iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gac-042607

UUCD1 version

UUC-GaA-00815

Ensembl Protein ID

ENSGACP00000020910.1

UniProt Accession

G3PTH4; G3PTH4_GASAC

Protein Name

Uncharacterized protein

Gene Name

nedd4a; NEDD4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGACG00000015840.1	ENSGACT00000020950.1	ENSGACP00000020910.1
ENSGACG00000015840.1	ENSGACT00000020952.1	ENSGACP00000020912.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.60e-133	444.2	580	910

Active Site

Position(s)	Description	Evidence
880	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlp 91
           + lk+rl+vef+gE+gld+gGv+re+++l+ske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld++
   Q: 580  DLLKARLWVEFEGEKGLDYGGVAREWFFLMSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDAF 668
           56899************************************************************************************ PP
   S: 92   lsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           + ++fyk++l+k+++l+d+e+vd+e+++slk+i+en   d ++  ldl+f+++ee++g+t+++eLkpgG++i +tne k+eY++lv+++
   Q: 669  FIRPFYKMMLQKPITLQDMESVDSEYFNSLKWILEN---DPTD--LDLRFTIDEELFGQTHQHELKPGGADIVITNETKKEYIHLVMQW 752
           **********************************99...6666..79999999************************************ PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvT 269
           r+ ++i++q++af+eGf e+ip++++++F+e+elell+cG  ++dv+d++++tkyk+ y +++ +i wFw+++  +++e+r ++LqFvT
   Q: 753  RFVNRIQKQMTAFKEGFFELIPQDVIKIFDENELELLMCGLGDVDVNDWRENTKYKNSYCSNHVVILWFWKTVLLMDAEKRIRLLQFVT 841
           ***************************************************************************************** PP
   S: 270  gssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           g+sr+P++Gfael     p+lf+i+++++ d+lP+++TCfn+L+LP+Y+s e+l+ekL +Aie+++gF+
   Q: 842  GTSRVPMNGFAELYgsngPQLFTIEQWGTRDKLPRAHTCFNRLDLPPYESFEELREKLHIAIENAQGFD 910
           ********************************************************************8 PP

Organism

Gasterosteus aculeatus

Protein Sequence
(Fasta)

SMAALSPQIR GLQIEEGDSR VLKVKVVAGI GLAKKDILGA SDPYTRLSLY DPINGEITSL 60
QTKTIKKSLD PKWNEEFFFK VNPQKHRLLL EVFDENRLTR DDFLGQVDIP LNQIPTENPN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCGGCTAGC CGCTAGGTCG GGTGGACGGC TGCTACCAGT GTAAACAAGA GCGCACAATC 60
GGGGCAGAGT GGCAACGGAA CACCGTTAAA AAGTCTTCTC GTCGCTCTCC GGGGGAGGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001201	Ailuropoda melanoleuca	68.17	0.00e+00	1122.00
IUUC-Apl-003886	Anas platyrhynchos	64.26	0.00e+00	1201.00
IUUC-Ame-011138	Astyanax mexicanus	70.74	0.00e+00	1283.00
IUUC-Bta-012453	Bos taurus	65.11	0.00e+00	1042.00
IUUC-Cpo-021648	Cavia porcellus	66.04	0.00e+00	1218.00
IUUC-Csa-023334	Chlorocebus sabaeus	67.43	0.00e+00	1228.00
IUUC-Cin-025157	Ciona intestinalis	65.45	0.00e+00	783.00
IUUC-Dre-027924	Danio rerio	71.70	0.00e+00	1098.00
IUUC-Dme-032166	Drosophila melanogaster	64.12	0.00e+00	720.00
IUUC-Ete-032409	Echinops telfairi	61.35	0.00e+00	864.00
IUUC-Eca-033441	Equus caballus	66.09	0.00e+00	1183.00
IUUC-Fca-036384	Felis catus	67.96	0.00e+00	1101.00
IUUC-Fal-037547	Ficedula albicollis	67.17	0.00e+00	1214.00
IUUC-Gmo-039679	Gadus morhua	74.86	0.00e+00	1360.00
IUUC-Gga-040524	Gallus gallus	67.06	0.00e+00	1212.00
IUUC-Itr-048383	Ictidomys tridecemlineatus	60.72	0.00e+00	869.00
IUUC-Lch-050445	Latimeria chalumnae	69.81	0.00e+00	1165.00
IUUC-Loc-052645	Lepisosteus oculatus	73.66	0.00e+00	1365.00
IUUC-Meu-056897	Macropus eugenii	87.46	2.00e-157	550.00
IUUC-Mga-059362	Meleagris gallopavo	64.75	0.00e+00	1197.00
IUUC-Mmr-061061	Microcebus murinus	67.59	0.00e+00	1100.00
IUUC-Mpu-066567	Mustela putorius furo	67.68	0.00e+00	1249.00
IUUC-Mlu-068148	Myotis lucifugus	67.39	0.00e+00	1094.00
IUUC-Nle-069225	Nomascus leucogenys	67.03	0.00e+00	1118.00
IUUC-Ont-071664	Oreochromis niloticus	75.32	0.00e+00	1389.00
IUUC-Oan-073019	Ornithorhynchus anatinus	68.54	0.00e+00	1172.00
IUUC-Oar-089797	Ovis aries	66.78	0.00e+00	1144.00
IUUC-Pfo-097145	Poecilia formosa	75.16	0.00e+00	1343.00
IUUC-Pab-098394	Pongo abelii	66.88	0.00e+00	1225.00
IUUC-Pca-100568	Procavia capensis	61.04	0.00e+00	892.00
IUUC-Sha-107370	Sarcophilus harrisii	63.96	0.00e+00	1064.00
IUUC-Sja-107786	Schizosaccharomyces japonicus	49.04	2.00e-153	536.00
IUUC-Tgu-117474	Taeniopygia guttata	67.02	0.00e+00	1223.00
IUUC-Tru-117675	Takifugu rubripes	73.33	0.00e+00	1340.00
IUUC-Tni-119993	Tetraodon nigroviridis	72.22	0.00e+00	1316.00
IUUC-Tbe-127408	Tupaia belangeri	62.77	0.00e+00	830.00
IUUC-Uma-129332	Ustilago maydis	47.02	9.00e-144	504.00
IUUC-Vpa-130503	Vicugna pacos	64.50	0.00e+00	955.00
IUUC-Xma-133630	Xiphophorus maculatus	73.64	0.00e+00	1178.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence