iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Eca-033720

Ensembl Protein ID

ENSECAP00000012868.1

UniProt Accession

F7DR40; F7DR40_HORSE

Protein Name

Tyrosine-protein kinase

Gene Name

ABL1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000014981.1	ENSECAT00000015960.1	ENSECAP00000012868.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.90e-14	52.9	58	115

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            +++ +lyd+ a+ d++L+++kG++++v+  ++++++W+++  ++++ +G +P+n+++ ++
   Q: 58   PNLFVALYDFVASGDNTLSITKGEKLRVL-GYNHNGEWCEA--QTKNGQGWVPSNYITPVN 115
           68899************************.***********..79999**********997 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

LKLVGCKSKK GLSSSSSCYL EEALQRPVAS DFEPQGLSEA ARWNSKENLL AGPSENDPNL 60
FVALYDFVAS GDNTLSITKG EKLRVLGYNH NGEWCEAQTK NGQGWVPSNY ITPVNSLEKH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTGAAGTTGG TGGGCTGCAA ATCCAAGAAG GGGCTCTCCT CGTCCTCCAG CTGCTACCTG 60
GAAGGTGAGC GCCGCGCCGC CGCCGGCGGG GGTCGAGGTG GCCGCGGGGG CACCGGCCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR033221--ABL1
IPR015015--F-actin_binding
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF08919--F_actin_bind
PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00109--TYRKINASE

SMART

SM00808--FABD
SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0031252--C:cell leading edge
GO:0005829--C:cytosol
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0016604--C:nuclear body
GO:0005730--C:nucleolus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005524--F:ATP binding
GO:0000287--F:magnesium ion binding
GO:0030145--F:manganese ion binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0090135--P:actin filament branching
GO:0050798--P:activated T cell proliferation
GO:1990051--P:activation of protein kinase C activity
GO:0046632--P:alpha-beta T cell differentiation
GO:0002322--P:B cell proliferation involved in immune response
GO:0050853--P:B cell receptor signaling pathway
GO:0001922--P:B-1 B cell homeostasis
GO:0060020--P:Bergmann glial cell differentiation
GO:0072358--P:cardiovascular system development
GO:0030154--P:cell differentiation
GO:0070301--P:cellular response to hydrogen peroxide
GO:0071222--P:cellular response to lipopolysaccharide
GO:0021587--P:cerebellum morphogenesis
GO:0048668--P:collateral sprouting
GO:0006975--P:DNA damage induced protein phosphorylation
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0045184--P:establishment of protein localization
GO:0045087--P:innate immune response
GO:0030035--P:microspike assembly
GO:0030514--P:negative regulation of BMP signaling pathway
GO:0022408--P:negative regulation of cell-cell adhesion
GO:2000773--P:negative regulation of cellular senescence
GO:2000352--P:negative regulation of endothelial cell apoptotic process
GO:0070373--P:negative regulation of ERK1 and ERK2 cascade
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045930--P:negative regulation of mitotic cell cycle
GO:1900275--P:negative regulation of phospholipase C activity
GO:0071901--P:negative regulation of protein serine/threonine kinase activity
GO:0051444--P:negative regulation of ubiquitin-protein transferase activity
GO:0001843--P:neural tube closure
GO:0060563--P:neuroepithelial cell differentiation
GO:0050885--P:neuromuscular process controlling balance
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0006909--P:phagocytosis
GO:0035791--P:platelet-derived growth factor receptor-beta signaling pathway
GO:1904531--P:positive regulation of actin filament binding
GO:0043065--P:positive regulation of apoptotic process
GO:0007204--P:positive regulation of cytosolic calcium ion concentration
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:1902715--P:positive regulation of interferon-gamma secretion
GO:1900042--P:positive regulation of interleukin-2 secretion
GO:1904528--P:positive regulation of microtubule binding
GO:0045931--P:positive regulation of mitotic cell cycle
GO:1901216--P:positive regulation of neuron death
GO:0033690--P:positive regulation of osteoblast proliferation
GO:0051353--P:positive regulation of oxidoreductase activity
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0051281--P:positive regulation of release of sequestered calcium ion into cytosol
GO:2000096--P:positive regulation of Wnt signaling pathway, planar cell polarity pathway
GO:0009791--P:post-embryonic development
GO:0032956--P:regulation of actin cytoskeleton organization
GO:0030516--P:regulation of axon extension
GO:0042127--P:regulation of cell proliferation
GO:1903053--P:regulation of extracellular matrix organization
GO:0031113--P:regulation of microtubule polymerization
GO:2001020--P:regulation of response to DNA damage stimulus
GO:0042770--P:signal transduction in response to DNA damage
GO:0048536--P:spleen development
GO:0034446--P:substrate adhesion-dependent cell spreading
GO:0048538--P:thymus development
GO:0002333--P:transitional one stage B cell differentiation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001550	Ailuropoda melanoleuca	93.76	0.00e+00	1823.00
IUUC-Atr-002778	Amborella trichopoda	32.99	1.00e-22	102.00
IUUC-Apl-003452	Anas platyrhynchos	80.32	0.00e+00	1651.00
IUUC-Aca-005312	Anolis carolinensis	75.04	0.00e+00	1454.00
IUUC-Ame-011903	Astyanax mexicanus	88.39	0.00e+00	1019.00
IUUC-Bta-012351	Bos taurus	92.14	0.00e+00	1818.00
IUUC-Cja-019491	Callithrix jacchus	91.14	0.00e+00	1877.00
IUUC-Cfa-021256	Canis familiaris	92.94	0.00e+00	1874.00
IUUC-Cpo-022046	Cavia porcellus	89.33	0.00e+00	1496.00
IUUC-Csa-023046	Chlorocebus sabaeus	91.43	0.00e+00	1904.00
IUUC-Dre-028190	Danio rerio	66.91	0.00e+00	1202.00
IUUC-Dno-029853	Dasypus novemcinctus	90.69	0.00e+00	1820.00
IUUC-Dor-030635	Dipodomys ordii	83.03	0.00e+00	1621.00
IUUC-Dme-032098	Drosophila melanogaster	74.89	0.00e+00	776.00
IUUC-Eeu-035173	Erinaceus europaeus	90.01	0.00e+00	1417.00
IUUC-Fca-035967	Felis catus	93.57	0.00e+00	1810.00
IUUC-Fal-036723	Ficedula albicollis	81.41	0.00e+00	1657.00
IUUC-Gmo-039550	Gadus morhua	78.17	0.00e+00	1087.00
IUUC-Gga-040481	Gallus gallus	81.68	0.00e+00	1626.00
IUUC-Gac-041643	Gasterosteus aculeatus	67.50	0.00e+00	1265.00
IUUC-Ggo-045299	Gorilla gorilla	90.93	0.00e+00	1891.00
IUUC-Hsa-047033	Homo sapiens	100.00	3.00e-42	162.00
IUUC-Itr-047935	Ictidomys tridecemlineatus	90.23	0.00e+00	1763.00
IUUC-Lch-050530	Latimeria chalumnae	77.01	0.00e+00	1538.00
IUUC-Loc-052430	Lepisosteus oculatus	92.61	0.00e+00	984.00
IUUC-Laf-053609	Loxodonta africana	91.49	0.00e+00	1776.00
IUUC-Mcc-055654	Macaca mulatta	91.50	0.00e+00	1929.00
IUUC-Meu-056488	Macropus eugenii	77.44	0.00e+00	1537.00
IUUC-Mga-059270	Meleagris gallopavo	81.34	0.00e+00	1666.00
IUUC-Mmr-060593	Microcebus murinus	91.39	0.00e+00	1863.00
IUUC-Mdo-062227	Monodelphis domestica	90.95	0.00e+00	1282.00
IUUC-Mmu-064002	Mus musculus	85.11	0.00e+00	1752.00
IUUC-Mpu-066197	Mustela putorius furo	93.12	0.00e+00	1830.00
IUUC-Mlu-067255	Myotis lucifugus	95.04	0.00e+00	1867.00
IUUC-Nle-069977	Nomascus leucogenys	87.87	0.00e+00	1320.00
IUUC-Opr-070327	Ochotona princeps	82.17	0.00e+00	1573.00
IUUC-Ont-072307	Oreochromis niloticus	64.98	0.00e+00	1224.00
IUUC-Oan-073100	Ornithorhynchus anatinus	84.25	0.00e+00	1709.00
IUUC-Ocu-074892	Oryctolagus cuniculus	82.87	0.00e+00	1597.00
IUUC-Ola-087389	Oryzias latipes	67.59	0.00e+00	1051.00
IUUC-Oga-088145	Otolemur garnettii	90.70	0.00e+00	1851.00
IUUC-Oar-090432	Ovis aries	95.11	0.00e+00	1478.00
IUUC-Ptr-090800	Pan troglodytes	91.50	0.00e+00	1895.00
IUUC-Psi-093078	Pelodiscus sinensis	80.78	0.00e+00	1727.00
IUUC-Pma-094420	Petromyzon marinus	78.34	0.00e+00	899.00
IUUC-Pfo-096979	Poecilia formosa	70.68	0.00e+00	1048.00
IUUC-Pca-100874	Procavia capensis	99.40	0.00e+00	673.00
IUUC-Pva-102415	Pteropus vampyrus	93.67	0.00e+00	1830.00
IUUC-Rno-105370	Rattus norvegicus	85.60	0.00e+00	1755.00
IUUC-Sha-106711	Sarcophilus harrisii	83.87	0.00e+00	1727.00
IUUC-Ssc-115472	Sus scrofa	93.93	0.00e+00	1824.00
IUUC-Tgu-117037	Taeniopygia guttata	81.81	0.00e+00	1677.00
IUUC-Tru-118324	Takifugu rubripes	61.46	0.00e+00	1081.00
IUUC-Tsy-119216	Tarsius syrichta	96.69	0.00e+00	1080.00
IUUC-Tni-119950	Tetraodon nigroviridis	60.44	0.00e+00	1053.00
IUUC-Ttr-128209	Tursiops truncatus	95.02	0.00e+00	1940.00
IUUC-Xtr-132477	Xenopus tropicalis	71.45	0.00e+00	1093.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence