iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aml-002331

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

ACTA01124571

Gene Name

USP45

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000008960.1	ENSAMET00000009851.1	ENSAMEP00000009446.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	9.60e-88	294.7	180	820

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenp...............kepkgellkslqklfeelwkskkkavsprell 74
           +G++NlgNtC++N+v+Q L++   l+el++e+k++ ++ +                  ++ g+l+++l  +++++ +++k+  sp+ l+
   Q: 180  KGISNLGNTCFFNAVMQNLAQSYVLMELMNENKENGTKLK-IfpspdsqlfdpliveLSSPGPLTSALLVFLHSMKETEKGPLSPKVLF 267
           59*****************************555555444.246677777777777777778*************************** PP
   S: 75   kalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde......aeekkkkknkslisdlFqgqlksqikcl 157
           ++l+++a++f++++qqD+qE+l++lld++++e +k+ + ++ ++ ++ ++++ d+      + +  +  + ++i+++F g+l+s+++c+
   Q: 268  NQLCQKAPRFKSFQQQDSQELLHYLLDAVRTEETKRIQASILKAYNNPTTKTADDdtrkkvKAYGREGVKMNFIDRIFIGELTSTVMCE 356
           *********************************99666666666555555555552222225566666666****************** PP
   S: 158  ecdnvssreepfldlslpvpgkeetkke............................................................. 185
           ec+n+ss ++pf+d+slp+ +++ + k+                                                             
   Q: 357  ECANISSVNDPFIDISLPIIEERVRRKNlmsplmskcrslqvtdnsqysdtvtientsqpgatknqssskdkknalevaglqrntvnlq 445
           ***********************998889************************************************************ PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 446  nqlvhgrkcirklspgedravvvprkhenldmngdssalasivntesaltesptdgsekeasrsessadadseasesesaseqavllrs 534
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 535  srgcsvhplapspqplaagpptreagrgdegvaeaisvlylsspvpgdrdfdrekkplnvpnrscsseekhrlsprpqnafqtlsqsyi 623
           ***************************************************************************************** PP
   S: 186  ......slqdcLesftkeeelegenkyycekckkkqe...................aekklklkklPevLilhLkRfsfseeqksreki 249
                 slq+cL +ft+ e l g+nk+ ce+c++k++                   a+k+l ++ +P +LilhLkRf  ++++ s +k+
   Q: 624  ttskecSLQSCLYQFTSMELLMGNNKLLCENCTEKKQrsqketgsaekkaegvytnARKQLLISAVPAILILHLKRF--HQAGLSLRKV 710
           *********************************99999999999999999999999*********************..9999****** PP
   S: 250  nkkvefpleLdlspfctspeekqke..kkkYeLiavvvHsGslssGHYvayvkn.......................ekgkWllfdDsk 313
           n++v+fpl+Ldl+pfc+ +++++++  k+ Y L++vv HsGs+++GHY+ayvk                        + g+W++++D+ 
   Q: 711  NRHVDFPLMLDLAPFCSATCKNVSVgdKVLYGLYGVVEHSGSMRGGHYTAYVKVrppsrvlshcvlrwtdvkepdseSAGQWVHVSDTC 799
           ******************99998777799*************************999999999999999999998877888******** PP
   S: 314  VtevkeeevleetgstaYvlfYkr 337
           V++v+e++ l+   ++aY+lfY+r
   Q: 800  VQVVPESRALS---AQAYLLFYER 820
           ***********...********98 PP

Organism

Ailuropoda melanoleuca

Protein Sequence
(Fasta)

VLSHSVGFTC QHVSHAISVN HVKKAVAENA WSVCSECLKE RRFCDGRPVL PSDIWLCLKC 60
GFQGCGRNSE SHHSLKHYKS WRTESHCITI SLSTWVIWCY ECDEKLSTQC NKKVLAQTVD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTTTGTCTC ATTCAGTAGG TTTCACTTGC CAGCATGTAA GTCATGCTAT CAGTGTGAAT 60
CATGTGAAGA AAGCAGTAGC TGAGAATGCG TGGTCAGTTT GCTCAGAATG TTTAAAAGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003512	Anas platyrhynchos	61.52	0.00e+00	909.00
IUUC-Aca-004284	Anolis carolinensis	55.23	0.00e+00	839.00
IUUC-Ame-010735	Astyanax mexicanus	63.36	4.00e-85	308.00
IUUC-Bta-012880	Bos taurus	75.52	0.00e+00	1135.00
IUUC-Cja-019144	Callithrix jacchus	72.66	0.00e+00	1139.00
IUUC-Cfa-020971	Canis familiaris	82.44	0.00e+00	704.00
IUUC-Cpo-022497	Cavia porcellus	63.08	0.00e+00	935.00
IUUC-Csa-023910	Chlorocebus sabaeus	72.82	0.00e+00	1045.00
IUUC-Cho-024358	Choloepus hoffmanni	67.27	2.00e-60	226.00
IUUC-Dre-028106	Danio rerio	58.99	1.00e-129	457.00
IUUC-Dno-029456	Dasypus novemcinctus	69.26	0.00e+00	638.00
IUUC-Dor-030438	Dipodomys ordii	60.66	0.00e+00	816.00
IUUC-Dme-031870	Drosophila melanogaster	50.32	3.00e-37	150.00
IUUC-Ete-032736	Echinops telfairi	61.16	0.00e+00	866.00
IUUC-Eca-034211	Equus caballus	76.64	0.00e+00	1197.00
IUUC-Eeu-034797	Erinaceus europaeus	72.60	9.00e-82	297.00
IUUC-Fca-035947	Felis catus	77.98	0.00e+00	1169.00
IUUC-Fal-037199	Ficedula albicollis	61.50	0.00e+00	805.00
IUUC-Gmo-039228	Gadus morhua	59.15	5.00e-133	468.00
IUUC-Gga-040823	Gallus gallus	59.32	4.00e-149	521.00
IUUC-Gac-042406	Gasterosteus aculeatus	59.37	2.00e-126	446.00
IUUC-Ggo-045402	Gorilla gorilla	73.91	0.00e+00	1132.00
IUUC-Hsa-046430	Homo sapiens	73.51	0.00e+00	1130.00
IUUC-Itr-048855	Ictidomys tridecemlineatus	73.33	0.00e+00	662.00
IUUC-Lch-049547	Latimeria chalumnae	53.22	0.00e+00	781.00
IUUC-Loc-052842	Lepisosteus oculatus	53.80	0.00e+00	780.00
IUUC-Laf-053988	Loxodonta africana	74.42	0.00e+00	1145.00
IUUC-Mcc-055491	Macaca mulatta	79.20	1.00e-178	620.00
IUUC-Meu-056256	Macropus eugenii	60.07	2.00e-160	559.00
IUUC-Mla-059026	Melampsora laricipopulina	32.67	9.00e-18	85.10
IUUC-Mga-059833	Meleagris gallopavo	56.10	4.00e-151	527.00
IUUC-Mmr-060952	Microcebus murinus	73.57	0.00e+00	1125.00
IUUC-Mdo-062642	Monodelphis domestica	64.34	0.00e+00	929.00
IUUC-Mmu-063945	Mus musculus	69.14	0.00e+00	1076.00
IUUC-Mpu-065944	Mustela putorius furo	80.88	0.00e+00	1224.00
IUUC-Mlu-067049	Myotis lucifugus	74.85	0.00e+00	1128.00
IUUC-Nle-069828	Nomascus leucogenys	73.30	0.00e+00	1124.00
IUUC-Ont-072121	Oreochromis niloticus	59.79	9.00e-126	444.00
IUUC-Oan-073656	Ornithorhynchus anatinus	59.64	0.00e+00	889.00
IUUC-Ocu-074323	Oryctolagus cuniculus	72.26	0.00e+00	1084.00
IUUC-Ola-087238	Oryzias latipes	58.31	1.00e-130	461.00
IUUC-Oga-088379	Otolemur garnettii	68.71	0.00e+00	1051.00
IUUC-Oar-089718	Ovis aries	75.58	0.00e+00	1135.00
IUUC-Ptr-091358	Pan troglodytes	74.00	0.00e+00	1136.00
IUUC-Pan-092023	Papio anubis	72.90	0.00e+00	1125.00
IUUC-Psi-093256	Pelodiscus sinensis	60.67	0.00e+00	881.00
IUUC-Pfo-097285	Poecilia formosa	55.06	9.00e-112	397.00
IUUC-Pab-098539	Pongo abelii	74.00	0.00e+00	1140.00
IUUC-Pca-100610	Procavia capensis	61.23	0.00e+00	813.00
IUUC-Pva-102985	Pteropus vampyrus	83.71	3.00e-173	602.00
IUUC-Rno-105538	Rattus norvegicus	70.56	0.00e+00	1077.00
IUUC-Sha-107022	Sarcophilus harrisii	65.56	1.00e-152	533.00
IUUC-Sja-107712	Schizosaccharomyces japonicus	29.87	1.00e-20	95.10
IUUC-Spo-108149	Schizosaccharomyces pombe	31.51	1.00e-21	99.00
IUUC-Sar-113637	Sorex araneus	66.06	0.00e+00	946.00
IUUC-Ssc-115870	Sus scrofa	75.76	0.00e+00	1188.00
IUUC-Tgu-116907	Taeniopygia guttata	61.82	0.00e+00	919.00
IUUC-Tru-117835	Takifugu rubripes	53.85	5.00e-106	378.00
IUUC-Tsy-118869	Tarsius syrichta	72.35	0.00e+00	1011.00
IUUC-Tni-119716	Tetraodon nigroviridis	65.07	1.00e-88	320.00
IUUC-Tbe-128041	Tupaia belangeri	67.45	6.00e-125	441.00
IUUC-Ttr-128901	Tursiops truncatus	75.03	0.00e+00	1148.00
IUUC-Vpa-130331	Vicugna pacos	76.99	0.00e+00	1142.00
IUUC-Xtr-131794	Xenopus tropicalis	51.20	0.00e+00	761.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence