iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-073996

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAGW02056966

Gene Name

SOCS1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000021836.1	ENSOCUT00000025756.1	ENSOCUP00000019110.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	1.40e-13	50.5	144	191

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 3    klwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
            ++l+++++r+Lq+LCR +I+ ++g+++l    ++PL+++L+dYL+++++q
   Q: 144  GAPLRQRRVRPLQELCRQRIVATVGRENL---ARIPLNPVLRDYLSSFPFQ 191
           6789*************************...***************9986 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

RRAERAAAVA AARLSAPEHA REPSRSPXPA PGDTHFRTFR SHADYRRITR TSALLDACGF 60
YWGPLSVHGA HERLRAEPVG TFLVRDSRQR NCFFALSVKM ASGPTSIRVH FQAGRFHLDG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCCGAGCAG AGCGAGCTGC GGCCGTGGCA GCTGCACGGC TCTCGGCCCC GGAGCATGCG 60
CGAGAGCCGT CCCGGAGCCC CCTGCCGCCC CGCCCGCGGC GCTCCGCGCC CCCGTCGCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028411--SOCS1
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0000932--C:P-body
GO:0019210--F:kinase inhibitor activity
GO:0071230--P:cellular response to amino acid stimulus
GO:0019221--P:cytokine-mediated signaling pathway
GO:0045444--P:fat cell differentiation
GO:0007259--P:JAK-STAT cascade
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0042512--P:negative regulation of tyrosine phosphorylation of Stat1 protein
GO:0042518--P:negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0010534--P:regulation of activation of JAK2 kinase activity
GO:0050707--P:regulation of cytokine secretion
GO:0060334--P:regulation of interferon-gamma-mediated signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001204	Ailuropoda melanoleuca	88.02	1.00e-78	285.00
IUUC-Apl-003313	Anas platyrhynchos	71.78	7.00e-72	263.00
IUUC-Aca-005109	Anolis carolinensis	68.99	4.00e-63	233.00
IUUC-Ame-011550	Astyanax mexicanus	50.00	1.00e-48	185.00
IUUC-Bta-013411	Bos taurus	98.14	2.00e-91	327.00
IUUC-Cja-019595	Callithrix jacchus	98.16	1.00e-92	332.00
IUUC-Cfa-020563	Canis familiaris	96.27	5.00e-89	319.00
IUUC-Cpo-021374	Cavia porcellus	99.38	1.00e-92	331.00
IUUC-Csa-023333	Chlorocebus sabaeus	98.14	2.00e-91	328.00
IUUC-Dre-028507	Danio rerio	46.79	2.00e-44	171.00
IUUC-Dno-029406	Dasypus novemcinctus	97.52	4.00e-90	323.00
IUUC-Ete-032399	Echinops telfairi	97.52	6.00e-90	323.00
IUUC-Eca-033519	Equus caballus	96.88	1.00e-86	312.00
IUUC-Fal-036726	Ficedula albicollis	72.39	3.00e-73	267.00
IUUC-Gmo-039667	Gadus morhua	49.56	2.00e-26	111.00
IUUC-Gga-040970	Gallus gallus	72.39	1.00e-72	265.00
IUUC-Gac-041838	Gasterosteus aculeatus	43.86	3.00e-36	144.00
IUUC-Ggo-045569	Gorilla gorilla	98.75	2.00e-91	327.00
IUUC-Hsa-046010	Homo sapiens	98.76	8.00e-92	328.00
IUUC-Itr-047995	Ictidomys tridecemlineatus	98.76	1.00e-91	328.00
IUUC-Lch-050219	Latimeria chalumnae	61.49	2.00e-62	231.00
IUUC-Loc-052494	Lepisosteus oculatus	57.86	9.00e-55	206.00
IUUC-Laf-054219	Loxodonta africana	95.59	2.00e-71	260.00
IUUC-Mcc-054830	Macaca mulatta	98.14	2.00e-91	328.00
IUUC-Meu-056565	Macropus eugenii	81.99	2.00e-78	284.00
IUUC-Mga-060153	Meleagris gallopavo	72.33	7.00e-71	259.00
IUUC-Mmr-061365	Microcebus murinus	98.76	9.00e-92	328.00
IUUC-Mdo-062824	Monodelphis domestica	79.64	4.00e-78	283.00
IUUC-Mmu-064120	Mus musculus	98.76	6.00e-92	329.00
IUUC-Mpu-066839	Mustela putorius furo	98.76	7.00e-92	329.00
IUUC-Mlu-067829	Myotis lucifugus	97.52	2.00e-90	324.00
IUUC-Nle-069592	Nomascus leucogenys	95.03	2.00e-87	314.00
IUUC-Ont-072173	Oreochromis niloticus	45.00	1.00e-37	149.00
IUUC-Oan-073586	Ornithorhynchus anatinus	51.69	2.00e-27	114.00
IUUC-Oba-075150	Oryza barthii	29.41	7.90e-02	30.00
IUUC-Ola-087158	Oryzias latipes	46.88	2.00e-39	155.00
IUUC-Oga-088076	Otolemur garnettii	96.39	1.00e-92	331.00
IUUC-Ptr-091241	Pan troglodytes	98.76	6.00e-92	329.00
IUUC-Pan-091836	Papio anubis	98.12	5.00e-91	326.00
IUUC-Psi-093628	Pelodiscus sinensis	69.83	5.00e-73	266.00
IUUC-Pfo-097501	Poecilia formosa	45.28	1.00e-36	145.00
IUUC-Pab-098170	Pongo abelii	98.76	9.00e-92	328.00
IUUC-Pop-100072	Populus trichocarpa	30.77	3.30e-02	32.30
IUUC-Pva-102796	Pteropus vampyrus	98.14	3.00e-91	327.00
IUUC-Rno-105319	Rattus norvegicus	98.76	6.00e-92	329.00
IUUC-Sha-107201	Sarcophilus harrisii	81.17	6.00e-74	268.00
IUUC-Ssc-116004	Sus scrofa	98.76	1.00e-91	328.00
IUUC-Tgu-116836	Taeniopygia guttata	72.39	2.00e-72	264.00
IUUC-Tru-118090	Takifugu rubripes	43.12	7.00e-36	143.00
IUUC-Tni-120719	Tetraodon nigroviridis	45.00	2.00e-32	132.00
IUUC-Vpa-130235	Vicugna pacos	98.76	9.00e-92	328.00
IUUC-Xtr-132610	Xenopus tropicalis	61.11	1.00e-67	249.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence