iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Rno-105091

UUCD1 version

UUC-RaN-00041

Ensembl Protein ID

ENSRNOP00000074788.1

UniProt Accession

B2GUZ0; B2GUZ0_RAT

Genbank Protein ID

AAI66459.1; EDL75674.1

Protein Name

S-phase kinase-associated protein 2; S-phase kinase-associated protein 2 (P45); Similar to S-phase kinase-associated protein 2 (F-box protein Skp2) (F-box/WD-40 protein 1) (Predicted), isoform CRA_b

Genbank Nucleotide ID

AABR07008439; CH474048

Gene Name

Skp2; RGD1562456_predicted; rCG_50990

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000059059.1	ENSRNOT00000089178.1	ENSRNOP00000074788.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
RAID2
Protein-protein Interaction
IID	PINA	HINT
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/SCF/F-box	27.16	5.00e-29	125.00	IUUC-Cel-018410
E3 adaptor/Cullin RING/SCF/F-box	88.15	0.00e+00	765.00	IUUC-Hsa-046512

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MHRKHLQEIP DQSSNVTTSF TWGWDSSKTS ELLSGMGVSA LEKEEVDSEN IPHGLLSNLG 60
HPQSPPRKRL KSKGSDKDFV IIRRPKLNRE NFPGVSWDSL PDELLLGIFS CLCLPELLRV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTAAGCAGCG CCCTAGAACG GGAGTCTGGA AGGCAGGCAG CTCTTCAATT AATTGAAGCA 60
TTCAAAACTC CTTAATCAGT GGACGCCATG CATAGGTAAA CCGATTGCAA AAAACCGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0418--Kinase
KW-1185--Reference proteome
KW-0808--Transferase

Interpro

IPR001810--F-box_dom
IPR032675--L_dom-like
IPR006553--Leu-rich_rpt_Cys-con_subtyp

PROSITE

PS50181--FBOX

Pfam

PF12937--F-box-like

SMART

SM00256--FBOX
SM00367--LRR_CC

Gene Ontology

GO:0005829--C:cytosol
GO:0005730--C:nucleolus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0016301--F:kinase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0071460--P:cellular response to cell-matrix adhesion
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0033148--P:positive regulation of intracellular estrogen receptor signaling pathway
GO:1902916--P:positive regulation of protein polyubiquitination
GO:0048661--P:positive regulation of smooth muscle cell proliferation
GO:0000209--P:protein polyubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0051726--P:regulation of cell cycle
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

rno:294790

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002197	Ailuropoda melanoleuca	86.97	0.00e+00	731.00
IUUC-Apl-003453	Anas platyrhynchos	64.26	1.00e-112	399.00
IUUC-Aca-005185	Anolis carolinensis	59.39	1.00e-134	472.00
IUUC-Ame-010665	Astyanax mexicanus	46.63	5.00e-87	314.00
IUUC-Bta-013450	Bos taurus	85.78	0.00e+00	753.00
IUUC-Cel-018410	Caenorhabditis elegans	26.23	3.00e-26	112.00
IUUC-Cja-019834	Callithrix jacchus	88.39	0.00e+00	765.00
IUUC-Cfa-020401	Canis familiaris	87.44	0.00e+00	763.00
IUUC-Cpo-022183	Cavia porcellus	87.91	0.00e+00	761.00
IUUC-Csa-023418	Chlorocebus sabaeus	87.68	0.00e+00	762.00
IUUC-Cho-024412	Choloepus hoffmanni	82.77	7.00e-173	600.00
IUUC-Cin-025248	Ciona intestinalis	30.79	7.00e-41	161.00
IUUC-Csv-026189	Ciona savignyi	30.11	2.00e-38	153.00
IUUC-Dre-028032	Danio rerio	47.73	2.00e-102	365.00
IUUC-Dno-029222	Dasypus novemcinctus	85.78	0.00e+00	751.00
IUUC-Dor-030505	Dipodomys ordii	77.75	9.00e-173	599.00
IUUC-Dme-031972	Drosophila melanogaster	33.42	3.00e-52	199.00
IUUC-Ete-032234	Echinops telfairi	81.85	3.00e-116	411.00
IUUC-Eca-033944	Equus caballus	87.20	0.00e+00	763.00
IUUC-Eeu-035008	Erinaceus europaeus	80.77	6.00e-116	410.00
IUUC-Fca-035412	Felis catus	86.97	0.00e+00	757.00
IUUC-Fal-037337	Ficedula albicollis	61.52	1.00e-133	469.00
IUUC-Gmo-038934	Gadus morhua	43.31	1.00e-39	157.00
IUUC-Gga-041152	Gallus gallus	63.01	1.00e-149	523.00
IUUC-Gac-041819	Gasterosteus aculeatus	46.09	8.00e-77	280.00
IUUC-Ggo-045479	Gorilla gorilla	88.14	0.00e+00	643.00
IUUC-Hsa-046512	Homo sapiens	88.15	0.00e+00	765.00
IUUC-Itr-048515	Ictidomys tridecemlineatus	87.90	0.00e+00	732.00
IUUC-Lch-050115	Latimeria chalumnae	56.09	7.00e-131	460.00
IUUC-Loc-052554	Lepisosteus oculatus	48.46	2.00e-101	362.00
IUUC-Laf-053563	Loxodonta africana	86.63	0.00e+00	724.00
IUUC-Mcc-055143	Macaca mulatta	87.14	0.00e+00	751.00
IUUC-Meu-056593	Macropus eugenii	52.86	4.00e-97	348.00
IUUC-Mga-060084	Meleagris gallopavo	56.67	6.00e-80	290.00
IUUC-Mmr-060660	Microcebus murinus	88.15	0.00e+00	770.00
IUUC-Mdo-062363	Monodelphis domestica	65.80	6.00e-153	533.00
IUUC-Mmu-063287	Mus musculus	96.45	0.00e+00	833.00
IUUC-Mpu-065791	Mustela putorius furo	86.97	0.00e+00	761.00
IUUC-Mlu-067714	Myotis lucifugus	84.87	0.00e+00	713.00
IUUC-Nle-069823	Nomascus leucogenys	88.15	0.00e+00	764.00
IUUC-Opr-071046	Ochotona princeps	71.48	3.00e-102	365.00
IUUC-Ont-071820	Oreochromis niloticus	45.31	1.00e-64	239.00
IUUC-Ocu-074868	Oryctolagus cuniculus	88.15	0.00e+00	765.00
IUUC-Ola-086608	Oryzias latipes	45.31	9.00e-71	260.00
IUUC-Oga-089044	Otolemur garnettii	86.26	0.00e+00	754.00
IUUC-Oar-089650	Ovis aries	85.55	0.00e+00	748.00
IUUC-Ptr-090743	Pan troglodytes	88.15	0.00e+00	765.00
IUUC-Pan-092501	Papio anubis	87.20	0.00e+00	757.00
IUUC-Psi-094032	Pelodiscus sinensis	63.51	2.00e-152	531.00
IUUC-Pfo-097279	Poecilia formosa	47.16	3.00e-65	242.00
IUUC-Pab-097821	Pongo abelii	88.14	0.00e+00	641.00
IUUC-Pca-100100	Procavia capensis	87.29	2.00e-176	611.00
IUUC-Pva-103181	Pteropus vampyrus	86.44	4.00e-174	603.00
IUUC-Sha-107226	Sarcophilus harrisii	66.82	4.00e-158	550.00
IUUC-Ssc-115665	Sus scrofa	87.68	0.00e+00	765.00
IUUC-Tgu-116982	Taeniopygia guttata	61.14	2.00e-131	462.00
IUUC-Tru-118276	Takifugu rubripes	45.99	2.00e-71	262.00
IUUC-Tsy-119074	Tarsius syrichta	87.29	0.00e+00	640.00
IUUC-Tni-120702	Tetraodon nigroviridis	48.20	5.00e-49	187.00
IUUC-Tbe-127990	Tupaia belangeri	86.24	2.00e-150	525.00
IUUC-Ttr-128661	Tursiops truncatus	73.08	2.00e-105	376.00
IUUC-Xtr-132166	Xenopus tropicalis	56.22	2.00e-124	439.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence