iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089310

Ensembl Protein ID

ENSOARP00000019826.1

UniProt Accession

W5QAT1; W5QAT1_SHEEP

Genbank Protein ID

ENSOARP00000019826

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01027872

Gene Name

AMFR

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000018465.1	ENSOART00000020099.1	ENSOARP00000019826.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	5.30e-09	36.6	258	296
UBD/Alpha-Helix/CUE	2.30e-11	43.6	373	414

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           CaiC+++++   + lpCgH+fh +Cl  w        +  +CP+Cr
   Q: 258  CAICWDSMQA-ARKLPCGHLFHNSCLRSW------LEQDTSCPTCR 296
           ********99.******************......9*********8 PP

UBD/Alpha-Helix/CUE

   S: 1    dletaleqLkeiFPnldysviqvvLeantgsleaavnnLLegs 43
           +l+ +++q++e+FP+++y ++ ++L ++t s+e +++n+Leg 
   Q: 373  QLNAMAHQIQEMFPQVPYHLVLQDL-QLTRSVEITTDNILEGR 414
           5889*********************.***************95 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

VQVLVNTACC ILMLVAKLIQ CIVFGPLRVS ERQHLKDKFW NFIFYKFIFI FGVLNVQTVE 60
EVVMWCLWFA GLVFLHLMVQ LCKDRFEYLS FSPTTPMSSH GRVLSLLIAM LLSCCGLAVV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTACAGGTTC TAGTGAATAC TGCTTGCTGC ATTTTGATGT TGGTGGCTAA GCTAATCCAG 60
TGTATTGTGT TTGGCCCTCT TCGAGTGAGC GAAAGACAGG TAAGTCCACA CAGCAAGGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR003892--CUE
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51140--CUE
PS50089--ZF_RING_2

Pfam

PF02845--CUE
PF13639--zf-RING_2

SMART

SM00546--CUE
SM00184--RING

Gene Ontology

GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0005794--C:Golgi apparatus
GO:0030176--C:integral component of endoplasmic reticulum membrane
GO:0048471--C:perinuclear region of cytoplasm
GO:0004872--F:receptor activity
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0008270--F:zinc ion binding
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0032092--P:positive regulation of protein binding
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0051259--P:protein oligomerization
GO:0030433--P:ubiquitin-dependent ERAD pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001300	Ailuropoda melanoleuca	94.79	0.00e+00	1014.00
IUUC-Apl-003404	Anas platyrhynchos	87.99	0.00e+00	930.00
IUUC-Aca-004559	Anolis carolinensis	85.47	0.00e+00	871.00
IUUC-Ame-011640	Astyanax mexicanus	76.79	0.00e+00	766.00
IUUC-Bta-012980	Bos taurus	98.93	0.00e+00	1072.00
IUUC-Cel-018598	Caenorhabditis elegans	24.53	3.00e-30	126.00
IUUC-Cja-019577	Callithrix jacchus	94.82	0.00e+00	1035.00
IUUC-Cfa-020793	Canis familiaris	95.54	0.00e+00	1043.00
IUUC-Cpo-022387	Cavia porcellus	95.71	0.00e+00	1008.00
IUUC-Csa-023168	Chlorocebus sabaeus	95.36	0.00e+00	1043.00
IUUC-Cho-024433	Choloepus hoffmanni	96.22	0.00e+00	855.00
IUUC-Cin-025215	Ciona intestinalis	49.43	7.00e-145	507.00
IUUC-Csv-026133	Ciona savignyi	49.71	5.00e-133	468.00
IUUC-Dre-027594	Danio rerio	75.30	0.00e+00	718.00
IUUC-Dno-029407	Dasypus novemcinctus	95.71	0.00e+00	1009.00
IUUC-Dor-030961	Dipodomys ordii	95.52	0.00e+00	1028.00
IUUC-Ete-032962	Echinops telfairi	87.28	0.00e+00	856.00
IUUC-Eca-033683	Equus caballus	94.81	0.00e+00	1003.00
IUUC-Eeu-034515	Erinaceus europaeus	99.26	2.00e-79	289.00
IUUC-Fca-035398	Felis catus	96.88	0.00e+00	1008.00
IUUC-Fal-036758	Ficedula albicollis	81.44	0.00e+00	874.00
IUUC-Gmo-039014	Gadus morhua	73.60	0.00e+00	706.00
IUUC-Gga-040575	Gallus gallus	87.86	0.00e+00	964.00
IUUC-Gac-041414	Gasterosteus aculeatus	72.88	0.00e+00	694.00
IUUC-Hsa-046272	Homo sapiens	95.18	0.00e+00	1040.00
IUUC-Itr-047956	Ictidomys tridecemlineatus	95.54	0.00e+00	1010.00
IUUC-Lch-050491	Latimeria chalumnae	81.35	0.00e+00	820.00
IUUC-Loc-052758	Lepisosteus oculatus	80.35	0.00e+00	776.00
IUUC-Laf-053452	Loxodonta africana	96.43	0.00e+00	1026.00
IUUC-Mcc-055820	Macaca mulatta	95.99	0.00e+00	1025.00
IUUC-Meu-056726	Macropus eugenii	87.33	0.00e+00	763.00
IUUC-Mga-059937	Meleagris gallopavo	87.86	0.00e+00	936.00
IUUC-Mmr-060730	Microcebus murinus	95.54	0.00e+00	1005.00
IUUC-Mdo-062771	Monodelphis domestica	93.04	0.00e+00	986.00
IUUC-Mmu-064219	Mus musculus	94.81	0.00e+00	1028.00
IUUC-Mpu-066796	Mustela putorius furo	96.90	0.00e+00	1034.00
IUUC-Mlu-068189	Myotis lucifugus	94.11	0.00e+00	988.00
IUUC-Nle-069239	Nomascus leucogenys	95.36	0.00e+00	1042.00
IUUC-Opr-070702	Ochotona princeps	88.04	3.00e-137	481.00
IUUC-Ont-072033	Oreochromis niloticus	74.76	0.00e+00	746.00
IUUC-Oan-073717	Ornithorhynchus anatinus	85.69	0.00e+00	865.00
IUUC-Ocu-074145	Oryctolagus cuniculus	93.21	0.00e+00	1018.00
IUUC-Ogl-077929	Oryza glaberrima	53.49	1.00e-11	62.80
IUUC-Ola-087152	Oryzias latipes	73.06	0.00e+00	730.00
IUUC-Oga-088486	Otolemur garnettii	95.89	0.00e+00	1010.00
IUUC-Ptr-090649	Pan troglodytes	95.34	0.00e+00	1039.00
IUUC-Pan-091692	Papio anubis	90.71	0.00e+00	978.00
IUUC-Psi-093064	Pelodiscus sinensis	95.23	0.00e+00	775.00
IUUC-Pma-094763	Petromyzon marinus	77.87	4.00e-97	347.00
IUUC-Ppa-095969	Physcomitrella patens	29.94	1.00e-35	144.00
IUUC-Pfo-096810	Poecilia formosa	74.57	0.00e+00	735.00
IUUC-Pab-097859	Pongo abelii	95.44	0.00e+00	1023.00
IUUC-Pop-099576	Populus trichocarpa	27.35	2.00e-28	120.00
IUUC-Pca-100344	Procavia capensis	93.95	0.00e+00	979.00
IUUC-Pva-103114	Pteropus vampyrus	68.93	0.00e+00	654.00
IUUC-Rno-105880	Rattus norvegicus	93.14	0.00e+00	1002.00
IUUC-Sha-107015	Sarcophilus harrisii	93.35	0.00e+00	971.00
IUUC-Sar-113397	Sorex araneus	98.38	0.00e+00	764.00
IUUC-Ssc-115988	Sus scrofa	94.10	7.00e-145	506.00
IUUC-Tgu-116717	Taeniopygia guttata	89.43	0.00e+00	910.00
IUUC-Tru-117805	Takifugu rubripes	71.53	0.00e+00	754.00
IUUC-Tsy-119442	Tarsius syrichta	89.25	0.00e+00	931.00
IUUC-Tni-119777	Tetraodon nigroviridis	72.56	4.00e-171	594.00
IUUC-Tbe-127322	Tupaia belangeri	68.67	2.00e-115	409.00
IUUC-Ttr-128181	Tursiops truncatus	97.67	0.00e+00	1062.00
IUUC-Vpa-130483	Vicugna pacos	85.95	0.00e+00	664.00
IUUC-Xtr-132614	Xenopus tropicalis	80.85	0.00e+00	762.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence