iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000017776.15	ENSMUST00000017920.13	ENSMUSP00000017920.7
ENSMUSG00000017776.15	ENSMUST00000108426.7	ENSMUSP00000104064.1
ENSMUSG00000017776.15	ENSMUST00000108425.7	ENSMUSP00000104063.1
ENSMUSG00000017776.15	ENSMUST00000093115.3	ENSMUSP00000090803.3
ENSMUSG00000017776.15	ENSMUST00000147718.1	ENSMUSP00000116527.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
Phospho.ELM	UniProt	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.10e-18	66.6	134	189

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
            e+v++l+d++++++++L +kkGd++++   ++ +e W+++ ++ egkrG++P  +vek
   Q: 134  AEYVRALFDFNGNDEEDLPFKKGDILRI--RDKPEEQWWNA-EDSEGKRGMIPVPYVEK 189
           689*************************..6999******9.5**************98 PP

Organism

Mus musculus

Functional Description
(View)

Isoform Crk-II: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.

Protein Sequence
(Fasta)

MAGNFDSEER SSWYWGRLSR QEAVALLQGQ RHGVFLVRDS STSPGDYVLS VSENSRVSHY 60
IINSSGPRPP VPPSPAQPPP GVSPSRLRIG DQEFDSLPAL LEFYKIHYLD TTTLIEPVAR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGTAGAGGG CGCGTCATTT CCGGTGGGGA AGGCCCGCGG CCGCCGCCGC CATTTCGGGC 60
GCTGCTGGGA GGCTGACACC GGAGCCGGTC CGCTGGGCGG CGGGCGCCAG GGCTGGAGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0677--Repeat
KW-0727--SH2 domain
KW-0728--SH3 domain

Interpro

IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1
PF07653--SH3_2

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0045121--C:membrane raft
GO:0005886--C:plasma membrane
GO:0046875--F:ephrin receptor binding
GO:0045309--F:protein phosphorylated amino acid binding
GO:0042169--F:SH2 domain binding
GO:0005070--F:SH3/SH2 adaptor activity
GO:1990859--P:cellular response to endothelin
GO:1990314--P:cellular response to insulin-like growth factor stimulus
GO:1990090--P:cellular response to nerve growth factor stimulus
GO:0071732--P:cellular response to nitric oxide
GO:0071560--P:cellular response to transforming growth factor beta stimulus
GO:0048013--P:ephrin receptor signaling pathway
GO:0045953--P:negative regulation of natural killer cell mediated cytotoxicity
GO:0014911--P:positive regulation of smooth muscle cell migration
GO:1900026--P:positive regulation of substrate adhesion-dependent cell spreading
GO:0032956--P:regulation of actin cytoskeleton organization
GO:0043087--P:regulation of GTPase activity
GO:0035020--P:regulation of Rac protein signal transduction
GO:0035728--P:response to hepatocyte growth factor
GO:0042542--P:response to hydrogen peroxide
GO:0001878--P:response to yeast

KEGG

mmu:12928

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001192	Ailuropoda melanoleuca	99.33	4.00e-160	556.00
IUUC-Apl-003225	Anas platyrhynchos	92.00	9.00e-123	432.00
IUUC-Aca-004818	Anolis carolinensis	77.92	1.00e-92	332.00
IUUC-Ame-011721	Astyanax mexicanus	68.35	2.00e-118	418.00
IUUC-Bta-012320	Bos taurus	99.67	2.00e-163	568.00
IUUC-Cel-018307	Caenorhabditis elegans	30.33	3.00e-26	112.00
IUUC-Cja-019935	Callithrix jacchus	96.05	1.00e-167	582.00
IUUC-Cfa-021221	Canis familiaris	99.34	3.00e-163	567.00
IUUC-Cpo-021592	Cavia porcellus	86.49	7.00e-138	483.00
IUUC-Csa-024128	Chlorocebus sabaeus	99.51	1.00e-100	358.00
IUUC-Cho-024775	Choloepus hoffmanni	97.70	7.00e-162	562.00
IUUC-Dre-027390	Danio rerio	68.94	1.00e-119	422.00
IUUC-Dno-029847	Dasypus novemcinctus	99.67	2.00e-163	568.00
IUUC-Dor-030360	Dipodomys ordii	89.47	2.00e-156	544.00
IUUC-Ete-032604	Echinops telfairi	96.41	6.00e-126	442.00
IUUC-Eca-033233	Equus caballus	98.03	7.00e-163	566.00
IUUC-Eeu-034642	Erinaceus europaeus	96.86	6.00e-128	449.00
IUUC-Fca-035955	Felis catus	99.11	4.00e-131	459.00
IUUC-Fal-037152	Ficedula albicollis	86.48	4.00e-141	493.00
IUUC-Gmo-038849	Gadus morhua	67.72	9.00e-118	416.00
IUUC-Gga-040861	Gallus gallus	83.61	4.00e-150	523.00
IUUC-Gac-041627	Gasterosteus aculeatus	66.67	2.00e-120	425.00
IUUC-Ggo-045475	Gorilla gorilla	99.67	2.00e-163	568.00
IUUC-Hsa-046008	Homo sapiens	99.67	2.00e-163	568.00
IUUC-Itr-048906	Ictidomys tridecemlineatus	99.23	5.00e-134	469.00
IUUC-Lch-050509	Latimeria chalumnae	80.97	6.00e-148	516.00
IUUC-Loc-052229	Lepisosteus oculatus	73.16	3.00e-108	384.00
IUUC-Laf-053896	Loxodonta africana	94.79	1.00e-166	578.00
IUUC-Mcc-055280	Macaca mulatta	99.67	2.00e-163	568.00
IUUC-Meu-056783	Macropus eugenii	96.41	2.00e-126	444.00
IUUC-Mga-059345	Meleagris gallopavo	91.93	1.00e-123	435.00
IUUC-Mdo-062691	Monodelphis domestica	88.31	5.00e-154	536.00
IUUC-Mpu-065737	Mustela putorius furo	99.34	2.00e-163	568.00
IUUC-Mlu-067005	Myotis lucifugus	96.38	8.00e-159	552.00
IUUC-Nle-070154	Nomascus leucogenys	99.11	7.00e-131	459.00
IUUC-Opr-071114	Ochotona princeps	98.03	8.00e-176	608.00
IUUC-Ont-071696	Oreochromis niloticus	69.75	3.00e-115	408.00
IUUC-Oan-072967	Ornithorhynchus anatinus	93.08	2.00e-132	465.00
IUUC-Ocu-074025	Oryctolagus cuniculus	98.52	4.00e-99	353.00
IUUC-Oga-088266	Otolemur garnettii	98.36	1.00e-162	565.00
IUUC-Oar-089221	Ovis aries	98.03	7.00e-159	552.00
IUUC-Ptr-091463	Pan troglodytes	95.07	2.00e-151	527.00
IUUC-Pan-092242	Papio anubis	99.34	2.00e-163	568.00
IUUC-Psi-093287	Pelodiscus sinensis	94.20	1.00e-126	445.00
IUUC-Pfo-097378	Poecilia formosa	66.46	2.00e-110	392.00
IUUC-Pab-097823	Pongo abelii	99.51	1.00e-100	358.00
IUUC-Pca-101068	Procavia capensis	99.67	2.00e-163	568.00
IUUC-Pgr-103636	Puccinia graminis	36.21	7.00e-09	53.90
IUUC-Rno-105288	Rattus norvegicus	99.34	6.00e-163	566.00
IUUC-Sar-113453	Sorex araneus	84.54	7.00e-147	513.00
IUUC-Tgu-116926	Taeniopygia guttata	86.23	1.00e-149	521.00
IUUC-Tru-118656	Takifugu rubripes	66.57	6.00e-120	423.00
IUUC-Tni-120497	Tetraodon nigroviridis	68.81	1.00e-114	406.00
IUUC-Tbe-127436	Tupaia belangeri	94.74	1.00e-144	505.00
IUUC-Ttr-129109	Tursiops truncatus	99.55	3.00e-130	457.00
IUUC-Vpa-130527	Vicugna pacos	99.34	2.00e-161	561.00
IUUC-Xtr-131808	Xenopus tropicalis	84.26	6.00e-150	523.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence