iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ont-071613

Ensembl Protein ID

ENSONIP00000005635.1

UniProt Accession

I3J9U5; I3J9U5_ORENI

Genbank Protein ID

ENSONIP00000005635

Protein Name

Histone deacetylase

Genbank Nucleotide ID

AERX01009574

Gene Name

hdac4 (1 of many); hdac4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000004475.1	ENSONIT00000005639.1	ENSONIP00000005635.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/Other	71.78	0.00e+00	1274.00	IUUC-Hsa-046925

Active Site

Position(s)	Description	Evidence
825	N/A	{ECO:0000256\|PIRSR:PIRSR037911-1}

Organism

Oreochromis niloticus

Functional Description
(View)

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

Protein Sequence
(Fasta)

MSTHSRQGGL TSTEKPLELI KPAAHNHFVD VSTAALPSTA TAILPMDLRV VDHAHHHQQQ 60
PSFGLVPPPH PTPPTSTSTE TGRGPVISQQ EQHLQQELVA LKHKQQLQRQ LLIAEFQRQH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGAAACACA GGGGGTTGTC TGACACGTGA TTAATTCAGT ATGGCGGATC TGTTGGCTGA 60
GTGATTTTTT TTTTTTTTTA ACGGCACCGA CGGGTCCTAA AACCCTGCTC CGTGGATGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc

Interpro

IPR033660--HDAC4
IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
IPR024643--Hist_deacetylase_Gln_rich_N
IPR017320--Histone_deAcase_II_euk
IPR015943--WD40/YVTN_repeat-like_dom

Pfam

PF12203--HDAC4_Gln
PF00850--Hist_deacetyl

PRINTS

PR01270--HDASUPER

Gene Ontology

GO:0000118--C:histone deacetylase complex
GO:0046872--F:metal ion binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0048701--P:embryonic cranial skeleton morphogenesis
GO:0001755--P:neural crest cell migration
GO:0090299--P:regulation of neural crest formation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002279	Ailuropoda melanoleuca	74.40	0.00e+00	1296.00
IUUC-Apl-003250	Anas platyrhynchos	71.15	0.00e+00	1234.00
IUUC-Aca-004668	Anolis carolinensis	81.09	0.00e+00	855.00
IUUC-Bta-013215	Bos taurus	75.00	0.00e+00	1284.00
IUUC-Cja-019816	Callithrix jacchus	72.27	0.00e+00	1281.00
IUUC-Cfa-020861	Canis familiaris	74.34	0.00e+00	1276.00
IUUC-Cpo-021562	Cavia porcellus	72.47	0.00e+00	1283.00
IUUC-Cre-022561	Chlamydomonas reinhardtii	52.70	7.00e-54	203.00
IUUC-Csa-023612	Chlorocebus sabaeus	71.41	0.00e+00	1251.00
IUUC-Csv-026359	Ciona savignyi	53.72	2.00e-90	325.00
IUUC-Dre-028284	Danio rerio	88.17	0.00e+00	881.00
IUUC-Dno-029951	Dasypus novemcinctus	69.02	0.00e+00	1174.00
IUUC-Dor-030362	Dipodomys ordii	63.32	0.00e+00	1038.00
IUUC-Dme-031766	Drosophila melanogaster	57.85	4.00e-155	542.00
IUUC-Fca-036187	Felis catus	74.68	0.00e+00	1319.00
IUUC-Gmo-038473	Gadus morhua	83.26	0.00e+00	796.00
IUUC-Gga-040501	Gallus gallus	73.59	0.00e+00	1264.00
IUUC-Gac-042335	Gasterosteus aculeatus	83.22	0.00e+00	1498.00
IUUC-Ggo-045380	Gorilla gorilla	72.07	0.00e+00	1254.00
IUUC-Hsa-046925	Homo sapiens	72.37	0.00e+00	1278.00
IUUC-Itr-048036	Ictidomys tridecemlineatus	71.77	0.00e+00	1251.00
IUUC-Lch-050325	Latimeria chalumnae	72.62	0.00e+00	1232.00
IUUC-Loc-052231	Lepisosteus oculatus	87.00	0.00e+00	865.00
IUUC-Laf-054490	Loxodonta africana	70.68	0.00e+00	1249.00
IUUC-Mcc-055265	Macaca mulatta	71.36	0.00e+00	1258.00
IUUC-Meu-056676	Macropus eugenii	80.82	7.00e-180	624.00
IUUC-Mmr-061633	Microcebus murinus	66.00	0.00e+00	1107.00
IUUC-Mmu-063089	Mus musculus	72.91	0.00e+00	1268.00
IUUC-Mpu-065887	Mustela putorius furo	75.10	0.00e+00	1308.00
IUUC-Mlu-067470	Myotis lucifugus	72.44	0.00e+00	1300.00
IUUC-Nle-069099	Nomascus leucogenys	64.62	0.00e+00	716.00
IUUC-Oan-073275	Ornithorhynchus anatinus	73.57	0.00e+00	1273.00
IUUC-Ola-087031	Oryzias latipes	81.16	0.00e+00	1490.00
IUUC-Oga-088201	Otolemur garnettii	66.21	0.00e+00	1147.00
IUUC-Oar-089997	Ovis aries	69.21	0.00e+00	1112.00
IUUC-Ptr-091116	Pan troglodytes	72.47	0.00e+00	1288.00
IUUC-Pan-092132	Papio anubis	71.30	0.00e+00	879.00
IUUC-Psi-093734	Pelodiscus sinensis	83.95	0.00e+00	834.00
IUUC-Pma-094347	Petromyzon marinus	68.41	0.00e+00	682.00
IUUC-Pfo-096293	Poecilia formosa	85.86	0.00e+00	1552.00
IUUC-Pab-098491	Pongo abelii	68.89	0.00e+00	1182.00
IUUC-Pca-101004	Procavia capensis	61.31	0.00e+00	635.00
IUUC-Pva-102961	Pteropus vampyrus	54.88	0.00e+00	635.00
IUUC-Rno-105005	Rattus norvegicus	72.81	0.00e+00	1263.00
IUUC-Sha-107646	Sarcophilus harrisii	63.08	1.00e-168	587.00
IUUC-Ssc-115428	Sus scrofa	72.51	0.00e+00	1278.00
IUUC-Tgu-116776	Taeniopygia guttata	70.86	0.00e+00	1212.00
IUUC-Tru-118180	Takifugu rubripes	81.55	0.00e+00	1529.00
IUUC-Tsy-119468	Tarsius syrichta	61.82	2.00e-151	530.00
IUUC-Tni-120196	Tetraodon nigroviridis	81.56	0.00e+00	1457.00
IUUC-Ttr-128360	Tursiops truncatus	67.39	0.00e+00	786.00
IUUC-Xtr-132956	Xenopus tropicalis	80.75	0.00e+00	821.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence