iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	HINT
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	UniProt	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	8.20e-82	276.2	111	410

Active Site

Position(s)	Description	Evidence
119	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
370	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeq 89
           Gl+NlgNtC+ N++LQcL+ +p+l++++l+ ++++++++     +  ++++++q+ +++ +++   +++p  +++ ++++a++f+  +q
   Q: 111  GLQNLGNTCFANAALQCLTYTPPLANYMLShEHSKTCHA-----EGFCMMCTMQTHITQALSNPGDVIKPMFVINEMRRIARHFRFGNQ 194
           9*****************************445555544.....578****************************************** PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpg 178
           +Da+Efl++ +d++++++                  l+ +++ + +++ ++l+ ++F+g l+s++kcl+c+ vs +++p ld++l+++ 
   Q: 195  EDAHEFLQYTVDAMQKAC------------------LNGSNKLDRHTQATTLVCQIFGGYLRSRVKCLNCKGVSDTFDPYLDITLEIKA 265
           ******************..................3344567789999**************************************** PP
   S: 179  keetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts 267
            +     s++++Le+f+k+e+l+gen y+c+kckk + a+k++++++ ++vL++ LkRf    ++    ki k v++p+ Ld++p++++
   Q: 266  AQ-----SVTKALEQFVKPEQLDGENSYKCSKCKKMVPASKRFTIHRSSNVLTISLKRF----ANFTGGKIAKDVKYPEYLDIRPYMSQ 345
           **.....9***************************************************....668889******************** PP
   S: 268  peekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           p+ +   + +Y L+av+vH+G +++ GHY++y+k ++g W++++Ds V++++   vl+   ++aYvlfY r
   Q: 346  PNGE---PIIYVLYAVLVHTGfNCHAGHYFCYIKASNGLWYQMNDSIVSTSDIRAVLN---QQAYVLFYIR 410
           9977...8**************************************************...********87 PP

Organism

Mus musculus

Functional Description
(View)

Deubiquitinating enzyme which may play an important role during spermatogenesis.

Protein Sequence
(Fasta)

MTIVDKTEPS DPSTCQNQPG SCEAVSPEDM DTGSASWGAV SSISDVSSHT LPLGPVPGAV 60
VYSNSSVPEK SKPSPPKDQV LGDGIAPPQK VLFPSEKICL KWQQSHRVGA GLQNLGNTCF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCGGCGGCG GTGCCCGGAT GGAGGCACGT CATTGTCCCC CGCCGGGCGG CTGGGCTGTG 60
TGCGGCGGCG GCGGCGGCGG CGGCCGAGGG GGATGGAGCG AGTGCCGAGC CGGGTCAGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0221--Differentiation
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0744--Spermatogenesis
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0030154--P:cell differentiation
GO:0016579--P:protein deubiquitination
GO:0007283--P:spermatogenesis
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mmu:76800

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000401	Aegilops tauschii	38.91	4.00e-70	259.00
IUUC-Aml-002303	Ailuropoda melanoleuca	65.75	0.00e+00	1292.00
IUUC-Atr-003102	Amborella trichopoda	47.23	1.00e-85	311.00
IUUC-Apl-003459	Anas platyrhynchos	54.31	0.00e+00	687.00
IUUC-Aca-004440	Anolis carolinensis	53.04	0.00e+00	980.00
IUUC-Ath-006710	Arabidopsis thaliana	42.81	4.00e-77	283.00
IUUC-Ago-007836	Ashbya gossypii	26.87	2.00e-34	141.00
IUUC-Ame-011358	Astyanax mexicanus	70.35	0.00e+00	658.00
IUUC-Bta-012803	Bos taurus	65.82	0.00e+00	1483.00
IUUC-Bol-015996	Brassica oleracea	33.59	2.00e-82	301.00
IUUC-Cja-019199	Callithrix jacchus	67.73	0.00e+00	1442.00
IUUC-Cfa-020597	Canis familiaris	69.08	0.00e+00	1548.00
IUUC-Cpo-021945	Cavia porcellus	66.89	0.00e+00	1535.00
IUUC-Csa-023485	Chlorocebus sabaeus	67.96	0.00e+00	1427.00
IUUC-Cho-024575	Choloepus hoffmanni	67.94	0.00e+00	895.00
IUUC-Dre-028442	Danio rerio	63.47	0.00e+00	651.00
IUUC-Dno-029673	Dasypus novemcinctus	68.14	0.00e+00	1640.00
IUUC-Dor-030518	Dipodomys ordii	57.05	8.00e-115	408.00
IUUC-Ete-033088	Echinops telfairi	56.10	0.00e+00	911.00
IUUC-Eca-033579	Equus caballus	68.36	0.00e+00	1565.00
IUUC-Eeu-034511	Erinaceus europaeus	48.92	0.00e+00	812.00
IUUC-Fca-035792	Felis catus	66.05	0.00e+00	1429.00
IUUC-Fal-037075	Ficedula albicollis	43.17	0.00e+00	797.00
IUUC-Gga-040504	Gallus gallus	55.08	0.00e+00	709.00
IUUC-Gma-044075	Glycine max	48.53	5.00e-86	312.00
IUUC-Ggo-044798	Gorilla gorilla	63.75	0.00e+00	1237.00
IUUC-Hsa-046072	Homo sapiens	67.93	0.00e+00	1414.00
IUUC-Hvu-047620	Hordeum vulgare	41.54	1.00e-73	271.00
IUUC-Itr-048078	Ictidomys tridecemlineatus	72.39	0.00e+00	1765.00
IUUC-Lch-049867	Latimeria chalumnae	66.62	0.00e+00	914.00
IUUC-Loc-052621	Lepisosteus oculatus	62.46	0.00e+00	677.00
IUUC-Laf-054330	Loxodonta africana	83.02	0.00e+00	1153.00
IUUC-Mcc-054900	Macaca mulatta	92.29	0.00e+00	738.00
IUUC-Mga-059501	Meleagris gallopavo	41.45	0.00e+00	697.00
IUUC-Mvi-060547	Microbotryum violaceum	43.65	1.00e-81	297.00
IUUC-Mmr-060864	Microcebus murinus	69.64	0.00e+00	1647.00
IUUC-Mdo-062395	Monodelphis domestica	57.68	0.00e+00	1352.00
IUUC-Mpu-065822	Mustela putorius furo	69.48	0.00e+00	1580.00
IUUC-Mlu-067091	Myotis lucifugus	67.21	0.00e+00	1434.00
IUUC-Nle-069004	Nomascus leucogenys	67.26	0.00e+00	1448.00
IUUC-Opr-071170	Ochotona princeps	57.91	0.00e+00	1045.00
IUUC-Ont-071832	Oreochromis niloticus	61.78	0.00e+00	648.00
IUUC-Oan-073711	Ornithorhynchus anatinus	54.37	0.00e+00	1192.00
IUUC-Ocu-074596	Oryctolagus cuniculus	91.20	0.00e+00	1007.00
IUUC-Oga-088641	Otolemur garnettii	69.10	0.00e+00	1597.00
IUUC-Oar-089760	Ovis aries	59.93	0.00e+00	1305.00
IUUC-Ptr-091445	Pan troglodytes	67.64	0.00e+00	1441.00
IUUC-Pan-092484	Papio anubis	67.76	0.00e+00	1389.00
IUUC-Psi-093277	Pelodiscus sinensis	51.69	0.00e+00	1065.00
IUUC-Pma-094651	Petromyzon marinus	37.93	2.00e-56	212.00
IUUC-Pfo-096469	Poecilia formosa	63.64	0.00e+00	645.00
IUUC-Pab-097794	Pongo abelii	66.75	0.00e+00	1322.00
IUUC-Ppe-101678	Prunus persica	46.58	1.00e-82	301.00
IUUC-Pva-103238	Pteropus vampyrus	63.35	0.00e+00	1321.00
IUUC-Rno-105068	Rattus norvegicus	91.94	0.00e+00	2238.00
IUUC-Sha-106713	Sarcophilus harrisii	57.89	0.00e+00	1380.00
IUUC-Smo-108727	Selaginella moellendorffii	48.05	3.00e-81	295.00
IUUC-Sar-113340	Sorex araneus	77.48	0.00e+00	1042.00
IUUC-Tgu-117149	Taeniopygia guttata	44.66	0.00e+00	791.00
IUUC-Tru-117776	Takifugu rubripes	65.15	6.00e-177	614.00
IUUC-Tsy-118974	Tarsius syrichta	67.31	0.00e+00	1570.00
IUUC-Tni-120774	Tetraodon nigroviridis	66.38	7.00e-173	600.00
IUUC-Tca-120936	Theobroma cacao	38.86	6.00e-86	312.00
IUUC-Tbe-128006	Tupaia belangeri	66.67	6.00e-131	462.00
IUUC-Ttr-128764	Tursiops truncatus	57.65	0.00e+00	1221.00
IUUC-Vvi-131535	Vitis vinifera	46.96	1.00e-86	315.00
IUUC-Xtr-132544	Xenopus tropicalis	57.35	0.00e+00	635.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence