iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000156273.15	ENST00000286800.7	ENSP00000286800.3
ENSG00000156273.15	ENST00000422809.5	ENSP00000416569.1
ENSG00000156273.15	ENST00000468059.1	ENSP00000470673.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	microRNA	TRANSFAC	TargetScan
miRecords	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	6.10e-12	47.4	34	98

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmele.esksklmveikd.vqpevfrallkFlYtgklde 67
           +Dv++ v+g++f+ah++vLaa+Ss+F++ + ++ + e    l +++ + v  + f+ l++F Yt kl +
   Q: 34   CDVTIFVEGQRFRAHRSVLAACSSYFHSRIVGQADgE----LNITLPEeVTVKGFEPLIQFAYTAKLIL 98
           8*****************************8876633....67999966*****************987 PP

Organism

Homo sapiens

Functional Description
(View)

Belongs to the bZIP family. CNC subfamily.

Protein Sequence
(Fasta)

MSLSENSVFA YESSVHSTNV LLSLNDQRKK DVLCDVTIFV EGQRFRAHRS VLAACSSYFH 60
SRIVGQADGE LNITLPEEVT VKGFEPLIQF AYTAKLILSK ENVDEVCKCV EFLSVHNIEE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAGAAGCTA TTCAAAAATG TCCAGGACTC TGTTATTTAT TCAGCAAGCT TACAAAGCCA 60
TCTTTGATTG ACTGATTCTT TGACAATGAC TATCTGGATG ACACAGGAAG GATGCAATTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation

Interpro

IPR000210--BTB/POZ_dom
IPR004827--bZIP
IPR004826--bZIP_Maf
IPR011333--SKP1/BTB/POZ
IPR008917--TF_DNA-bd

PROSITE

PS50097--BTB
PS50217--BZIP
PS00036--BZIP_BASIC

Pfam

PF00651--BTB
PF03131--bZIP_Maf

SMART

SM00338--BRLZ
SM00225--BTB

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0020037--F:heme binding
GO:0000980--F:RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0001205--F:transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0001078--F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001206--F:transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0006310--P:DNA recombination
GO:0006281--P:DNA repair
GO:0006302--P:double-strand break repair
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0016567--P:protein ubiquitination
GO:0061418--P:regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0000083--P:regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000117--P:regulation of transcription involved in G2/M transition of mitotic cell cycle
GO:0006355--P:regulation of transcription, DNA-templated

KEGG

hsa:571

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002273	Ailuropoda melanoleuca	86.08	0.00e+00	1181.00
IUUC-Apl-003378	Anas platyrhynchos	67.22	0.00e+00	770.00
IUUC-Aca-004992	Anolis carolinensis	56.36	0.00e+00	656.00
IUUC-Ame-011817	Astyanax mexicanus	40.34	8.00e-45	175.00
IUUC-Bta-012599	Bos taurus	81.02	0.00e+00	1136.00
IUUC-Cja-019778	Callithrix jacchus	94.70	0.00e+00	1369.00
IUUC-Cfa-020459	Canis familiaris	85.05	0.00e+00	1204.00
IUUC-Cpo-021433	Cavia porcellus	81.67	0.00e+00	1141.00
IUUC-Csa-023346	Chlorocebus sabaeus	98.10	0.00e+00	1406.00
IUUC-Cho-024893	Choloepus hoffmanni	84.98	0.00e+00	1204.00
IUUC-Cin-025467	Ciona intestinalis	45.38	8.00e-27	112.00
IUUC-Csv-026178	Ciona savignyi	42.64	2.00e-26	114.00
IUUC-Dre-028155	Danio rerio	38.06	1.00e-42	167.00
IUUC-Dno-029607	Dasypus novemcinctus	86.76	0.00e+00	1219.00
IUUC-Dor-031026	Dipodomys ordii	60.43	1.00e-137	483.00
IUUC-Ete-032304	Echinops telfairi	75.51	0.00e+00	1025.00
IUUC-Eca-033379	Equus caballus	82.99	0.00e+00	959.00
IUUC-Eeu-035358	Erinaceus europaeus	81.71	0.00e+00	899.00
IUUC-Fca-035499	Felis catus	85.96	0.00e+00	1210.00
IUUC-Fal-037171	Ficedula albicollis	64.51	0.00e+00	696.00
IUUC-Gga-041169	Gallus gallus	62.50	0.00e+00	814.00
IUUC-Ggo-044485	Gorilla gorilla	99.18	0.00e+00	1442.00
IUUC-Itr-047970	Ictidomys tridecemlineatus	88.11	0.00e+00	1251.00
IUUC-Loc-052298	Lepisosteus oculatus	45.30	7.00e-58	218.00
IUUC-Laf-054320	Loxodonta africana	83.11	0.00e+00	929.00
IUUC-Mcc-055644	Macaca mulatta	98.51	0.00e+00	1409.00
IUUC-Mga-059196	Meleagris gallopavo	62.27	0.00e+00	798.00
IUUC-Mmr-061053	Microcebus murinus	91.20	0.00e+00	1305.00
IUUC-Mdo-062091	Monodelphis domestica	60.63	0.00e+00	748.00
IUUC-Mmu-063403	Mus musculus	79.73	0.00e+00	1120.00
IUUC-Mpu-065768	Mustela putorius furo	85.70	0.00e+00	1180.00
IUUC-Mlu-067451	Myotis lucifugus	76.81	0.00e+00	1026.00
IUUC-Nle-069507	Nomascus leucogenys	98.51	0.00e+00	1432.00
IUUC-Oan-073692	Ornithorhynchus anatinus	68.06	6.00e-100	358.00
IUUC-Ocu-074850	Oryctolagus cuniculus	91.47	0.00e+00	1139.00
IUUC-Oga-088762	Otolemur garnettii	88.11	0.00e+00	1238.00
IUUC-Oar-089511	Ovis aries	83.66	0.00e+00	1035.00
IUUC-Ptr-091232	Pan troglodytes	99.73	0.00e+00	1450.00
IUUC-Pan-091803	Papio anubis	98.37	0.00e+00	1407.00
IUUC-Pab-098303	Pongo abelii	98.37	0.00e+00	1424.00
IUUC-Pca-100147	Procavia capensis	74.14	0.00e+00	687.00
IUUC-Pva-102920	Pteropus vampyrus	87.14	0.00e+00	1244.00
IUUC-Rno-105893	Rattus norvegicus	78.92	0.00e+00	1103.00
IUUC-Sha-107059	Sarcophilus harrisii	69.71	0.00e+00	894.00
IUUC-Sar-113133	Sorex araneus	82.37	6.00e-173	601.00
IUUC-Ssc-115328	Sus scrofa	84.79	0.00e+00	1152.00
IUUC-Tgu-116625	Taeniopygia guttata	63.93	0.00e+00	815.00
IUUC-Tru-117726	Takifugu rubripes	51.01	6.00e-40	159.00
IUUC-Tni-120400	Tetraodon nigroviridis	52.45	7.00e-39	155.00
IUUC-Ttr-128805	Tursiops truncatus	86.72	0.00e+00	863.00
IUUC-Xtr-132494	Xenopus tropicalis	47.81	8.00e-166	577.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence