iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Rno-105455

Ensembl Protein ID

ENSRNOP00000037964.2

UniProt Accession

F1LQ74; F1LQ74_RAT

Genbank Protein ID

ENSRNOP00000037964

Protein Name

Rho guanine nucleotide exchange factor 37

Genbank Nucleotide ID

AABR07032251

Gene Name

Arhgef37

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000025502.3	ENSRNOT00000032189.3	ENSRNOP00000037964.2

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC	RAID2
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.10e-12	48.1	605	663

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlvi..ekeeqdegWlkgvkelegkrGlfPenFvek 61
           + +v + y++ a ++ eL+l++G  v+++  ++++ + +W     e++g+rG +P+nF ++
   Q: 605  MSQVVAVYPFVARSTHELSLQAGQPVTILeaQDKKGNPEWSLV--EANGQRGYVPSNFLAR 663
           67899************************9889999****977..9************987 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MADFETDEAS SKSESPEQEG QGSEDKSLLH QRLAIRELID TEVSYLHTLR LCTSDIRGHL 60
QQLPPGDLDI LFSNIDDIIQ VSSRFLHGLQ ETACKEEKQA HLIGNLFLEF QEELEQVYKV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCAACTGAC AAAGGCGGGG GCGCGCTCTG CGCGTGCACA GCAGACAGAG GAGCTGCACT 60
CGCAGCCGGA GCCCAGCGGG TGCGAGTGAC ACCGGAGGGC ATCCGGCGCG TGCGCGGTGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR027267--AH/BAR-dom
IPR004148--BAR_dom
IPR000219--DH-domain
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS51021--BAR
PS50010--DH_2
PS50002--SH3

Pfam

PF00621--RhoGEF
PF07653--SH3_2
PF14604--SH3_9

SMART

SM00721--BAR
SM00325--RhoGEF
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0035023--P:regulation of Rho protein signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ame-011907	Astyanax mexicanus	38.96	5.00e-127	448.00
IUUC-Bta-012848	Bos taurus	78.55	0.00e+00	1019.00
IUUC-Cfa-021281	Canis familiaris	78.55	0.00e+00	1035.00
IUUC-Csa-023043	Chlorocebus sabaeus	80.92	0.00e+00	1076.00
IUUC-Dre-028496	Danio rerio	40.21	5.00e-130	458.00
IUUC-Ggo-044900	Gorilla gorilla	81.07	0.00e+00	1084.00
IUUC-Hsa-045684	Homo sapiens	80.92	0.00e+00	1106.00
IUUC-Lch-050096	Latimeria chalumnae	48.04	2.00e-168	585.00
IUUC-Loc-051937	Lepisosteus oculatus	41.15	5.00e-135	474.00
IUUC-Mcc-054950	Macaca mulatta	80.62	0.00e+00	1070.00
IUUC-Meu-056383	Macropus eugenii	65.71	2.00e-168	585.00
IUUC-Mdo-062021	Monodelphis domestica	65.39	0.00e+00	864.00
IUUC-Mmu-064186	Mus musculus	91.57	0.00e+00	1212.00
IUUC-Ptr-090508	Pan troglodytes	80.77	0.00e+00	1080.00
IUUC-Pan-092517	Papio anubis	80.62	0.00e+00	1057.00
IUUC-Pfo-096703	Poecilia formosa	39.20	3.00e-124	439.00
IUUC-Pab-098542	Pongo abelii	80.47	0.00e+00	1071.00
IUUC-Sha-106562	Sarcophilus harrisii	64.41	0.00e+00	874.00
IUUC-Ttr-128242	Tursiops truncatus	75.59	0.00e+00	989.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence