iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	98.44	0.00e+00	976.00	IUUC-Hsa-046029
E3 activity/RING/RING	99.61	0.00e+00	982.00	IUUC-Mmu-064242

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MASGSVAESL QQETTCPVCL QYFVEPMMLD CGHNICCACL ARCWGAAETN VSCPQCRETF 60
PQRHMRPNRH LANVTQLVKQ LRTERPSGPD GEMGVCEKHR EPLKLYCEQD QMPICVVCDR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGATCCCTT CCGACGCGGC CACGTTGCCC GGTGAGCCAT CCTGCAGCGC CGGGTTCCCG 60
ACACCCCTCT GCTCGGCTCT CAGCCGGGCC CTGGGGCCCA GGCCTTCCCG CGCTGTCCGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR020457--Znf_B-box_chordata
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01406--BBOXZNFINGER
PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005829--C:cytosol
GO:0005768--C:endosome
GO:0001650--C:fibrillar center
GO:0031965--C:nuclear membrane
GO:0005654--C:nucleoplasm
GO:0030904--C:retromer complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0034314--P:Arp2/3 complex-mediated actin nucleation
GO:0045087--P:innate immune response
GO:0072643--P:interferon-gamma secretion
GO:0002820--P:negative regulation of adaptive immune response
GO:0090281--P:negative regulation of calcium ion import
GO:0045814--P:negative regulation of gene expression, epigenetic
GO:1900041--P:negative regulation of interleukin-2 secretion
GO:0006469--P:negative regulation of protein kinase activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0032720--P:negative regulation of tumor necrosis factor production
GO:1902187--P:negative regulation of viral release from host cell
GO:0032897--P:negative regulation of viral transcription
GO:0051127--P:positive regulation of actin nucleation
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0070534--P:protein K63-linked ubiquitination
GO:0070206--P:protein trimerization
GO:0042147--P:retrograde transport, endosome to Golgi

KEGG

rno:291171

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001890	Ailuropoda melanoleuca	97.83	0.00e+00	965.00
IUUC-Apl-003609	Anas platyrhynchos	40.29	1.00e-96	346.00
IUUC-Bta-013520	Bos taurus	98.83	0.00e+00	979.00
IUUC-Cja-019557	Callithrix jacchus	97.27	0.00e+00	964.00
IUUC-Cfa-020583	Canis familiaris	98.16	0.00e+00	917.00
IUUC-Cpo-021738	Cavia porcellus	90.45	0.00e+00	877.00
IUUC-Csa-023502	Chlorocebus sabaeus	98.44	0.00e+00	976.00
IUUC-Cho-024563	Choloepus hoffmanni	95.29	3.00e-178	618.00
IUUC-Dno-029747	Dasypus novemcinctus	95.78	0.00e+00	907.00
IUUC-Dor-030243	Dipodomys ordii	95.71	0.00e+00	925.00
IUUC-Ete-032749	Echinops telfairi	84.13	0.00e+00	794.00
IUUC-Eca-034246	Equus caballus	98.66	0.00e+00	691.00
IUUC-Eeu-034481	Erinaceus europaeus	88.11	0.00e+00	861.00
IUUC-Fca-036152	Felis catus	98.40	0.00e+00	689.00
IUUC-Gac-042288	Gasterosteus aculeatus	35.87	1.00e-74	274.00
IUUC-Ggo-044987	Gorilla gorilla	88.72	0.00e+00	860.00
IUUC-Hsa-046029	Homo sapiens	98.44	0.00e+00	976.00
IUUC-Itr-048438	Ictidomys tridecemlineatus	98.64	0.00e+00	953.00
IUUC-Laf-054488	Loxodonta africana	98.82	0.00e+00	973.00
IUUC-Mcc-055352	Macaca mulatta	98.44	0.00e+00	976.00
IUUC-Mmr-060883	Microcebus murinus	98.44	0.00e+00	975.00
IUUC-Mmu-064242	Mus musculus	99.61	0.00e+00	982.00
IUUC-Mpu-065958	Mustela putorius furo	98.25	0.00e+00	976.00
IUUC-Mlu-068005	Myotis lucifugus	84.79	0.00e+00	652.00
IUUC-Nle-069710	Nomascus leucogenys	97.46	0.00e+00	631.00
IUUC-Opr-071200	Ochotona princeps	97.86	0.00e+00	965.00
IUUC-Ont-072259	Oreochromis niloticus	35.44	1.00e-63	237.00
IUUC-Ocu-074081	Oryctolagus cuniculus	96.92	0.00e+00	837.00
IUUC-Ola-087166	Oryzias latipes	33.58	2.00e-70	259.00
IUUC-Oga-088784	Otolemur garnettii	98.44	0.00e+00	976.00
IUUC-Oar-089433	Ovis aries	98.83	0.00e+00	979.00
IUUC-Ptr-090595	Pan troglodytes	98.44	0.00e+00	976.00
IUUC-Pan-092027	Papio anubis	98.44	0.00e+00	976.00
IUUC-Psi-093179	Pelodiscus sinensis	47.56	4.00e-117	414.00
IUUC-Pfo-096858	Poecilia formosa	33.96	1.00e-68	254.00
IUUC-Pab-098331	Pongo abelii	98.44	0.00e+00	976.00
IUUC-Pca-101091	Procavia capensis	98.83	0.00e+00	979.00
IUUC-Pva-103141	Pteropus vampyrus	98.70	0.00e+00	712.00
IUUC-Sar-113713	Sorex araneus	89.84	0.00e+00	892.00
IUUC-Ssc-115594	Sus scrofa	98.83	0.00e+00	977.00
IUUC-Tru-118630	Takifugu rubripes	34.08	2.00e-71	263.00
IUUC-Tsy-119235	Tarsius syrichta	98.44	0.00e+00	700.00
IUUC-Tni-120295	Tetraodon nigroviridis	37.58	1.00e-74	273.00
IUUC-Tbe-127796	Tupaia belangeri	88.64	6.00e-139	487.00
IUUC-Ttr-128738	Tursiops truncatus	98.93	0.00e+00	691.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence