iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132436

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin-specific peptidase 28

Genbank Nucleotide ID

AAMC01073757

Gene Name

usp28

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000022958.3	ENSXETT00000049661.3	ENSXETP00000049661.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.70e-60	204.5	141	625

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.....kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeef 84
           +GlkN+gNtC++ +v+Q+L+++pe+r+l+++     +  ek++ ++ ++++ +++++lq lf+ ++ s++k v+p+  l+ lk++  + 
   Q: 141  VGLKNIGNTCWFSAVIQSLFHLPEFRRLVHSysitqSMLEKCQSRD-EKRNLAFMQELQCLFTLMVGSNRKFVDPSPALELLKDAFLS- 227
           6*******************************99998899998876.79999*******************************98876. PP
   S: 85   sgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldls 173
           ++ +qqD++Ef++ lld le++++                     + e++  k+++++++lF g++ ++    e ++  s  e+f +++
   Q: 228  EEAQQQDVSEFTHKLLDWLEDAFQL------------------TVNGEDPRDKSENPMVQLFYGTFLNEGFL-EANKAFSNIETFGQYP 297
           9**********************22..................2345679999**************99766.556666799******* PP
   S: 174  lpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdls 262
           l+v+g +     +l++cLe+ + e e+e+   +++ +     + +++ +++klP+vL+++L+Rf+f+++ +++eki++k+efp+ + ++
   Q: 298  LQVNGFS-----NLNECLEAAMVEGEIEN---MQTAQSA---RYRQERWFTKLPPVLTFELSRFEFNQSLGQPEKIHNKLEFPEIIYMD 375
           *******.....9**************96...3333333...3456789**************************************** PP
   S: 263  pfcts.................................................................................... 267
           +f+ +                                                                                    
   Q: 376  RFMYKnkelmrrkhsetrrlkgcidhlnqklesylkygsgpnrcplpdmlqyvlefantksaewcpptesnmqkiscplnrlffskdql 464
           ****9777777777777777777777777777777777777777777777777777666666666666555555555555555555555 PP
   S: 268  .peekqke................................................................................. 274
            +                                                                                       
   Q: 465  sS-----Gnndtetsnddspkcestsslppfvghtvpndcipaedpthgsdtleeirsvaaclqrwrtevekdiqdlkdsiasctksie 548
           50.....0555555556666666677777777777777777777777777777788888888888888888888888888888888888 PP
   S: 275  .........kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg.....staYvlfYk 336
                    ++ Y+L+av+vH+G+++ GHY+ay+++++++ Wl+++D +Vte ++ee ++++      ++aY+l+Y 
   Q: 549  evfidqdlsQVPYRLHAVLVHEGQANAGHYWAYIYSHSRCcWLKYNDVSVTEANWEELVRDSYggmrnASAYCLMYI 625
           999999999***************************77778****************9998779************6 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

QMLLNQLREI TGIQDSALLY EALKASNNDL TQAVGILTES VNEPATREVA FELSDTGGNA 60
TDKQVSVLVK SVPMHNKEVL QTTVAPSLQK DTGHQLNAVQ CGRSSESQDS ESKGRTKRKR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAAATGCTTC TAAACCAGCT GAGAGAGATT ACTGGTATTC AGGATTCAGC TTTATTGTAC 60
GAAGCACTTA AGGTACAACG TTATGCTCTG TAGGAAAATA AACCATGCAT TTCAAATTAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR009060--UBA-like
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0021551--P:central nervous system morphogenesis
GO:0000077--P:DNA damage checkpoint
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001836	Ailuropoda melanoleuca	62.85	0.00e+00	1298.00
IUUC-Apl-004010	Anas platyrhynchos	61.67	0.00e+00	1273.00
IUUC-Aca-004741	Anolis carolinensis	54.91	0.00e+00	748.00
IUUC-Acl-008164	Aspergillus clavatus	32.76	4.00e-12	67.40
IUUC-Afu-008871	Aspergillus fumigatus	31.03	4.00e-11	63.90
IUUC-Ani-009503	Aspergillus nidulans	29.92	3.00e-12	67.80
IUUC-Ang-009577	Aspergillus niger	29.69	1.00e-11	66.20
IUUC-Bta-013377	Bos taurus	62.22	0.00e+00	1257.00
IUUC-Cja-019977	Callithrix jacchus	63.53	0.00e+00	1289.00
IUUC-Cpo-021817	Cavia porcellus	61.70	0.00e+00	1280.00
IUUC-Cho-024717	Choloepus hoffmanni	54.60	0.00e+00	770.00
IUUC-Csv-025911	Ciona savignyi	34.67	4.00e-138	485.00
IUUC-Cme-027167	Cyanidioschyzon merolae	30.99	5.00e-13	70.10
IUUC-Dno-029559	Dasypus novemcinctus	61.30	0.00e+00	994.00
IUUC-Dor-030955	Dipodomys ordii	60.68	0.00e+00	1232.00
IUUC-Ete-032828	Echinops telfairi	58.13	0.00e+00	791.00
IUUC-Eca-034300	Equus caballus	62.06	0.00e+00	1258.00
IUUC-Eeu-034458	Erinaceus europaeus	62.04	0.00e+00	1107.00
IUUC-Fca-035753	Felis catus	63.38	0.00e+00	1304.00
IUUC-Fal-037062	Ficedula albicollis	55.00	0.00e+00	1124.00
IUUC-Gmo-039593	Gadus morhua	50.38	0.00e+00	976.00
IUUC-Gga-040878	Gallus gallus	56.00	0.00e+00	1121.00
IUUC-Gac-041867	Gasterosteus aculeatus	51.35	0.00e+00	1016.00
IUUC-Ggo-045384	Gorilla gorilla	62.81	0.00e+00	1289.00
IUUC-Hsa-046277	Homo sapiens	63.05	0.00e+00	1295.00
IUUC-Itr-048276	Ictidomys tridecemlineatus	56.96	0.00e+00	707.00
IUUC-Lch-049692	Latimeria chalumnae	59.91	0.00e+00	1220.00
IUUC-Laf-053808	Loxodonta africana	58.01	0.00e+00	1159.00
IUUC-Meu-056416	Macropus eugenii	52.86	0.00e+00	990.00
IUUC-Mga-060011	Meleagris gallopavo	59.08	0.00e+00	1197.00
IUUC-Mmr-060720	Microcebus murinus	60.99	0.00e+00	1236.00
IUUC-Mdo-061955	Monodelphis domestica	58.48	0.00e+00	1121.00
IUUC-Mmu-063870	Mus musculus	59.91	0.00e+00	1198.00
IUUC-Mlu-067487	Myotis lucifugus	60.06	0.00e+00	1206.00
IUUC-Nle-070044	Nomascus leucogenys	62.96	0.00e+00	1297.00
IUUC-Opr-070888	Ochotona princeps	67.87	6.00e-110	392.00
IUUC-Ocu-074523	Oryctolagus cuniculus	62.51	0.00e+00	1281.00
IUUC-Ola-086393	Oryzias latipes	51.38	0.00e+00	1033.00
IUUC-Oga-088618	Otolemur garnettii	62.68	0.00e+00	1281.00
IUUC-Ptr-091630	Pan troglodytes	63.41	0.00e+00	1017.00
IUUC-Psi-093422	Pelodiscus sinensis	58.62	0.00e+00	1252.00
IUUC-Pma-094250	Petromyzon marinus	50.47	3.00e-61	228.00
IUUC-Pno-095093	Phaeosphaeria nodorum	32.14	1.00e-11	65.50
IUUC-Pab-098337	Pongo abelii	63.05	0.00e+00	1295.00
IUUC-Pca-100901	Procavia capensis	65.29	0.00e+00	708.00
IUUC-Pva-102226	Pteropus vampyrus	59.54	0.00e+00	1118.00
IUUC-Pyt-104434	Pyrenophora triticirepentis	21.69	2.00e-13	71.60
IUUC-Sha-107489	Sarcophilus harrisii	63.43	0.00e+00	1297.00
IUUC-Ssl-108532	Sclerotinia sclerotiorum	27.59	6.00e-10	60.10
IUUC-Sre-115145	Sporisorium reilianum	25.32	3.00e-11	64.70
IUUC-Tgu-116609	Taeniopygia guttata	60.39	0.00e+00	1200.00
IUUC-Tru-117807	Takifugu rubripes	51.56	0.00e+00	1007.00
IUUC-Tsy-118971	Tarsius syrichta	59.56	0.00e+00	830.00
IUUC-Tni-119983	Tetraodon nigroviridis	50.32	0.00e+00	1025.00
IUUC-Ttr-128887	Tursiops truncatus	58.59	0.00e+00	1178.00
IUUC-Vda-129742	Verticillium dahliae	45.33	5.00e-11	63.90

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence