iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-004668

UUCD1 version

UUC-AnC-00673

Ensembl Protein ID

ENSACAP00000009498.3

UniProt Accession

G1KJ78; G1KJ78_ANOCA

Protein Name

Histone deacetylase

Gene Name

HDAC4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000009425.3	ENSACAT00000009695.3	ENSACAP00000009498.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/Other	83.21	0.00e+00	1658.00	IUUC-Hsa-046925

Active Site

Position(s)	Description	Evidence
854	N/A	{ECO:0000256\|PIRSR:PIRSR037911-1}

Organism

Anolis carolinensis

Functional Description
(View)

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

Protein Sequence
(Fasta)

MSSQSHPDGL SGRDQPVELL NPTRVNHMPS SVDVTTTLPL QVAPTVVPMD LRLDHQFSIP 60
VAEPTLREQQ LQQELLALKQ KQQIQRQILI AEFQRQHEQL SRQHEAQLHE HIKQQQEILA 120

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Nucleotide Sequence
(Fasta)

GCTTATATTG TGAAAACAAA TTGAATTGTA TATCCTGTTC CAGATTGCAA AACTTTACAG 60
CCTGAAATGT CTATCTGAAT GGACGTTTAT CTGGTGGCTA TGAACATGTT TCCTGGATGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc

Interpro

IPR033660--HDAC4
IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
IPR024643--Hist_deacetylase_Gln_rich_N
IPR017320--Histone_deAcase_II_euk
IPR015943--WD40/YVTN_repeat-like_dom

Pfam

PF12203--HDAC4_Gln
PF00850--Hist_deacetyl

PRINTS

PR01270--HDASUPER

Gene Ontology

GO:0042641--C:actomyosin
GO:0005829--C:cytosol
GO:0000118--C:histone deacetylase complex
GO:0031594--C:neuromuscular junction
GO:0017053--C:transcriptional repressor complex
GO:0003682--F:chromatin binding
GO:0001047--F:core promoter binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0030955--F:potassium ion binding
GO:0043565--F:sequence-specific DNA binding
GO:0003714--F:transcription corepressor activity
GO:0008270--F:zinc ion binding
GO:0006338--P:chromatin remodeling
GO:0070933--P:histone H4 deacetylation
GO:0008285--P:negative regulation of cell proliferation
GO:0045820--P:negative regulation of glycolytic process
GO:0010832--P:negative regulation of myotube differentiation
GO:0045668--P:negative regulation of osteoblast differentiation
GO:1902894--P:negative regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0002076--P:osteoblast development
GO:0034983--P:peptidyl-lysine deacetylation
GO:0008284--P:positive regulation of cell proliferation
GO:0033235--P:positive regulation of protein sumoylation
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0010882--P:regulation of cardiac muscle contraction by calcium ion signaling
GO:0040029--P:regulation of gene expression, epigenetic
GO:0043393--P:regulation of protein binding
GO:0048742--P:regulation of skeletal muscle fiber development
GO:0014894--P:response to denervation involved in regulation of muscle adaptation
GO:0070555--P:response to interleukin-1
GO:0001501--P:skeletal system development
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002279	Ailuropoda melanoleuca	80.34	0.00e+00	1600.00
IUUC-Apl-003250	Anas platyrhynchos	83.96	0.00e+00	1602.00
IUUC-Ang-009522	Aspergillus niger	28.13	3.00e-35	143.00
IUUC-Bta-013215	Bos taurus	80.11	0.00e+00	1584.00
IUUC-Cja-019816	Callithrix jacchus	81.02	0.00e+00	1630.00
IUUC-Cfa-020861	Canis familiaris	81.19	0.00e+00	1598.00
IUUC-Cpo-021562	Cavia porcellus	80.55	0.00e+00	1624.00
IUUC-Csa-023612	Chlorocebus sabaeus	80.64	0.00e+00	1595.00
IUUC-Csv-026359	Ciona savignyi	53.38	1.00e-91	328.00
IUUC-Dre-028284	Danio rerio	67.83	0.00e+00	1269.00
IUUC-Dno-029951	Dasypus novemcinctus	77.97	0.00e+00	1446.00
IUUC-Dor-030362	Dipodomys ordii	70.92	0.00e+00	1321.00
IUUC-Dme-031766	Drosophila melanogaster	56.85	1.00e-158	554.00
IUUC-Fca-036187	Felis catus	80.70	0.00e+00	1555.00
IUUC-Gmo-038473	Gadus morhua	74.27	0.00e+00	736.00
IUUC-Gga-040501	Gallus gallus	84.14	0.00e+00	1649.00
IUUC-Gac-042335	Gasterosteus aculeatus	65.56	0.00e+00	1233.00
IUUC-Ggo-045380	Gorilla gorilla	80.82	0.00e+00	1600.00
IUUC-Hsa-046925	Homo sapiens	80.82	0.00e+00	1610.00
IUUC-Itr-048036	Ictidomys tridecemlineatus	79.52	0.00e+00	1514.00
IUUC-Lch-050325	Latimeria chalumnae	79.57	0.00e+00	1517.00
IUUC-Loc-052231	Lepisosteus oculatus	77.27	0.00e+00	1442.00
IUUC-Laf-054490	Loxodonta africana	77.60	0.00e+00	1532.00
IUUC-Mcc-055265	Macaca mulatta	80.40	0.00e+00	1620.00
IUUC-Meu-056676	Macropus eugenii	85.62	0.00e+00	758.00
IUUC-Mmr-061633	Microcebus murinus	74.33	0.00e+00	1395.00
IUUC-Mmu-063089	Mus musculus	80.02	0.00e+00	1540.00
IUUC-Mpu-065887	Mustela putorius furo	80.91	0.00e+00	1607.00
IUUC-Mlu-067470	Myotis lucifugus	81.03	0.00e+00	1589.00
IUUC-Nle-069099	Nomascus leucogenys	75.55	0.00e+00	1020.00
IUUC-Ont-071613	Oreochromis niloticus	68.56	0.00e+00	1248.00
IUUC-Oan-073275	Ornithorhynchus anatinus	81.84	0.00e+00	1605.00
IUUC-Ola-087031	Oryzias latipes	61.57	0.00e+00	1144.00
IUUC-Oga-088201	Otolemur garnettii	73.47	0.00e+00	1373.00
IUUC-Oar-089997	Ovis aries	77.54	0.00e+00	1328.00
IUUC-Ptr-091116	Pan troglodytes	81.09	0.00e+00	1636.00
IUUC-Pan-092132	Papio anubis	87.75	0.00e+00	1095.00
IUUC-Psi-093734	Pelodiscus sinensis	81.98	0.00e+00	1556.00
IUUC-Pma-094347	Petromyzon marinus	70.43	0.00e+00	701.00
IUUC-Pfo-096293	Poecilia formosa	64.92	0.00e+00	1139.00
IUUC-Pab-098491	Pongo abelii	78.59	0.00e+00	1543.00
IUUC-Pca-101004	Procavia capensis	77.24	0.00e+00	868.00
IUUC-Pva-102961	Pteropus vampyrus	64.49	0.00e+00	820.00
IUUC-Rno-105005	Rattus norvegicus	80.29	0.00e+00	1523.00
IUUC-Sha-107646	Sarcophilus harrisii	64.60	0.00e+00	979.00
IUUC-Ssc-115428	Sus scrofa	79.20	0.00e+00	1510.00
IUUC-Tgu-116776	Taeniopygia guttata	82.75	0.00e+00	1618.00
IUUC-Tru-118180	Takifugu rubripes	66.61	0.00e+00	1251.00
IUUC-Tsy-119468	Tarsius syrichta	81.74	0.00e+00	726.00
IUUC-Tni-120196	Tetraodon nigroviridis	65.54	0.00e+00	1246.00
IUUC-Ttr-128360	Tursiops truncatus	80.22	0.00e+00	948.00
IUUC-Xtr-132956	Xenopus tropicalis	71.65	0.00e+00	1390.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence