iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003959

Ensembl Protein ID

ENSAPLP00000013945.1

UniProt Accession

U3J368; U3J368_ANAPL

Genbank Protein ID

ENSAPLP00000013945

Protein Name

Presenilin

Genbank Nucleotide ID

ADON01091445

Gene Name

PSEN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000014082.1	ENSAPLT00000014712.1	ENSAPLP00000013945.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	1.30e-06	28.0	284	319

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavn 37
           +eta+e++++iFP+l+ys+ + + + +++ ++aa +
   Q: 284  VETAQERNEPIFPALIYSSAMIWTVGMAKPDTAARG 319
           89**********************999987777766 PP

Organism

Anas platyrhynchos

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

MITFMNNSDS EDETCNERTS LMSAESPPIP SYQDGLQASE AGEAQIHRKR HAGSSRSPNN 60
VADGDMADSG VRARGSALEN EEEELTLKYG AKHVIMLFVP VTLCMIVVVA TIKSVRFYTE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCAGCCGTG AGTAGCTCCT GGCTGTGCCT CTCTGGAGTG AGTGCTCCCC AGGAAAGTGA 60
CGATGATCAC GTTCATGAAC AACTCAGACA GTGAGGATGA GACCTGTAAC GAGAGAACAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001493--Pept_A22A_PS2
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN

SMART

SM00730--PSN

Gene Ontology

GO:0005813--C:centrosome
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0005887--C:integral component of plasma membrane
GO:0000776--C:kinetochore
GO:0005637--C:nuclear inner membrane
GO:0004190--F:aspartic-type endopeptidase activity
GO:0035556--P:intracellular signal transduction
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0007219--P:Notch signaling pathway
GO:0043085--P:positive regulation of catalytic activity
GO:0016485--P:protein processing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002356	Ailuropoda melanoleuca	69.25	1.00e-130	459.00
IUUC-Aca-005160	Anolis carolinensis	82.40	0.00e+00	627.00
IUUC-Aly-005455	Arabidopsis lyrata	60.49	2.00e-17	83.60
IUUC-Ath-006730	Arabidopsis thaliana	60.49	1.00e-17	84.00
IUUC-Ame-010686	Astyanax mexicanus	76.72	7.00e-139	486.00
IUUC-Bta-013097	Bos taurus	75.91	1.00e-160	559.00
IUUC-Bdi-014196	Brachypodium distachyon	32.96	2.00e-30	126.00
IUUC-Bra-017580	Brassica rapa	61.73	8.00e-18	84.30
IUUC-Cja-018824	Callithrix jacchus	74.68	2.00e-157	548.00
IUUC-Cfa-020253	Canis familiaris	75.32	6.00e-160	556.00
IUUC-Cpo-021401	Cavia porcellus	74.36	8.00e-159	553.00
IUUC-Cre-022747	Chlamydomonas reinhardtii	33.64	3.00e-27	116.00
IUUC-Csa-023369	Chlorocebus sabaeus	75.53	2.00e-161	561.00
IUUC-Dre-028526	Danio rerio	69.26	2.00e-145	508.00
IUUC-Dor-031127	Dipodomys ordii	73.33	9.00e-157	546.00
IUUC-Ete-033081	Echinops telfairi	67.58	3.00e-72	265.00
IUUC-Eca-034387	Equus caballus	74.19	9.00e-153	532.00
IUUC-Eeu-034846	Erinaceus europaeus	59.03	1.00e-104	373.00
IUUC-Fca-035396	Felis catus	75.22	2.00e-165	575.00
IUUC-Fal-037457	Ficedula albicollis	90.75	0.00e+00	717.00
IUUC-Gmo-038550	Gadus morhua	72.25	3.00e-124	437.00
IUUC-Gga-040706	Gallus gallus	93.12	0.00e+00	723.00
IUUC-Gac-042511	Gasterosteus aculeatus	65.42	7.00e-133	466.00
IUUC-Gma-043822	Glycine max	38.93	4.00e-23	101.00
IUUC-Ggo-045338	Gorilla gorilla	75.53	2.00e-161	561.00
IUUC-Hsa-046455	Homo sapiens	75.53	2.00e-161	561.00
IUUC-Itr-048731	Ictidomys tridecemlineatus	75.70	3.00e-160	557.00
IUUC-Lch-049638	Latimeria chalumnae	68.34	1.00e-149	522.00
IUUC-Loc-052427	Lepisosteus oculatus	73.67	6.00e-162	563.00
IUUC-Laf-053758	Loxodonta africana	73.68	7.00e-168	583.00
IUUC-Mcc-054755	Macaca mulatta	75.53	3.00e-161	561.00
IUUC-Mtr-058392	Medicago truncatula	34.13	2.00e-29	122.00
IUUC-Mmr-060890	Microcebus murinus	74.41	8.00e-159	552.00
IUUC-Mdo-062197	Monodelphis domestica	77.71	2.00e-172	598.00
IUUC-Mmu-063823	Mus musculus	74.41	5.00e-160	556.00
IUUC-Mac-064858	Musa acuminata	38.59	3.00e-21	95.10
IUUC-Mpu-066181	Mustela putorius furo	75.48	5.00e-160	556.00
IUUC-Nle-069596	Nomascus leucogenys	72.42	2.00e-146	511.00
IUUC-Opr-070344	Ochotona princeps	74.89	3.00e-162	564.00
IUUC-Ont-071867	Oreochromis niloticus	68.90	2.00e-134	471.00
IUUC-Oan-073378	Ornithorhynchus anatinus	74.33	1.00e-153	535.00
IUUC-Ocu-074652	Oryctolagus cuniculus	74.84	4.00e-159	554.00
IUUC-Ola-086707	Oryzias latipes	72.90	2.00e-105	375.00
IUUC-Oga-088560	Otolemur garnettii	74.84	6.00e-157	546.00
IUUC-Oar-089200	Ovis aries	75.48	2.00e-158	551.00
IUUC-Ptr-090569	Pan troglodytes	75.32	8.00e-161	559.00
IUUC-Pan-091742	Papio anubis	75.53	2.00e-161	561.00
IUUC-Psi-093297	Pelodiscus sinensis	83.33	1.00e-159	555.00
IUUC-Pma-094612	Petromyzon marinus	76.56	4.00e-126	444.00
IUUC-Ppa-095431	Physcomitrella patens	32.11	1.00e-24	107.00
IUUC-Pab-098531	Pongo abelii	75.53	2.00e-161	561.00
IUUC-Pca-101120	Procavia capensis	72.69	6.00e-150	523.00
IUUC-Pva-102934	Pteropus vampyrus	70.11	9.00e-153	533.00
IUUC-Rno-106052	Rattus norvegicus	74.47	7.00e-164	569.00
IUUC-Sha-106876	Sarcophilus harrisii	77.45	2.00e-170	591.00
IUUC-Ssc-115380	Sus scrofa	75.48	8.00e-161	559.00
IUUC-Tgu-117280	Taeniopygia guttata	90.54	0.00e+00	711.00
IUUC-Tbe-127632	Tupaia belangeri	73.07	4.00e-132	464.00
IUUC-Ttr-129008	Tursiops truncatus	74.46	1.00e-155	542.00
IUUC-Vvi-131312	Vitis vinifera	49.07	1.00e-17	84.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence