iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-074630

UUCD1 version

UUC-OrC-01021

Ensembl Protein ID

ENSOCUP00000000588.2

UniProt Accession

G1SDU0; G1SDU0_RABIT

Protein Name

Ubiquitinyl hydrolase 1

Gene Name

USP20

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000000679.2	ENSOCUT00000000678.2	ENSOCUP00000000588.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.90e-111	371.9	145	685

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           tG+kNlgN+CYmN++LQ+Lsn+p+l++++le     +    ++++k +l+ks+qkl++e+w  ++ ++v p++l + +k ++++f+gy+
   Q: 145  TGMKNLGNSCYMNAALQALSNCPPLTQFFLE-----CGGLVRTDKKPALCKSYQKLVSEVWhRKRPSYVVPTSLSHGIKLVNPMFRGYA 228
           7******************************.....999999*******************889999********************** PP
   S: 89   qqDaqEflaflldqleeelkk..............eknkpkeeeeeedkselsde.................................. 129
           qqD+qEfl++l+dql+eelk+              ++++++ee++e d+s ++de                                  
   Q: 229  QQDTQEFLRCLMDQLHEELKEpavaavaalteardSDSSDTEEKREGDRSPSEDEflscdsssdrgegdgqgrggggsqaetellipde 317
           *******************998887777777766666666666666666666666********************************** PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 318  agraisekermkdrkfswgqqrtnseqvdedadvdtamatldeqptetqppsprsaspcrtpepdndahmrsssrpcspthrhgghgkl 406
           ***************************************************************************************** PP
   S: 130  ...........................aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke...... 185
                                      ++++k+++++s+isd+F+g++ s ++cl+cd+vs++ e+f+dlslp+pgke+ +k+      
   Q: 407  pssppraspvrvgpsyvlkkaqvpsagSRRRKEQHYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLAKLhsaiyq 495
           ***************************99*************************************************99888****** PP
   S: 186  ...........................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLi 231
                                                      +l+dcL++f++++el+g+n+y+ce+ckk+++ +k +k+ +lPevL+
   Q: 496  nvpakpgacgdsyaaqgwlafiveyirrfvvsctpswfwgpvvTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEVLC 584
           ***************************************************************************************** PP
   S: 232  lhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevk 318
           +hLkRf  ++e + + ki+++v+fple Ldl+pf+++++++q   ++Y+L++v++H+G+++sGHY+ay++n  +g+W++fdD++Vtev+
   Q: 585  IHLKRF--RHEVMYSFKISSHVSFPLEgLDLRPFLAKECTSQ--ITTYDLLSVICHHGTAGSGHYIAYCQNvINGQWYEFDDQYVTEVH 669
           ******..9999***************************999..9**************************78999************* PP
   S: 319  eeevleetgstaYvlfYkr 337
           e+ v++   ++aYvlfY++
   Q: 670  ETVVQN---AEAYVLFYRK 685
           ******...********98 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MGDSRELCPH LDSIGEVTKE DLLLKSKGTC QSCGVTGPNL WACLQVACPY VGCGESFADH 60
STIHAQAKKH NLTVNLTTLR VWCYACEKEV FLDQRLAAPP RGSSPTFSEQ DSPPPSHPLR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGGGACT CCAGGGAACT CTGCCCTCAC CTGGACTCCA TAGGGGAGGT GACCAAAGAG 60
GACCTGCTGC TCAAGTCTAA GGTAACGGAT CAGGCCTGTG GGCCCGGGGC ATGGCCTCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP

SMART

SM00695--DUSP
SM00290--ZnF_UBP

Gene Ontology

GO:0005813--C:centrosome
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0008277--P:regulation of G-protein coupled receptor protein signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002209	Ailuropoda melanoleuca	89.29	0.00e+00	1588.00
IUUC-Apl-003351	Anas platyrhynchos	82.63	0.00e+00	1500.00
IUUC-Aca-005077	Anolis carolinensis	73.12	0.00e+00	1047.00
IUUC-Ame-011777	Astyanax mexicanus	72.55	0.00e+00	1272.00
IUUC-Bta-013063	Bos taurus	90.17	0.00e+00	1583.00
IUUC-Cja-019868	Callithrix jacchus	90.39	0.00e+00	1650.00
IUUC-Cfa-020761	Canis familiaris	89.73	0.00e+00	1603.00
IUUC-Cpo-022267	Cavia porcellus	83.33	0.00e+00	1478.00
IUUC-Csa-024251	Chlorocebus sabaeus	90.93	0.00e+00	1655.00
IUUC-Cho-024483	Choloepus hoffmanni	92.92	1.00e-118	420.00
IUUC-Dre-028061	Danio rerio	73.10	0.00e+00	1189.00
IUUC-Dno-029423	Dasypus novemcinctus	90.72	0.00e+00	1615.00
IUUC-Dor-030877	Dipodomys ordii	88.02	0.00e+00	1037.00
IUUC-Dme-031837	Drosophila melanogaster	48.15	4.00e-130	459.00
IUUC-Ete-032802	Echinops telfairi	78.92	2.00e-134	473.00
IUUC-Eca-034283	Equus caballus	89.29	0.00e+00	1591.00
IUUC-Eeu-034620	Erinaceus europaeus	90.35	0.00e+00	1184.00
IUUC-Fca-036357	Felis catus	90.60	0.00e+00	1591.00
IUUC-Fal-037411	Ficedula albicollis	83.04	0.00e+00	1499.00
IUUC-Gga-041101	Gallus gallus	82.97	0.00e+00	1484.00
IUUC-Gac-041315	Gasterosteus aculeatus	69.95	0.00e+00	1257.00
IUUC-Ggo-045600	Gorilla gorilla	90.57	0.00e+00	1601.00
IUUC-Hsa-045825	Homo sapiens	91.29	0.00e+00	1617.00
IUUC-Itr-048549	Ictidomys tridecemlineatus	77.35	0.00e+00	1305.00
IUUC-Lch-050002	Latimeria chalumnae	73.60	0.00e+00	1261.00
IUUC-Loc-052574	Lepisosteus oculatus	74.92	0.00e+00	1341.00
IUUC-Laf-054428	Loxodonta africana	89.75	0.00e+00	1596.00
IUUC-Mcc-055736	Macaca mulatta	90.71	0.00e+00	1650.00
IUUC-Mga-059781	Meleagris gallopavo	82.56	0.00e+00	1487.00
IUUC-Mdo-063048	Monodelphis domestica	83.57	0.00e+00	1452.00
IUUC-Mmu-064079	Mus musculus	88.21	0.00e+00	1572.00
IUUC-Mpu-066616	Mustela putorius furo	88.00	0.00e+00	1635.00
IUUC-Mlu-067294	Myotis lucifugus	87.88	0.00e+00	1526.00
IUUC-Nle-070015	Nomascus leucogenys	90.74	0.00e+00	1578.00
IUUC-Opr-070328	Ochotona princeps	89.64	0.00e+00	1608.00
IUUC-Ont-071464	Oreochromis niloticus	70.98	0.00e+00	1249.00
IUUC-Oan-073259	Ornithorhynchus anatinus	75.48	0.00e+00	1229.00
IUUC-Ola-087240	Oryzias latipes	71.91	0.00e+00	1250.00
IUUC-Oga-088761	Otolemur garnettii	89.51	0.00e+00	1627.00
IUUC-Oar-089490	Ovis aries	85.54	0.00e+00	1425.00
IUUC-Ptr-091662	Pan troglodytes	91.29	0.00e+00	1615.00
IUUC-Pan-092199	Papio anubis	90.54	0.00e+00	1647.00
IUUC-Psi-093726	Pelodiscus sinensis	83.55	0.00e+00	1494.00
IUUC-Pma-094389	Petromyzon marinus	63.58	2.00e-101	361.00
IUUC-Pab-098632	Pongo abelii	90.96	0.00e+00	1603.00
IUUC-Pca-100614	Procavia capensis	81.91	0.00e+00	1220.00
IUUC-Pva-102922	Pteropus vampyrus	90.88	0.00e+00	972.00
IUUC-Rno-105215	Rattus norvegicus	88.09	0.00e+00	1575.00
IUUC-Sce-106176	Saccharomyces cerevisiae	32.97	5.00e-26	112.00
IUUC-Sha-106601	Sarcophilus harrisii	82.94	0.00e+00	1440.00
IUUC-Ssc-115533	Sus scrofa	88.34	0.00e+00	1558.00
IUUC-Tgu-117364	Taeniopygia guttata	83.10	0.00e+00	1473.00
IUUC-Tru-117770	Takifugu rubripes	69.30	0.00e+00	1238.00
IUUC-Tni-120001	Tetraodon nigroviridis	70.20	0.00e+00	1209.00
IUUC-Ttr-128732	Tursiops truncatus	90.82	0.00e+00	1603.00
IUUC-Xtr-132157	Xenopus tropicalis	73.69	0.00e+00	1293.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence