iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Eca-034387

Ensembl Protein ID

ENSECAP00000006514.1

UniProt Accession

F6WAW1; F6WAW1_HORSE

Protein Name

Presenilin

Gene Name

PSEN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000008285.1	ENSECAT00000008666.1	ENSECAP00000006514.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	3.60e-08	33.4	285	323

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavnnLL 40
           +eta+e++++iFP+l+ys+ +v+ + +++ +++++++L 
   Q: 285  VETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQ 323
           89********************************99986 PP

Organism

Equus caballus

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

GASHGGAMLT FMASDSEEEV CDERTSLMSA ESPTPRSCQE GRPGPEDGES AAPWRGQDGE 60
EDHEEDPDHY VCSGVPGRPP GLEEELTLKY GAKHVIMLFV PVTLCMIVVV ATIKSVRFYT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTGCTTCCC ACGGTGGGGC TATGCTTACG TTCATGGCCT CTGACAGTGA GGAAGAAGTG 60
TGCGACGAGC GGACGTCCCT GATGTCAGCC GAGAGCCCCA CGCCGCGCTC CTGCCAGGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001493--Pept_A22A_PS2
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN
PR01074--PRESENILIN2

SMART

SM00730--PSN

Gene Ontology

GO:0005813--C:centrosome
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0005887--C:integral component of plasma membrane
GO:0000776--C:kinetochore
GO:0043025--C:neuronal cell body
GO:0005637--C:nuclear inner membrane
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0030018--C:Z disc
GO:0004190--F:aspartic-type endopeptidase activity
GO:0004175--F:endopeptidase activity
GO:0042987--P:amyloid precursor protein catabolic process
GO:0050435--P:beta-amyloid metabolic process
GO:0006816--P:calcium ion transport
GO:0035556--P:intracellular signal transduction
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0043066--P:negative regulation of apoptotic process
GO:0007220--P:Notch receptor processing
GO:0007219--P:Notch signaling pathway
GO:0043085--P:positive regulation of catalytic activity
GO:0016485--P:protein processing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000686	Aegilops tauschii	58.02	3.00e-15	77.40
IUUC-Aml-002356	Ailuropoda melanoleuca	88.13	1.00e-179	622.00
IUUC-Atr-003039	Amborella trichopoda	31.86	2.00e-20	93.20
IUUC-Apl-003959	Anas platyrhynchos	75.97	6.00e-161	560.00
IUUC-Aca-005160	Anolis carolinensis	75.79	5.00e-158	550.00
IUUC-Ang-009768	Aspergillus niger	44.44	4.10e+00	26.60
IUUC-Ame-010686	Astyanax mexicanus	79.95	2.00e-147	515.00
IUUC-Bta-013097	Bos taurus	95.32	0.00e+00	712.00
IUUC-Cel-018553	Caenorhabditis elegans	48.12	4.00e-91	328.00
IUUC-Cja-018824	Callithrix jacchus	93.63	0.00e+00	726.00
IUUC-Cfa-020253	Canis familiaris	94.87	0.00e+00	731.00
IUUC-Cpo-021401	Cavia porcellus	95.09	0.00e+00	732.00
IUUC-Cre-022747	Chlamydomonas reinhardtii	33.89	1.00e-29	124.00
IUUC-Csa-023369	Chlorocebus sabaeus	95.98	0.00e+00	743.00
IUUC-Cho-024735	Choloepus hoffmanni	64.65	1.00e-117	416.00
IUUC-Cin-025780	Ciona intestinalis	60.90	2.00e-115	408.00
IUUC-Csv-025967	Ciona savignyi	61.06	2.00e-116	412.00
IUUC-Dre-028526	Danio rerio	71.21	3.00e-144	504.00
IUUC-Dno-029758	Dasypus novemcinctus	71.14	3.00e-125	441.00
IUUC-Dor-031127	Dipodomys ordii	90.67	0.00e+00	682.00
IUUC-Dme-031929	Drosophila melanogaster	63.60	1.00e-81	296.00
IUUC-Ete-033081	Echinops telfairi	83.33	5.00e-92	331.00
IUUC-Eeu-034846	Erinaceus europaeus	80.52	1.00e-149	522.00
IUUC-Fca-035396	Felis catus	94.04	0.00e+00	752.00
IUUC-Fal-037457	Ficedula albicollis	76.09	4.00e-160	557.00
IUUC-Gmo-038550	Gadus morhua	83.62	4.00e-106	377.00
IUUC-Gga-040706	Gallus gallus	76.04	3.00e-156	544.00
IUUC-Gac-042511	Gasterosteus aculeatus	66.88	5.00e-130	457.00
IUUC-Gma-043822	Glycine max	37.29	7.00e-23	101.00
IUUC-Ggo-045338	Gorilla gorilla	95.82	0.00e+00	752.00
IUUC-Hsa-046455	Homo sapiens	95.82	0.00e+00	752.00
IUUC-Itr-048731	Ictidomys tridecemlineatus	95.76	0.00e+00	739.00
IUUC-Lch-049638	Latimeria chalumnae	68.88	3.00e-145	508.00
IUUC-Lpe-051132	Leersia perrieri	36.23	8.00e-17	81.30
IUUC-Loc-052427	Lepisosteus oculatus	74.56	8.00e-158	549.00
IUUC-Laf-053758	Loxodonta africana	88.91	0.00e+00	716.00
IUUC-Mcc-054755	Macaca mulatta	95.60	0.00e+00	749.00
IUUC-Meu-056004	Macropus eugenii	75.64	1.00e-91	330.00
IUUC-Mtr-058392	Medicago truncatula	34.05	2.00e-29	123.00
IUUC-Mga-059466	Meleagris gallopavo	72.98	4.00e-129	454.00
IUUC-Mmr-060890	Microcebus murinus	95.09	0.00e+00	727.00
IUUC-Mdo-062197	Monodelphis domestica	80.56	8.00e-176	609.00
IUUC-Mmu-063823	Mus musculus	94.64	0.00e+00	735.00
IUUC-Mac-064858	Musa acuminata	43.86	6.00e-23	101.00
IUUC-Mpu-066181	Mustela putorius furo	94.42	0.00e+00	726.00
IUUC-Mlu-067079	Myotis lucifugus	71.07	9.00e-133	466.00
IUUC-Nle-069596	Nomascus leucogenys	96.20	0.00e+00	696.00
IUUC-Opr-070344	Ochotona princeps	93.39	0.00e+00	746.00
IUUC-Ont-071867	Oreochromis niloticus	71.46	2.00e-133	468.00
IUUC-Oan-073378	Ornithorhynchus anatinus	74.70	7.00e-155	540.00
IUUC-Ocu-074652	Oryctolagus cuniculus	93.85	0.00e+00	706.00
IUUC-Oba-075256	Oryza barthii	60.49	3.00e-16	79.30
IUUC-Obr-076302	Oryza brachyantha	36.23	1.00e-16	81.30
IUUC-Ogl-077097	Oryza glaberrima	36.23	2.00e-16	80.10
IUUC-Ogu-078570	Oryza glumaepatula	36.23	2.00e-16	80.10
IUUC-Oin-079244	Oryza indica	36.96	1.00e-16	80.90
IUUC-Olo-080484	Oryza longistaminata	60.49	1.00e-16	79.70
IUUC-Ome-081814	Oryza meridionalis	35.75	8.00e-17	81.60
IUUC-Oni-082057	Oryza nivara	36.96	1.00e-16	80.90
IUUC-Oru-084618	Oryza rufipogon	36.96	1.00e-16	80.50
IUUC-Osa-085602	Oryza sativa	36.31	8.00e-17	81.30
IUUC-Ola-086707	Oryzias latipes	70.55	8.00e-107	379.00
IUUC-Olu-087811	Ostreococcus lucimarinus	38.81	1.00e-46	179.00
IUUC-Oga-088560	Otolemur garnettii	94.90	0.00e+00	696.00
IUUC-Oar-089200	Ovis aries	94.88	0.00e+00	694.00
IUUC-Ptr-090569	Pan troglodytes	95.98	0.00e+00	741.00
IUUC-Pan-091742	Papio anubis	96.21	0.00e+00	742.00
IUUC-Psi-093505	Pelodiscus sinensis	72.66	3.00e-130	458.00
IUUC-Pma-094612	Petromyzon marinus	78.10	8.00e-129	453.00
IUUC-Ppa-095431	Physcomitrella patens	31.40	3.00e-27	116.00
IUUC-Pfo-097396	Poecilia formosa	68.58	2.00e-128	452.00
IUUC-Pab-098531	Pongo abelii	95.98	0.00e+00	743.00
IUUC-Pop-099661	Populus trichocarpa	32.27	3.00e-29	122.00
IUUC-Pca-101120	Procavia capensis	91.63	0.00e+00	712.00
IUUC-Ppe-101495	Prunus persica	33.33	2.00e-21	97.10
IUUC-Pva-102934	Pteropus vampyrus	85.93	0.00e+00	702.00
IUUC-Rno-106052	Rattus norvegicus	93.97	0.00e+00	749.00
IUUC-Sha-106876	Sarcophilus harrisii	79.53	6.00e-175	606.00
IUUC-Smo-109325	Selaginella moellendorffii	37.62	1.00e-30	126.00
IUUC-Stu-112433	Solanum tuberosum	33.33	4.00e-17	82.40
IUUC-Ssc-115380	Sus scrofa	97.10	0.00e+00	770.00
IUUC-Tgu-117280	Taeniopygia guttata	76.74	8.00e-161	559.00
IUUC-Tru-117732	Takifugu rubripes	69.02	7.00e-122	430.00
IUUC-Tsy-119624	Tarsius syrichta	60.72	2.00e-122	432.00
IUUC-Tni-119852	Tetraodon nigroviridis	65.24	3.00e-114	405.00
IUUC-Tca-121865	Theobroma cacao	35.91	1.00e-20	94.40
IUUC-Tbe-127632	Tupaia belangeri	95.36	0.00e+00	627.00
IUUC-Ttr-129008	Tursiops truncatus	94.24	0.00e+00	727.00
IUUC-Vvi-131312	Vitis vinifera	38.24	1.00e-19	90.90
IUUC-Xtr-132756	Xenopus tropicalis	72.08	7.00e-164	570.00
IUUC-Xma-133377	Xiphophorus maculatus	68.78	4.00e-126	444.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence