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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046964
UUCD1 version UUC-HoS-00432
Ensembl Protein ID ENSP00000307298.4
UniProt Accession Q9UK73; O43146; FEM1B_HUMAN
Genbank Protein ID AAF05314.1; AAF69303.1; BAA23692.2; BAF82856.1; EAW77818.1; AAH10122.1; AAH14558.1
Protein Name Protein fem-1 homolog B; FEM1-beta; Fem-1-like death receptor-binding protein alpha; Fem-1-like in apoptotic pathway protein alpha
Genbank Nucleotide ID AF178632; AF204883; AB007856; AK290167; AC021553; BC010122; BC014558
Gene Name FEM1B; F1AA; KIAA0396
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000169018.5 ENST00000306917.4 ENSP00000307298.4
ENSG00000169018.5 ENST00000566008.1 ENSP00000456968.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box SOCS 15601820
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1.
 Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1.
Protein Sequence
(Fasta)
MEGLAGYVYK AASEGKVLTL AALLLNRSES DIRYLLGYVS QQGGQRSTPL IIAARNGHAK 60
VVRLLLEHYR VQTQQTGTVR FDGYVIDGAT ALWCAAGAGH FEVVKLLVSH GANVNHTTVT 120
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Protein Fasta Sequence


>IUUC-Hsa-046964|E3,SOCS|Homo sapiens
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Nucleotide Sequence
(Fasta)
CGCTCTTGCG GGAGCGTTCC GCATCGCCCC GGGGGCCCCT ACGCGAGGAT CTCCGGGGCC 60
GTTGGCAGCG CCTGGCACTT CTGAGCTCGG CGGACGAGAG CCTGCAGGTT TCCTCCAGTC 120
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Nucleotide Fasta Sequence


>IUUC-Hsa-046964|E3,SOCS|Homo sapiens
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Sequence Source Ensembl
Keyword

KW-0040--ANK repeat
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0802--TPR repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR011991--WHTH_DNA-bd_dom
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
Pfam

PF00023--Ank
PF12796--Ank_2
PRINTS

PR01415--ANKYRIN
SMART

SM00248--ANK
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005123--F:death receptor binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006915--P:apoptotic process
GO:0060442--P:branching involved in prostate gland morphogenesis
GO:0060743--P:epithelial cell maturation involved in prostate gland development
GO:2000001--P:regulation of DNA damage checkpoint
GO:1902041--P:regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0051438--P:regulation of ubiquitin-protein transferase activity
KEGG hsa:10116
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001977 Ailuropoda melanoleuca 99.52 0.00e+00 1296.00
IUUC-Apl-003175 Anas platyrhynchos 89.69 0.00e+00 1141.00
IUUC-Aca-004307 Anolis carolinensis 87.24 0.00e+00 1159.00
IUUC-Ani-009163 Aspergillus nidulans 31.92 1.00e-09 57.80
IUUC-Ame-011780 Astyanax mexicanus 82.14 0.00e+00 1065.00
IUUC-Bta-013169 Bos taurus 99.52 0.00e+00 1296.00
IUUC-Cja-018787 Callithrix jacchus 99.84 0.00e+00 1300.00
IUUC-Cfa-020246 Canis familiaris 98.56 0.00e+00 1283.00
IUUC-Cpo-021778 Cavia porcellus 99.36 0.00e+00 1296.00
IUUC-Csa-023153 Chlorocebus sabaeus 99.09 0.00e+00 1134.00
IUUC-Cin-025726 Ciona intestinalis 46.47 7.00e-154 537.00
IUUC-Csv-026048 Ciona savignyi 47.69 1.00e-165 576.00
IUUC-Dre-028359 Danio rerio 80.22 0.00e+00 1040.00
IUUC-Dno-029353 Dasypus novemcinctus 99.33 0.00e+00 1226.00
IUUC-Dor-030825 Dipodomys ordii 90.43 0.00e+00 1115.00
IUUC-Dme-031842 Drosophila melanogaster 40.51 3.00e-118 419.00
IUUC-Ete-032259 Echinops telfairi 97.98 0.00e+00 1109.00
IUUC-Eca-033405 Equus caballus 99.68 0.00e+00 1298.00
IUUC-Eeu-034682 Erinaceus europaeus 91.39 0.00e+00 1034.00
IUUC-Fca-036111 Felis catus 99.66 0.00e+00 1214.00
IUUC-Fal-036910 Ficedula albicollis 87.84 0.00e+00 1132.00
IUUC-Gmo-039115 Gadus morhua 77.94 0.00e+00 668.00
IUUC-Gga-040350 Gallus gallus 90.91 0.00e+00 1200.00
IUUC-Gac-042402 Gasterosteus aculeatus 78.79 0.00e+00 1036.00
IUUC-Ggo-044845 Gorilla gorilla 100.00 0.00e+00 1301.00
IUUC-Itr-048687 Ictidomys tridecemlineatus 99.36 0.00e+00 1291.00
IUUC-Lch-049773 Latimeria chalumnae 86.92 0.00e+00 1154.00
IUUC-Loc-052171 Lepisosteus oculatus 85.33 0.00e+00 1126.00
IUUC-Laf-054457 Loxodonta africana 98.13 0.00e+00 1186.00
IUUC-Mcc-054620 Macaca mulatta 75.51 0.00e+00 914.00
IUUC-Meu-056651 Macropus eugenii 89.55 1.00e-144 506.00
IUUC-Mga-059705 Meleagris gallopavo 88.71 0.00e+00 1033.00
IUUC-Mvi-060501 Microbotryum violaceum 31.25 1.00e-16 82.40
IUUC-Mmr-061523 Microcebus murinus 99.52 0.00e+00 1298.00
IUUC-Mdo-062255 Monodelphis domestica 92.82 0.00e+00 1221.00
IUUC-Mmu-063328 Mus musculus 99.04 0.00e+00 1293.00
IUUC-Mpu-065695 Mustela putorius furo 99.68 0.00e+00 1298.00
IUUC-Mlu-067547 Myotis lucifugus 99.36 0.00e+00 1296.00
IUUC-Nfi-068574 Neosartorya fischeri 34.96 6.00e-08 52.80
IUUC-Nle-069891 Nomascus leucogenys 100.00 0.00e+00 1301.00
IUUC-Opr-070956 Ochotona princeps 98.50 0.00e+00 1227.00
IUUC-Ont-072598 Oreochromis niloticus 79.43 0.00e+00 1059.00
IUUC-Oan-073603 Ornithorhynchus anatinus 86.61 0.00e+00 986.00
IUUC-Ocu-074309 Oryctolagus cuniculus 97.58 0.00e+00 1259.00
IUUC-Ola-087018 Oryzias latipes 79.43 0.00e+00 1048.00
IUUC-Oga-088965 Otolemur garnettii 99.20 0.00e+00 1293.00
IUUC-Oar-089640 Ovis aries 98.09 0.00e+00 1271.00
IUUC-Ptr-090739 Pan troglodytes 100.00 0.00e+00 1301.00
IUUC-Pan-091722 Papio anubis 100.00 0.00e+00 1301.00
IUUC-Psi-093697 Pelodiscus sinensis 89.00 0.00e+00 1180.00
IUUC-Pma-094633 Petromyzon marinus 68.21 2.00e-147 515.00
IUUC-Pfo-096128 Poecilia formosa 79.27 0.00e+00 1048.00
IUUC-Pab-098328 Pongo abelii 100.00 0.00e+00 1301.00
IUUC-Pca-100953 Procavia capensis 98.04 0.00e+00 1244.00
IUUC-Rno-105584 Rattus norvegicus 99.20 0.00e+00 1294.00
IUUC-Sha-107455 Sarcophilus harrisii 91.74 0.00e+00 1054.00
IUUC-Sar-113373 Sorex araneus 97.98 0.00e+00 1117.00
IUUC-Ssc-115680 Sus scrofa 99.68 0.00e+00 1298.00
IUUC-Tgu-116500 Taeniopygia guttata 90.33 0.00e+00 1143.00
IUUC-Tru-118757 Takifugu rubripes 79.11 0.00e+00 1043.00
IUUC-Tni-120735 Tetraodon nigroviridis 78.47 0.00e+00 1035.00
IUUC-Tbe-127905 Tupaia belangeri 99.20 0.00e+00 1285.00
IUUC-Ttr-128292 Tursiops truncatus 99.21 0.00e+00 1043.00
IUUC-Vpa-130405 Vicugna pacos 99.68 0.00e+00 1298.00
IUUC-Xtr-132441 Xenopus tropicalis 83.89 0.00e+00 1110.00
Created Date 25-Jun-2017

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