iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-047023

UUCD1 version

UUC-HoS-00235

Ensembl Protein ID

ENSP00000367552.2

UniProt Accession

Q8NDN9; Q8IY29; Q969U9; RCBT1_HUMAN

Genbank Protein ID

AAK38372.1; CAC40027.1; BAC04833.1; CAD38683.1; CAH71047.1; AAH38104.1

Protein Name

RCC1 and BTB domain-containing protein 1; Chronic lymphocytic leukemia deletion region gene 7 protein; Regulator of chromosome condensation and BTB domain-containing protein 1

Genbank Nucleotide ID

AF334406; AJ319660; AK096654; AL833821; AL139321; BC038104

Gene Name

RCBTB1; CLLD7; E4.5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000136144.11	ENST00000378302.6	ENSP00000367552.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus	dbPTM	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_3-box	BTB_3-box	19256485

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	6.10e-14	53.8	370	436
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	9.10e-07	28.2	469	499

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklden 68
           aD  + ++g+++++hk+vL  +++ F+++f++ ++e  +k+ +ei++ ++ v ra+l++lYt+++d++
   Q: 370  ADLKFRIDGKYIHVHKAVLKIRCEHFRSMFQSYWNED-MKEVIEIDQFSYPVYRAFLQYLYTDTVDLP 436
           6899*******************************97.6**************************986 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhF 31
           +eN+++++++A +yd++dL +++++f+++h 
   Q: 469  VENAFSLFSAAVRYDAEDLEEFCFKFCINHL 499
           79****************************6 PP

Organism

Homo sapiens

Functional Description
(View)

May be involved in cell cycle regulation by chromatin remodeling.

Protein Sequence
(Fasta)

MVDVGKWPIF TLLSPQEIAS IRKACVFGTS ASEALYVTDN DEVFVFGLNY SNCLGTGDNQ 60
STLVPKKLEG LCGKKIKSLS YGSGPHVLLS TEDGVVYAWG HNGYSQLGNG TTNQGIAPVQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACCCGGCGG GCCCGGCGCC CTGGCGCTCC TCCTCTTCGC TGCCGGTGGG CACCGCCGCT 60
CGCTCGCACT TCTGCGCCCA TTGGAGCTTC GGAGATCCCT GCGGTCCCGC GGGACGGCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation

Interpro

IPR000210--BTB/POZ_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00651--BTB
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00225--BTB

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0007049--P:cell cycle
GO:0016569--P:covalent chromatin modification
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:55213

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003506	Anas platyrhynchos	90.02	0.00e+00	981.00
IUUC-Aca-005307	Anolis carolinensis	87.55	0.00e+00	964.00
IUUC-Afu-009090	Aspergillus fumigatus	33.58	4.00e-16	79.70
IUUC-Ate-010432	Aspergillus terreus	34.33	2.00e-16	81.30
IUUC-Ame-011588	Astyanax mexicanus	84.90	0.00e+00	858.00
IUUC-Bta-012713	Bos taurus	97.18	0.00e+00	1046.00
IUUC-Cja-019520	Callithrix jacchus	99.44	0.00e+00	1070.00
IUUC-Cfa-020570	Canis familiaris	98.68	0.00e+00	1063.00
IUUC-Cpo-021788	Cavia porcellus	96.99	0.00e+00	1047.00
IUUC-Csa-023089	Chlorocebus sabaeus	99.44	0.00e+00	1068.00
IUUC-Cho-024516	Choloepus hoffmanni	82.86	0.00e+00	870.00
IUUC-Cin-025336	Ciona intestinalis	56.24	5.00e-154	537.00
IUUC-Csv-026044	Ciona savignyi	52.86	4.00e-158	551.00
IUUC-Dre-028368	Danio rerio	81.92	0.00e+00	903.00
IUUC-Dno-029235	Dasypus novemcinctus	97.18	0.00e+00	1048.00
IUUC-Dse-031195	Dothistroma septosporum	28.87	5.00e-14	73.20
IUUC-Eca-033498	Equus caballus	98.87	0.00e+00	1065.00
IUUC-Fca-035477	Felis catus	99.25	0.00e+00	1066.00
IUUC-Fal-037618	Ficedula albicollis	90.96	0.00e+00	988.00
IUUC-Gga-040259	Gallus gallus	89.83	0.00e+00	981.00
IUUC-Gac-041900	Gasterosteus aculeatus	79.21	0.00e+00	875.00
IUUC-Ggo-044764	Gorilla gorilla	93.47	0.00e+00	855.00
IUUC-Itr-048427	Ictidomys tridecemlineatus	98.31	0.00e+00	1059.00
IUUC-Lch-050249	Latimeria chalumnae	85.50	0.00e+00	935.00
IUUC-Loc-052089	Lepisosteus oculatus	85.88	0.00e+00	939.00
IUUC-Laf-053405	Loxodonta africana	96.23	0.00e+00	1043.00
IUUC-Mcc-055101	Macaca mulatta	99.44	0.00e+00	1068.00
IUUC-Meu-056234	Macropus eugenii	97.00	2.00e-117	416.00
IUUC-Mga-059496	Meleagris gallopavo	89.64	0.00e+00	979.00
IUUC-Mmr-060652	Microcebus murinus	99.25	0.00e+00	1070.00
IUUC-Mdo-062637	Monodelphis domestica	95.67	0.00e+00	1030.00
IUUC-Mmu-064392	Mus musculus	96.05	0.00e+00	1040.00
IUUC-Mpu-066560	Mustela putorius furo	99.06	0.00e+00	1066.00
IUUC-Mlu-067665	Myotis lucifugus	97.36	0.00e+00	1038.00
IUUC-Nfi-068521	Neosartorya fischeri	33.58	5.00e-16	79.70
IUUC-Nle-069827	Nomascus leucogenys	99.81	0.00e+00	1072.00
IUUC-Opr-070696	Ochotona princeps	98.87	0.00e+00	1063.00
IUUC-Ont-072097	Oreochromis niloticus	81.73	0.00e+00	891.00
IUUC-Oan-072798	Ornithorhynchus anatinus	94.73	0.00e+00	1023.00
IUUC-Ocu-074269	Oryctolagus cuniculus	98.12	0.00e+00	1058.00
IUUC-Ola-087318	Oryzias latipes	81.54	0.00e+00	898.00
IUUC-Oga-087951	Otolemur garnettii	98.87	0.00e+00	1066.00
IUUC-Oar-090182	Ovis aries	97.55	0.00e+00	1053.00
IUUC-Ptr-091506	Pan troglodytes	100.00	0.00e+00	1072.00
IUUC-Pan-092089	Papio anubis	99.44	0.00e+00	1068.00
IUUC-Psi-093903	Pelodiscus sinensis	90.40	0.00e+00	992.00
IUUC-Pfo-097389	Poecilia formosa	80.98	0.00e+00	897.00
IUUC-Pab-098593	Pongo abelii	99.81	0.00e+00	1072.00
IUUC-Pca-100535	Procavia capensis	95.67	0.00e+00	1005.00
IUUC-Pva-102383	Pteropus vampyrus	97.74	0.00e+00	1052.00
IUUC-Rno-106075	Rattus norvegicus	95.67	0.00e+00	1032.00
IUUC-Sha-107410	Sarcophilus harrisii	95.86	0.00e+00	1036.00
IUUC-Ssc-115660	Sus scrofa	98.49	0.00e+00	1060.00
IUUC-Tgu-116665	Taeniopygia guttata	90.96	0.00e+00	988.00
IUUC-Tru-118597	Takifugu rubripes	78.99	0.00e+00	880.00
IUUC-Tsy-119171	Tarsius syrichta	79.58	1.00e-116	413.00
IUUC-Tni-120370	Tetraodon nigroviridis	79.29	0.00e+00	889.00
IUUC-Ttr-128800	Tursiops truncatus	89.08	0.00e+00	939.00
IUUC-Vpa-130080	Vicugna pacos	97.97	8.00e-147	513.00
IUUC-Xtr-131943	Xenopus tropicalis	73.82	0.00e+00	854.00
IUUC-Xma-133127	Xiphophorus maculatus	80.23	0.00e+00	877.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence