• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Tag Content
UUCD2 ID IUUC-Bta-012711
UUCD1 version UUC-BoT-00834
Ensembl Protein ID ENSBTAP00000026031.5
UniProt Accession Q0P564; CRBN_BOVIN
Genbank Protein ID AAI20453.1
Protein Name Protein cereblon
Genbank Nucleotide ID BC120452
Gene Name CRBN
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000019536.5 ENSBTAT00000026031.5 ENSBTAP00000026031.5
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/Other 94.37 0.00e+00 851.00 IUUC-Hsa-046888
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Bos taurus
Functional Description
(View)

Functional Description


     Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8 (By similarity). May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1 (By similarity).
 Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8 (By similarity). May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1 (By similarity).
Protein Sequence
(Fasta)
MAGEGDPEDA AHNMGNHLPL LPAEEEEEDE IEMEVEDQDN KEPKKPNIIN FDTSLPTSHT 60
YLGSDMEEFH GRTLHDDDSC PVIPVLPQVV MTLIPGQTLP LQLFSPQEVS MVRNLIQKDR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Bta-012711|E3,E3 activity/Other|Bos taurus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CAGACATGGC CGGCGAGGGA GACCCGGAGG ACGCTGCGCA CAACATGGGC AATCACCTGC 60
CGCTCCTTCC CGGTAACTGC CTGGGGCCTG TTCCTGGCAG CGGGAGAAGG CGAGGCCGGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Bta-012711|E3,E3 activity/Other|Bos taurus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
Interpro

IPR034750--CULT
IPR003111--Lon_substr-bd
IPR015947--PUA-like_domain
IPR004910--Yippee/Mis18/Cereblon
PROSITE

PS51788--CULT
PS51787--LON_N
Pfam

PF02190--LON_substr_bdg
PF03226--Yippee-Mis18
SMART

SM00464--LON
Gene Ontology

GO:0031464--C:Cul4A-RING E3 ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0016020--C:membrane
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination
KEGG bta:511585
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000549 Aegilops tauschii 30.61 1.00e-23 104.00
IUUC-Aml-002159 Ailuropoda melanoleuca 95.51 0.00e+00 853.00
IUUC-Atr-002820 Amborella trichopoda 38.80 2.00e-37 150.00
IUUC-Apl-003508 Anas platyrhynchos 79.42 0.00e+00 734.00
IUUC-Aca-004675 Anolis carolinensis 83.72 0.00e+00 734.00
IUUC-Aly-005404 Arabidopsis lyrata 36.84 4.00e-38 152.00
IUUC-Ath-006819 Arabidopsis thaliana 36.32 1.00e-37 150.00
IUUC-Ani-009423 Aspergillus nidulans 36.84 1.60e-01 31.20
IUUC-Ame-010773 Astyanax mexicanus 67.71 3.00e-173 600.00
IUUC-Bdi-014416 Brachypodium distachyon 28.89 4.00e-43 169.00
IUUC-Bol-015668 Brassica oleracea 36.87 2.00e-39 157.00
IUUC-Bra-016836 Brassica rapa 36.62 1.00e-39 157.00
IUUC-Cja-019624 Callithrix jacchus 94.37 0.00e+00 854.00
IUUC-Cpo-022319 Cavia porcellus 92.57 0.00e+00 836.00
IUUC-Csa-023791 Chlorocebus sabaeus 94.14 0.00e+00 850.00
IUUC-Cho-024850 Choloepus hoffmanni 94.48 0.00e+00 678.00
IUUC-Csv-025832 Ciona savignyi 44.03 7.00e-89 321.00
IUUC-Cgl-026484 Colletotrichum gloeosporioides 34.09 5.50e-02 32.30
IUUC-Dre-028071 Danio rerio 67.70 2.00e-175 608.00
IUUC-Dno-029431 Dasypus novemcinctus 94.37 0.00e+00 857.00
IUUC-Dor-030571 Dipodomys ordii 78.15 0.00e+00 674.00
IUUC-Dme-031920 Drosophila melanogaster 28.43 1.00e-36 147.00
IUUC-Eca-033462 Equus caballus 94.59 0.00e+00 849.00
IUUC-Fca-036279 Felis catus 95.44 0.00e+00 842.00
IUUC-Fal-037498 Ficedula albicollis 78.94 0.00e+00 718.00
IUUC-Fox-037856 Fusarium oxysporum 42.86 2.50e-01 30.40
IUUC-Gmo-038734 Gadus morhua 71.69 1.00e-178 619.00
IUUC-Gga-040615 Gallus gallus 83.63 0.00e+00 746.00
IUUC-Gac-041426 Gasterosteus aculeatus 71.49 0.00e+00 629.00
IUUC-Gma-043891 Glycine max 37.14 3.00e-40 159.00
IUUC-Ggo-045108 Gorilla gorilla 93.92 0.00e+00 847.00
IUUC-Hsa-046888 Homo sapiens 94.37 0.00e+00 851.00
IUUC-Itr-047937 Ictidomys tridecemlineatus 94.81 0.00e+00 810.00
IUUC-Lch-050189 Latimeria chalumnae 76.66 9.00e-179 619.00
IUUC-Lpe-050808 Leersia perrieri 39.39 2.00e-42 167.00
IUUC-Loc-051762 Lepisosteus oculatus 78.23 0.00e+00 650.00
IUUC-Laf-053882 Loxodonta africana 94.14 0.00e+00 837.00
IUUC-Mcc-054883 Macaca mulatta 94.14 0.00e+00 850.00
IUUC-Mtr-058216 Medicago truncatula 37.33 2.00e-40 160.00
IUUC-Mdo-062260 Monodelphis domestica 85.17 0.00e+00 767.00
IUUC-Mmu-063438 Mus musculus 91.24 0.00e+00 838.00
IUUC-Mac-064610 Musa acuminata 44.90 6.00e-46 179.00
IUUC-Mpu-066362 Mustela putorius furo 94.82 0.00e+00 850.00
IUUC-Nle-069908 Nomascus leucogenys 94.14 0.00e+00 848.00
IUUC-Ont-072223 Oreochromis niloticus 73.84 0.00e+00 640.00
IUUC-Ocu-074151 Oryctolagus cuniculus 94.53 0.00e+00 803.00
IUUC-Oba-075882 Oryza barthii 41.49 6.00e-42 165.00
IUUC-Obr-076670 Oryza brachyantha 37.88 1.00e-40 160.00
IUUC-Ogl-077753 Oryza glaberrima 41.49 6.00e-42 165.00
IUUC-Ogu-078786 Oryza glumaepatula 41.49 6.00e-42 165.00
IUUC-Oin-079191 Oryza indica 41.49 5.00e-42 165.00
IUUC-Olo-080357 Oryza longistaminata 41.49 5.00e-42 165.00
IUUC-Ome-081227 Oryza meridionalis 29.76 6.00e-19 88.60
IUUC-Oni-082557 Oryza nivara 39.90 6.00e-42 165.00
IUUC-Opu-083920 Oryza punctata 39.39 3.00e-41 163.00
IUUC-Oru-085227 Oryza rufipogon 41.49 6.00e-42 165.00
IUUC-Ola-087321 Oryzias latipes 71.76 2.00e-172 598.00
IUUC-Oga-088413 Otolemur garnettii 95.05 0.00e+00 861.00
IUUC-Oar-089512 Ovis aries 98.22 0.00e+00 882.00
IUUC-Ptr-090764 Pan troglodytes 94.37 0.00e+00 851.00
IUUC-Pan-091942 Papio anubis 94.14 0.00e+00 850.00
IUUC-Psi-092985 Pelodiscus sinensis 85.85 0.00e+00 735.00
IUUC-Ppa-095670 Physcomitrella patens 36.60 4.00e-45 176.00
IUUC-Pfo-097251 Poecilia formosa 74.88 0.00e+00 632.00
IUUC-Pab-097842 Pongo abelii 93.92 0.00e+00 850.00
IUUC-Pop-099118 Populus trichocarpa 36.91 9.00e-43 167.00
IUUC-Pca-101077 Procavia capensis 82.43 0.00e+00 722.00
IUUC-Ppe-101706 Prunus persica 37.86 2.00e-41 163.00
IUUC-Pva-102245 Pteropus vampyrus 78.80 7.00e-147 513.00
IUUC-Rno-105788 Rattus norvegicus 91.69 0.00e+00 840.00
IUUC-Smo-109165 Selaginella moellendorffii 42.51 6.00e-47 182.00
IUUC-Sit-109818 Setaria italica 41.00 1.00e-42 167.00
IUUC-Sly-111062 Solanum lycopersicum 38.58 5.00e-44 172.00
IUUC-Sbi-114298 Sorghum bicolor 39.34 9.00e-44 171.00
IUUC-Ssc-115779 Sus scrofa 97.40 0.00e+00 752.00
IUUC-Tgu-117378 Taeniopygia guttata 81.17 0.00e+00 734.00
IUUC-Tru-118515 Takifugu rubripes 71.53 7.00e-172 596.00
IUUC-Tsy-119555 Tarsius syrichta 84.68 0.00e+00 756.00
IUUC-Tni-119679 Tetraodon nigroviridis 72.98 6.00e-171 593.00
IUUC-Tca-121374 Theobroma cacao 37.64 1.00e-32 134.00
IUUC-Tae-123098 Triticum aestivum 33.33 5.00e-53 202.00
IUUC-Tur-126689 Triticum urartu 30.99 8.00e-17 81.60
IUUC-Vpa-130719 Vicugna pacos 82.92 0.00e+00 738.00
IUUC-Vvi-131014 Vitis vinifera 40.33 2.00e-40 160.00
IUUC-Xtr-131811 Xenopus tropicalis 71.43 0.00e+00 635.00
IUUC-Xma-133238 Xiphophorus maculatus 73.19 0.00e+00 633.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved