iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xma-134191

Ensembl Protein ID

ENSXMAP00000011586.1

UniProt Accession

M4AAU2; M4AAU2_XIPMA

Genbank Protein ID

ENSXMAP00000011586

Protein Name

Ubiquitin thioesterase

Genbank Nucleotide ID

AGAJ01008727

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXMAG00000011561.1	ENSXMAT00000011600.1	ENSXMAP00000011586.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	6.20e-44	149.8	76	266

Active Site

Position(s)	Description	Evidence
83	N/A	{ECO:0000256\|PIRSR:PIRSR013503-1}
86	Nucleophile	{ECO:0000256\|PIRSR:PIRSR013503-1}
260		{ECO:0000256\|PIRSR:PIRSR013503-1}

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqs..........................................................llgvfdddslsd 32
           +i+kt++DGnC++rA++++                                                          ll++f+d+ +sd
   Q: 76   YIRKTRPDGNCFYRAFGFAhlesllddskelqkfkavaakskldlvsegfteftiedfhntfmdlielcekhprlqeLLNSFNDQNMSD 164
           89*************************************************************************************** PP
   S: 33   alveaLreltseylqkesdffsefieekedekefcqklvepeak.geeihifaLaqiLsrpiivvdvdsleskvggillpllfpeeklk 120
           ++v++Lr+lts ylq+e+ ff++fie+++++kefcq++vep++k +++ihi+aLa++L+++i v+++d++e   gg ++ ++fpe   +
   Q: 165  YVVVYLRLLTSGYLQREHGFFEHFIEGGRTIKEFCQQEVEPMSKeSDHIHIIALAKALNVSILVEYMDRGE---GGSVNNHIFPEGG-D 249
           **********************************************************************9...9************.* PP
   S: 121  kpivLlYrsgHYdaLva 137
           ++i LlYr+gHYd+L++
   Q: 250  PRIFLLYRPGHYDILYK 266
           ***************96 PP

Organism

Xiphophorus maculatus

Protein Sequence
(Fasta)

MAEEQQESSQ GEMEGVNCLA YDEAIIAQQD RIQQEIANSN PLVSDRQDLS VLQREYAEDD 60
TVYQLKLKDL YKKYAYIRKT RPDGNCFYRA FGFAHLESLL DDSKELQKFK AVAAKSKLDL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCACGGAGA AGGAGGAAAC AGATCTCGAT CGCTAAGATG GCGGAGGAAC AGCAGGAATC 60
CTCGCAGGGA GAGATGGAAG GTGAGAAAAT CAGCTGCTCG TGAAAATCTC CAACAAGGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR003323--OTU_dom
IPR030298--OTUB1
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0005634--C:nucleus
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0071108--P:protein K48-linked deubiquitination

KEGG

xma:102221374

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001871	Ailuropoda melanoleuca	78.23	1.00e-125	442.00
IUUC-Apl-003233	Anas platyrhynchos	56.92	8.00e-16	74.70
IUUC-Aca-004648	Anolis carolinensis	77.43	2.00e-117	414.00
IUUC-Aly-005710	Arabidopsis lyrata	40.79	4.00e-50	191.00
IUUC-Ath-007112	Arabidopsis thaliana	40.65	2.00e-49	188.00
IUUC-Afl-008439	Aspergillus flavus	31.65	3.00e-07	48.90
IUUC-Ame-010662	Astyanax mexicanus	88.35	2.00e-144	504.00
IUUC-Bta-013533	Bos taurus	81.03	6.00e-124	436.00
IUUC-Bol-016100	Brassica oleracea	40.53	1.00e-48	186.00
IUUC-Bra-017705	Brassica rapa	38.08	1.00e-42	166.00
IUUC-Cel-018295	Caenorhabditis elegans	34.43	2.00e-40	159.00
IUUC-Cja-019190	Callithrix jacchus	81.42	3.00e-124	437.00
IUUC-Cfa-020430	Canis familiaris	80.71	1.00e-123	435.00
IUUC-Cpo-022355	Cavia porcellus	81.03	3.00e-124	437.00
IUUC-Cre-022997	Chlamydomonas reinhardtii	37.04	3.00e-42	165.00
IUUC-Csa-023286	Chlorocebus sabaeus	78.63	5.00e-122	430.00
IUUC-Cho-024411	Choloepus hoffmanni	44.19	1.00e-27	115.00
IUUC-Cin-025507	Ciona intestinalis	46.11	6.00e-45	173.00
IUUC-Csv-026273	Ciona savignyi	48.98	2.00e-66	245.00
IUUC-Dre-028315	Danio rerio	85.02	6.00e-129	452.00
IUUC-Dno-029165	Dasypus novemcinctus	82.00	8.00e-99	352.00
IUUC-Dor-030943	Dipodomys ordii	81.03	3.00e-124	437.00
IUUC-Dme-031922	Drosophila melanogaster	54.80	2.00e-74	272.00
IUUC-Ete-032296	Echinops telfairi	77.36	1.00e-72	266.00
IUUC-Eca-033695	Equus caballus	80.31	4.00e-123	433.00
IUUC-Eeu-034775	Erinaceus europaeus	45.09	1.00e-55	209.00
IUUC-Fca-036441	Felis catus	80.71	1.00e-123	435.00
IUUC-Gmo-038908	Gadus morhua	87.97	3.00e-142	497.00
IUUC-Ggr-040020	Gaeumannomyces graminis	32.85	1.00e-30	127.00
IUUC-Gga-040460	Gallus gallus	71.43	3.00e-114	404.00
IUUC-Gac-042417	Gasterosteus aculeatus	91.20	5.00e-139	486.00
IUUC-Gma-043712	Glycine max	41.64	6.00e-50	191.00
IUUC-Ggo-044552	Gorilla gorilla	80.50	3.00e-75	275.00
IUUC-Hsa-046766	Homo sapiens	81.42	2.00e-124	437.00
IUUC-Itr-048312	Ictidomys tridecemlineatus	81.03	3.00e-124	437.00
IUUC-Lch-050602	Latimeria chalumnae	75.40	2.00e-111	395.00
IUUC-Laf-053705	Loxodonta africana	81.03	3.00e-124	437.00
IUUC-Mcc-055745	Macaca mulatta	76.01	8.00e-121	426.00
IUUC-Meu-056569	Macropus eugenii	69.70	6.00e-108	383.00
IUUC-Mtr-057712	Medicago truncatula	40.28	8.00e-46	177.00
IUUC-Mvi-060358	Microbotryum violaceum	33.33	9.00e-16	77.40
IUUC-Mmr-061123	Microcebus murinus	82.63	3.00e-103	368.00
IUUC-Mdo-062613	Monodelphis domestica	72.32	3.00e-100	358.00
IUUC-Mmu-063658	Mus musculus	81.03	3.00e-124	437.00
IUUC-Mac-065274	Musa acuminata	35.60	2.00e-35	142.00
IUUC-Mpu-066172	Mustela putorius furo	81.42	2.00e-124	437.00
IUUC-Mlu-066966	Myotis lucifugus	81.18	8.00e-125	439.00
IUUC-Nle-069519	Nomascus leucogenys	71.51	6.00e-76	277.00
IUUC-Opr-070761	Ochotona princeps	37.04	9.00e-27	112.00
IUUC-Ont-071901	Oreochromis niloticus	92.83	6.00e-141	493.00
IUUC-Oan-072922	Ornithorhynchus anatinus	44.20	1.00e-56	213.00
IUUC-Ocu-074643	Oryctolagus cuniculus	44.64	7.00e-56	210.00
IUUC-Oni-082026	Oryza nivara	28.14	1.00e-11	64.30
IUUC-Oru-084761	Oryza rufipogon	28.14	1.00e-11	64.30
IUUC-Ola-087331	Oryzias latipes	86.84	3.00e-96	344.00
IUUC-Oga-088064	Otolemur garnettii	81.42	2.00e-124	437.00
IUUC-Oar-089251	Ovis aries	80.63	2.00e-122	431.00
IUUC-Ptr-091430	Pan troglodytes	81.42	5.00e-124	437.00
IUUC-Pan-091969	Papio anubis	44.64	4.00e-56	211.00
IUUC-Psi-093823	Pelodiscus sinensis	75.95	1.00e-116	412.00
IUUC-Pma-094366	Petromyzon marinus	70.19	3.00e-99	354.00
IUUC-Pfo-096734	Poecilia formosa	98.41	2.00e-137	481.00
IUUC-Pab-097919	Pongo abelii	82.16	6.00e-102	363.00
IUUC-Pop-099401	Populus trichocarpa	39.86	3.00e-48	185.00
IUUC-Pca-100252	Procavia capensis	41.05	1.00e-17	83.20
IUUC-Ppe-101977	Prunus persica	41.64	1.00e-49	190.00
IUUC-Pva-102499	Pteropus vampyrus	81.27	5.00e-123	433.00
IUUC-Rno-105233	Rattus norvegicus	81.03	3.00e-124	437.00
IUUC-Sha-107081	Sarcophilus harrisii	80.16	1.00e-122	432.00
IUUC-Sja-107853	Schizosaccharomyces japonicus	30.00	4.60e+00	26.90
IUUC-Sly-111640	Solanum lycopersicum	40.52	1.00e-46	180.00
IUUC-Sar-113295	Sorex araneus	45.54	3.00e-55	207.00
IUUC-Ssc-116202	Sus scrofa	81.42	2.00e-124	437.00
IUUC-Tru-117664	Takifugu rubripes	89.67	5.00e-146	509.00
IUUC-Tca-121467	Theobroma cacao	40.81	1.00e-48	186.00
IUUC-Tbe-128116	Tupaia belangeri	79.50	1.00e-75	276.00
IUUC-Ttr-128622	Tursiops truncatus	80.63	8.00e-122	429.00
IUUC-Uma-129443	Ustilago maydis	31.40	2.00e-25	109.00
IUUC-Vvi-131389	Vitis vinifera	40.81	5.00e-49	187.00
IUUC-Xtr-131951	Xenopus tropicalis	43.86	6.00e-53	200.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence