iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gac-041933

UUCD1 version

UUC-GaA-00791

Ensembl Protein ID

ENSGACP00000020206.1

UniProt Accession

G3PRH1; G3PRH1_GASAC

Protein Name

Uncharacterized protein

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGACG00000015321.1	ENSGACT00000020245.1	ENSGACP00000020206.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.90e-105	353.3	551	877

Active Site

Position(s)	Description	Evidence
846	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkk+l+vef+gE+g+d gGv++ef++l+++e++npd+g+f+y+e+ k  ++ np+s     e++  ++++G++lg+a++++ +ld+
   Q: 551  PADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDERTKLFWF-NPSSL----ENEGQYTLIGIVLGLAIYNNCILDV 634
           689*******************************************99888876.88887....6799********************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseei.lgetkeeeLkpgGenipVtneNkeeYvklvv 178
           +++ ++y++l+gkk ++ dl++ +p ly+slke++e+ e ++e+  + +tf++se+  +g+   ++L ++G++ipVtneN++e+v +++
   Q: 635  HFPMVVYRKLMGKKGTFRDLADANPVLYQSLKELLEY-EGSVEDD-MMITFQISETDlFGNPLMHDLRENGDKIPVTNENRKEFVAQYA 721
           *************************************.6677775.99***96655449****************************** PP
   S: 179  eyrlkegikeqveafreGfneviple.llslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLq 266
           ey l++++++q++afr+Gf+ v +++ l  lF++ee+ellicG++++d+ +l+++t+y+ggy++ds+ i+ Fwe+l++f +e+++ fLq
   Q: 722  EYMLNKSVEKQFKAFRRGFHMVTNESpLKYLFRPEEIELLICGSRNLDFLALEETTEYDGGYNRDSRIIKEFWETLHSFGEEQKRLFLQ 810
           ***********************99934558********************************************************** PP
   S: 267  FvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           F+Tg++r+P+gG+ +lk   ++i k++ d drlP+s+TCfn+L LPeY+++e+l+e+Ll Ai+++kgF++
   Q: 811  FTTGTDRAPVGGLGKLK---MIIAKNGPDtDRLPTSHTCFNVLLLPEYNNMEKLRERLLKAITYAKGFGM 877
           *****************...8888866666**************************************97 PP

Organism

Gasterosteus aculeatus

Protein Sequence
(Fasta)

ATAQHECLKE YVEPEIENPE ASRMKRAAAK HLIERYYHQL TEGCGNESCS NSWCASSAGF 60
TRMDNNAAAV KALELYKLNA KLCDPHPSKK VTASAHLESS AHSNSACSNR KLNHKDVHSV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGACAGCTC AGCATGAATG TTTGAAATAA GGACAGCTTG CTAGCTACCT TTAGCTACAT 60
TAACTTAGCT CGCTAAATTA GCGTCAGGAT CTGCAGCGCC CCGTGTTTCC CCTTTACTCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR032353--AZUL
IPR000569--HECT_dom
IPR017134--UBE3A

PROSITE

PS50237--HECT

Pfam

PF16558--AZUL
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0061630--F:ubiquitin protein ligase activity
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002214	Ailuropoda melanoleuca	84.70	0.00e+00	1411.00
IUUC-Atr-003144	Amborella trichopoda	46.53	3.00e-93	335.00
IUUC-Apl-003742	Anas platyrhynchos	86.32	0.00e+00	1445.00
IUUC-Aca-004873	Anolis carolinensis	85.24	0.00e+00	1457.00
IUUC-Ame-011166	Astyanax mexicanus	86.85	0.00e+00	1459.00
IUUC-Bta-013286	Bos taurus	83.96	0.00e+00	1390.00
IUUC-Cja-019707	Callithrix jacchus	83.01	0.00e+00	1420.00
IUUC-Cfa-020154	Canis familiaris	84.45	0.00e+00	1413.00
IUUC-Cpo-021292	Cavia porcellus	84.80	0.00e+00	1404.00
IUUC-Cre-022790	Chlamydomonas reinhardtii	50.31	2.00e-82	299.00
IUUC-Csa-023378	Chlorocebus sabaeus	83.29	0.00e+00	1419.00
IUUC-Cho-025059	Choloepus hoffmanni	81.68	0.00e+00	1331.00
IUUC-Cin-025643	Ciona intestinalis	43.49	0.00e+00	672.00
IUUC-Csv-026282	Ciona savignyi	44.42	0.00e+00	632.00
IUUC-Cme-027151	Cyanidioschyzon merolae	43.38	8.00e-97	348.00
IUUC-Dre-027901	Danio rerio	85.56	0.00e+00	1433.00
IUUC-Dno-029320	Dasypus novemcinctus	83.98	0.00e+00	1423.00
IUUC-Dor-030756	Dipodomys ordii	90.18	0.00e+00	629.00
IUUC-Dme-032035	Drosophila melanogaster	43.40	1.00e-157	550.00
IUUC-Eca-033843	Equus caballus	85.05	0.00e+00	1382.00
IUUC-Eeu-035109	Erinaceus europaeus	83.63	0.00e+00	1365.00
IUUC-Fca-036344	Felis catus	83.64	0.00e+00	1415.00
IUUC-Fal-036747	Ficedula albicollis	86.07	0.00e+00	1446.00
IUUC-Gmo-039089	Gadus morhua	90.68	0.00e+00	1081.00
IUUC-Gga-040399	Gallus gallus	86.43	0.00e+00	1447.00
IUUC-Ggo-044804	Gorilla gorilla	82.88	0.00e+00	1423.00
IUUC-Hsa-045727	Homo sapiens	82.88	0.00e+00	1423.00
IUUC-Itr-048289	Ictidomys tridecemlineatus	81.40	0.00e+00	1316.00
IUUC-Lch-050197	Latimeria chalumnae	85.37	0.00e+00	1434.00
IUUC-Loc-052743	Lepisosteus oculatus	88.16	0.00e+00	1492.00
IUUC-Lma-053245	Leptosphaeria maculans	34.40	1.00e-58	222.00
IUUC-Laf-053615	Loxodonta africana	84.36	0.00e+00	1410.00
IUUC-Mcc-054934	Macaca mulatta	83.29	0.00e+00	1418.00
IUUC-Meu-056061	Macropus eugenii	82.13	0.00e+00	1290.00
IUUC-Mga-059271	Meleagris gallopavo	87.08	0.00e+00	1429.00
IUUC-Mmr-061288	Microcebus murinus	85.14	0.00e+00	1428.00
IUUC-Mdo-062975	Monodelphis domestica	85.50	0.00e+00	1444.00
IUUC-Mmu-063674	Mus musculus	81.68	0.00e+00	1381.00
IUUC-Mpu-066568	Mustela putorius furo	84.44	0.00e+00	1427.00
IUUC-Mlu-067522	Myotis lucifugus	79.52	0.00e+00	1336.00
IUUC-Nle-069505	Nomascus leucogenys	82.88	0.00e+00	1423.00
IUUC-Opr-070570	Ochotona princeps	78.11	0.00e+00	1264.00
IUUC-Ont-071527	Oreochromis niloticus	94.64	0.00e+00	1580.00
IUUC-Oan-073446	Ornithorhynchus anatinus	83.05	0.00e+00	935.00
IUUC-Ocu-074922	Oryctolagus cuniculus	83.03	0.00e+00	1412.00
IUUC-Ola-086996	Oryzias latipes	92.42	0.00e+00	1557.00
IUUC-Oga-088261	Otolemur garnettii	85.28	0.00e+00	1406.00
IUUC-Oar-090024	Ovis aries	83.96	0.00e+00	1390.00
IUUC-Ptr-090455	Pan troglodytes	82.88	0.00e+00	1423.00
IUUC-Pan-092509	Papio anubis	80.85	0.00e+00	1264.00
IUUC-Psi-092974	Pelodiscus sinensis	86.62	0.00e+00	1428.00
IUUC-Pma-094643	Petromyzon marinus	70.45	0.00e+00	1211.00
IUUC-Pno-094886	Phaeosphaeria nodorum	35.84	1.00e-58	222.00
IUUC-Pfo-096905	Poecilia formosa	91.75	0.00e+00	1566.00
IUUC-Pab-097840	Pongo abelii	83.08	0.00e+00	1367.00
IUUC-Pca-100869	Procavia capensis	84.15	0.00e+00	1399.00
IUUC-Pva-103040	Pteropus vampyrus	88.39	4.00e-179	621.00
IUUC-Rno-105453	Rattus norvegicus	81.46	0.00e+00	1382.00
IUUC-Sha-107651	Sarcophilus harrisii	85.50	0.00e+00	1447.00
IUUC-Smo-108858	Selaginella moellendorffii	48.05	1.00e-112	400.00
IUUC-Sar-113293	Sorex araneus	85.28	0.00e+00	1412.00
IUUC-Ssc-115979	Sus scrofa	85.15	0.00e+00	1412.00
IUUC-Tgu-116901	Taeniopygia guttata	86.07	0.00e+00	1446.00
IUUC-Tru-118368	Takifugu rubripes	94.23	0.00e+00	1572.00
IUUC-Tsy-119516	Tarsius syrichta	81.43	0.00e+00	1298.00
IUUC-Tni-120143	Tetraodon nigroviridis	94.58	0.00e+00	1565.00
IUUC-Tbe-127484	Tupaia belangeri	78.81	0.00e+00	942.00
IUUC-Ttr-129078	Tursiops truncatus	84.70	0.00e+00	1387.00
IUUC-Vpa-130312	Vicugna pacos	77.06	0.00e+00	1170.00
IUUC-Xtr-132881	Xenopus tropicalis	84.25	0.00e+00	1433.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence