• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064230
UUCD1 version UUC-MuM-01152
Ensembl Protein ID ENSMUSP00000023061.5
UniProt Accession Q9DBJ6; Q3U3E9; JOS1_MOUSE
Genbank Protein ID BAB23664.1; BAE32837.1; AAH06928.1; AAH86769.1
Protein Name Josephin-1; Josephin domain-containing protein 1
Genbank Nucleotide ID AK004913; AK154799; BC006928; BC086769
Gene Name Josd1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000022426.5 ENSMUST00000023061.5 ENSMUSP00000023061.5
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
miRTarBasemicroRNATRANSFACRepTar
RAID2
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/Josephin 6.60e-100 333.4 1 201
Active Site
Position(s) Description Evidence
36 Nucleophile ECO:0000255|PROSITE-ProRule:PRU00331}
139 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU00331}
Domain Profile

   DUB/Josephin
   S: 1    msqvpg............aqaapesiyhekqrrelCalhalnnvlqd.elfsreeldeiakrldeeerlqPs.kslldtGnydvnvisa 75
           ms+vp+            +qaap++iyhekqrrelCalhalnnv+qd ++f+re+l+ei++rl+++++++P+ ks+l++Gnydvnvi+a
   Q: 1    MSCVPWkgdkakaessdlPQAAPPQIYHEKQRRELCALHALNNVFQDsNAFTRETLQEIFQRLSPNTMVTPHkKSMLGNGNYDVNVIMA 89
           8**********************************************9************************99*************** PP
   S: 76   alkvlGleavwfdkrrelqklaldnvlgfilnlpsslslgllklplkkqhWvtvrkvgkayynldsklkaPeligdetelrkflakllq 164
           al+++G+eavw+dkrr+++++al+nv+gfi+nlpssl++g+lklplk+qhW++vr+vg+ayynldsklk+Pe+ig+e+elrkfl+ +l+
   Q: 90   ALQTKGYEAVWWDKRRDVGVIALTNVMGFIMNLPSSLCWGPLKLPLKRQHWICVREVGGAYYNLDSKLKMPEWIGGESELRKFLKYHLR 178
           ***************************************************************************************** PP
   S: 165  qkyselllvvkeevedkesdqrld 188
           +k++elllvv+eeve+++s+ r d
   Q: 179  GKNCELLLVVPEEVEAHQSW-RAD 201
           ********************.665 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity (By similarity).
 Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity (By similarity).
Protein Sequence
(Fasta)
MSCVPWKGDK AKAESSDLPQ AAPPQIYHEK QRRELCALHA LNNVFQDSNA FTRETLQEIF 60
QRLSPNTMVT PHKKSMLGNG NYDVNVIMAA LQTKGYEAVW WDKRRDVGVI ALTNVMGFIM 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064230|DUB,Josephin|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGAGTGAACG CCGCTGACGT CGGGCTCAGG TGCGCGTGCC CGCCCGCTCC GCCGCCTGCT 60
TGTCCGCGCG TGGGCCAGGT GGCGGCCCGC AAGCTCCAGG TGGCGGCGTC GGGGAGACGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064230|DUB,Josephin|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR006155--Josephin
PROSITE

PS50957--JOSEPHIN
Pfam

PF02099--Josephin
SMART

SM01246--Josephin
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005886--C:plasma membrane
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
KEGG mmu:100043771; mmu:74158
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002429 Ailuropoda melanoleuca 96.53 4.00e-109 386.00
IUUC-Apl-003240 Anas platyrhynchos 89.16 4.00e-96 343.00
IUUC-Aca-004262 Anolis carolinensis 89.60 2.00e-102 364.00
IUUC-Afl-008651 Aspergillus flavus 31.88 1.20e-01 28.90
IUUC-Ame-011040 Astyanax mexicanus 69.59 1.00e-80 292.00
IUUC-Bta-012440 Bos taurus 96.53 1.00e-109 388.00
IUUC-Cja-019461 Callithrix jacchus 96.04 8.00e-109 385.00
IUUC-Cfa-021002 Canis familiaris 96.53 4.00e-109 386.00
IUUC-Cpo-021309 Cavia porcellus 97.52 2.00e-110 391.00
IUUC-Csa-023194 Chlorocebus sabaeus 96.53 8.00e-110 389.00
IUUC-Cho-025019 Choloepus hoffmanni 95.54 5.00e-109 386.00
IUUC-Cin-025666 Ciona intestinalis 60.37 2.00e-54 205.00
IUUC-Csv-026011 Ciona savignyi 57.00 1.00e-58 219.00
IUUC-Dre-028692 Danio rerio 68.98 9.00e-80 289.00
IUUC-Dno-029803 Dasypus novemcinctus 95.54 9.00e-109 385.00
IUUC-Dor-030619 Dipodomys ordii 99.29 3.00e-73 267.00
IUUC-Ete-032777 Echinops telfairi 95.19 8.00e-106 375.00
IUUC-Eca-034395 Equus caballus 95.05 2.00e-108 384.00
IUUC-Eeu-035075 Erinaceus europaeus 74.26 2.00e-76 278.00
IUUC-Fca-035819 Felis catus 97.03 4.00e-110 390.00
IUUC-Fal-037330 Ficedula albicollis 91.09 1.00e-99 355.00
IUUC-Gmo-038979 Gadus morhua 79.77 2.00e-75 275.00
IUUC-Gga-040456 Gallus gallus 93.60 8.00e-100 355.00
IUUC-Gac-041797 Gasterosteus aculeatus 73.63 9.00e-81 292.00
IUUC-Ggo-045586 Gorilla gorilla 97.03 3.00e-110 390.00
IUUC-Hsa-047008 Homo sapiens 97.03 3.00e-110 390.00
IUUC-Itr-048432 Ictidomys tridecemlineatus 97.03 5.00e-110 389.00
IUUC-Lch-049682 Latimeria chalumnae 78.71 7.00e-85 306.00
IUUC-Loc-051775 Lepisosteus oculatus 80.23 9.00e-77 279.00
IUUC-Laf-054283 Loxodonta africana 96.08 5.00e-108 382.00
IUUC-Mcc-055073 Macaca mulatta 96.88 2.00e-111 394.00
IUUC-Meu-056650 Macropus eugenii 92.08 6.00e-104 369.00
IUUC-Mga-059703 Meleagris gallopavo 93.56 4.00e-101 360.00
IUUC-Mdo-062114 Monodelphis domestica 93.07 8.00e-106 375.00
IUUC-Mpu-065845 Mustela putorius furo 96.04 9.00e-109 385.00
IUUC-Mlu-067564 Myotis lucifugus 93.07 4.00e-99 353.00
IUUC-Nfi-068472 Neosartorya fischeri 30.00 2.00e-01 29.30
IUUC-Nle-069516 Nomascus leucogenys 96.53 1.00e-109 388.00
IUUC-Opr-070945 Ochotona princeps 79.70 7.00e-85 306.00
IUUC-Ont-071439 Oreochromis niloticus 69.59 7.00e-78 283.00
IUUC-Oan-073122 Ornithorhynchus anatinus 90.91 1.00e-68 251.00
IUUC-Ocu-074128 Oryctolagus cuniculus 85.12 3.00e-55 206.00
IUUC-Ola-086972 Oryzias latipes 66.99 2.00e-70 258.00
IUUC-Oga-088786 Otolemur garnettii 96.04 5.00e-116 409.00
IUUC-Oar-089212 Ovis aries 96.06 3.00e-108 384.00
IUUC-Ptr-090936 Pan troglodytes 97.03 3.00e-110 390.00
IUUC-Pan-092234 Papio anubis 97.03 3.00e-110 390.00
IUUC-Psi-093448 Pelodiscus sinensis 93.07 1.00e-104 372.00
IUUC-Pfo-096711 Poecilia formosa 81.25 2.00e-78 285.00
IUUC-Pab-097628 Pongo abelii 96.53 2.00e-108 384.00
IUUC-Pop-099793 Populus trichocarpa 36.14 4.00e-23 100.00
IUUC-Pca-100555 Procavia capensis 94.90 3.00e-85 306.00
IUUC-Pva-102259 Pteropus vampyrus 96.53 2.00e-109 388.00
IUUC-Rno-105045 Rattus norvegicus 97.03 3.00e-110 390.00
IUUC-Sha-107606 Sarcophilus harrisii 93.56 2.00e-106 377.00
IUUC-Ssc-115663 Sus scrofa 97.52 2.00e-110 391.00
IUUC-Tgu-117374 Taeniopygia guttata 90.59 1.00e-101 361.00
IUUC-Tru-118030 Takifugu rubripes 80.11 8.00e-77 279.00
IUUC-Tsy-119298 Tarsius syrichta 96.04 2.00e-108 384.00
IUUC-Tni-119797 Tetraodon nigroviridis 79.55 1.00e-76 278.00
IUUC-Tca-121220 Theobroma cacao 38.64 3.00e-29 122.00
IUUC-Tbe-127896 Tupaia belangeri 97.52 1.00e-110 391.00
IUUC-Ttr-128523 Tursiops truncatus 96.04 1.00e-108 384.00
IUUC-Vpa-130184 Vicugna pacos 93.56 2.00e-111 394.00
IUUC-Xtr-131903 Xenopus tropicalis 84.16 8.00e-94 335.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved