iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Mmu-064415

Ensembl Protein ID

ENSMUSP00000047403.9

UniProt Accession

Q8BM54; Q3TX01; Q8BLY9; Q91Z47; MYLIP_MOUSE

Genbank Protein ID

AAQ98867.1; BAC28868.1; BAC30716.1; BAE35115.1; AAH10206.1

Protein Name

E3 ubiquitin-protein ligase MYLIP; Inducible degrader of the LDL-receptor; Myosin regulatory light chain-interacting protein; RING-type E3 ubiquitin transferase MYLIP

Genbank Nucleotide ID

AY434449; AK034887; AK040836; AK159478; BC010206

Gene Name

Mylip

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000038175.9	ENSMUST00000038275.9	ENSMUSP00000047403.9

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
miRecords	miRNAMap	RAID2
Protein-protein Interaction
IID	Mentha
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	96.18	0.00e+00	810.00	IUUC-Hsa-046869

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.

Protein Sequence
(Fasta)

MLCYVTRPDA VLMEVEVEAK ANGEDCLNQV CRRLGIIEVD YFGLQFTGSK GESLWLNLRN 60
RISQQMDGLA PYRLKLRVKF FVEPHLILQE QTRHIFFLHI KESLLAGHLQ CSPEQAVELS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTAGGGCTG TCGGAGCGGC GCGGCCGTGT AGCTCCCGGG AACTGGCTGT CGTGGGGGTG 60
GCGGGGACGC GAGTGGCGGC TGCGTGGGGT GCAGGGCGGG TGGCCGCACG GCTGCACCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0408--Iron
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR019749--Band_41_domain
IPR000798--Ez/rad/moesin-like
IPR014352--FERM/acyl-CoA-bd_prot_3-hlx
IPR019748--FERM_central
IPR000299--FERM_domain
IPR018979--FERM_N
IPR018980--FERM_PH-like_C
IPR011993--PH_dom-like
IPR029071--Ubiquitin-rel_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50057--FERM_3
PS50089--ZF_RING_2

Pfam

PF09380--FERM_C
PF00373--FERM_M
PF09379--FERM_N

PRINTS

PR00935--BAND41
PR00661--ERMFAMILY

SMART

SM00295--B41
SM01196--FERM_C

Gene Ontology

GO:0005737--C:cytoplasm
GO:0019898--C:extrinsic component of membrane
GO:0005622--C:intracellular
GO:0005886--C:plasma membrane
GO:0008092--F:cytoskeletal protein binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0042632--P:cholesterol homeostasis
GO:0010989--P:negative regulation of low-density lipoprotein particle clearance
GO:0007399--P:nervous system development
GO:0045732--P:positive regulation of protein catabolic process
GO:0031648--P:protein destabilization
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032803--P:regulation of low-density lipoprotein particle receptor catabolic process
GO:0055098--P:response to low-density lipoprotein particle

KEGG

mmu:218203

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001425	Ailuropoda melanoleuca	94.71	0.00e+00	788.00
IUUC-Apl-003704	Anas platyrhynchos	89.98	0.00e+00	766.00
IUUC-Aca-004645	Anolis carolinensis	88.76	0.00e+00	758.00
IUUC-Ame-011401	Astyanax mexicanus	74.55	0.00e+00	652.00
IUUC-Bta-012752	Bos taurus	93.68	0.00e+00	700.00
IUUC-Cja-019734	Callithrix jacchus	95.06	0.00e+00	840.00
IUUC-Cfa-020145	Canis familiaris	94.74	0.00e+00	715.00
IUUC-Cpo-021436	Cavia porcellus	95.26	0.00e+00	714.00
IUUC-Csa-024248	Chlorocebus sabaeus	95.73	0.00e+00	845.00
IUUC-Cho-024528	Choloepus hoffmanni	83.60	0.00e+00	674.00
IUUC-Cin-025748	Ciona intestinalis	36.33	3.00e-47	181.00
IUUC-Csv-025837	Ciona savignyi	38.85	1.00e-90	327.00
IUUC-Dre-027847	Danio rerio	74.77	0.00e+00	660.00
IUUC-Dno-029860	Dasypus novemcinctus	93.68	0.00e+00	673.00
IUUC-Dor-030664	Dipodomys ordii	83.37	0.00e+00	687.00
IUUC-Dse-031509	Dothistroma septosporum	45.10	3.00e-09	57.40
IUUC-Dme-031990	Drosophila melanogaster	29.57	3.00e-34	140.00
IUUC-Ete-032496	Echinops telfairi	75.81	1.00e-144	506.00
IUUC-Eca-033674	Equus caballus	93.99	0.00e+00	844.00
IUUC-Eeu-035048	Erinaceus europaeus	86.07	0.00e+00	756.00
IUUC-Fca-036547	Felis catus	95.19	0.00e+00	790.00
IUUC-Fal-037504	Ficedula albicollis	90.41	0.00e+00	753.00
IUUC-Fox-037905	Fusarium oxysporum	27.85	7.00e-03	33.10
IUUC-Gmo-038660	Gadus morhua	74.71	4.00e-154	537.00
IUUC-Gga-040123	Gallus gallus	90.79	0.00e+00	801.00
IUUC-Gac-042073	Gasterosteus aculeatus	71.97	0.00e+00	631.00
IUUC-Ggo-045387	Gorilla gorilla	96.18	0.00e+00	848.00
IUUC-Hsa-046869	Homo sapiens	96.18	0.00e+00	854.00
IUUC-Itr-047917	Ictidomys tridecemlineatus	95.06	0.00e+00	829.00
IUUC-Lch-049990	Latimeria chalumnae	81.57	0.00e+00	765.00
IUUC-Loc-051908	Lepisosteus oculatus	76.12	0.00e+00	663.00
IUUC-Lma-053223	Leptosphaeria maculans	52.50	6.00e-08	53.90
IUUC-Laf-053915	Loxodonta africana	93.48	0.00e+00	826.00
IUUC-Mcc-054865	Macaca mulatta	95.51	0.00e+00	843.00
IUUC-Meu-056826	Macropus eugenii	84.42	1.00e-73	270.00
IUUC-Mga-059827	Meleagris gallopavo	89.95	0.00e+00	722.00
IUUC-Mmr-060734	Microcebus murinus	95.73	0.00e+00	847.00
IUUC-Mdo-062988	Monodelphis domestica	93.26	0.00e+00	835.00
IUUC-Mpu-066118	Mustela putorius furo	94.74	0.00e+00	711.00
IUUC-Mlu-067131	Myotis lucifugus	94.38	0.00e+00	808.00
IUUC-Nle-070112	Nomascus leucogenys	95.96	0.00e+00	845.00
IUUC-Opr-071193	Ochotona princeps	92.71	0.00e+00	790.00
IUUC-Ont-072635	Oreochromis niloticus	74.27	0.00e+00	649.00
IUUC-Oan-073266	Ornithorhynchus anatinus	89.18	0.00e+00	745.00
IUUC-Ocu-074903	Oryctolagus cuniculus	92.58	0.00e+00	816.00
IUUC-Ola-087533	Oryzias latipes	71.59	2.00e-176	612.00
IUUC-Oga-087979	Otolemur garnettii	96.18	0.00e+00	851.00
IUUC-Oar-089747	Ovis aries	93.75	0.00e+00	771.00
IUUC-Ptr-090732	Pan troglodytes	96.40	0.00e+00	850.00
IUUC-Pan-092032	Papio anubis	95.73	0.00e+00	845.00
IUUC-Psi-093296	Pelodiscus sinensis	89.98	0.00e+00	762.00
IUUC-Pma-094351	Petromyzon marinus	49.16	2.00e-32	131.00
IUUC-Pfo-097183	Poecilia formosa	73.52	4.00e-176	610.00
IUUC-Pab-098177	Pongo abelii	95.96	0.00e+00	847.00
IUUC-Pca-100734	Procavia capensis	91.91	0.00e+00	819.00
IUUC-Pva-102778	Pteropus vampyrus	95.43	0.00e+00	795.00
IUUC-Rno-106039	Rattus norvegicus	99.33	0.00e+00	860.00
IUUC-Sha-106869	Sarcophilus harrisii	93.03	0.00e+00	776.00
IUUC-Sar-113587	Sorex araneus	64.90	4.00e-141	494.00
IUUC-Ssc-116212	Sus scrofa	94.83	0.00e+00	834.00
IUUC-Tgu-116871	Taeniopygia guttata	90.17	0.00e+00	750.00
IUUC-Tru-117925	Takifugu rubripes	73.48	0.00e+00	669.00
IUUC-Tsy-118815	Tarsius syrichta	93.75	0.00e+00	767.00
IUUC-Tni-120007	Tetraodon nigroviridis	73.42	0.00e+00	639.00
IUUC-Tbe-127381	Tupaia belangeri	92.05	0.00e+00	635.00
IUUC-Ttr-129025	Tursiops truncatus	92.24	5.00e-115	407.00
IUUC-Vpa-130164	Vicugna pacos	77.53	2.00e-175	608.00
IUUC-Xtr-132800	Xenopus tropicalis	83.15	0.00e+00	736.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence