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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046123
UUCD1 version UUC-HoS-00341
Ensembl Protein ID ENSP00000346916.5
UniProt Accession Q9BYJ4; D3DQS7; Q9C016; Q9HCR0; Q9HCR1; Q9HCR2; TRI34_HUMAN
Genbank Protein ID BAB17049.1; BAB17050.1; BAB17051.1; AAG53516.1; AAG53517.1; BAB55424.1; EAW68778.1; EAW68780.1; CAC29498.1
Protein Name Tripartite motif-containing protein 34; Interferon-responsive finger protein 1; RING finger protein 21
Genbank Nucleotide ID AB039902; AB039903; AB039904; AF220143; AF220144; AK027876; CH471064; CH471064; AL583914
Gene Name TRIM34; IFP1; RNF21
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000258588.3 ENST00000354852.5 ENSP00000346916.5
Annotation
Cancer Mutation
TCGAICGCCOSMICIntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbcircBasemiRTarBasemicroRNA
TRANSFACTargetScanRepTarmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLMPhosphositePlusdbPTMmUbiSiDa
Protein Expression/Proteomics
THPAGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 19690564
Classification
Family E-value Score Start End
E3 activity/RING/U-box 1.80e-11 45.6 37 106
E3 activity/RING/RING 8.30e-14 53.5 43 88
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/U-box
   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwl......asggktcPvtrqplteedlvPnltlrrli 65
           + ee  CpI lel ++P  + +G+++ +++I          ++g+++cPv++++ ++ +l Pn  l +++
   Q: 37   IREEVTCPICLELLTEPLSIDCGHSFCQACITPNGresvigQEGERSCPVCQTSYQPGNLRPNRHLANIV 106
           678999*************************874433334666666*****************9987765 PP
   

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadCl.....qkwpglknssskefrCPlCr 46
           C+iCle + + pl+ +CgH f++ C+     + +      + +e +CP+C+
   Q: 43   CPICLELLTE-PLSIDCGHSFCQACItpngrESV----IGQEGERSCPVCQ 88
           ********99.***************87655555....999*********7 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     May function as antiviral protein and may contribute to the defense against retroviral infections.
 May function as antiviral protein and may contribute to the defense against retroviral infections.
Protein Sequence
(Fasta)
MCGSERILQA GNILEIRVGQ AGARRVATMT SPVLVDIREE VTCPICLELL TEPLSIDCGH 60
SFCQACITPN GRESVIGQEG ERSCPVCQTS YQPGNLRPNR HLANIVRRLR EVVLGPGKQL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046123|E3,RING;E3,U-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTGCCTTTCT CGGAACGGAA CGGAGCAGAG TCGTGCGTGG TTGAGTTTAG ATAAAAGCCG 60
AGTGAGCGCG CTCTGTTCCT TAAGATTAGT TTAAGGTGCC TTGGATTGCT CTGAAGAGCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046123|E3,RING;E3,U-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0051--Antiviral defense
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00622--SPRY
PF00643--zf-B_box
PRINTS

PR01407--BUTYPHLNCDUF
SMART

SM00336--BBOX
SM00184--RING
SM00449--SPRY
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0008270--F:zinc ion binding
GO:0051607--P:defense response to virus
GO:0060333--P:interferon-gamma-mediated signaling pathway
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0070206--P:protein trimerization
KEGG hsa:53840
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001740 Ailuropoda melanoleuca 74.03 0.00e+00 653.00
IUUC-Bta-013071 Bos taurus 73.60 0.00e+00 1144.00
IUUC-Cja-018923 Callithrix jacchus 80.53 0.00e+00 1159.00
IUUC-Cfa-021152 Canis familiaris 73.51 0.00e+00 1156.00
IUUC-Cpo-021369 Cavia porcellus 66.26 2.00e-164 572.00
IUUC-Csa-023747 Chlorocebus sabaeus 94.67 0.00e+00 1170.00
IUUC-Dno-029492 Dasypus novemcinctus 62.79 0.00e+00 953.00
IUUC-Dor-030480 Dipodomys ordii 77.74 7.00e-136 478.00
IUUC-Ete-032316 Echinops telfairi 59.76 0.00e+00 876.00
IUUC-Eca-034130 Equus caballus 76.37 0.00e+00 1177.00
IUUC-Fca-035480 Felis catus 73.88 0.00e+00 691.00
IUUC-Ggo-045449 Gorilla gorilla 84.48 0.00e+00 1268.00
IUUC-Laf-053984 Loxodonta africana 73.27 0.00e+00 653.00
IUUC-Mcc-055647 Macaca mulatta 91.45 0.00e+00 1385.00
IUUC-Mga-060031 Meleagris gallopavo 31.41 3.00e-85 309.00
IUUC-Mmr-060724 Microcebus murinus 60.59 0.00e+00 785.00
IUUC-Mmu-063285 Mus musculus 67.62 6.00e-176 610.00
IUUC-Mpu-066802 Mustela putorius furo 69.67 1.00e-174 605.00
IUUC-Mlu-067658 Myotis lucifugus 74.39 0.00e+00 1140.00
IUUC-Nle-069376 Nomascus leucogenys 90.93 0.00e+00 1381.00
IUUC-Ocu-073956 Oryctolagus cuniculus 63.39 0.00e+00 919.00
IUUC-Oar-089984 Ovis aries 71.43 7.00e-179 620.00
IUUC-Ptr-091205 Pan troglodytes 99.18 0.00e+00 875.00
IUUC-Pan-091941 Papio anubis 94.67 0.00e+00 839.00
IUUC-Pab-098713 Pongo abelii 97.15 0.00e+00 1516.00
IUUC-Pca-100258 Procavia capensis 69.15 0.00e+00 699.00
IUUC-Pva-102482 Pteropus vampyrus 69.00 0.00e+00 767.00
IUUC-Rno-105230 Rattus norvegicus 66.87 9.00e-168 583.00
IUUC-Sha-107352 Sarcophilus harrisii 27.14 4.00e-66 246.00
IUUC-Ssc-115780 Sus scrofa 69.57 0.00e+00 1019.00
IUUC-Tsy-119181 Tarsius syrichta 77.58 1.00e-180 627.00
Created Date 25-Jun-2017

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