iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pfo-096984

Ensembl Protein ID

ENSPFOP00000008208.2

UniProt Accession

A0A087XR05; A0A087XR05_POEFO

Genbank Protein ID

ENSPFOP00000008208

Protein Name

Phosphoinositide phospholipase C

Genbank Nucleotide ID

AYCK01007027

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPFOG00000007841.2	ENSPFOT00000008220.2	ENSPFOP00000008208.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.20e-11	44.9	789	844

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGl.fPenFvekle 63
           +v+++y+y+aq ddeL++ k  v++ +  ++q++gW+kg  +  gk+ + fP+n+ve+++
   Q: 789  TVKAMYEYKAQRDDELSFSKNAVITNV--DKQEGGWWKG--DCGGKKQMwFPANYVEEIS 844
           79************************9..9*********..666655544*******996 PP

Organism

Poecilia formosa

Protein Sequence
(Fasta)

MAGTSGFLSN GPVPWMDDTE MNNLYRDLEL GTVMTLFYSK KSQRPERRTF QVKLETRTII 60
WTRSTDKIEG EIDIREIKEI RPGQKSRDFE RYVEDSAVRL DNFCFVILYG TEFRLKSLSL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTGAAAATCC GCAGCGGAAG CTTGCTTTTT GACTCTGCTT GGGATGATGC CGCTGCCGGT 60
GGACTGAGAG GGGGGAAGGG CCTCCGCTGG TTGGATCCGA GAACAGACAA ACTTACGTAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0106--Calcium
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0442--Lipid degradation
KW-0443--Lipid metabolism
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0807--Transducer

Interpro

IPR000008--C2_dom
IPR011992--EF-hand-dom_pair
IPR018247--EF_Hand_1_Ca_BS
IPR002048--EF_hand_dom
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001192--PI-PLC_fam
IPR016279--PLC-gamma
IPR028380--PLC-gamma1
IPR017946--PLC-like_Pdiesterase_TIM-brl
IPR000909--PLipase_C_PInositol-sp_X_dom
IPR001711--PLipase_C_Pinositol-sp_Y
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50004--C2
PS00018--EF_HAND_1
PS50222--EF_HAND_2
PS50003--PH_DOMAIN
PS50007--PIPLC_X_DOMAIN
PS50008--PIPLC_Y_DOMAIN
PS50001--SH2
PS50002--SH3

Pfam

PF00168--C2
PF00388--PI-PLC-X
PF00387--PI-PLC-Y
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00390--PHPHLIPASEC
PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00239--C2
SM00233--PH
SM00148--PLCXc
SM00149--PLCYc
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005622--C:intracellular
GO:0005509--F:calcium ion binding
GO:0004435--F:phosphatidylinositol phospholipase C activity
GO:0004871--F:signal transducer activity
GO:0001525--P:angiogenesis
GO:0048844--P:artery morphogenesis
GO:0031101--P:fin regeneration
GO:0030851--P:granulocyte differentiation
GO:0060218--P:hematopoietic stem cell differentiation
GO:0035556--P:intracellular signal transduction
GO:0009395--P:phospholipid catabolic process
GO:0035477--P:regulation of angioblast cell migration involved in selective angioblast sprouting
GO:0008016--P:regulation of heart contraction
GO:0001570--P:vasculogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001452	Ailuropoda melanoleuca	71.44	0.00e+00	1932.00
IUUC-Apl-003541	Anas platyrhynchos	65.55	0.00e+00	1695.00
IUUC-Aca-005291	Anolis carolinensis	72.71	0.00e+00	1911.00
IUUC-Ame-011004	Astyanax mexicanus	75.81	0.00e+00	1939.00
IUUC-Bta-012660	Bos taurus	72.26	0.00e+00	1846.00
IUUC-Bdi-014986	Brachypodium distachyon	20.27	2.90e-01	30.00
IUUC-Cja-019206	Callithrix jacchus	71.85	0.00e+00	1919.00
IUUC-Cfa-020257	Canis familiaris	72.27	0.00e+00	1859.00
IUUC-Cpo-022391	Cavia porcellus	67.51	0.00e+00	1790.00
IUUC-Csa-024170	Chlorocebus sabaeus	73.99	0.00e+00	1455.00
IUUC-Cin-025520	Ciona intestinalis	47.16	0.00e+00	1067.00
IUUC-Dre-027944	Danio rerio	79.18	0.00e+00	2067.00
IUUC-Dno-029440	Dasypus novemcinctus	72.23	0.00e+00	1791.00
IUUC-Dor-031001	Dipodomys ordii	71.28	0.00e+00	1927.00
IUUC-Eca-033809	Equus caballus	72.37	0.00e+00	1860.00
IUUC-Fca-036510	Felis catus	72.59	0.00e+00	1865.00
IUUC-Fal-037541	Ficedula albicollis	73.31	0.00e+00	1782.00
IUUC-Gmo-038630	Gadus morhua	71.73	0.00e+00	1583.00
IUUC-Gga-040142	Gallus gallus	72.83	0.00e+00	1914.00
IUUC-Ggo-045063	Gorilla gorilla	71.83	0.00e+00	1946.00
IUUC-Hsa-046428	Homo sapiens	71.83	0.00e+00	1945.00
IUUC-Itr-048245	Ictidomys tridecemlineatus	72.24	0.00e+00	1918.00
IUUC-Lch-049766	Latimeria chalumnae	73.28	0.00e+00	1841.00
IUUC-Loc-052285	Lepisosteus oculatus	80.40	0.00e+00	2155.00
IUUC-Laf-053365	Loxodonta africana	71.87	0.00e+00	1848.00
IUUC-Mcc-054871	Macaca mulatta	72.10	0.00e+00	1939.00
IUUC-Meu-056724	Macropus eugenii	68.85	0.00e+00	1708.00
IUUC-Mga-059329	Meleagris gallopavo	72.11	0.00e+00	1810.00
IUUC-Mmr-061110	Microcebus murinus	71.95	0.00e+00	1935.00
IUUC-Mdo-062448	Monodelphis domestica	72.65	0.00e+00	1954.00
IUUC-Mmu-063565	Mus musculus	71.56	0.00e+00	1944.00
IUUC-Mpu-066683	Mustela putorius furo	72.19	0.00e+00	1947.00
IUUC-Mlu-067779	Myotis lucifugus	72.19	0.00e+00	1861.00
IUUC-Nle-069219	Nomascus leucogenys	75.66	0.00e+00	1692.00
IUUC-Opr-070766	Ochotona princeps	68.72	0.00e+00	1081.00
IUUC-Ont-072524	Oreochromis niloticus	86.85	0.00e+00	2249.00
IUUC-Oan-073214	Ornithorhynchus anatinus	57.38	2.00e-37	147.00
IUUC-Ocu-074361	Oryctolagus cuniculus	72.02	0.00e+00	1904.00
IUUC-Ola-086820	Oryzias latipes	84.24	0.00e+00	2227.00
IUUC-Oga-088172	Otolemur garnettii	72.04	0.00e+00	1951.00
IUUC-Oar-090306	Ovis aries	70.27	0.00e+00	1791.00
IUUC-Ptr-090682	Pan troglodytes	71.83	0.00e+00	1946.00
IUUC-Pan-092835	Papio anubis	73.08	0.00e+00	1409.00
IUUC-Psi-093344	Pelodiscus sinensis	72.24	0.00e+00	1920.00
IUUC-Pab-097871	Pongo abelii	72.49	0.00e+00	1923.00
IUUC-Pca-100772	Procavia capensis	66.00	0.00e+00	1743.00
IUUC-Pva-102790	Pteropus vampyrus	71.98	0.00e+00	1911.00
IUUC-Rno-105974	Rattus norvegicus	71.73	0.00e+00	1946.00
IUUC-Sar-112995	Sorex araneus	71.76	0.00e+00	1892.00
IUUC-Ssc-115360	Sus scrofa	72.19	0.00e+00	1934.00
IUUC-Tgu-116585	Taeniopygia guttata	70.53	0.00e+00	1824.00
IUUC-Tru-117742	Takifugu rubripes	85.94	0.00e+00	2267.00
IUUC-Tsy-119259	Tarsius syrichta	76.01	0.00e+00	684.00
IUUC-Tni-120833	Tetraodon nigroviridis	66.86	0.00e+00	1642.00
IUUC-Tbe-127504	Tupaia belangeri	64.59	0.00e+00	1069.00
IUUC-Xtr-132862	Xenopus tropicalis	68.51	0.00e+00	1786.00
IUUC-Xma-133619	Xiphophorus maculatus	96.93	0.00e+00	2523.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence