomys ordii	56.07	0.00e+00	793.00
IUUC-Ete-032828	Echinops telfairi	58.43	2.00e-156	546.00
IUUC-Eca-034300	Equus caballus	58.41	0.00e+00	835.00
IUUC-Eeu-034458	Erinaceus europaeus	57.86	0.00e+00	790.00
IUUC-Fca-035753	Felis catus	60.26	0.00e+00	863.00
IUUC-Fal-037062	Ficedula albicollis	63.77	0.00e+00	1340.00
IUUC-Gmo-039593	Gadus morhua	51.02	0.00e+00	635.00
IUUC-Gac-041867	Gasterosteus aculeatus	50.26	0.00e+00	1040.00
IUUC-Ggo-045384	Gorilla gorilla	59.05	0.00e+00	849.00
IUUC-Hsa-046277	Homo sapiens	59.26	0.00e+00	851.00
IUUC-Loc-052636	Lepisosteus oculatus	54.64	0.00e+00	1188.00
IUUC-Laf-053808	Loxodonta africana	55.57	0.00e+00	821.00
IUUC-Mcc-055473	Macaca mulatta	61.93	0.00e+00	1368.00
IUUC-Meu-056416	Macropus eugenii	49.01	1.00e-176	613.00
IUUC-Mla-058944	Melampsora laricipopulina	23.94	2.00e-10	61.60
IUUC-Mga-060011	Meleagris gallopavo	60.26	0.00e+00	846.00
IUUC-Mdo-061955	Monodelphis domestica	62.48	0.00e+00	1306.00
IUUC-Mmu-063870	Mus musculus	57.39	0.00e+00	861.00
IUUC-Mpu-066454	Mustela putorius furo	61.77	0.00e+00	1308.00
IUUC-Mlu-067487	Myotis lucifugus	55.07	0.00e+00	771.00
IUUC-Nle-070044	Nomascus leucogenys	59.39	0.00e+00	856.00
IUUC-Opr-070888	Ochotona princeps	66.06	1.00e-109	391.00
IUUC-Ont-072150	Oreochromis niloticus	45.17	0.00e+00	962.00
IUUC-Ola-086393	Oryzias latipes	48.73	0.00e+00	1020.00
IUUC-Oga-088618	Otolemur garnettii	58.57	0.00e+00	831.00
IUUC-Oar-089848	Ovis aries	61.38	0.00e+00	1342.00
IUUC-Pan-092882	Papio anubis	62.18	0.00e+00	1051.00
IUUC-Psi-093422	Pelodiscus sinensis	66.49	0.00e+00	1454.00
IUUC-Pma-094250	Petromyzon marinus	45.67	2.00e-68	251.00
IUUC-Pfo-096466	Poecilia formosa	49.54	0.00e+00	703.00
IUUC-Pab-098337	Pongo abelii	59.13	0.00e+00	850.00
IUUC-Pva-102226	Pteropus vampyrus	52.75	0.00e+00	667.00
IUUC-Rno-105735	Rattus norvegicus	62.04	0.00e+00	1358.00
IUUC-Sha-107489	Sarcophilus harrisii	61.14	0.00e+00	863.00
IUUC-Ssl-108532	Sclerotinia sclerotiorum	33.73	2.00e-09	58.90
IUUC-Sre-115145	Sporisorium reilianum	24.37	1.00e-10	62.80
IUUC-Ssc-115463	Sus scrofa	52.98	0.00e+00	770.00
IUUC-Tgu-116609	Taeniopygia guttata	60.00	0.00e+00	811.00
IUUC-Tru-117807	Takifugu rubripes	49.12	0.00e+00	663.00
IUUC-Tni-119983	Tetraodon nigroviridis	47.45	0.00e+00	676.00
IUUC-Ttr-128887	Tursiops truncatus	53.99	0.00e+00	753.00
IUUC-Uma-129338	Ustilago maydis	23.05	8.00e-13	70.10
IUUC-Xtr-132436	Xenopus tropicalis	54.91	0.00e+00	762.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence