iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066318

Ensembl Protein ID

ENSMPUP00000013393.1

UniProt Accession

M3YPY5; M3YPY5_MUSPF

Genbank Protein ID

ENSMPUP00000013393

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AEYP01006178

Gene Name

USP49

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000013495.1	ENSMPUT00000013608.1	ENSMPUP00000013393.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	7.20e-99	331.2	254	657

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenp............................................... 42
           tGl+NlgNtCYmNS+LQ+Ls+++++re++l+ +++++++  p                                               
   Q: 254  TGLRNLGNTCYMNSILQVLSHLQKFRECFLNLDPSQTQQLFPkapngkaplsgrpaggsatelsarsegadacerealcfnggasisrs 342
           7******************************8888888777777889999999999999999999999999999999999999999999 PP
   S: 43   .........kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeed 122
                    ++++ +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ ll+++++el         e+e+++
   Q: 343  leliqnkepSSKHISLCHELHTLFRVMWSGKWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLHKVQQEL---------ESEGTT 422
           99999999888899************************************************************.........668888 PP
   S: 123  kselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke..........slqdcLesftkeeele 201
           ++ l   +++k +k+  ++++++F+gql sq++c +c+ +s++ epf+dlsl++p++ ++ ++           l+++L++ft++e le
   Q: 423  RRILIPFSQRKLTKQVLKVVNTIFHGQLLSQVTCVSCNYKSNTIEPFWDLSLEFPERYHCIEKgfvplnqtecLLTEMLAKFTETEALE 511
           8999999***************************************************998879************************* PP
   S: 202  genkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke..kkk 277
           g+  y c++c++k++           a+k+l++ +lP+vL lhLkRf++s + ++reki  +v f + L+++p+c+++  ++ +  +  
   Q: 512  GRI-YACDQCNSKRRksnpkplvlseARKQLMIYRLPQVLRLHLKRFRWSGR-NHREKIGVHVVFDQVLTMEPYCCRDMLSSLDkeTFA 598
           965.*******9999999*******************************997.8889********************876654433999 PP
   S: 278  YeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
           Y+L+avv+H+G +++sGHY+ay++n++g+ W++++Dsk ++++ eev++   ++aY+lfY++
   Q: 599  YDLSAVVMHHGkGFGSGHYTAYCYNTEGGfWVHCNDSKLNVCSVEEVCK---TQAYILFYTQ 657
           *************************9999********************...********98 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MDRCKHVGRL RLAQDHSILN PQKWCCRECA TTESVWACLK CSHVACGRYI EDHALKHFEE 60
TGHPLAMEVR DLYVFCYLCK DYVLNDNPEG DLKLLRSSLL AVRGQKQDPP LRRGRTLRSM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATAGAT GCAAACATGT CGGGCGGTTG CGGCTCGCCC AGGACCACTC CATCCTGAAC 60
CCACAGAAGT GGTGCTGCCG GGAGTGCGCC ACCACCGAGT CCGTGTGGGC TTGTCTCAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0035616--P:histone H2B conserved C-terminal lysine deubiquitination
GO:0000398--P:mRNA splicing, via spliceosome
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002395	Ailuropoda melanoleuca	97.89	0.00e+00	872.00
IUUC-Bta-012911	Bos taurus	94.99	0.00e+00	854.00
IUUC-Cja-019171	Callithrix jacchus	94.27	0.00e+00	859.00
IUUC-Cfa-020408	Canis familiaris	97.93	0.00e+00	881.00
IUUC-Cpo-022233	Cavia porcellus	88.38	0.00e+00	805.00
IUUC-Csa-024272	Chlorocebus sabaeus	93.90	0.00e+00	641.00
IUUC-Cho-025051	Choloepus hoffmanni	89.71	0.00e+00	653.00
IUUC-Dno-029856	Dasypus novemcinctus	93.39	0.00e+00	860.00
IUUC-Fca-035919	Felis catus	96.99	0.00e+00	807.00
IUUC-Gmo-039249	Gadus morhua	77.67	1.00e-145	510.00
IUUC-Gga-040383	Gallus gallus	84.58	0.00e+00	753.00
IUUC-Ggo-044979	Gorilla gorilla	94.72	0.00e+00	865.00
IUUC-Hsa-046743	Homo sapiens	94.50	0.00e+00	862.00
IUUC-Itr-048251	Ictidomys tridecemlineatus	95.44	0.00e+00	878.00
IUUC-Loc-051961	Lepisosteus oculatus	77.43	0.00e+00	645.00
IUUC-Laf-053819	Loxodonta africana	93.69	0.00e+00	846.00
IUUC-Mcc-055048	Macaca mulatta	94.95	0.00e+00	867.00
IUUC-Meu-055971	Macropus eugenii	57.36	8.00e-123	434.00
IUUC-Mga-059720	Meleagris gallopavo	85.32	0.00e+00	754.00
IUUC-Mmu-064095	Mus musculus	91.12	0.00e+00	837.00
IUUC-Mlu-067090	Myotis lucifugus	91.80	0.00e+00	844.00
IUUC-Nle-069486	Nomascus leucogenys	94.95	0.00e+00	867.00
IUUC-Opr-070563	Ochotona princeps	90.68	0.00e+00	830.00
IUUC-Oan-073245	Ornithorhynchus anatinus	89.43	0.00e+00	625.00
IUUC-Ocu-074851	Oryctolagus cuniculus	95.09	0.00e+00	644.00
IUUC-Ola-086413	Oryzias latipes	71.26	4.00e-170	591.00
IUUC-Oga-088862	Otolemur garnettii	94.76	0.00e+00	846.00
IUUC-Oar-089462	Ovis aries	91.10	0.00e+00	817.00
IUUC-Ptr-091525	Pan troglodytes	94.43	0.00e+00	744.00
IUUC-Pan-092363	Papio anubis	95.40	0.00e+00	825.00
IUUC-Pma-094155	Petromyzon marinus	59.73	8.00e-82	296.00
IUUC-Pab-098592	Pongo abelii	93.60	0.00e+00	639.00
IUUC-Pca-100449	Procavia capensis	92.05	0.00e+00	827.00
IUUC-Pva-102868	Pteropus vampyrus	94.75	0.00e+00	867.00
IUUC-Rno-105190	Rattus norvegicus	88.61	0.00e+00	817.00
IUUC-Sar-113561	Sorex araneus	94.61	7.00e-94	337.00
IUUC-Ssc-115735	Sus scrofa	94.75	0.00e+00	870.00
IUUC-Tsy-118814	Tarsius syrichta	93.62	0.00e+00	842.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence