iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-052116

Ensembl Protein ID

ENSLOCP00000012670.1

UniProt Accession

W5MWB1; W5MWB1_LEPOC

Genbank Protein ID

ENSLOCP00000012670

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AHAT01017486

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000010335.1	ENSLOCT00000012694.1	ENSLOCP00000012670.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.80e-135	451.8	572	907

Active Site

Position(s)	Description	Evidence
876	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f+gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl++F f+Gr++++al++g+++d+
   Q: 572  PYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKSNYCLQINPASTI-NPDHLSYFCFIGRFIAMALFHGKFIDT 659
           6799*******************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+kkl+++dle++dpe+y+sl +i+++++++iee+gl++ fsv+ eilg++++++Lk gG n  Vt+eNkeeY+ l++e
   Q: 660  GFSLPFYKRMLNKKLTIKDLESIDPEFYNSLIWISHKRDNNIEECGLEMYFSVDMEILGKVTSHDLKAGGTNLLVTEENKEEYIGLMAE 748
           ***************************************************************************************** PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +g++eq++af +Gfnev+pl++l++F+e+ele+++cG++e+d++d++++t y++ yt++s++i+wFw++++e+++e r +++qFv
   Q: 749  WRFSRGVEEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLQDWQRNTVYRH-YTRNSKQIIWFWQFVKEVDNEVRLRLMQFV 836
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlPlgGfael+    p++f+i+k ++d++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 837  TGTCRLPLGGFAELMgsngPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 907
           *********************************************************************96 PP

Organism

Lepisosteus oculatus

Protein Sequence
(Fasta)

MATASTRSDS SNRHNGRSQL HTTVSSAKLK RKKNWFGTAI YVEVATDGEA KKTAKSNSSS 60
NPKWDERLTL NVTPHTKLDF KVWSHHTLKA DVLLGKATLD INQVLELHER KLENVREVLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGGGCTTCA TCTACTCACG CCTGGGTATC GCAGCAACAG GGTAACTGTG CGTGGTGACG 60
TCGCCAGGCG GGAGCTGTGC GTGTCCTGCG TGTGCGCGCA CGCTGCGGGT AGAGCAGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001213	Ailuropoda melanoleuca	75.97	0.00e+00	1392.00
IUUC-Apl-003310	Anas platyrhynchos	77.20	0.00e+00	1433.00
IUUC-Aca-005388	Anolis carolinensis	74.97	0.00e+00	1355.00
IUUC-Bta-012857	Bos taurus	77.35	0.00e+00	1396.00
IUUC-Cel-018299	Caenorhabditis elegans	67.41	0.00e+00	839.00
IUUC-Cja-019448	Callithrix jacchus	76.85	0.00e+00	1422.00
IUUC-Cfa-020728	Canis familiaris	76.62	0.00e+00	1396.00
IUUC-Cpo-021635	Cavia porcellus	74.28	0.00e+00	1387.00
IUUC-Csa-023805	Chlorocebus sabaeus	88.89	0.00e+00	1142.00
IUUC-Cin-025212	Ciona intestinalis	73.54	0.00e+00	914.00
IUUC-Csv-026256	Ciona savignyi	72.81	0.00e+00	907.00
IUUC-Dre-028245	Danio rerio	77.32	0.00e+00	1278.00
IUUC-Dno-029618	Dasypus novemcinctus	75.85	0.00e+00	1400.00
IUUC-Dme-032041	Drosophila melanogaster	70.16	0.00e+00	905.00
IUUC-Ete-032779	Echinops telfairi	90.37	0.00e+00	1068.00
IUUC-Eca-033313	Equus caballus	76.91	0.00e+00	1393.00
IUUC-Eeu-035259	Erinaceus europaeus	70.04	0.00e+00	1229.00
IUUC-Fca-035420	Felis catus	76.15	0.00e+00	1399.00
IUUC-Fal-037335	Ficedula albicollis	76.75	0.00e+00	1430.00
IUUC-Gmo-039172	Gadus morhua	89.47	0.00e+00	1078.00
IUUC-Gga-040246	Gallus gallus	77.13	0.00e+00	1427.00
IUUC-Gac-042211	Gasterosteus aculeatus	95.58	0.00e+00	1200.00
IUUC-Ggo-045001	Gorilla gorilla	76.37	0.00e+00	1238.00
IUUC-Hsa-046544	Homo sapiens	76.50	0.00e+00	1411.00
IUUC-Itr-048860	Ictidomys tridecemlineatus	76.95	0.00e+00	1380.00
IUUC-Lch-050398	Latimeria chalumnae	79.46	0.00e+00	1437.00
IUUC-Laf-053551	Loxodonta africana	75.86	0.00e+00	1387.00
IUUC-Mga-059986	Meleagris gallopavo	76.91	0.00e+00	1431.00
IUUC-Mmr-060945	Microcebus murinus	72.86	0.00e+00	1347.00
IUUC-Mdo-063024	Monodelphis domestica	74.23	0.00e+00	1332.00
IUUC-Mmu-063202	Mus musculus	76.71	0.00e+00	1362.00
IUUC-Mpu-065773	Mustela putorius furo	76.05	0.00e+00	1386.00
IUUC-Nle-069188	Nomascus leucogenys	76.49	0.00e+00	1418.00
IUUC-Opr-070965	Ochotona princeps	75.22	0.00e+00	1353.00
IUUC-Ont-072226	Oreochromis niloticus	95.60	0.00e+00	1214.00
IUUC-Oan-073497	Ornithorhynchus anatinus	78.36	0.00e+00	1424.00
IUUC-Ocu-073891	Oryctolagus cuniculus	73.49	0.00e+00	1301.00
IUUC-Ola-087438	Oryzias latipes	94.01	0.00e+00	1211.00
IUUC-Oga-087922	Otolemur garnettii	76.41	0.00e+00	1400.00
IUUC-Oar-089429	Ovis aries	75.91	0.00e+00	1321.00
IUUC-Ptr-090484	Pan troglodytes	76.50	0.00e+00	1410.00
IUUC-Pan-092117	Papio anubis	75.96	0.00e+00	1409.00
IUUC-Psi-093338	Pelodiscus sinensis	78.55	0.00e+00	1452.00
IUUC-Pma-094279	Petromyzon marinus	72.23	0.00e+00	832.00
IUUC-Pfo-096171	Poecilia formosa	96.11	0.00e+00	1217.00
IUUC-Pab-098654	Pongo abelii	85.60	0.00e+00	1106.00
IUUC-Pva-102811	Pteropus vampyrus	70.26	0.00e+00	1239.00
IUUC-Rno-106125	Rattus norvegicus	76.78	0.00e+00	1382.00
IUUC-Sha-107243	Sarcophilus harrisii	76.28	0.00e+00	1409.00
IUUC-Sre-114929	Sporisorium reilianum	45.35	3.00e-150	525.00
IUUC-Ssc-115368	Sus scrofa	76.64	0.00e+00	1383.00
IUUC-Tgu-117079	Taeniopygia guttata	76.96	0.00e+00	1427.00
IUUC-Tru-118062	Takifugu rubripes	77.08	0.00e+00	1429.00
IUUC-Tsy-119507	Tarsius syrichta	71.69	0.00e+00	1287.00
IUUC-Tni-120151	Tetraodon nigroviridis	95.60	0.00e+00	1201.00
IUUC-Xtr-132877	Xenopus tropicalis	67.94	0.00e+00	1187.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence