iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tni-120043

Ensembl Protein ID

ENSTNIP00000016380.1

UniProt Accession

H3D789; H3D789_TETNG

Protein Name

E3 ubiquitin-protein ligase parkin

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTNIG00000013388.1	ENSTNIT00000016593.1	ENSTNIP00000016380.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UBQ/UBQ_PIM	2.70e-18	65.9	2	71

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_PIM

   S: 2    kltvktlkgkefelevseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvv 71
            + v+ + g e+ +ev+e+ tv+elKe +a+++gv+pe++++++aG++Lk  +tL+++++ ++s+vh++v
   Q: 2    PVIVRYNLGPEVVVEVQEEATVAELKEVVARQQGVQPERLRVLFAGRELKSTSTLQDCDLPEQSTVHVLV 71
           588999999**********************************************************997 PP

Organism

Tetraodon nigroviridis

Functional Description
(View)

Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

Protein Sequence
(Fasta)

VPVIVRYNLG PEVVVEVQEE ATVAELKEVV ARQQGVQPER LRVLFAGREL KSTSTLQDCD 60
LPEQSTVHVL VPPPAASSSK VHLLQEHQAR GEEEDHDSLT RLDLSSSRLT TTTSGLAVIL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGCCAGTGA TTGTGAGGTA TAACCTAGGA CCAGAGGTGG TCGTGGAGGT GCAAGAGGAG 60
GCCACCGTGG CTGAGCTGAA GGAGGTGGTG GCTCGTCAGC AGGGAGTGCA GCCGGAGCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR003977--Parkin
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50053--UBIQUITIN_2

Pfam

PF01485--IBR
PF00240--ubiquitin

PRINTS

PR01475--PARKIN

SMART

SM00647--IBR
SM00213--UBQ

Gene Ontology

GO:0005829--C:cytosol
GO:0005739--C:mitochondrion
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0046872--F:metal ion binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006120--P:mitochondrial electron transport, NADH to ubiquinone
GO:0051865--P:protein autoubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0006979--P:response to oxidative stress
GO:0009266--P:response to temperature stimulus

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001814	Ailuropoda melanoleuca	47.27	1.00e-69	256.00
IUUC-Apl-003304	Anas platyrhynchos	60.75	2.00e-121	428.00
IUUC-Aca-004908	Anolis carolinensis	54.21	6.00e-34	135.00
IUUC-Ame-011856	Astyanax mexicanus	60.04	2.00e-158	551.00
IUUC-Bta-013014	Bos taurus	51.33	7.00e-109	387.00
IUUC-Cel-018687	Caenorhabditis elegans	31.66	5.00e-41	161.00
IUUC-Cja-019274	Callithrix jacchus	48.23	9.00e-70	256.00
IUUC-Cfa-020461	Canis familiaris	47.44	9.00e-70	256.00
IUUC-Cpo-022251	Cavia porcellus	47.44	3.00e-69	254.00
IUUC-Csa-023112	Chlorocebus sabaeus	48.72	2.00e-67	248.00
IUUC-Cho-024504	Choloepus hoffmanni	38.92	5.00e-80	291.00
IUUC-Dre-028202	Danio rerio	60.46	2.00e-147	515.00
IUUC-Dno-028946	Dasypus novemcinctus	49.04	4.00e-26	108.00
IUUC-Dor-030508	Dipodomys ordii	43.46	7.00e-74	270.00
IUUC-Dme-031980	Drosophila melanogaster	39.92	3.00e-102	365.00
IUUC-Ete-032281	Echinops telfairi	42.81	5.00e-51	194.00
IUUC-Eca-033228	Equus caballus	47.12	6.00e-69	253.00
IUUC-Fal-037507	Ficedula albicollis	50.91	8.00e-137	479.00
IUUC-Gmo-038744	Gadus morhua	58.30	1.00e-91	330.00
IUUC-Gga-040353	Gallus gallus	50.91	3.00e-139	488.00
IUUC-Gac-042519	Gasterosteus aculeatus	65.06	8.00e-171	593.00
IUUC-Hsa-046016	Homo sapiens	52.26	9.00e-131	459.00
IUUC-Itr-048744	Ictidomys tridecemlineatus	50.83	3.00e-126	444.00
IUUC-Loc-052389	Lepisosteus oculatus	55.21	1.00e-140	492.00
IUUC-Mcc-054933	Macaca mulatta	52.47	9.00e-131	459.00
IUUC-Meu-055963	Macropus eugenii	42.09	1.00e-83	303.00
IUUC-Mga-059626	Meleagris gallopavo	62.67	3.00e-23	99.40
IUUC-Mmr-061566	Microcebus murinus	60.83	6.00e-64	236.00
IUUC-Mdo-061952	Monodelphis domestica	66.04	1.00e-19	87.40
IUUC-Mmu-063561	Mus musculus	52.99	3.00e-138	484.00
IUUC-Mpu-065799	Mustela putorius furo	48.08	2.00e-69	255.00
IUUC-Mlu-068134	Myotis lucifugus	48.18	2.00e-87	315.00
IUUC-Nle-070078	Nomascus leucogenys	47.99	5.00e-73	267.00
IUUC-Opr-070541	Ochotona princeps	52.88	1.00e-122	432.00
IUUC-Ont-071743	Oreochromis niloticus	75.77	6.00e-152	530.00
IUUC-Ola-086426	Oryzias latipes	70.76	2.00e-73	267.00
IUUC-Oga-088867	Otolemur garnettii	52.16	8.00e-129	453.00
IUUC-Oar-089365	Ovis aries	50.91	1.00e-98	352.00
IUUC-Ptr-091371	Pan troglodytes	52.06	2.00e-129	455.00
IUUC-Pan-092443	Papio anubis	47.76	1.00e-68	252.00
IUUC-Psi-093851	Pelodiscus sinensis	46.15	3.00e-59	221.00
IUUC-Pfo-097194	Poecilia formosa	72.14	1.00e-143	502.00
IUUC-Pab-097999	Pongo abelii	55.75	7.00e-52	197.00
IUUC-Pca-100410	Procavia capensis	47.78	3.00e-105	375.00
IUUC-Pva-102300	Pteropus vampyrus	45.87	2.00e-103	369.00
IUUC-Rno-105556	Rattus norvegicus	48.28	6.00e-71	260.00
IUUC-Sar-113121	Sorex araneus	65.18	4.00e-41	161.00
IUUC-Ssc-116435	Sus scrofa	48.06	4.00e-70	257.00
IUUC-Tgu-117489	Taeniopygia guttata	51.33	7.00e-137	480.00
IUUC-Tru-117927	Takifugu rubripes	83.33	0.00e+00	767.00
IUUC-Tsy-119372	Tarsius syrichta	61.99	6.00e-115	407.00
IUUC-Tbe-127539	Tupaia belangeri	45.98	7.00e-105	374.00
IUUC-Ttr-129149	Tursiops truncatus	50.21	1.00e-132	466.00
IUUC-Vpa-130439	Vicugna pacos	45.22	7.00e-81	294.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence