iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oan-072717

UUCD1 version

UUC-OrA-00029

Ensembl Protein ID

ENSOANP00000008896.2

UniProt Accession

F6PXT1; F6PXT1_ORNAN

Protein Name

Apoptotic protease-activating factor 1

Gene Name

APAF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000005592.2	ENSOANT00000008898.2	ENSOANP00000008896.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.90e-62	204.6	741	775
UBD/Beta-Prp	2.80e-95	319.1	958	1225

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtg 33
           gH+dsv+ ++f +d ++l+s+s Dgt+k+W++ + 
   Q: 741  GHSDSVNHCKFsPDdKYLASCSADGTLKLWEVASA 775
           8***********777****************9775 PP

UBD/Beta-Prp

   S: 5    lkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlk 91
           l ++++s i+c + sp    la g +dgt+k+ ++ +g +++s  +h+++v+ ++f +dgk+ +++s+D +i+vw  +t ++v  l+
   Q: 958  LTEAQESLICCCCLSPTLISLAFGEEDGTVKILELPNGRMFKSKIKHKKPVQHCRFTSDGKTVISSSDDPVIQVWIWQTEEYVF-LQ 1043
           56789999***********************************************************************99986.77 PP
   S: 92   ghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgg 178
           +h++sv + ++ + +++l s s d ti+vw++ tg++ +  +  h+g+v + +++pd+  + s s+D+t ++W+ ++ +ll++l+g 
   Q: 1044 AHQESVKDFRLLQ-NSRLFSWSFDGTIKVWNILTGKVEK-DFFCHQGAVLSCNISPDATKFSSTSADKTAKIWSFENSSLLHELSG- 1127
           7************.999*********************9.8999*****************************************9. PP
   S: 179  htdsvyslsfdsngkelvsgsldgtvklwdlqtgec........vrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdll 257
           h++ v++ +f++++  l++g+++g +++wd+++ge+        v +   h  +v+++ fsp++++lvs++  g ++ W++++g+ l
   Q: 1128 HEGCVRCSAFSDDSSLLATGDDNGEIRIWDVSKGEIlhlcapgpVGEASTHGGWVTDLCFSPDSKILVSAG--GFLKWWNMDTGESL 1212
           ***********************************999999999***************************..************** PP
   S: 258  ktlqlhnssvisv 270
           +t+    +++  +
   Q: 1213 QTFYTNGTNLKTI 1225
           **97765554444 PP

Organism

Ornithorhynchus anatinus

Functional Description
(View)

Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.

Protein Sequence
(Fasta)

MDARARNCLL KHMEALEKDI KTSYIMDHMI SDRTLTLSEE EKVRNQGTQE ERAAMLIKLI 60
LEKDNFSYIS FYNALLHEGY RDLAALLQDG IPFTASPKGN DSLDGVTSYV RTVLCEGGVP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCCTCTCTC CGGGGAATTG CTGTGTTGGT CTTGGAAGGG ATATAGATTT TACTCTCTGC 60
CTGCTGTCGT TTTAGGCTTC TGAATCTTCG CGCCAGTTTG CCCTAGACTG TGTGAAAACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR017251--Apaf-1
IPR001315--CARD
IPR011029--DEATH-like_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002182--NB-ARC
IPR027417--P-loop_NTPase
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50209--CARD
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00619--CARD
PF00931--NB-ARC
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0043293--C:apoptosome
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0043531--F:ADP binding
GO:0005524--F:ATP binding
GO:0008656--F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0008635--P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0030900--P:forebrain development
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0001843--P:neural tube closure
GO:0051402--P:neuron apoptotic process
GO:2001235--P:positive regulation of apoptotic signaling pathway
GO:1902510--P:regulation of apoptotic DNA fragmentation

KEGG

oaa:100073402

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001432	Ailuropoda melanoleuca	81.04	0.00e+00	2101.00
IUUC-Apl-004201	Anas platyrhynchos	73.44	0.00e+00	1899.00
IUUC-Aca-004638	Anolis carolinensis	70.63	0.00e+00	1875.00
IUUC-Afu-008928	Aspergillus fumigatus	25.75	7.00e-57	215.00
IUUC-Ani-009285	Aspergillus nidulans	26.33	6.00e-68	252.00
IUUC-Ate-010309	Aspergillus terreus	28.53	1.00e-64	241.00
IUUC-Ame-011062	Astyanax mexicanus	56.37	0.00e+00	1434.00
IUUC-Bta-012865	Bos taurus	80.43	0.00e+00	2123.00
IUUC-Cja-018815	Callithrix jacchus	73.47	0.00e+00	1865.00
IUUC-Cfa-020222	Canis familiaris	77.31	0.00e+00	1980.00
IUUC-Cpo-021524	Cavia porcellus	80.19	0.00e+00	2089.00
IUUC-Csa-023861	Chlorocebus sabaeus	81.61	0.00e+00	2123.00
IUUC-Cho-024484	Choloepus hoffmanni	71.11	0.00e+00	1089.00
IUUC-Dre-028006	Danio rerio	54.62	0.00e+00	1323.00
IUUC-Dno-029591	Dasypus novemcinctus	81.47	0.00e+00	2140.00
IUUC-Dor-030237	Dipodomys ordii	66.62	0.00e+00	958.00
IUUC-Ete-032620	Echinops telfairi	77.42	0.00e+00	993.00
IUUC-Eca-033569	Equus caballus	81.39	0.00e+00	2116.00
IUUC-Eeu-035354	Erinaceus europaeus	57.56	2.00e-157	549.00
IUUC-Fca-036337	Felis catus	81.17	0.00e+00	2138.00
IUUC-Fal-037077	Ficedula albicollis	72.46	0.00e+00	1870.00
IUUC-Gmo-039687	Gadus morhua	51.11	0.00e+00	951.00
IUUC-Ggr-039828	Gaeumannomyces graminis	23.84	2.00e-41	164.00
IUUC-Gga-040299	Gallus gallus	71.70	0.00e+00	1897.00
IUUC-Gac-041762	Gasterosteus aculeatus	53.01	0.00e+00	1319.00
IUUC-Ggo-045563	Gorilla gorilla	81.37	0.00e+00	2113.00
IUUC-Hsa-046771	Homo sapiens	81.22	0.00e+00	2113.00
IUUC-Lch-050200	Latimeria chalumnae	67.39	0.00e+00	1702.00
IUUC-Loc-052090	Lepisosteus oculatus	61.19	0.00e+00	1577.00
IUUC-Laf-053861	Loxodonta africana	80.91	0.00e+00	2128.00
IUUC-Mcc-055543	Macaca mulatta	81.93	0.00e+00	2130.00
IUUC-Meu-056688	Macropus eugenii	79.57	0.00e+00	2039.00
IUUC-Mtr-058421	Medicago truncatula	25.96	2.00e-22	99.00
IUUC-Mga-059243	Meleagris gallopavo	71.91	0.00e+00	1902.00
IUUC-Mmr-061134	Microcebus murinus	76.75	0.00e+00	1804.00
IUUC-Mdo-062913	Monodelphis domestica	78.04	0.00e+00	2046.00
IUUC-Mmu-063811	Mus musculus	79.95	0.00e+00	2105.00
IUUC-Mpu-066780	Mustela putorius furo	80.93	0.00e+00	2084.00
IUUC-Mlu-067276	Myotis lucifugus	80.37	0.00e+00	2107.00
IUUC-Nfi-068459	Neosartorya fischeri	26.83	2.00e-58	220.00
IUUC-Nle-069129	Nomascus leucogenys	81.06	0.00e+00	2108.00
IUUC-Opr-071007	Ochotona princeps	61.68	0.00e+00	1013.00
IUUC-Ont-071348	Oreochromis niloticus	55.93	0.00e+00	1446.00
IUUC-Ocu-074286	Oryctolagus cuniculus	82.10	0.00e+00	1805.00
IUUC-Ola-086895	Oryzias latipes	52.13	0.00e+00	1246.00
IUUC-Oga-088678	Otolemur garnettii	80.42	0.00e+00	2102.00
IUUC-Oar-089359	Ovis aries	80.43	0.00e+00	2107.00
IUUC-Ptr-091062	Pan troglodytes	80.98	0.00e+00	2109.00
IUUC-Pan-092528	Papio anubis	85.28	0.00e+00	1287.00
IUUC-Psi-093430	Pelodiscus sinensis	76.87	0.00e+00	2006.00
IUUC-Pma-094690	Petromyzon marinus	37.83	6.00e-154	537.00
IUUC-Pfo-097204	Poecilia formosa	54.93	0.00e+00	1410.00
IUUC-Pab-097690	Pongo abelii	81.45	0.00e+00	2121.00
IUUC-Pca-100778	Procavia capensis	64.72	0.00e+00	1083.00
IUUC-Pva-102870	Pteropus vampyrus	78.46	0.00e+00	1891.00
IUUC-Pyt-104620	Pyrenophora triticirepentis	27.80	6.00e-58	219.00
IUUC-Rno-104889	Rattus norvegicus	79.47	0.00e+00	2060.00
IUUC-Sha-107465	Sarcophilus harrisii	79.20	0.00e+00	2092.00
IUUC-Ssl-108421	Sclerotinia sclerotiorum	27.34	5.00e-62	231.00
IUUC-Sar-113268	Sorex araneus	78.92	1.00e-168	587.00
IUUC-Ssc-115654	Sus scrofa	80.35	0.00e+00	2133.00
IUUC-Tgu-117302	Taeniopygia guttata	73.02	0.00e+00	1892.00
IUUC-Tru-118363	Takifugu rubripes	55.45	0.00e+00	1414.00
IUUC-Tsy-119007	Tarsius syrichta	78.26	0.00e+00	2028.00
IUUC-Tni-120910	Tetraodon nigroviridis	54.06	0.00e+00	1374.00
IUUC-Tbe-127413	Tupaia belangeri	70.58	0.00e+00	1303.00
IUUC-Ttr-129213	Tursiops truncatus	75.22	0.00e+00	1935.00
IUUC-Vpa-130146	Vicugna pacos	75.99	0.00e+00	1454.00
IUUC-Xtr-132559	Xenopus tropicalis	61.07	0.00e+00	1592.00
IUUC-Xma-133445	Xiphophorus maculatus	55.08	0.00e+00	1387.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence