iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.10e-09	39.0	14	65

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf....kdgplvlpCgHvfhadClqkw.....pglknssskefrCPlCr 46
           C++C+e f        ++l+CgHvf++dCl k+     ++ +   ++++ CP+Cr
   Q: 14   CPVCYEKFrdleG-ASRTLSCGHVFCHDCLVKYllstrVDGQ--VQRTIVCPICR 65
           ********55532.3899************999888665555..889999****8 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MSEGESKDSS GSECPVCYEK FRDLEGASRT LSCGHVFCHD CLVKYLLSTR VDGQVQRTIV 60
CPICRYVTFL SKKSSRWPSM LDKSSQTLAV PVGLPSTPSP DRGGHTNPLV ISHQVWRQSP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGTCATTAG GAAATGCCTC CACAGCCGGC ACAGTGACAG CAGCTGTCAG TCCAGCTGGG 60
TGGCTCCCCA TCTGCGGAGG CCTTGGATAG AAAGACAGAC ACCACTCTCT CAGGTACAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR027370--Znf-RING_LisH
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13445--zf-RING_UBOX

SMART

SM00184--RING

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0033768--C:SUMO-targeted ubiquitin ligase complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0033234--P:negative regulation of protein sumoylation
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination

KEGG

rno:363627

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001331	Ailuropoda melanoleuca	89.25	2.00e-46	177.00
IUUC-Atr-002488	Amborella trichopoda	33.33	9.00e-07	47.00
IUUC-Apl-003509	Anas platyrhynchos	47.71	3.00e-35	141.00
IUUC-Aca-004916	Anolis carolinensis	36.95	1.00e-22	99.40
IUUC-Bta-013443	Bos taurus	84.71	2.00e-71	261.00
IUUC-Cja-019637	Callithrix jacchus	82.61	1.00e-64	239.00
IUUC-Cfa-020737	Canis familiaris	82.35	2.00e-65	241.00
IUUC-Cpo-022224	Cavia porcellus	88.96	1.00e-67	249.00
IUUC-Csa-024175	Chlorocebus sabaeus	81.01	1.00e-73	269.00
IUUC-Dre-028060	Danio rerio	36.84	2.00e-23	102.00
IUUC-Dno-030024	Dasypus novemcinctus	80.98	4.00e-66	244.00
IUUC-Dor-030936	Dipodomys ordii	89.41	3.00e-80	290.00
IUUC-Eca-033759	Equus caballus	89.07	4.00e-78	283.00
IUUC-Fal-037142	Ficedula albicollis	44.22	8.00e-31	126.00
IUUC-Gmo-039196	Gadus morhua	36.19	1.00e-20	92.40
IUUC-Gga-041189	Gallus gallus	49.38	9.00e-33	132.00
IUUC-Gac-041497	Gasterosteus aculeatus	40.74	2.00e-23	102.00
IUUC-Ggo-045020	Gorilla gorilla	83.03	5.00e-69	253.00
IUUC-Hsa-046317	Homo sapiens	83.03	2.00e-65	241.00
IUUC-Itr-048656	Ictidomys tridecemlineatus	93.53	3.00e-85	307.00
IUUC-Lch-049885	Latimeria chalumnae	38.46	4.00e-24	104.00
IUUC-Laf-053457	Loxodonta africana	77.65	4.00e-68	250.00
IUUC-Mcc-054653	Macaca mulatta	81.65	4.00e-64	237.00
IUUC-Mga-059753	Meleagris gallopavo	50.27	2.00e-36	145.00
IUUC-Mdo-062993	Monodelphis domestica	73.27	2.00e-69	254.00
IUUC-Mmu-063225	Mus musculus	97.06	3.00e-79	287.00
IUUC-Mpu-066299	Mustela putorius furo	83.53	4.00e-66	243.00
IUUC-Mlu-066988	Myotis lucifugus	84.30	7.00e-68	249.00
IUUC-Nle-069011	Nomascus leucogenys	82.91	7.00e-66	243.00
IUUC-Opr-070258	Ochotona princeps	86.03	4.00e-71	260.00
IUUC-Ont-071886	Oreochromis niloticus	42.29	9.00e-25	106.00
IUUC-Ocu-074282	Oryctolagus cuniculus	91.18	2.00e-73	268.00
IUUC-Oga-088403	Otolemur garnettii	77.09	2.00e-68	251.00
IUUC-Oar-089665	Ovis aries	83.67	2.00e-20	90.10
IUUC-Ptr-090580	Pan troglodytes	83.64	8.00e-67	246.00
IUUC-Pan-092447	Papio anubis	82.28	1.00e-64	239.00
IUUC-Psi-093673	Pelodiscus sinensis	44.89	3.00e-38	151.00
IUUC-Ppa-095340	Physcomitrella patens	36.49	8.00e-08	50.80
IUUC-Pfo-096933	Poecilia formosa	38.60	2.00e-21	95.50
IUUC-Pab-097867	Pongo abelii	83.54	4.00e-63	234.00
IUUC-Pva-102146	Pteropus vampyrus	90.00	2.00e-76	278.00
IUUC-Sha-107282	Sarcophilus harrisii	67.33	1.00e-55	208.00
IUUC-Sar-113260	Sorex araneus	89.41	2.00e-82	298.00
IUUC-Ssc-115449	Sus scrofa	82.35	6.00e-54	203.00
IUUC-Tgu-117349	Taeniopygia guttata	43.65	1.00e-29	122.00
IUUC-Xtr-132180	Xenopus tropicalis	39.88	1.00e-24	106.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence