iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oan-072691

UUCD1 version

UUC-OrA-00667

Ensembl Protein ID

ENSOANP00000014909.3

UniProt Accession

F7FEN4; F7FEN4_ORNAN

Protein Name

Uncharacterized protein

Gene Name

KEAP1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000009371.4	ENSOANT00000014912.3	ENSOANP00000014909.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	4.60e-16	59.2	46	117
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	7.40e-10	38.0	150	180

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvv....g.geeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklden 68
           +Dv+l+v    +   +f ahk+vLa+sS+vF+a+f+++l+e+   + v i+++ p v++ l++F Yt ++++ 
   Q: 46   CDVTLQVryegApAAQFVAHKVVLASSSPVFKAMFTTGLREQG-MEVVSIEGIHPRVMERLIEFAYTASISMG 117
           89*****88852699**************************98.***********************998875 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhF 31
           ++N++gi  fA++ +c++L+++a+++i  hF
   Q: 150  PSNAIGIANFAEQIGCTELHQRAREYIYMHF 180
           89****************************9 PP

Organism

Ornithorhynchus anatinus

Protein Sequence
(Fasta)

MYAPECKAEV TPSQQGGHRT FSYTLEDHTR QAFGVMNELR LSQQLCDVTL QVRYEGAPAA 60
QFVAHKVVLA SSSPVFKAMF TTGLREQGME VVSIEGIHPR VMERLIEFAY TASISMGEKC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

NNNNNNNNNN NNNNNNNNNN NCCTCTCTCT CTTTCCTTCT TTCCAGGTGG CCGACTCTGA 60
GGGCCACTAG TGCTTCTCTG GCGTAGCGGG CGAGACCCTC CCAGCCCTGT CCGCTCTCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR030563--KEAP1
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0005884--C:actin filament
GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005815--C:microtubule organizing center
GO:0030496--C:midbody
GO:0005654--C:nucleoplasm
GO:0008134--F:transcription factor binding
GO:0071353--P:cellular response to interleukin-4
GO:0042994--P:cytoplasmic sequestering of transcription factor
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0010499--P:proteasomal ubiquitin-independent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0045604--P:regulation of epidermal cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001377	Ailuropoda melanoleuca	76.10	0.00e+00	935.00
IUUC-Aca-005389	Anolis carolinensis	78.95	0.00e+00	893.00
IUUC-Ame-010749	Astyanax mexicanus	73.29	0.00e+00	822.00
IUUC-Bta-013505	Bos taurus	76.10	0.00e+00	936.00
IUUC-Cja-018823	Callithrix jacchus	75.28	0.00e+00	922.00
IUUC-Cfa-021202	Canis familiaris	76.42	0.00e+00	939.00
IUUC-Cpo-021830	Cavia porcellus	67.44	2.00e-167	581.00
IUUC-Csa-023728	Chlorocebus sabaeus	75.77	0.00e+00	932.00
IUUC-Cin-025195	Ciona intestinalis	51.37	1.00e-163	569.00
IUUC-Csv-026155	Ciona savignyi	48.79	6.00e-148	516.00
IUUC-Dre-027388	Danio rerio	72.71	0.00e+00	797.00
IUUC-Dno-029066	Dasypus novemcinctus	69.76	0.00e+00	827.00
IUUC-Dor-030674	Dipodomys ordii	67.36	4.00e-167	580.00
IUUC-Dme-032165	Drosophila melanogaster	45.94	6.00e-134	470.00
IUUC-Eca-034381	Equus caballus	74.92	0.00e+00	913.00
IUUC-Eeu-034791	Erinaceus europaeus	89.93	0.00e+00	763.00
IUUC-Fca-036067	Felis catus	75.61	0.00e+00	929.00
IUUC-Gmo-039691	Gadus morhua	72.84	0.00e+00	815.00
IUUC-Gga-040266	Gallus gallus	76.90	0.00e+00	862.00
IUUC-Gac-041866	Gasterosteus aculeatus	73.03	0.00e+00	808.00
IUUC-Ggo-044719	Gorilla gorilla	75.61	0.00e+00	927.00
IUUC-Hsa-046255	Homo sapiens	75.61	0.00e+00	927.00
IUUC-Itr-048457	Ictidomys tridecemlineatus	75.61	0.00e+00	929.00
IUUC-Kpa-049266	Komagataella pastoris	26.44	1.60e-02	32.70
IUUC-Lch-049646	Latimeria chalumnae	77.13	0.00e+00	869.00
IUUC-Loc-052296	Lepisosteus oculatus	52.94	4.00e-153	534.00
IUUC-Laf-054579	Loxodonta africana	75.93	0.00e+00	935.00
IUUC-Mcc-055315	Macaca mulatta	75.77	0.00e+00	932.00
IUUC-Meu-056288	Macropus eugenii	80.44	0.00e+00	977.00
IUUC-Mmr-061639	Microcebus murinus	75.45	0.00e+00	930.00
IUUC-Mdo-062072	Monodelphis domestica	76.38	0.00e+00	940.00
IUUC-Mmu-063622	Mus musculus	75.28	0.00e+00	923.00
IUUC-Mpu-066737	Mustela putorius furo	82.97	0.00e+00	934.00
IUUC-Mlu-068173	Myotis lucifugus	75.77	0.00e+00	932.00
IUUC-Nle-069336	Nomascus leucogenys	48.81	8.00e-137	479.00
IUUC-Opr-070432	Ochotona princeps	76.26	0.00e+00	936.00
IUUC-Ont-072160	Oreochromis niloticus	72.33	0.00e+00	799.00
IUUC-Ocu-073798	Oryctolagus cuniculus	75.77	0.00e+00	932.00
IUUC-Ola-086367	Oryzias latipes	68.67	0.00e+00	764.00
IUUC-Oga-088231	Otolemur garnettii	75.93	0.00e+00	933.00
IUUC-Oar-089227	Ovis aries	74.80	0.00e+00	912.00
IUUC-Ptr-091460	Pan troglodytes	75.61	0.00e+00	927.00
IUUC-Pan-092713	Papio anubis	75.77	0.00e+00	932.00
IUUC-Pfo-096468	Poecilia formosa	68.87	0.00e+00	832.00
IUUC-Pab-098357	Pongo abelii	75.61	0.00e+00	927.00
IUUC-Pca-100837	Procavia capensis	75.61	0.00e+00	925.00
IUUC-Pva-103249	Pteropus vampyrus	73.50	0.00e+00	872.00
IUUC-Rno-106086	Rattus norvegicus	74.47	0.00e+00	911.00
IUUC-Sha-107245	Sarcophilus harrisii	76.38	0.00e+00	941.00
IUUC-Sar-112985	Sorex araneus	75.57	0.00e+00	932.00
IUUC-Ssc-115756	Sus scrofa	76.26	0.00e+00	936.00
IUUC-Tgu-116838	Taeniopygia guttata	55.61	8.00e-119	419.00
IUUC-Tru-117644	Takifugu rubripes	72.24	0.00e+00	811.00
IUUC-Tni-120245	Tetraodon nigroviridis	71.88	0.00e+00	800.00
IUUC-Tbe-127472	Tupaia belangeri	92.90	1.00e-95	343.00
IUUC-Ttr-128953	Tursiops truncatus	89.97	7.00e-175	606.00
IUUC-Vpa-130683	Vicugna pacos	81.65	0.00e+00	908.00
IUUC-Xtr-132827	Xenopus tropicalis	68.42	0.00e+00	778.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence