iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053803

UUCD1 version

UUC-LoA-01072

Ensembl Protein ID

ENSLAFP00000015513.3

UniProt Accession

G3TKY5; G3TKY5_LOXAF

Protein Name

Uncharacterized protein

Gene Name

USP4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000018507.3	ENSLAFT00000018508.3	ENSLAFP00000015513.3
ENSLAFG00000018507.3	ENSLAFT00000027799.1	ENSLAFP00000027928.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.70e-113	379.6	302	920
ULD/UDP/UBQ/UBQ_Other	2.80e-17	62.7	143	221

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgye 88
           +Gl NlgNtC+mNS+LQcLsn+ +l++++l+ +++ ++n++np ++kge+++++++l++++w++++++v+pr+++++++++a++fsgy+
   Q: 302  CGLGNLGNTCFMNSALQCLSNTAPLTDYFLKdEYEAEINRDNPLGMKGEIAEAYAELIKQMWSGRDTHVAPRMFKTQVGRFAPQFSGYQ 390
           7******************************9********************************************************* PP
   S: 89   qqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
           qqD+qE+laflld+l+e+l++ k+kp+ e+++++   ++d      a+e++  +n+s+i+d+F+g +ks+++c+ec++vs++++pf++l
   Q: 391  QQDSQELLAFLLDGLHEDLNRVKKKPYLELKDAN--GRPDAvvakeAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYL 477
           ******************************8888..5555556777******************************************* PP
   S: 173  slpvpgkeetkke............................................................................ 185
           +lp+p k+++ +e                                                                            
   Q: 478  TLPLPLKKDRIMEvflvpadpccrptqyrvtvplmgavsdlcealsrlsgiaaenmvvtdvynhrfhkifqmdeglnhimprddifvye 566
           ********99888**************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 567  vcsasadgsecvtlpvyfrerksrpsstssgavlygqplllsvpkhkltleslyqavcerisryikqplpdepgssplelgacngsrgs 655
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 656  ceggeeeemehqeegkeelsetegsgeeelgsetiqkkvegqtcpkrlftfslvnsygtadinslatdgkllklnsrstlaidwdsetr 744
           ***************************************************************************************** PP
   S: 186  .............................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqks 245
                                         l+dc+e ft+ e+l +++ +yc++ckk+q+a+kk++l++lP++L++hLkRfs++++   
   Q: 745  nlyydeqeseayekhvsmlqpqkkkktsvALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRY--W 831
           *********************************************************************************99885..5 PP
   S: 246  rekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkne.kgkWllfdDskVtevkeeevleetgstaYv 332
           r k+++ vefp + L++s+f+++ +    +++ Y+Liav +H+G ++ GHY+ay+kn+ +gkW++fdDs+V+  +e+++++   + aYv
   Q: 832  RDKLDTVVEFPVRaLNMSEFVCDLSA---RPYVYDLIAVSNHYGAMGVGHYTAYAKNKlNGKWYYFDDSSVSLASEDQIVT---KAAYV 914
           67******************999443...49**************************52666*******************...***** PP
   S: 333  lfYkrr 338
           lfY+rr
   Q: 915  LFYQRR 920
           ****96 PP

ULD/UDP/UBQ/UBQ_Other

   S: 5    vksldgs.eltlkvnpsdtVaeLKekiekklgip.peqqrLiyk......GkiL.eddktLadyglkdgstihllekksg 75
           ++++d + +l+++++++dt+a++ ++++k+++ip +++ rL++k       + L + d+t++d gl++g+++++++++++
   Q: 143  CENSDPTnVLSCHFSKADTIATIEKEMRKLFNIPaERETRLWNKymsntyEQ-LsKLDNTVQDAGLYQGQVLVIEPQNED 221
           78999999**************************888*****9999977444.46********************99986 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MAEGGGCRER PDAETQKSEL GALMRTTLQR GAQWYLIDSR WFKQWKKYVG FDSWDMYNVG 60
EHNLFPGPID NSGLFSDPES QTLKEHLIDE LDYVLVPTEA WNKLLNWYGC VEGQQPIVRK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGAAG GCGGAGGCTG CCGTGAGCGA CCGGATGCGG AGACCCAGAA ATCCGAGCTA 60
GGTGCCTTGA TGAGGACCAC GCTCCAACGG GGGGCGCAGT GGTAAGCTGT GGGCCCGCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR028135--Ub_USP-typ
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF06337--DUSP
PF14836--Ubiquitin_3
PF00443--UCH

SMART

SM00695--DUSP

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0031397--P:negative regulation of protein ubiquitination
GO:0016579--P:protein deubiquitination
GO:0034394--P:protein localization to cell surface
GO:0031647--P:regulation of protein stability
GO:0000244--P:spliceosomal tri-snRNP complex assembly
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001597	Ailuropoda melanoleuca	92.84	0.00e+00	1675.00
IUUC-Atr-002991	Amborella trichopoda	35.89	3.00e-145	509.00
IUUC-Apl-004068	Anas platyrhynchos	72.25	0.00e+00	1224.00
IUUC-Aca-004459	Anolis carolinensis	69.76	0.00e+00	1265.00
IUUC-Ath-007343	Arabidopsis thaliana	37.11	1.00e-152	533.00
IUUC-Ago-007911	Ashbya gossypii	38.26	8.00e-63	236.00
IUUC-Afu-008878	Aspergillus fumigatus	28.74	5.00e-57	216.00
IUUC-Ang-009562	Aspergillus niger	44.80	4.00e-55	210.00
IUUC-Bta-012929	Bos taurus	93.26	0.00e+00	1721.00
IUUC-Bdi-014013	Brachypodium distachyon	36.07	4.00e-152	531.00
IUUC-Bol-015244	Brassica oleracea	36.18	3.00e-154	539.00
IUUC-Bra-016885	Brassica rapa	35.68	3.00e-152	532.00
IUUC-Cja-018798	Callithrix jacchus	92.01	0.00e+00	1658.00
IUUC-Cfa-020599	Canis familiaris	95.02	0.00e+00	1714.00
IUUC-Cpo-022144	Cavia porcellus	90.32	0.00e+00	1621.00
IUUC-Csa-023770	Chlorocebus sabaeus	93.73	0.00e+00	1566.00
IUUC-Cho-024595	Choloepus hoffmanni	82.88	0.00e+00	1095.00
IUUC-Cin-025292	Ciona intestinalis	44.05	0.00e+00	755.00
IUUC-Dre-027869	Danio rerio	69.12	0.00e+00	905.00
IUUC-Dno-029316	Dasypus novemcinctus	91.28	0.00e+00	1723.00
IUUC-Dor-031038	Dipodomys ordii	86.47	0.00e+00	856.00
IUUC-Ete-032970	Echinops telfairi	82.49	0.00e+00	1071.00
IUUC-Eca-034012	Equus caballus	94.18	0.00e+00	1700.00
IUUC-Eeu-035158	Erinaceus europaeus	75.76	0.00e+00	779.00
IUUC-Fca-035373	Felis catus	91.08	0.00e+00	1686.00
IUUC-Fal-037634	Ficedula albicollis	75.14	0.00e+00	1328.00
IUUC-Fox-037986	Fusarium oxysporum	42.00	1.00e-64	241.00
IUUC-Fso-038291	Fusarium solani	31.31	5.00e-72	266.00
IUUC-Gmo-038866	Gadus morhua	68.08	0.00e+00	864.00
IUUC-Ggr-039740	Gaeumannomyces graminis	43.59	7.00e-62	233.00
IUUC-Gga-040729	Gallus gallus	68.63	0.00e+00	1260.00
IUUC-Gac-042631	Gasterosteus aculeatus	67.40	0.00e+00	1261.00
IUUC-Gma-043077	Glycine max	37.70	5.00e-156	545.00
IUUC-Ggo-045337	Gorilla gorilla	92.97	0.00e+00	1513.00
IUUC-Hsa-045669	Homo sapiens	94.29	0.00e+00	1694.00
IUUC-Itr-048610	Ictidomys tridecemlineatus	93.67	0.00e+00	1719.00
IUUC-Lpe-051424	Leersia perrieri	36.43	3.00e-150	526.00
IUUC-Lma-052981	Leptosphaeria maculans	38.70	3.00e-67	251.00
IUUC-Mcc-055556	Macaca mulatta	90.15	0.00e+00	1580.00
IUUC-Meu-056742	Macropus eugenii	78.95	0.00e+00	963.00
IUUC-Mor-056985	Magnaporthe oryzae	39.74	4.00e-62	233.00
IUUC-Mpo-057486	Magnaporthe poae	44.32	6.00e-62	233.00
IUUC-Mtr-058138	Medicago truncatula	37.53	4.00e-156	545.00
IUUC-Mla-058848	Melampsora laricipopulina	32.22	2.00e-78	288.00
IUUC-Mga-059300	Meleagris gallopavo	71.44	0.00e+00	1231.00
IUUC-Mdo-061848	Monodelphis domestica	84.40	0.00e+00	1583.00
IUUC-Mmu-063960	Mus musculus	90.24	0.00e+00	1660.00
IUUC-Mpu-066920	Mustela putorius furo	95.02	0.00e+00	1715.00
IUUC-Mlu-068088	Myotis lucifugus	92.01	0.00e+00	1687.00
IUUC-Nfi-068330	Neosartorya fischeri	29.04	2.00e-56	215.00
IUUC-Ncr-068879	Neurospora crassa	31.66	4.00e-68	253.00
IUUC-Nle-070010	Nomascus leucogenys	94.29	0.00e+00	1691.00
IUUC-Opr-070740	Ochotona princeps	88.37	0.00e+00	1207.00
IUUC-Oan-073363	Ornithorhynchus anatinus	76.18	0.00e+00	1419.00
IUUC-Ocu-074242	Oryctolagus cuniculus	89.07	0.00e+00	1622.00
IUUC-Obr-076902	Oryza brachyantha	36.16	4.00e-147	515.00
IUUC-Olu-087717	Ostreococcus lucimarinus	40.52	2.00e-122	432.00
IUUC-Oga-088562	Otolemur garnettii	84.64	0.00e+00	1480.00
IUUC-Oar-090439	Ovis aries	92.84	0.00e+00	1689.00
IUUC-Ptr-090801	Pan troglodytes	94.08	0.00e+00	1692.00
IUUC-Pan-092717	Papio anubis	89.22	0.00e+00	1552.00
IUUC-Psi-093942	Pelodiscus sinensis	75.45	0.00e+00	1313.00
IUUC-Pab-098522	Pongo abelii	92.39	0.00e+00	1214.00
IUUC-Pop-099313	Populus trichocarpa	36.75	9.00e-154	537.00
IUUC-Pca-100161	Procavia capensis	84.44	0.00e+00	1531.00
IUUC-Rno-106081	Rattus norvegicus	88.58	0.00e+00	1691.00
IUUC-Sha-106937	Sarcophilus harrisii	82.16	0.00e+00	1530.00
IUUC-Spo-108291	Schizosaccharomyces pombe	44.00	9.00e-74	271.00
IUUC-Sit-109948	Setaria italica	36.56	8.00e-141	494.00
IUUC-Sly-111746	Solanum lycopersicum	37.99	1.00e-157	550.00
IUUC-Stu-112671	Solanum tuberosum	37.71	2.00e-155	543.00
IUUC-Sar-113542	Sorex araneus	87.10	0.00e+00	1628.00
IUUC-Sbi-114874	Sorghum bicolor	36.54	3.00e-142	499.00
IUUC-Ssc-115637	Sus scrofa	93.46	0.00e+00	1736.00
IUUC-Tgu-117267	Taeniopygia guttata	72.84	0.00e+00	1317.00
IUUC-Tca-121001	Theobroma cacao	35.98	2.00e-156	546.00
IUUC-Tae-125295	Triticum aestivum	36.04	4.00e-151	528.00
IUUC-Tme-127062	Tuber melanosporum	35.98	6.00e-79	289.00
IUUC-Tbe-127669	Tupaia belangeri	75.08	0.00e+00	895.00
IUUC-Ttr-128778	Tursiops truncatus	93.15	0.00e+00	1692.00
IUUC-Uma-129498	Ustilago maydis	42.30	4.00e-72	266.00
IUUC-Vda-129781	Verticillium dahliae	29.86	1.00e-70	262.00
IUUC-Vpa-130571	Vicugna pacos	96.94	0.00e+00	1160.00
IUUC-Vvi-131010	Vitis vinifera	39.04	8.00e-157	547.00
IUUC-Xtr-132305	Xenopus tropicalis	70.42	0.00e+00	1299.00
IUUC-Yli-134392	Yarrowia lipolytica	42.61	3.00e-62	234.00
IUUC-Zma-135699	Zea mays	36.22	1.00e-144	507.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence