iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-034211

UUCD1 version

UUC-EqC-01048

Ensembl Protein ID

ENSECAP00000020532.1

UniProt Accession

F6TCV1; F6TCV1_HORSE

Protein Name

Ubiquitinyl hydrolase 1

Gene Name

USP45

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000023010.1	ENSECAT00000024702.1	ENSECAP00000020532.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.10e-86	289.4	191	816

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenp.............kepkgellkslqklfeelwkskkkavsprellka 76
           +G++NlgNtC++N+v+Q L++   l+el++e+k++ ++ + +              ++ g+l+++l  +++++ +++k+  sp+ l+++
   Q: 191  KGITNLGNTCFFNAVMQNLAQSYILTELMNESKENGTKLKISpssdsqldplvveLSSPGPLTSALFLFLHSMKETEKGPLSPKVLFNQ 279
           59*****************************55555554433455666666666666777***************************** PP
   S: 77   lkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknk......slisdlFqgqlksqikclec 159
           l+++a++f++++qqD+qE+l++lld++++e +k+ + ++ +++++ ++++ d++ +kk k +       ++i+++F g+l+s+++c+ec
   Q: 280  LCQKAPRFKSFQQQDSQELLHYLLDAVRTEETKRIQASILKAFNNPTTKTADDETRKKVKAYGregvkmNFIDQIFVGELTSTVMCEEC 368
           *******************************99888888888888888887775555544444556666******************** PP
   S: 160  dnvssreepfldlslpvpgkeetkke............................................................... 185
           +n+s  ++pf+d+slp+ +++ +k+                                                                
   Q: 369  ANISMVKDPFIDISLPIIEERVSKPVllgrvskyrslqetdngqysgtstiehthhprankkhpsskeknqlihgrkhirklssgedka 457
           *********************98777*************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 458  vdihwknenlemdgdssvlasiantestltgsptdgsekeashsessvdadseasesesatkqtvllrstggytvhamghlhhvstsep 546
           ***************************************************************************************** PP
   S: 186  ...........................................................................slqdcLesftkeee 199
                                                                                      s+q+cL +ft+ e 
   Q: 547  ptretdrghegvaeamaelrlsstvtgdrdfekenqplnvsnnlcfsegkhmvshspqnafqtlsqsyittskecSVQSCLYQFTSMEL 635
           ***************************************************************************************** PP
   S: 200  legenkyycekck.......kkqe...............aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfct 266
           l g+nk+ ce+c+       +  +               a+k+l ++ +P +LilhLkRf  ++++ s +k+n++v+fpl+Ldl+pfc+
   Q: 636  LMGNNKLLCENCTltkkqkyQ--KesssaekkaegvytnARKQLLISAVPAILILHLKRF--HQAGLSLRKVNRHVDFPLMLDLAPFCS 720
           ************966665550..0555555555666666*********************..9999*********************** PP
   S: 267  speekqke..kkkYeLiavvvHsGslssGHYvayvkn..........................ekgkWllfdDskVtevkeeevleetg 327
            +++++++  k+ Y L++vv HsGs+++GHY+ayvk                           + g+W++++D++V++v+e++ l+   
   Q: 721  ATCKNVNVgdKVLYGLYGVVEHSGSMRGGHYTAYVKVrtpsrrllehitgkrnvpglkepdseSAGQWVHVSDTYVQVVPESRALS--- 806
           *99998878899*************************999999999999999999999988877888*******************... PP
   S: 328  staYvlfYkr 337
           ++aY+lfY+r
   Q: 807  AQAYLLFYER 816
           ********98 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MRVKEPSKAL PEKAKRSKRP TLPHDEDSSD DIAVGFTCQH VNLAVSVNHV KRAIAENLWS 60
VCSECLKERR FYDGQPVLLT DVWLCLKCGF QGCGQSSESQ HSLKHFKSQR TELHCIIINL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTAAATAACA GATGCGGGTG AAGGAGCCAT CCAAAGCTTT ACCTGAGAAA GCCAAAAGAA 60
GTAAAAGGCC TACGCTACCT CATGATGAAG ACTCTTCAGA TGACATTGCT GGTAAATTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ecb:100071616

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002331	Ailuropoda melanoleuca	76.64	0.00e+00	1165.00
IUUC-Apl-003512	Anas platyrhynchos	67.92	0.00e+00	1078.00
IUUC-Aca-004284	Anolis carolinensis	62.02	0.00e+00	967.00
IUUC-Ame-010735	Astyanax mexicanus	63.98	2.00e-86	312.00
IUUC-Bta-012880	Bos taurus	86.31	0.00e+00	1362.00
IUUC-Cja-019144	Callithrix jacchus	82.05	0.00e+00	1348.00
IUUC-Cfa-020971	Canis familiaris	82.29	0.00e+00	753.00
IUUC-Cpo-022497	Cavia porcellus	78.81	0.00e+00	732.00
IUUC-Csa-023910	Chlorocebus sabaeus	81.19	0.00e+00	1238.00
IUUC-Cho-024358	Choloepus hoffmanni	61.78	7.00e-114	404.00
IUUC-Dre-028106	Danio rerio	53.16	1.00e-147	516.00
IUUC-Dno-029456	Dasypus novemcinctus	77.56	0.00e+00	732.00
IUUC-Dor-030438	Dipodomys ordii	64.59	0.00e+00	973.00
IUUC-Dme-031870	Drosophila melanogaster	50.32	1.00e-36	148.00
IUUC-Ete-032736	Echinops telfairi	64.77	0.00e+00	956.00
IUUC-Eeu-034797	Erinaceus europaeus	80.90	1.00e-92	333.00
IUUC-Fca-035947	Felis catus	80.81	0.00e+00	1216.00
IUUC-Fal-037199	Ficedula albicollis	67.35	0.00e+00	937.00
IUUC-Gmo-039228	Gadus morhua	60.25	3.00e-139	489.00
IUUC-Gga-040823	Gallus gallus	65.82	3.00e-177	614.00
IUUC-Gac-042406	Gasterosteus aculeatus	58.87	1.00e-137	483.00
IUUC-Ggo-045402	Gorilla gorilla	83.05	0.00e+00	1350.00
IUUC-Hsa-046430	Homo sapiens	82.66	0.00e+00	1349.00
IUUC-Itr-048855	Ictidomys tridecemlineatus	82.68	0.00e+00	784.00
IUUC-Lch-049547	Latimeria chalumnae	59.06	0.00e+00	929.00
IUUC-Loc-052842	Lepisosteus oculatus	57.95	0.00e+00	906.00
IUUC-Laf-053988	Loxodonta africana	84.17	0.00e+00	1378.00
IUUC-Mcc-055491	Macaca mulatta	78.27	0.00e+00	1256.00
IUUC-Meu-056256	Macropus eugenii	66.05	0.00e+00	638.00
IUUC-Mla-059026	Melampsora laricipopulina	32.20	4.00e-17	83.20
IUUC-Mga-059833	Meleagris gallopavo	62.50	2.00e-179	622.00
IUUC-Mmr-060952	Microcebus murinus	81.81	0.00e+00	1300.00
IUUC-Mdo-062642	Monodelphis domestica	71.10	0.00e+00	1103.00
IUUC-Mmu-063945	Mus musculus	78.63	0.00e+00	1257.00
IUUC-Mpu-065944	Mustela putorius furo	79.71	0.00e+00	1241.00
IUUC-Mlu-067049	Myotis lucifugus	83.17	0.00e+00	1334.00
IUUC-Nle-069828	Nomascus leucogenys	82.68	0.00e+00	1344.00
IUUC-Opr-070672	Ochotona princeps	69.19	1.00e-139	490.00
IUUC-Ont-072121	Oreochromis niloticus	58.52	2.00e-133	469.00
IUUC-Oan-073656	Ornithorhynchus anatinus	65.30	0.00e+00	1045.00
IUUC-Ocu-074323	Oryctolagus cuniculus	78.51	0.00e+00	1238.00
IUUC-Ola-087238	Oryzias latipes	52.08	0.00e+00	801.00
IUUC-Oga-088379	Otolemur garnettii	76.90	0.00e+00	1240.00
IUUC-Oar-089718	Ovis aries	85.73	0.00e+00	1350.00
IUUC-Ptr-091358	Pan troglodytes	83.15	0.00e+00	1356.00
IUUC-Pan-092023	Papio anubis	82.17	0.00e+00	1332.00
IUUC-Psi-093256	Pelodiscus sinensis	66.95	0.00e+00	997.00
IUUC-Pfo-097285	Poecilia formosa	50.42	0.00e+00	722.00
IUUC-Pab-098539	Pongo abelii	83.03	0.00e+00	1353.00
IUUC-Pca-100610	Procavia capensis	67.66	0.00e+00	927.00
IUUC-Pva-102985	Pteropus vampyrus	90.54	0.00e+00	701.00
IUUC-Rno-105538	Rattus norvegicus	77.66	0.00e+00	1252.00
IUUC-Sha-107022	Sarcophilus harrisii	61.25	0.00e+00	977.00
IUUC-Sja-107712	Schizosaccharomyces japonicus	28.21	8.00e-22	99.00
IUUC-Spo-108149	Schizosaccharomyces pombe	29.90	9.00e-20	92.40
IUUC-Sar-113637	Sorex araneus	73.02	0.00e+00	1103.00
IUUC-Ssc-115870	Sus scrofa	85.94	0.00e+00	1415.00
IUUC-Tgu-116907	Taeniopygia guttata	67.48	0.00e+00	1073.00
IUUC-Tru-117835	Takifugu rubripes	44.79	4.00e-106	379.00
IUUC-Tsy-118869	Tarsius syrichta	82.55	0.00e+00	1169.00
IUUC-Tni-119716	Tetraodon nigroviridis	64.23	2.00e-92	333.00
IUUC-Tbe-128041	Tupaia belangeri	66.06	0.00e+00	957.00
IUUC-Ttr-128901	Tursiops truncatus	84.47	0.00e+00	1360.00
IUUC-Vpa-130331	Vicugna pacos	85.66	0.00e+00	1273.00
IUUC-Xtr-131794	Xenopus tropicalis	52.39	0.00e+00	769.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence