iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oan-073046

UUCD1 version

UUC-OrA-00347

Ensembl Protein ID

ENSOANP00000001129.1

UniProt Accession

F6ZDQ7; F6ZDQ7_ORNAN

Protein Name

Uncharacterized protein

Gene Name

HUWE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000000714.5	ENSOANT00000001130.2	ENSOANP00000001129.1
ENSOANG00000000714.5	ENSOANT00000001129.4	ENSOANP00000001128.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.00e-121	405.1	4043	4379
UBD/Alpha-Helix/UBA	7.00e-08	32.6	1324	1361

Active Site

Position(s)	Description	Evidence
4347	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrll 88
           ++++k+rl++ f+gEeg+d+gG+ re++  +s+e++np++ lf++s++d+ t+++np+s + np+hl++F+f+Gr+++ka++d+rll
   Q: 4043 PEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHC-NPNHLSYFKFVGRIVAKAVYDNRLL 4128
           6799*******************************************************86.99*********************** PP
   S: 89   dlplsksfyklllgkklsl..edleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeY 173
           ++ +++sfyk++lgk++s    d+e+ d ++y+ l +++en   d+++lg dltfs++ +++g +++++Lkp+G+ni Vt+eNk+eY
   Q: 4129 ECYFTRSFYKHILGKSVSCryTDMESEDYHFYQGLVYLLEN---DVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEY 4212
           ***************7665449*****************99...******************************************* PP
   S: 174  vklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefssee 260
           v+lv+++r++  i++q++af eGf+e+ip++l+s+Fte+elelli+G ++id++dlk++t+y++ y+++s +iqwFw++l++f++ +
   Q: 4213 VHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEYHK-YQSNSIQIQWFWRALRSFDQAD 4298
           **************************************************************66.********************** PP
   S: 261  rkafLqFvTgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           r++fLqFvTg+s++Pl+Gfa+l+     ++f+i++ d+s+drlPs++TCfn+L+LP Y+s+e+l+++Ll+Ai+e+ +gF+l
   Q: 4299 RAKFLQFVTGTSKVPLQGFAALEgmngIQKFQIHRdDRSTDRLPSAHTCFNQLDLPAYESYEKLRHMLLLAIQECsEGFGL 4379
           ***********************99998999999988899***************************************97 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLldg 41
           ++++l+ql++MGF+re+a +aL++   + e A+eyLl++
   Q: 1324 NQQQLQQLMDMGFTREHAMEALLN-TSTMEQATEYLLTH 1361
           89**********************.7***********98 PP

Organism

Ornithorhynchus anatinus

Protein Sequence
(Fasta)

MKVDRTKLKK TPTEAPADCR ALIDKLKVCN DEQLLLELQQ IKTWNIGKCE LYHWVDLLDR 60
FDGILADAGQ TVENMSWMLV CDRPEKEQLK SLLLAVLNFT ALLIEYSFSR HLYSSIEHLT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGACTTGCAT TTGTGTTCTA ACTTGATGTC CTTTTCTTGC AGGGTCCCGA AGTAAAAAAT 60
TATAAAAATG AAAGTGGACA GGACTAAACT GAAGAAAACG CCTACTGAGG CTGTAAGTAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR025527--DUF4414
IPR010309--E3_Ub_ligase_DUF908
IPR010314--E3_Ub_ligase_DUF913
IPR000569--HECT_dom
IPR015940--UBA
IPR009060--UBA-like
IPR004170--WWE-dom
IPR018123--WWE-dom_subgr

PROSITE

PS50237--HECT
PS50030--UBA
PS50918--WWE

Pfam

PF14377--DUF4414
PF06012--DUF908
PF06025--DUF913
PF00632--HECT
PF00627--UBA
PF02825--WWE

SMART

SM00119--HECTc
SM00165--UBA
SM00678--WWE

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005654--C:nucleoplasm
GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006284--P:base-excision repair
GO:0016574--P:histone ubiquitination
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000627	Aegilops tauschii	40.88	2.00e-105	378.00
IUUC-Aml-001684	Ailuropoda melanoleuca	87.88	0.00e+00	5189.00
IUUC-Atr-003044	Amborella trichopoda	52.45	6.00e-125	443.00
IUUC-Apl-003729	Anas platyrhynchos	93.02	0.00e+00	689.00
IUUC-Aca-005263	Anolis carolinensis	90.17	0.00e+00	3013.00
IUUC-Aly-006083	Arabidopsis lyrata	51.54	2.00e-125	444.00
IUUC-Ath-007472	Arabidopsis thaliana	51.54	2.00e-125	445.00
IUUC-Ago-008005	Ashbya gossypii	45.89	7.00e-132	466.00
IUUC-Acl-008254	Aspergillus clavatus	46.65	6.00e-134	473.00
IUUC-Afl-008712	Aspergillus flavus	45.59	5.00e-136	478.00
IUUC-Afu-009022	Aspergillus fumigatus	46.47	2.00e-133	471.00
IUUC-Ani-009412	Aspergillus nidulans	47.03	3.00e-135	477.00
IUUC-Ang-009771	Aspergillus niger	47.03	3.00e-134	474.00
IUUC-Aor-010186	Aspergillus oryzae	44.85	4.00e-126	445.00
IUUC-Ate-010253	Aspergillus terreus	46.15	1.00e-134	475.00
IUUC-Ame-011067	Astyanax mexicanus	77.02	0.00e+00	3400.00
IUUC-Bgr-012043	Blumeria graminis	46.82	4.00e-139	490.00
IUUC-Bta-012813	Bos taurus	87.90	0.00e+00	5227.00
IUUC-Bci-013995	Botrytis cinerea	46.17	1.00e-137	485.00
IUUC-Bdi-014884	Brachypodium distachyon	51.75	5.00e-126	446.00
IUUC-Bol-016533	Brassica oleracea	57.91	4.00e-88	317.00
IUUC-Bra-016637	Brassica rapa	43.49	8.00e-123	436.00
IUUC-Cel-018179	Caenorhabditis elegans	61.48	0.00e+00	640.00
IUUC-Cja-018741	Callithrix jacchus	87.60	0.00e+00	5167.00
IUUC-Cfa-020083	Canis familiaris	87.12	0.00e+00	5184.00
IUUC-Cpo-021923	Cavia porcellus	86.54	0.00e+00	6450.00
IUUC-Cre-022900	Chlamydomonas reinhardtii	48.60	6.00e-119	419.00
IUUC-Csa-023853	Chlorocebus sabaeus	88.13	0.00e+00	5196.00
IUUC-Cho-024718	Choloepus hoffmanni	99.20	0.00e+00	806.00
IUUC-Cin-025627	Ciona intestinalis	40.33	0.00e+00	1764.00
IUUC-Csv-025824	Ciona savignyi	44.69	0.00e+00	1285.00
IUUC-Cgl-026647	Colletotrichum gloeosporioides	45.32	3.00e-137	484.00
IUUC-Cne-027095	Cryptococcus neoformans	41.73	3.00e-105	377.00
IUUC-Cme-027267	Cyanidioschyzon merolae	50.00	3.00e-115	410.00
IUUC-Dre-028525	Danio rerio	77.93	0.00e+00	3371.00
IUUC-Dno-029680	Dasypus novemcinctus	89.41	0.00e+00	3852.00
IUUC-Dor-030902	Dipodomys ordii	85.35	0.00e+00	1127.00
IUUC-Dse-031197	Dothistroma septosporum	46.77	1.00e-138	489.00
IUUC-Dme-032122	Drosophila melanogaster	68.13	0.00e+00	787.00
IUUC-Ete-032690	Echinops telfairi	87.82	0.00e+00	1219.00
IUUC-Eca-033915	Equus caballus	87.74	0.00e+00	5189.00
IUUC-Eeu-034963	Erinaceus europaeus	83.13	0.00e+00	2537.00
IUUC-Fca-035824	Felis catus	88.27	0.00e+00	5196.00
IUUC-Fox-037756	Fusarium oxysporum	45.73	1.00e-137	485.00
IUUC-Fso-038464	Fusarium solani	54.69	1.00e-136	482.00
IUUC-Gmo-039073	Gadus morhua	78.64	0.00e+00	3373.00
IUUC-Ggr-039946	Gaeumannomyces graminis	44.84	2.00e-134	474.00
IUUC-Gga-040309	Gallus gallus	98.06	0.00e+00	647.00
IUUC-Gac-042430	Gasterosteus aculeatus	79.28	0.00e+00	3471.00
IUUC-Gma-043129	Glycine max	47.32	4.00e-125	444.00
IUUC-Ggo-044785	Gorilla gorilla	89.40	0.00e+00	4290.00
IUUC-Hsa-046879	Homo sapiens	88.25	0.00e+00	5167.00
IUUC-Hvu-047697	Hordeum vulgare	44.83	1.00e-126	449.00
IUUC-Itr-048430	Ictidomys tridecemlineatus	97.16	0.00e+00	1451.00
IUUC-Kpa-049228	Komagataella pastoris	48.97	9.00e-141	495.00
IUUC-Lch-050252	Latimeria chalumnae	83.71	0.00e+00	5810.00
IUUC-Lpe-051550	Leersia perrieri	51.75	8.00e-126	446.00
IUUC-Loc-052472	Lepisosteus oculatus	79.19	0.00e+00	3473.00
IUUC-Lma-053159	Leptosphaeria maculans	45.71	8.00e-136	479.00
IUUC-Laf-054154	Loxodonta africana	88.02	0.00e+00	5192.00
IUUC-Mcc-055085	Macaca mulatta	86.72	0.00e+00	5129.00
IUUC-Meu-056727	Macropus eugenii	93.95	0.00e+00	1892.00
IUUC-Mor-057201	Magnaporthe oryzae	45.62	3.00e-135	477.00
IUUC-Mpo-057597	Magnaporthe poae	45.37	4.00e-133	470.00
IUUC-Mtr-058273	Medicago truncatula	52.21	2.00e-125	445.00
IUUC-Mla-058888	Melampsora laricipopulina	49.13	1.00e-115	409.00
IUUC-Mvi-060320	Microbotryum violaceum	42.15	2.00e-122	435.00
IUUC-Mmr-060820	Microcebus murinus	86.75	0.00e+00	5169.00
IUUC-Mdo-062930	Monodelphis domestica	86.78	0.00e+00	5098.00
IUUC-Mmu-063601	Mus musculus	88.06	0.00e+00	5100.00
IUUC-Mac-065557	Musa acuminata	51.85	9.00e-118	419.00
IUUC-Mpu-066653	Mustela putorius furo	86.49	0.00e+00	5059.00
IUUC-Mlu-067418	Myotis lucifugus	87.22	0.00e+00	5208.00
IUUC-Nfi-068278	Neosartorya fischeri	46.65	8.00e-134	473.00
IUUC-Ncr-068813	Neurospora crassa	45.71	9.00e-137	483.00
IUUC-Nle-069418	Nomascus leucogenys	87.93	0.00e+00	5128.00
IUUC-Opr-070187	Ochotona princeps	92.35	0.00e+00	636.00
IUUC-Ont-071300	Oreochromis niloticus	78.93	0.00e+00	3439.00
IUUC-Ocu-074178	Oryctolagus cuniculus	87.64	0.00e+00	6718.00
IUUC-Oba-075757	Oryza barthii	51.52	8.00e-126	446.00
IUUC-Obr-076553	Oryza brachyantha	45.00	4.00e-125	443.00
IUUC-Ogl-077520	Oryza glaberrima	51.52	8.00e-126	446.00
IUUC-Ogu-078278	Oryza glumaepatula	51.52	5.00e-126	446.00
IUUC-Oin-079767	Oryza indica	51.52	7.00e-126	446.00
IUUC-Olo-080380	Oryza longistaminata	51.04	4.00e-124	440.00
IUUC-Ome-081925	Oryza meridionalis	51.04	4.00e-124	440.00
IUUC-Oni-082619	Oryza nivara	51.52	7.00e-126	446.00
IUUC-Opu-083684	Oryza punctata	51.04	3.00e-124	441.00
IUUC-Oru-084501	Oryza rufipogon	51.52	7.00e-126	446.00
IUUC-Osa-086251	Oryza sativa	51.52	2.00e-124	439.00
IUUC-Ola-087437	Oryzias latipes	79.82	0.00e+00	1956.00
IUUC-Olu-087813	Ostreococcus lucimarinus	50.25	5.00e-113	400.00
IUUC-Oga-088903	Otolemur garnettii	88.00	0.00e+00	5192.00
IUUC-Oar-090210	Ovis aries	86.94	0.00e+00	5184.00
IUUC-Ptr-090502	Pan troglodytes	88.47	0.00e+00	4290.00
IUUC-Pan-092368	Papio anubis	88.29	0.00e+00	4324.00
IUUC-Pma-094246	Petromyzon marinus	67.83	0.00e+00	1130.00
IUUC-Pno-094871	Phaeosphaeria nodorum	52.75	5.00e-134	473.00
IUUC-Ppa-095657	Physcomitrella patens	51.13	3.00e-124	441.00
IUUC-Pfo-096232	Poecilia formosa	76.56	0.00e+00	3410.00
IUUC-Pab-098583	Pongo abelii	88.16	0.00e+00	5167.00
IUUC-Pop-099613	Populus trichocarpa	52.91	5.00e-127	449.00
IUUC-Pca-100310	Procavia capensis	85.44	0.00e+00	1677.00
IUUC-Ppe-102109	Prunus persica	52.21	1.00e-125	445.00
IUUC-Pva-102116	Pteropus vampyrus	86.38	0.00e+00	4470.00
IUUC-Pgr-103465	Puccinia graminis	43.31	2.00e-126	448.00
IUUC-Ptt-103813	Puccinia triticina	41.24	3.00e-114	407.00
IUUC-Pte-104018	Pyrenophora teres	52.75	3.00e-133	471.00
IUUC-Pyt-104713	Pyrenophora triticirepentis	52.63	5.00e-133	470.00
IUUC-Rno-105889	Rattus norvegicus	81.63	0.00e+00	4506.00
IUUC-Sce-106449	Saccharomyces cerevisiae	44.67	1.00e-128	455.00
IUUC-Sha-106961	Sarcophilus harrisii	85.21	0.00e+00	4125.00
IUUC-Sja-107814	Schizosaccharomyces japonicus	45.75	4.00e-128	453.00
IUUC-Spo-108024	Schizosaccharomyces pombe	45.89	3.00e-131	464.00
IUUC-Smo-109428	Selaginella moellendorffii	50.88	1.00e-129	458.00
IUUC-Sit-110598	Setaria italica	44.62	1.00e-126	449.00
IUUC-Sly-111285	Solanum lycopersicum	51.44	8.00e-127	449.00
IUUC-Stu-112582	Solanum tuberosum	32.43	3.00e-56	213.00
IUUC-Sar-113291	Sorex araneus	82.14	0.00e+00	3610.00
IUUC-Sbi-114042	Sorghum bicolor	52.21	6.00e-127	449.00
IUUC-Sre-114958	Sporisorium reilianum	48.28	1.00e-138	486.00
IUUC-Ssc-115754	Sus scrofa	88.08	0.00e+00	5203.00
IUUC-Tru-118570	Takifugu rubripes	78.48	0.00e+00	3470.00
IUUC-Tsy-119159	Tarsius syrichta	87.21	0.00e+00	2979.00
IUUC-Tni-120836	Tetraodon nigroviridis	69.53	0.00e+00	2837.00
IUUC-Tca-121479	Theobroma cacao	51.05	1.00e-123	438.00
IUUC-Tre-121909	Trichoderma reesei	53.63	8.00e-133	469.00
IUUC-Tvi-122370	Trichoderma virens	53.40	9.00e-133	469.00
IUUC-Tae-125214	Triticum aestivum	50.81	3.00e-124	440.00
IUUC-Tme-127172	Tuber melanosporum	46.65	5.00e-140	493.00
IUUC-Tbe-127506	Tupaia belangeri	91.37	0.00e+00	1402.00
IUUC-Ttr-129253	Tursiops truncatus	90.16	0.00e+00	2015.00
IUUC-Uma-129355	Ustilago maydis	48.18	1.00e-140	492.00
IUUC-Vda-129886	Verticillium dahliae	47.64	2.00e-138	488.00
IUUC-Vpa-130708	Vicugna pacos	87.66	0.00e+00	3403.00
IUUC-Vvi-131170	Vitis vinifera	50.78	8.00e-126	444.00
IUUC-Xtr-132123	Xenopus tropicalis	83.22	0.00e+00	4902.00
IUUC-Xma-133869	Xiphophorus maculatus	76.64	0.00e+00	3427.00
IUUC-Yli-134657	Yarrowia lipolytica	45.64	4.00e-130	460.00
IUUC-Zma-135570	Zea mays	45.37	4.00e-127	450.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence