iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ola-087467

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

BAAF04080837

Gene Name

nedd4l

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSORLG00000005975.1	ENSORLT00000007520.1	ENSORLP00000007519.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.80e-134	448.0	651	982

Active Site

Position(s)	Description	Evidence
952	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++ lk+rl++ef+ E+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld 
   Q: 651  PDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVFHGKLLDG 739
           57899************************************************************************************ PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
           ++ ++fyk++lgk++sl+d+e+vd+e+y+slk+i+en   d +e  ldl+f+++e+++g+t++++Lkp+G++  Vtn+Nk+eY++lv++
   Q: 740  FFIRPFYKMMLGKSISLKDMESVDSEYYNSLKWILEN---DPTE--LDLRFCIDEDNFGQTYQVDLKPSGSELVVTNDNKKEYIDLVIQ 823
           ***********************************99...6666..7****************************************** PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +++++q++af eGf+e+i+++l+++F+e+elell+cG  ++dv+d++++t yk+ y +++p+iqwFw+v+  +++e+r ++LqFv
   Q: 824  WRFVNRVQKQMNAFLEGFTELIQIDLIKIFDENELELLMCGLGDVDVNDWRQHTVYKNSYCPNHPVIQWFWKVVLLMDAEKRIRLLQFV 912
           ***************************************************************************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           Tg+sr+P++Gfael     p+lf+i++++++d+lP+++TCfn+L+LP Y+s e l+ekLl+A+e+++gFe
   Q: 913  TGTSRVPMNGFAELYgsngPQLFTIEQWGTPDKLPRAHTCFNRLDLPAYESFEDLREKLLMAVENAQGFE 982
           *********************************************************************8 PP

Organism

Oryzias latipes

Protein Sequence
(Fasta)

MAANYEPIYG LSEDENETRV LRVKVIAGID LAKKDILGAS DPYVKLSLYV ADENKELALV 60
QTKTIKKTLN PKWNEEFYFR VCPQNHRLLF EVFDENRLTR DDFLGQVDVP LNHLPTEDPA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCAGCGA ATTACGAACC TATTTACGGG CTTTCAGAAG ATGAGGTAAG ACTTAACTAT 60
ATCCGGGCCT ATTACTTTAT TTTTAATTTA AAAGAAACCC AGTTGTTTAA AGACTCTGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

PRINTS

PR00360--C2DOMAIN

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	77.78	0.00e+00	1394.00
IUUC-Apl-003893	Anas platyrhynchos	79.41	0.00e+00	1443.00
IUUC-Aca-004744	Anolis carolinensis	76.69	0.00e+00	1396.00
IUUC-Ago-007742	Ashbya gossypii	49.00	1.00e-160	560.00
IUUC-Acl-008273	Aspergillus clavatus	48.61	1.00e-161	563.00
IUUC-Afl-008713	Aspergillus flavus	48.91	3.00e-160	558.00
IUUC-Afu-009103	Aspergillus fumigatus	49.42	3.00e-162	565.00
IUUC-Ani-009259	Aspergillus nidulans	48.12	2.00e-160	559.00
IUUC-Ang-009738	Aspergillus niger	53.91	5.00e-152	531.00
IUUC-Aor-010053	Aspergillus oryzae	56.71	2.00e-99	355.00
IUUC-Ate-010529	Aspergillus terreus	49.42	2.00e-162	566.00
IUUC-Ame-010810	Astyanax mexicanus	89.07	0.00e+00	1070.00
IUUC-Bgr-012148	Blumeria graminis	47.08	8.00e-153	534.00
IUUC-Bta-012679	Bos taurus	78.50	0.00e+00	1298.00
IUUC-Bci-013785	Botrytis cinerea	47.49	5.00e-155	541.00
IUUC-Cel-018564	Caenorhabditis elegans	50.99	3.00e-178	618.00
IUUC-Cja-018732	Callithrix jacchus	79.76	0.00e+00	1489.00
IUUC-Cfa-021226	Canis familiaris	79.53	0.00e+00	1477.00
IUUC-Cpo-021671	Cavia porcellus	78.03	0.00e+00	1438.00
IUUC-Csa-023344	Chlorocebus sabaeus	78.18	0.00e+00	1471.00
IUUC-Cho-024832	Choloepus hoffmanni	94.03	0.00e+00	711.00
IUUC-Cin-025157	Ciona intestinalis	62.24	0.00e+00	775.00
IUUC-Csv-026098	Ciona savignyi	58.87	0.00e+00	648.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	47.92	4.00e-154	538.00
IUUC-Cne-026849	Cryptococcus neoformans	49.16	7.00e-159	554.00
IUUC-Dre-027770	Danio rerio	83.92	0.00e+00	1550.00
IUUC-Dno-029466	Dasypus novemcinctus	79.41	0.00e+00	1481.00
IUUC-Dor-030138	Dipodomys ordii	76.05	0.00e+00	1353.00
IUUC-Dse-031241	Dothistroma septosporum	47.62	1.00e-157	550.00
IUUC-Dme-032166	Drosophila melanogaster	68.13	0.00e+00	719.00
IUUC-Ete-033145	Echinops telfairi	73.51	0.00e+00	1053.00
IUUC-Eca-033445	Equus caballus	78.49	0.00e+00	1290.00
IUUC-Eeu-035247	Erinaceus europaeus	77.63	0.00e+00	1166.00
IUUC-Fca-035489	Felis catus	76.34	0.00e+00	1242.00
IUUC-Fal-037604	Ficedula albicollis	77.30	0.00e+00	1467.00
IUUC-Fox-037774	Fusarium oxysporum	47.67	1.00e-155	543.00
IUUC-Fso-038393	Fusarium solani	47.76	5.00e-153	535.00
IUUC-Gmo-039674	Gadus morhua	85.32	0.00e+00	1563.00
IUUC-Ggr-040107	Gaeumannomyces graminis	47.08	7.00e-155	541.00
IUUC-Gga-040703	Gallus gallus	79.15	0.00e+00	1492.00
IUUC-Gac-042020	Gasterosteus aculeatus	90.56	0.00e+00	1645.00
IUUC-Ggo-045332	Gorilla gorilla	78.40	0.00e+00	1410.00
IUUC-Hsa-045968	Homo sapiens	79.61	0.00e+00	1484.00
IUUC-Itr-048383	Ictidomys tridecemlineatus	64.16	0.00e+00	815.00
IUUC-Lch-050443	Latimeria chalumnae	80.04	0.00e+00	1323.00
IUUC-Loc-052662	Lepisosteus oculatus	81.73	0.00e+00	1485.00
IUUC-Laf-053850	Loxodonta africana	78.19	0.00e+00	1454.00
IUUC-Mcc-055821	Macaca mulatta	79.69	0.00e+00	1463.00
IUUC-Meu-056712	Macropus eugenii	60.48	6.00e-161	561.00
IUUC-Mor-057097	Magnaporthe oryzae	47.25	1.00e-154	540.00
IUUC-Mpo-057442	Magnaporthe poae	51.65	3.00e-145	509.00
IUUC-Mla-058996	Melampsora laricipopulina	53.73	3.00e-149	522.00
IUUC-Mga-059362	Meleagris gallopavo	63.51	0.00e+00	1150.00
IUUC-Mvi-060395	Microbotryum violaceum	54.73	1.00e-152	533.00
IUUC-Mmr-060798	Microcebus murinus	76.05	0.00e+00	1362.00
IUUC-Mdo-062173	Monodelphis domestica	78.10	0.00e+00	1491.00
IUUC-Mmu-064136	Mus musculus	79.27	0.00e+00	1465.00
IUUC-Mpu-066765	Mustela putorius furo	79.84	0.00e+00	1456.00
IUUC-Mlu-067565	Myotis lucifugus	78.54	0.00e+00	1304.00
IUUC-Nfi-068427	Neosartorya fischeri	49.59	3.00e-162	565.00
IUUC-Ncr-068918	Neurospora crassa	47.66	5.00e-154	538.00
IUUC-Nle-069070	Nomascus leucogenys	77.16	0.00e+00	1423.00
IUUC-Opr-071044	Ochotona princeps	83.85	0.00e+00	1079.00
IUUC-Ont-072044	Oreochromis niloticus	89.95	0.00e+00	1736.00
IUUC-Oan-073032	Ornithorhynchus anatinus	75.06	0.00e+00	1181.00
IUUC-Ocu-074160	Oryctolagus cuniculus	77.93	0.00e+00	1438.00
IUUC-Oga-088460	Otolemur garnettii	77.55	0.00e+00	1288.00
IUUC-Oar-090198	Ovis aries	79.37	0.00e+00	1449.00
IUUC-Ptr-090939	Pan troglodytes	79.61	0.00e+00	1484.00
IUUC-Pan-092284	Papio anubis	79.51	0.00e+00	1482.00
IUUC-Psi-093645	Pelodiscus sinensis	79.61	0.00e+00	1495.00
IUUC-Pma-094364	Petromyzon marinus	81.64	0.00e+00	856.00
IUUC-Pno-095118	Phaeosphaeria nodorum	44.71	8.00e-160	557.00
IUUC-Pfo-097145	Poecilia formosa	80.50	0.00e+00	821.00
IUUC-Pab-098088	Pongo abelii	79.61	0.00e+00	1471.00
IUUC-Pca-100714	Procavia capensis	76.61	0.00e+00	947.00
IUUC-Pva-102354	Pteropus vampyrus	77.80	0.00e+00	1391.00
IUUC-Pgr-103620	Puccinia graminis	53.32	9.00e-148	517.00
IUUC-Ptt-103806	Puccinia triticina	53.38	2.00e-123	436.00
IUUC-Pte-104016	Pyrenophora teres	47.84	2.00e-159	556.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	47.84	2.00e-159	556.00
IUUC-Rno-105318	Rattus norvegicus	78.26	0.00e+00	1427.00
IUUC-Sce-106289	Saccharomyces cerevisiae	48.40	4.00e-162	565.00
IUUC-Sha-107482	Sarcophilus harrisii	78.37	0.00e+00	1338.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	47.66	1.00e-155	543.00
IUUC-Stu-112582	Solanum tuberosum	35.26	7.00e-54	205.00
IUUC-Ssc-115950	Sus scrofa	63.18	0.00e+00	1046.00
IUUC-Tgu-117130	Taeniopygia guttata	79.49	0.00e+00	1482.00
IUUC-Tru-118610	Takifugu rubripes	91.28	0.00e+00	1733.00
IUUC-Tsy-119492	Tarsius syrichta	75.08	0.00e+00	1318.00
IUUC-Tni-120113	Tetraodon nigroviridis	85.18	0.00e+00	1565.00
IUUC-Tre-122203	Trichoderma reesei	43.91	9.00e-153	533.00
IUUC-Tvi-122595	Trichoderma virens	47.00	1.00e-154	540.00
IUUC-Tme-126897	Tuber melanosporum	53.10	1.00e-148	520.00
IUUC-Tbe-127408	Tupaia belangeri	75.86	0.00e+00	745.00
IUUC-Ttr-128235	Tursiops truncatus	89.83	0.00e+00	991.00
IUUC-Uma-129332	Ustilago maydis	52.48	5.00e-141	494.00
IUUC-Vda-129753	Verticillium dahliae	47.85	1.00e-154	540.00
IUUC-Vpa-130503	Vicugna pacos	79.46	0.00e+00	801.00
IUUC-Xtr-132859	Xenopus tropicalis	79.86	0.00e+00	1477.00
IUUC-Xma-133797	Xiphophorus maculatus	93.42	0.00e+00	1709.00
IUUC-Yli-134668	Yarrowia lipolytica	47.00	2.00e-160	559.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence