iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089670

Ensembl Protein ID

ENSOARP00000010231.1

UniProt Accession

W5PIG2; W5PIG2_SHEEP

Genbank Protein ID

ENSOARP00000010231

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AMGL01066660

Gene Name

YES1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000009530.1	ENSOART00000010381.1	ENSOARP00000010231.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	9.80e-15	54.5	94	149

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           + +lydyea ++++L++kkG+  ++i  ++++++W+++ + ++gk+G +P+n+v+ ++
   Q: 94   FVALYDYEARTTEDLSFKKGERFQII--NNTEGDWWEARSIATGKNGYIPSNYVAPAD 149
           789***********************..8999**********************9875 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MGCIKSKENK SPSIKYRPES TPEPVGTGVG HHGAEHAVVA PASSAKSTSA SFSSLSLTPF 60
GGPSAVTPFG GASSSFSVAP GSYPAGLTGG VTIFVALYDY EARTTEDLSF KKGERFQIIN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGAGAAATG CCTGGTTTAA AGGCAGCTGC TAAAGTATAC CTCTTCTGAA GCATCCTTTA 60
TGATAACTGC TTCTCACACT TTGCCTTATC ACCTTGGTAG GCTTGATAAT GGGCTGCATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005884--C:actin filament
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005925--C:focal adhesion
GO:0005794--C:Golgi apparatus
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0036120--P:cellular response to platelet-derived growth factor stimulus
GO:0071300--P:cellular response to retinoic acid
GO:0071560--P:cellular response to transforming growth factor beta stimulus
GO:0015758--P:glucose transport
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter

KEGG

oas:101104362

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002374	Ailuropoda melanoleuca	95.76	0.00e+00	1021.00
IUUC-Apl-004032	Anas platyrhynchos	90.39	0.00e+00	1002.00
IUUC-Aca-004255	Anolis carolinensis	90.02	0.00e+00	1008.00
IUUC-Ame-010954	Astyanax mexicanus	85.74	0.00e+00	964.00
IUUC-Bta-013503	Bos taurus	97.97	0.00e+00	1031.00
IUUC-Cja-019694	Callithrix jacchus	94.29	0.00e+00	1001.00
IUUC-Cfa-020402	Canis familiaris	95.93	0.00e+00	1021.00
IUUC-Cpo-022506	Cavia porcellus	95.38	0.00e+00	1014.00
IUUC-Csa-023713	Chlorocebus sabaeus	95.21	0.00e+00	1015.00
IUUC-Dre-027978	Danio rerio	84.07	0.00e+00	929.00
IUUC-Dno-029897	Dasypus novemcinctus	94.54	0.00e+00	908.00
IUUC-Dor-030202	Dipodomys ordii	98.01	0.00e+00	932.00
IUUC-Eca-034157	Equus caballus	96.30	0.00e+00	1023.00
IUUC-Eeu-034950	Erinaceus europaeus	86.08	3.00e-171	594.00
IUUC-Fca-036233	Felis catus	95.93	0.00e+00	1060.00
IUUC-Fal-037461	Ficedula albicollis	90.57	0.00e+00	1017.00
IUUC-Gmo-038929	Gadus morhua	80.69	0.00e+00	892.00
IUUC-Gga-041107	Gallus gallus	90.02	0.00e+00	1001.00
IUUC-Gac-042321	Gasterosteus aculeatus	83.42	0.00e+00	919.00
IUUC-Hsa-047010	Homo sapiens	95.76	0.00e+00	1017.00
IUUC-Lch-050239	Latimeria chalumnae	89.09	0.00e+00	986.00
IUUC-Lpe-051166	Leersia perrieri	34.93	4.00e-23	103.00
IUUC-Loc-052314	Lepisosteus oculatus	86.24	0.00e+00	915.00
IUUC-Laf-053517	Loxodonta africana	95.19	0.00e+00	993.00
IUUC-Mcc-055626	Macaca mulatta	95.21	0.00e+00	1015.00
IUUC-Mga-059310	Meleagris gallopavo	90.02	0.00e+00	1001.00
IUUC-Mmr-061652	Microcebus murinus	94.82	0.00e+00	1013.00
IUUC-Mdo-062963	Monodelphis domestica	90.20	0.00e+00	993.00
IUUC-Mmu-064128	Mus musculus	94.45	0.00e+00	1028.00
IUUC-Mpu-065906	Mustela putorius furo	96.12	0.00e+00	1023.00
IUUC-Mlu-067035	Myotis lucifugus	95.04	0.00e+00	1011.00
IUUC-Nle-069041	Nomascus leucogenys	91.71	0.00e+00	957.00
IUUC-Opr-070299	Ochotona princeps	85.95	0.00e+00	897.00
IUUC-Ont-072337	Oreochromis niloticus	85.19	0.00e+00	951.00
IUUC-Oan-072997	Ornithorhynchus anatinus	97.58	0.00e+00	931.00
IUUC-Ocu-074171	Oryctolagus cuniculus	95.19	0.00e+00	1019.00
IUUC-Oba-075994	Oryza barthii	34.85	6.00e-21	96.30
IUUC-Ogl-077331	Oryza glaberrima	35.35	3.00e-23	103.00
IUUC-Ogu-078962	Oryza glumaepatula	34.62	3.00e-23	103.00
IUUC-Oin-079172	Oryza indica	35.35	2.00e-23	103.00
IUUC-Olo-080286	Oryza longistaminata	35.35	3.00e-23	103.00
IUUC-Ome-081400	Oryza meridionalis	35.35	2.00e-23	104.00
IUUC-Oru-084741	Oryza rufipogon	35.35	2.00e-23	104.00
IUUC-Ola-086619	Oryzias latipes	83.45	0.00e+00	945.00
IUUC-Oga-087957	Otolemur garnettii	94.09	0.00e+00	998.00
IUUC-Ptr-091352	Pan troglodytes	95.76	0.00e+00	1017.00
IUUC-Pan-092202	Papio anubis	95.21	0.00e+00	1015.00
IUUC-Psi-093310	Pelodiscus sinensis	89.83	0.00e+00	1008.00
IUUC-Pma-094232	Petromyzon marinus	87.90	0.00e+00	860.00
IUUC-Pfo-096137	Poecilia formosa	83.70	0.00e+00	936.00
IUUC-Pab-098301	Pongo abelii	99.17	0.00e+00	963.00
IUUC-Pva-102592	Pteropus vampyrus	91.50	0.00e+00	957.00
IUUC-Rno-105544	Rattus norvegicus	95.01	0.00e+00	1011.00
IUUC-Sar-113364	Sorex araneus	91.50	0.00e+00	957.00
IUUC-Tgu-117380	Taeniopygia guttata	90.57	0.00e+00	1017.00
IUUC-Tru-117594	Takifugu rubripes	83.67	0.00e+00	941.00
IUUC-Tni-120433	Tetraodon nigroviridis	82.79	0.00e+00	920.00
IUUC-Ttr-128893	Tursiops truncatus	96.12	0.00e+00	1024.00
IUUC-Vpa-130060	Vicugna pacos	96.30	0.00e+00	1026.00
IUUC-Xtr-132322	Xenopus tropicalis	88.54	0.00e+00	984.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence