iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-117843

UUCD1 version

UUC-TaR-00210

Ensembl Protein ID

ENSTRUP00000011082.1

UniProt Accession

H2SFA1; H2SFA1_TAKRU

Protein Name

Uncharacterized protein

Gene Name

smurf1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000004668.1	ENSTRUT00000011142.1	ENSTRUP00000011082.1
ENSTRUG00000004668.1	ENSTRUT00000011143.1	ENSTRUP00000011083.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.60e-126	423.5	419	751

Active Site

Position(s)	Description	Evidence
720	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkkrl+v+f+gEegld+gGv+re+l+ll++e+ np++glf+ys ++ +tlq+npds + np+hl++F+f+Gr++g+a++++++++ 
   Q: 419  PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYTLQINPDSSI-NPDHLSYFHFVGRVMGLAVFHSHYING 506
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++++fyk+llgk+++l+dle++dpel+ksl +i+en   di+   ld tf+v+++ +g+ +++eLkp+G+ni Vt+eNk+eYv+l+v+
   Q: 507  SFTQPFYKQLLGKPIQLSDLETTDPELHKSLVWILEN---DITSV-LDHTFCVEHNAFGKLSQHELKPNGRNIAVTEENKKEYVRLYVN 591
           ***********************************99...99998.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gf+e+ip++ll+ F+++elel+i G  +id+ d+k +t+ k+ +t++s++++wFw+++e+f++e r ++LqFv
   Q: 592  WRFMRGIEAQFLALQKGFTELIPQHLLKPFDHKELELIIGGLGKIDIADWKTNTRLKH-CTSESNVVRWFWQAVEAFNEERRGRLLQFV 679
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgs r+Pl+Gf++l+    prlf+i+  da++d+lP+++TCfn++++P+Y+s+e+l+ekLl+A+eet gF +
   Q: 680  TGSTRVPLQGFKALQgsagPRLFTIHLiDANTDNLPKAHTCFNRIDVPPYESYEKLYEKLLTAVEETCGFAV 751
           ***************************99999**************************************76 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MSNPGSRRNG SSIKIRLTVL CAKNLAKKDF FRLPDPFAKV VVDGSGQCHS TDTVKSTLDP 60
KWNQHYDLYI GKTDSITISI WNHKKIHKRQ GAGFLGCIRL LSNAISRLKD TGYQRLDLCK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCGAATC CTGGGAGTCG GAGGAACGGG TCCAGCATCA AAATCCGCCT GACAGGTAAA 60
AACCACAGCG AAATTAAACA AAAGCCCAGT GTGTGTGTTT TAGTCGCATC CCAGATAAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001459	Ailuropoda melanoleuca	81.25	0.00e+00	1240.00
IUUC-Apl-004155	Anas platyrhynchos	79.66	0.00e+00	1242.00
IUUC-Aca-005238	Anolis carolinensis	82.30	0.00e+00	1261.00
IUUC-Ame-010901	Astyanax mexicanus	86.28	0.00e+00	1329.00
IUUC-Bta-013221	Bos taurus	79.67	0.00e+00	1203.00
IUUC-Cja-018985	Callithrix jacchus	80.25	0.00e+00	1271.00
IUUC-Cfa-020568	Canis familiaris	78.26	0.00e+00	1222.00
IUUC-Cpo-022531	Cavia porcellus	80.00	0.00e+00	1267.00
IUUC-Csa-024145	Chlorocebus sabaeus	83.07	0.00e+00	1289.00
IUUC-Cho-024963	Choloepus hoffmanni	64.81	0.00e+00	774.00
IUUC-Dre-028341	Danio rerio	86.54	0.00e+00	1332.00
IUUC-Dno-029705	Dasypus novemcinctus	78.18	0.00e+00	1206.00
IUUC-Eca-034125	Equus caballus	79.40	0.00e+00	1231.00
IUUC-Fca-035905	Felis catus	81.25	0.00e+00	1229.00
IUUC-Fal-037336	Ficedula albicollis	82.54	0.00e+00	1238.00
IUUC-Gmo-039486	Gadus morhua	86.15	0.00e+00	905.00
IUUC-Gga-040218	Gallus gallus	82.03	0.00e+00	1279.00
IUUC-Gac-041707	Gasterosteus aculeatus	91.30	0.00e+00	1367.00
IUUC-Ggo-045408	Gorilla gorilla	75.36	0.00e+00	1140.00
IUUC-Hsa-045878	Homo sapiens	80.25	0.00e+00	1271.00
IUUC-Itr-048317	Ictidomys tridecemlineatus	79.90	0.00e+00	1234.00
IUUC-Loc-052628	Lepisosteus oculatus	82.58	0.00e+00	1313.00
IUUC-Laf-053644	Loxodonta africana	81.23	0.00e+00	1216.00
IUUC-Mga-059723	Meleagris gallopavo	81.92	0.00e+00	1240.00
IUUC-Mdo-063005	Monodelphis domestica	82.72	0.00e+00	1281.00
IUUC-Mmu-063634	Mus musculus	82.61	0.00e+00	1263.00
IUUC-Mpu-065898	Mustela putorius furo	81.64	0.00e+00	1235.00
IUUC-Mlu-067584	Myotis lucifugus	79.07	0.00e+00	1231.00
IUUC-Nle-069033	Nomascus leucogenys	79.92	0.00e+00	1236.00
IUUC-Ont-072265	Oreochromis niloticus	87.93	0.00e+00	1379.00
IUUC-Oan-073621	Ornithorhynchus anatinus	80.76	0.00e+00	1272.00
IUUC-Ocu-073960	Oryctolagus cuniculus	78.80	0.00e+00	1204.00
IUUC-Ola-086960	Oryzias latipes	81.32	0.00e+00	1207.00
IUUC-Oga-088579	Otolemur garnettii	80.25	0.00e+00	1272.00
IUUC-Oar-090396	Ovis aries	78.99	0.00e+00	1184.00
IUUC-Ptr-091624	Pan troglodytes	80.25	0.00e+00	1271.00
IUUC-Pan-092479	Papio anubis	79.79	0.00e+00	1236.00
IUUC-Pfo-097203	Poecilia formosa	91.41	0.00e+00	1393.00
IUUC-Pab-097540	Pongo abelii	79.65	0.00e+00	1202.00
IUUC-Rno-105396	Rattus norvegicus	82.61	0.00e+00	1263.00
IUUC-Sha-107216	Sarcophilus harrisii	79.20	0.00e+00	1244.00
IUUC-Ssc-116413	Sus scrofa	80.85	0.00e+00	1221.00
IUUC-Tgu-116723	Taeniopygia guttata	79.66	0.00e+00	1216.00
IUUC-Tsy-119455	Tarsius syrichta	79.16	0.00e+00	1148.00
IUUC-Tni-120037	Tetraodon nigroviridis	88.92	0.00e+00	1321.00
IUUC-Tbe-127879	Tupaia belangeri	66.97	0.00e+00	976.00
IUUC-Ttr-128423	Tursiops truncatus	78.98	0.00e+00	1165.00
IUUC-Xtr-132237	Xenopus tropicalis	78.39	0.00e+00	1236.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence