iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-059723

UUCD1 version

UUC-MeG-00196

Ensembl Protein ID

ENSMGAP00000003802.1

UniProt Accession

G1MY18; G1MY18_MELGA

Protein Name

Uncharacterized protein

Gene Name

SMURF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000003983.1	ENSMGAT00000004510.1	ENSMGAP00000003802.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.00e-126	422.6	407	740

Active Site

Position(s)	Description	Evidence
709	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGv.treflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           ++dlkkrl+v+f+gEegld+gGv +re+l+ll++e+ np++glf+ys ++ ++lq+npds + np+hl++F+f+Gr++g+a+++g++++
   Q: 407  PKDLKKRLMVKFRGEEGLDYGGVaSREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYIN 494
           689*******************9459***********************************9.89************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvv 178
             ++ +fyk+llgk+++l+dle+vdpel+ksl +i+en   di+   ld tf+v+++ +g + ++eLkp+G+nipVt+eNk+eYv+l+v
   Q: 495  GGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILEN---DITPV-LDHTFCVEHNAFGRILQHELKPNGRNIPVTEENKKEYVRLYV 579
           ************************************99...9***8.****************************************** PP
   S: 179  eyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqF 267
           ++r+ +gi+ q+ a+++Gfne+ip++ll+ F+++elel+i G ++id++d+k++t+ k+ +++ds+ ++wFw+++e f++e r+++LqF
   Q: 580  NWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKH-CMADSNIVKWFWQAVETFDEERRARLLQF 667
           *********************************************************99.***************************** PP
   S: 268  vTgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           vTgs r+Pl+Gf++l+    prlf+i+  da++d+lP+++TCfn++++P+Y+s+e+l+ekLl+A+eet gF +
   Q: 668  VTGSTRVPLQGFKALQgaagPRLFTIHLiDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAV 740
           ****************************99999**************************************76 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

LCNNGTNQQS PFPITVLCAK NLAKKDFFRL PDPFAKIVVD GSGQCHSTDT VKNTLDPKWN 60
QHYDLYVGKT DSITISVWNH KKIHKKQGAG FLGCVRLLSN AISRLKDTGY QRLDLCKLNP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTTGCAACA ACGGAACAAA CCAGCAAAGT CCATTTCCAA TCACAGATAA AGAACATGAT 60
GCTCATATTT AATATTTGGG TTTCTTACAA GAATTAAGAT CAGTAGTATT GTAAGGGTAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005739--C:mitochondrion
GO:0005886--C:plasma membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0030509--P:BMP signaling pathway
GO:0061736--P:engulfment of target by autophagosome
GO:0030279--P:negative regulation of ossification
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1903861--P:positive regulation of dendrite extension
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006611--P:protein export from nucleus
GO:0034394--P:protein localization to cell surface
GO:0000209--P:protein polyubiquitination
GO:0071211--P:protein targeting to vacuole involved in autophagy
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0061753--P:substrate localization to autophagosome
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001459	Ailuropoda melanoleuca	91.70	0.00e+00	1390.00
IUUC-Apl-004155	Anas platyrhynchos	92.49	0.00e+00	1432.00
IUUC-Aca-005238	Anolis carolinensis	92.82	0.00e+00	1409.00
IUUC-Ame-010901	Astyanax mexicanus	87.69	0.00e+00	1319.00
IUUC-Bta-013221	Bos taurus	89.76	0.00e+00	1325.00
IUUC-Cja-018985	Callithrix jacchus	89.95	0.00e+00	1391.00
IUUC-Cfa-020568	Canis familiaris	89.43	0.00e+00	1379.00
IUUC-Cpo-022531	Cavia porcellus	89.43	0.00e+00	1382.00
IUUC-Csa-024145	Chlorocebus sabaeus	93.22	0.00e+00	1410.00
IUUC-Cho-024963	Choloepus hoffmanni	72.43	0.00e+00	881.00
IUUC-Cin-025126	Ciona intestinalis	64.00	0.00e+00	911.00
IUUC-Csv-026339	Ciona savignyi	63.83	0.00e+00	933.00
IUUC-Dre-028341	Danio rerio	87.57	0.00e+00	1326.00
IUUC-Dno-029705	Dasypus novemcinctus	88.45	0.00e+00	1378.00
IUUC-Ete-032715	Echinops telfairi	72.53	0.00e+00	1068.00
IUUC-Eca-034125	Equus caballus	89.79	0.00e+00	1385.00
IUUC-Eeu-034945	Erinaceus europaeus	74.36	0.00e+00	1050.00
IUUC-Fca-035905	Felis catus	92.30	0.00e+00	1390.00
IUUC-Fal-037336	Ficedula albicollis	94.85	0.00e+00	1430.00
IUUC-Gmo-039486	Gadus morhua	80.53	0.00e+00	859.00
IUUC-Gga-040218	Gallus gallus	93.99	0.00e+00	1432.00
IUUC-Gac-041707	Gasterosteus aculeatus	81.59	0.00e+00	1220.00
IUUC-Ggo-045408	Gorilla gorilla	84.16	0.00e+00	1278.00
IUUC-Hsa-045878	Homo sapiens	89.82	0.00e+00	1391.00
IUUC-Itr-048317	Ictidomys tridecemlineatus	90.04	0.00e+00	1387.00
IUUC-Lch-050026	Latimeria chalumnae	74.61	0.00e+00	1147.00
IUUC-Loc-052628	Lepisosteus oculatus	84.90	0.00e+00	1318.00
IUUC-Laf-053644	Loxodonta africana	91.54	0.00e+00	1376.00
IUUC-Mcc-055479	Macaca mulatta	84.73	0.00e+00	1244.00
IUUC-Meu-056436	Macropus eugenii	58.61	0.00e+00	838.00
IUUC-Mmr-060806	Microcebus murinus	76.82	0.00e+00	1151.00
IUUC-Mdo-063005	Monodelphis domestica	93.91	0.00e+00	1416.00
IUUC-Mmu-063634	Mus musculus	92.30	0.00e+00	1382.00
IUUC-Mpu-065898	Mustela putorius furo	91.95	0.00e+00	1393.00
IUUC-Mlu-067584	Myotis lucifugus	89.66	0.00e+00	1383.00
IUUC-Nle-069033	Nomascus leucogenys	89.92	0.00e+00	1387.00
IUUC-Opr-070591	Ochotona princeps	71.97	0.00e+00	1061.00
IUUC-Ont-072265	Oreochromis niloticus	79.82	0.00e+00	1234.00
IUUC-Oan-073621	Ornithorhynchus anatinus	92.55	0.00e+00	1419.00
IUUC-Ocu-073960	Oryctolagus cuniculus	88.77	0.00e+00	1366.00
IUUC-Ola-086597	Oryzias latipes	72.68	0.00e+00	1117.00
IUUC-Oga-088579	Otolemur garnettii	89.82	0.00e+00	1389.00
IUUC-Oar-090396	Ovis aries	87.21	0.00e+00	1291.00
IUUC-Ptr-091624	Pan troglodytes	89.82	0.00e+00	1391.00
IUUC-Pan-092479	Papio anubis	89.79	0.00e+00	1386.00
IUUC-Psi-093298	Pelodiscus sinensis	76.35	0.00e+00	1155.00
IUUC-Pma-094354	Petromyzon marinus	66.09	0.00e+00	984.00
IUUC-Pfo-097203	Poecilia formosa	82.08	0.00e+00	1246.00
IUUC-Pab-097540	Pongo abelii	89.22	0.00e+00	1320.00
IUUC-Pca-100379	Procavia capensis	71.61	6.00e-179	620.00
IUUC-Pva-102754	Pteropus vampyrus	75.64	0.00e+00	1115.00
IUUC-Rno-105396	Rattus norvegicus	92.30	0.00e+00	1384.00
IUUC-Sha-107216	Sarcophilus harrisii	90.61	0.00e+00	1404.00
IUUC-Sar-113122	Sorex araneus	66.71	0.00e+00	948.00
IUUC-Ssc-116413	Sus scrofa	91.03	0.00e+00	1350.00
IUUC-Tgu-116723	Taeniopygia guttata	91.36	0.00e+00	1404.00
IUUC-Tru-117843	Takifugu rubripes	81.92	0.00e+00	1240.00
IUUC-Tsy-119455	Tarsius syrichta	88.62	0.00e+00	1300.00
IUUC-Tni-120829	Tetraodon nigroviridis	79.79	0.00e+00	1194.00
IUUC-Tbe-127879	Tupaia belangeri	76.59	0.00e+00	1123.00
IUUC-Ttr-128423	Tursiops truncatus	88.73	0.00e+00	1323.00
IUUC-Vpa-130591	Vicugna pacos	69.58	0.00e+00	1023.00
IUUC-Xtr-132237	Xenopus tropicalis	84.80	0.00e+00	1321.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence