iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Mmu-063370

UUCD1 version

UUC-MuM-00985

Ensembl Protein ID

ENSMUSP00000099038.3

UniProt Accession

Q9JIY2; Q3TMC0; Q8C7W5; Q8VCL9; HAKAI_MOUSE

Genbank Protein ID

AAF89617.1; BAC33568.1; BAE38522.1; AAH19529.1

Protein Name

E3 ubiquitin-protein ligase Hakai; Casitas B-lineage lymphoma-transforming sequence-like protein 1; E-cadherin binding protein E7; RING-type E3 ubiquitin transferase Hakai; c-Cbl-like protein 1

Genbank Nucleotide ID

AF167441; AK049141; AK166017; BC019529

Gene Name

Cbll1; Hakai

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000020659.15	ENSMUST00000101499.9	ENSMUSP00000099038.3
ENSMUSG00000020659.15	ENSMUST00000185739.6	ENSMUSP00000141007.1
ENSMUSG00000020659.15	ENSMUST00000188326.1	ENSMUSP00000139809.1
ENSMUSG00000020659.15	ENSMUST00000064240.12	ENSMUSP00000063266.6
ENSMUSG00000020659.15	ENSMUST00000085487.11	ENSMUSP00000082616.5

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	97.35	0.00e+00	636.00	IUUC-Hsa-046501

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

Promotes ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1. Targets CDH1 for endocytosis and degradation.

Protein Sequence
(Fasta)

MDHTDNELQG TNSSGSLGGL DVRRRIPIKL ISKQASKVKP APRTQRTVSR MPAKAPQGDE 60
EGFDYNEEQR YDCKGGELFG NQRRFPGHLF WDFKINILGE KDDTPVHFCD KCGLPIKVYG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCCGGAAGG TAGGGCGCAG GCGCTTACTG CGACTCCGGA GCGACTGACT TCCGTTCCCA 60
CTGTGCCCCG CGAGCCGAAT CATGGATCAC ACTGGTAAGG AGGCGGAGGC AGCGGGGGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Gene Ontology

GO:0016607--C:nuclear speck
GO:0042802--F:identical protein binding
GO:0003676--F:nucleic acid binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007162--P:negative regulation of cell adhesion
GO:0030335--P:positive regulation of cell migration
GO:0045807--P:positive regulation of endocytosis
GO:0016337--P:single organismal cell-cell adhesion

KEGG

mmu:104836

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001549	Ailuropoda melanoleuca	93.45	1.00e-175	609.00
IUUC-Apl-003352	Anas platyrhynchos	86.73	9.00e-158	550.00
IUUC-Aca-005084	Anolis carolinensis	79.34	9.00e-143	500.00
IUUC-Bta-013383	Bos taurus	96.54	9.00e-180	623.00
IUUC-Bol-015734	Brassica oleracea	36.17	7.00e-13	69.30
IUUC-Cja-019505	Callithrix jacchus	97.76	0.00e+00	637.00
IUUC-Cfa-020255	Canis familiaris	96.95	0.00e+00	629.00
IUUC-Cpo-022545	Cavia porcellus	91.16	1.00e-143	501.00
IUUC-Cre-022922	Chlamydomonas reinhardtii	41.18	5.00e-06	45.80
IUUC-Csa-023318	Chlorocebus sabaeus	97.56	0.00e+00	634.00
IUUC-Cho-024701	Choloepus hoffmanni	91.10	3.00e-79	288.00
IUUC-Dre-028785	Danio rerio	55.47	3.00e-103	368.00
IUUC-Dor-030317	Dipodomys ordii	97.56	2.00e-175	608.00
IUUC-Eca-033554	Equus caballus	96.54	2.00e-180	625.00
IUUC-Fca-035864	Felis catus	96.30	1.00e-175	609.00
IUUC-Fal-037144	Ficedula albicollis	86.07	6.00e-154	537.00
IUUC-Gmo-039139	Gadus morhua	70.98	4.00e-80	291.00
IUUC-Gga-040912	Gallus gallus	86.00	4.00e-161	561.00
IUUC-Ggo-044818	Gorilla gorilla	97.35	0.00e+00	632.00
IUUC-Hsa-046501	Homo sapiens	97.35	0.00e+00	632.00
IUUC-Itr-048234	Ictidomys tridecemlineatus	98.37	0.00e+00	635.00
IUUC-Lch-049697	Latimeria chalumnae	83.13	6.00e-130	457.00
IUUC-Lpe-051438	Leersia perrieri	23.13	5.00e-04	40.80
IUUC-Loc-052013	Lepisosteus oculatus	68.90	2.00e-125	442.00
IUUC-Laf-054485	Loxodonta africana	95.43	2.00e-168	585.00
IUUC-Mcc-054964	Macaca mulatta	53.09	4.00e-85	308.00
IUUC-Meu-056453	Macropus eugenii	59.22	3.00e-95	341.00
IUUC-Mga-060082	Meleagris gallopavo	85.62	1.00e-155	543.00
IUUC-Mmr-061363	Microcebus murinus	97.35	0.00e+00	630.00
IUUC-Mdo-062085	Monodelphis domestica	93.89	8.00e-175	606.00
IUUC-Mpu-066221	Mustela putorius furo	96.33	1.00e-179	622.00
IUUC-Mlu-067612	Myotis lucifugus	96.34	1.00e-179	622.00
IUUC-Nle-069315	Nomascus leucogenys	96.72	5.00e-161	560.00
IUUC-Opr-070202	Ochotona princeps	93.52	2.00e-152	531.00
IUUC-Ont-071478	Oreochromis niloticus	60.20	3.00e-102	365.00
IUUC-Oan-073158	Ornithorhynchus anatinus	83.54	3.00e-141	495.00
IUUC-Ocu-074385	Oryctolagus cuniculus	95.98	3.00e-160	558.00
IUUC-Oin-079075	Oryza indica	34.04	1.00e-11	65.10
IUUC-Oni-083087	Oryza nivara	34.04	1.00e-11	65.10
IUUC-Opu-083232	Oryza punctata	34.04	5.00e-12	65.90
IUUC-Osa-085908	Oryza sativa	34.04	1.00e-11	64.70
IUUC-Oar-089223	Ovis aries	96.12	5.00e-177	613.00
IUUC-Ptr-091633	Pan troglodytes	97.35	0.00e+00	632.00
IUUC-Pan-092923	Papio anubis	96.75	6.00e-179	620.00
IUUC-Ppa-095417	Physcomitrella patens	37.62	9.00e-14	71.60
IUUC-Pfo-097005	Poecilia formosa	58.04	2.00e-90	326.00
IUUC-Pab-098077	Pongo abelii	97.25	2.00e-170	591.00
IUUC-Pgr-103634	Puccinia graminis	21.76	7.00e-06	43.90
IUUC-Rno-105254	Rattus norvegicus	99.39	0.00e+00	648.00
IUUC-Sha-106599	Sarcophilus harrisii	93.48	1.00e-174	605.00
IUUC-Sar-113753	Sorex araneus	94.70	4.00e-146	511.00
IUUC-Sbi-114064	Sorghum bicolor	23.29	1.00e-03	39.30
IUUC-Ssc-116446	Sus scrofa	94.08	0.00e+00	651.00
IUUC-Tgu-117363	Taeniopygia guttata	85.87	1.00e-155	542.00
IUUC-Tru-118121	Takifugu rubripes	63.06	8.00e-114	404.00
IUUC-Tsy-119618	Tarsius syrichta	95.75	3.00e-122	432.00
IUUC-Tni-119858	Tetraodon nigroviridis	61.35	5.00e-103	368.00
IUUC-Ttr-129190	Tursiops truncatus	96.54	2.00e-180	625.00
IUUC-Vpa-130418	Vicugna pacos	47.74	4.00e-14	72.40
IUUC-Vvi-131653	Vitis vinifera	30.33	7.00e-15	75.50

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence