iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Sha-106559

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEFK01172517

Gene Name

TNFAIP3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000010469.1	ENSSHAT00000012313.1	ENSSHAP00000012214.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	3.40e-39	134.6	94	263
UBD/ZnF/ZnF_A20	1.20e-22	79.7	760	791

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseyl....qkesdffsefieek........edekefcqklvepe... 74
           ++lkt+gDGnCL++A+sq+++gv+d+d+ l++al+++L+e+  +++    q es + +ef+e++        ++e++++ k+++++   
   Q: 94   VALKTNGDGNCLMHATSQYMWGVQDTDLvLRKALYSTLKETDIRNFkfrwQLESLKSQEFVETGlrydtrnwNEEWDNLIKMASTDtsv 182
           789*******************************************99*9************************************666 PP
   S: 75   akg.......eeihifaLaqiLsrpiivvdvdsles..........kvggillpllfpeek.lkkpivLlYrsgHYdaLva 137
           a+g       eeih+f+L++iL+rpii++++++l+s          kvggi+lpl++p+++ +++pivL+Y+s H+ +Lv+
   Q: 183  ARGglqyhslEEIHVFVLSNILRRPIIIIADKMLRSlesgsnfaplKVGGIYLPLHWPAQEcYRYPIVLGYDSQHFAPLVT 263
           5547***************************************************************************97 PP

UBD/ZnF/ZnF_A20

   S: 3    skllCkk.gCgfYGnpetngyCSkCyreelrr 33
           +k++C++ +C+++Gn ++ngyC++Cy++++ +
   Q: 760  PKQRCRApACDHFGNTKCNGYCNECYQFKQLY 791
           79***************************977 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MAEQQVLPQA LYLSNMRKAV KIRERTPEDI IKPTNGIIYH FKTMHRYTME MFRTCQFCPQ 60
FREFILVALI DRSIQNSLEN QRKLNWCREV RKLVALKTNG DGNCLMHATS QYMWGVQDTD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCAGAGCCT AGCTGGAAAT CCCCGGGCTG ATATTACCCG GCCTAAAAGA AAGGAAAAAA 60
GAGAACTTGC GCAGTCGTTT GCTTCAAGTT CTAGGATCTA GGATTGGAGC TTGCGGGGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR033478--A20
IPR003323--OTU_dom
IPR002653--Znf_A20

PROSITE

PS50802--OTU
PS51036--ZF_A20

Pfam

PF02338--OTU
PF01754--zf-A20

SMART

SM00259--ZnF_A20

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0001922--P:B-1 B cell homeostasis
GO:0070301--P:cellular response to hydrogen peroxide
GO:0072666--P:establishment of protein localization to vacuole
GO:0050869--P:negative regulation of B cell activation
GO:2000349--P:negative regulation of CD40 signaling pathway
GO:0002677--P:negative regulation of chronic inflammatory response
GO:0045736--P:negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:2000352--P:negative regulation of endothelial cell apoptotic process
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045824--P:negative regulation of innate immune response
GO:0032691--P:negative regulation of interleukin-1 beta production
GO:0032703--P:negative regulation of interleukin-2 production
GO:0032715--P:negative regulation of interleukin-6 production
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0070429--P:negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070433--P:negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0031397--P:negative regulation of protein ubiquitination
GO:0048662--P:negative regulation of smooth muscle cell proliferation
GO:0034140--P:negative regulation of toll-like receptor 3 signaling pathway
GO:0034148--P:negative regulation of toll-like receptor 5 signaling pathway
GO:0032720--P:negative regulation of tumor necrosis factor production
GO:1903364--P:positive regulation of cellular protein catabolic process
GO:2000347--P:positive regulation of hepatocyte proliferation
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0002634--P:regulation of germinal center formation
GO:0032495--P:response to muramyl dipeptide
GO:0072573--P:tolerance induction to lipopolysaccharide

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001825	Ailuropoda melanoleuca	79.42	0.00e+00	1287.00
IUUC-Apl-003501	Anas platyrhynchos	65.88	0.00e+00	1058.00
IUUC-Aca-004245	Anolis carolinensis	64.85	0.00e+00	1078.00
IUUC-Ame-011789	Astyanax mexicanus	45.41	0.00e+00	684.00
IUUC-Bta-012664	Bos taurus	75.66	0.00e+00	1203.00
IUUC-Cja-019895	Callithrix jacchus	79.55	0.00e+00	1277.00
IUUC-Cfa-020754	Canis familiaris	79.55	0.00e+00	1288.00
IUUC-Cpo-021780	Cavia porcellus	77.47	0.00e+00	1241.00
IUUC-Csa-023568	Chlorocebus sabaeus	80.05	0.00e+00	1297.00
IUUC-Cho-024300	Choloepus hoffmanni	84.59	1.00e-175	609.00
IUUC-Dre-028577	Danio rerio	48.37	0.00e+00	674.00
IUUC-Dno-029382	Dasypus novemcinctus	74.59	0.00e+00	1204.00
IUUC-Dor-030874	Dipodomys ordii	75.41	0.00e+00	1197.00
IUUC-Ete-032721	Echinops telfairi	84.69	0.00e+00	736.00
IUUC-Eca-033596	Equus caballus	76.91	0.00e+00	1240.00
IUUC-Eeu-035159	Erinaceus europaeus	75.55	0.00e+00	948.00
IUUC-Fca-035847	Felis catus	79.55	0.00e+00	1284.00
IUUC-Fal-036681	Ficedula albicollis	65.97	0.00e+00	1091.00
IUUC-Gmo-038521	Gadus morhua	57.39	3.00e-143	502.00
IUUC-Gga-040975	Gallus gallus	64.65	0.00e+00	1075.00
IUUC-Gac-042216	Gasterosteus aculeatus	60.14	6.00e-153	534.00
IUUC-Ggo-045258	Gorilla gorilla	79.55	0.00e+00	1288.00
IUUC-Hsa-046071	Homo sapiens	79.67	0.00e+00	1291.00
IUUC-Itr-048386	Ictidomys tridecemlineatus	79.30	0.00e+00	1274.00
IUUC-Lch-050326	Latimeria chalumnae	57.99	0.00e+00	937.00
IUUC-Loc-051945	Lepisosteus oculatus	46.31	1.00e-179	623.00
IUUC-Laf-053722	Loxodonta africana	78.54	0.00e+00	1267.00
IUUC-Mcc-055503	Macaca mulatta	79.92	0.00e+00	1296.00
IUUC-Meu-056481	Macropus eugenii	85.73	0.00e+00	1362.00
IUUC-Mga-059690	Meleagris gallopavo	61.86	0.00e+00	975.00
IUUC-Mmr-061233	Microcebus murinus	78.22	0.00e+00	1250.00
IUUC-Mdo-062446	Monodelphis domestica	89.95	0.00e+00	1489.00
IUUC-Mmu-063436	Mus musculus	78.18	0.00e+00	1229.00
IUUC-Mpu-066808	Mustela putorius furo	80.05	0.00e+00	1299.00
IUUC-Mlu-067339	Myotis lucifugus	79.72	0.00e+00	1278.00
IUUC-Nle-069888	Nomascus leucogenys	79.92	0.00e+00	1297.00
IUUC-Opr-070303	Ochotona princeps	76.88	0.00e+00	1246.00
IUUC-Ont-072283	Oreochromis niloticus	57.73	1.00e-146	513.00
IUUC-Oan-072925	Ornithorhynchus anatinus	77.07	0.00e+00	1268.00
IUUC-Ocu-073889	Oryctolagus cuniculus	77.83	0.00e+00	1243.00
IUUC-Ola-087417	Oryzias latipes	58.70	3.00e-148	518.00
IUUC-Oga-088708	Otolemur garnettii	76.79	0.00e+00	1192.00
IUUC-Oar-089271	Ovis aries	76.41	0.00e+00	1224.00
IUUC-Ptr-091296	Pan troglodytes	79.67	0.00e+00	1291.00
IUUC-Pan-092474	Papio anubis	79.92	0.00e+00	1295.00
IUUC-Psi-093447	Pelodiscus sinensis	69.00	0.00e+00	1113.00
IUUC-Pfo-096511	Poecilia formosa	58.45	3.00e-149	521.00
IUUC-Pab-098700	Pongo abelii	79.92	0.00e+00	1295.00
IUUC-Pca-100246	Procavia capensis	66.50	0.00e+00	1032.00
IUUC-Pva-102606	Pteropus vampyrus	71.65	5.00e-163	568.00
IUUC-Rno-105818	Rattus norvegicus	78.21	0.00e+00	1250.00
IUUC-Sar-113454	Sorex araneus	89.06	8.00e-178	617.00
IUUC-Ssc-116064	Sus scrofa	78.06	0.00e+00	1249.00
IUUC-Tgu-117212	Taeniopygia guttata	65.24	0.00e+00	1066.00
IUUC-Tru-118230	Takifugu rubripes	59.71	3.00e-152	532.00
IUUC-Tsy-119066	Tarsius syrichta	77.05	0.00e+00	1243.00
IUUC-Tni-119825	Tetraodon nigroviridis	46.68	0.00e+00	672.00
IUUC-Tbe-127601	Tupaia belangeri	88.45	7.00e-178	617.00
IUUC-Ttr-128930	Tursiops truncatus	76.84	0.00e+00	1219.00
IUUC-Vpa-130450	Vicugna pacos	86.07	0.00e+00	724.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence