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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046282
Ensembl Protein ID ENSP00000352314.4
UniProt Accession Q9P2G3; A6NNW1; B4DHA0; Q8WU41; KLH14_HUMAN
Genbank Protein ID BAA92622.1; EAX01296.1; EAX01295.1; AAH21267.1; BAG58061.1
Protein Name Kelch-like protein 14; Protein interactor of Torsin-1A
Genbank Nucleotide ID AB037805; AC025887; CH471088; BC021267; AK294996
Gene Name KLHL14; KIAA1384
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000197705.9 ENST00000359358.8 ENSP00000352314.4
ENSG00000197705.9 ENST00000358095.4 ENSP00000350808.4
ENSG00000197705.9 ENST00000583263.1 ENSP00000463803.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
miRNAMapSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 1.90e-11 45.8 33 148
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmelees..................................................ksklm 42
           +Dv+l  +g++f++hk+vLa++S++F++lf+++ + +                                                  +  + 
   Q: 33   CDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPPLGggvggqdglgapkdqqqppqqqpsqqqqpppqeepgtpssspddklltspRAINN 124
           9*********************************9777***********************************************9977999 PP
   S: 43   veikdvqpevfrallkFlYtgkld 66
            ++++ +   +r +l++lYt  ++
   Q: 125  LVLQGCSSIGLRLVLEYLYTANVT 148
           9999****************9876 PP
   
Organism Homo sapiens
Protein Sequence
(Fasta)
MSRSGDRTST FDPSHSDNLL HGLNLLWRKQ LFCDVTLTAQ GQQFHCHKAV LASCSQYFRS 60
LFSSHPPLGG GVGGQDGLGA PKDQQQPPQQ QPSQQQQPPP QEEPGTPSSS PDDKLLTSPR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046282|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGCACGACCG TTTCTCTCCC CAACCGTGGA TTTCCTATTA CTCTCGTTAC GACTCACTGA 60
GCCCCAGGCC CAAGGATAAT GATGTGTTGT TTCTTGGTAG CATAATTTGT CACACGTACA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046282|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0256--Endoplasmic reticulum
KW-0880--Kelch repeat
KW-0472--Membrane
KW-1185--Reference proteome
KW-0677--Repeat
Interpro

IPR011705--BACK
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR030584--KLHL14
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0016235--C:aggresome
GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0043005--C:neuron projection
GO:0043025--C:neuronal cell body
GO:0016567--P:protein ubiquitination
KEGG hsa:57565
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001196 Ailuropoda melanoleuca 96.91 1.00e-177 615.00
IUUC-Bta-012869 Bos taurus 96.82 0.00e+00 1185.00
IUUC-Cja-018731 Callithrix jacchus 97.45 0.00e+00 1194.00
IUUC-Cfa-020355 Canis familiaris 98.25 0.00e+00 1192.00
IUUC-Cpo-021612 Cavia porcellus 98.09 0.00e+00 1167.00
IUUC-Csa-023993 Chlorocebus sabaeus 99.52 0.00e+00 1172.00
IUUC-Dre-027629 Danio rerio 86.46 0.00e+00 1077.00
IUUC-Dno-029185 Dasypus novemcinctus 97.46 0.00e+00 1190.00
IUUC-Fca-036303 Felis catus 97.77 0.00e+00 1186.00
IUUC-Fal-037175 Ficedula albicollis 93.15 0.00e+00 1148.00
IUUC-Gmo-038807 Gadus morhua 85.69 0.00e+00 1061.00
IUUC-Gga-040750 Gallus gallus 93.98 0.00e+00 1139.00
IUUC-Gac-041372 Gasterosteus aculeatus 85.35 0.00e+00 1065.00
IUUC-Ggo-044702 Gorilla gorilla 95.24 0.00e+00 1161.00
IUUC-Lch-049564 Latimeria chalumnae 91.26 0.00e+00 1145.00
IUUC-Loc-051831 Lepisosteus oculatus 89.81 0.00e+00 1128.00
IUUC-Laf-054353 Loxodonta africana 98.09 0.00e+00 1191.00
IUUC-Mcc-055080 Macaca mulatta 99.16 1.00e-171 595.00
IUUC-Meu-056733 Macropus eugenii 85.74 0.00e+00 819.00
IUUC-Mmr-061263 Microcebus murinus 99.21 0.00e+00 1167.00
IUUC-Mdo-061930 Monodelphis domestica 88.58 0.00e+00 1058.00
IUUC-Mmu-064251 Mus musculus 97.62 0.00e+00 1192.00
IUUC-Mpu-066871 Mustela putorius furo 98.09 0.00e+00 1194.00
IUUC-Mlu-067725 Myotis lucifugus 83.33 0.00e+00 808.00
IUUC-Nle-069427 Nomascus leucogenys 97.14 0.00e+00 1171.00
IUUC-Ont-072429 Oreochromis niloticus 86.78 0.00e+00 1088.00
IUUC-Ocu-074635 Oryctolagus cuniculus 97.46 0.00e+00 1189.00
IUUC-Ola-086870 Oryzias latipes 88.39 0.00e+00 1089.00
IUUC-Oga-088397 Otolemur garnettii 98.10 0.00e+00 1192.00
IUUC-Oar-089280 Ovis aries 99.21 0.00e+00 1020.00
IUUC-Ptr-091356 Pan troglodytes 94.90 0.00e+00 1091.00
IUUC-Pan-092718 Papio anubis 99.52 0.00e+00 1172.00
IUUC-Psi-093970 Pelodiscus sinensis 92.26 0.00e+00 1085.00
IUUC-Pfo-096550 Poecilia formosa 87.12 0.00e+00 1085.00
IUUC-Pab-097802 Pongo abelii 98.89 0.00e+00 1162.00
IUUC-Pca-101125 Procavia capensis 93.16 0.00e+00 1110.00
IUUC-Pva-102888 Pteropus vampyrus 99.48 0.00e+00 1103.00
IUUC-Rno-105007 Rattus norvegicus 97.46 0.00e+00 1192.00
IUUC-Sar-113671 Sorex araneus 96.03 0.00e+00 1157.00
IUUC-Ssc-116060 Sus scrofa 97.46 0.00e+00 1193.00
IUUC-Tgu-116795 Taeniopygia guttata 86.01 0.00e+00 1016.00
IUUC-Tru-118216 Takifugu rubripes 88.24 0.00e+00 1110.00
IUUC-Tsy-118816 Tarsius syrichta 96.02 0.00e+00 632.00
IUUC-Tni-120281 Tetraodon nigroviridis 80.19 0.00e+00 956.00
IUUC-Tbe-128057 Tupaia belangeri 93.81 0.00e+00 1115.00
IUUC-Ttr-128618 Tursiops truncatus 84.71 0.00e+00 1022.00
IUUC-Vpa-130468 Vicugna pacos 98.06 0.00e+00 731.00
IUUC-Xtr-132753 Xenopus tropicalis 89.21 0.00e+00 1102.00
Created Date 25-Jun-2017

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