iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Itr-048281

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AGTP01110313

Gene Name

USP51

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000016321.2	ENSSTOT00000016322.2	ENSSTOP00000014613.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.20e-90	304.1	285	628

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqq 90
           Gl NlgNtC+mN+++Q+L++ip l++++l+ +k+k+  +   +p+ +l++++ +lf+++++++++   p +ll+ ++  ae++ gy+qq
   Q: 285  GLINLGNTCFMNCIVQALTHIPLLKDFFLS-DKHKCIMT---SPSLCLVCEMSSLFHAMYSGSRTPHIPYKLLHLIWIHAEHLAGYRQQ 369
           9*****************************.99999875...78********************************************* PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk 179
           Da+Efl  +ld l+++ k                  s e+e ++++  +++i+++F g l+s+++c++c++vs++ +p +d+sl++pg+
   Q: 370  DAHEFLIAILDVLHRHSKD----------------DSVEQEASNPNCCNCIIDQIFTGGLQSDVTCQTCHSVSTTIDPCWDISLDLPGS 442
           *****************22................344566899*******************************************99 PP
   S: 180  eetkke....................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrek 248
             t  +                    sl+dcL+ ft++e+l ++ k++c++c+++qe++k+l++kklP v ++hLkRf  ++ +k+r+k
   Q: 443  CATFSSqsperadstvsrddripgipSLTDCLQWFTRPEHLGSSAKIKCSSCQSYQESTKQLTMKKLPIVACFHLKRF--EHVGKQRRK 529
           9876669999********************************************************************..88889**** PP
   S: 249  inkkvefpleLdlspfctspeekqke............kkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevlee 325
           in+ ++fpleLd++pf++s++e+  +            ++kY+L+av++H+G+l+sGHY+++++++k++W+ +dD  +t+ + e+ l  
   Q: 530  INTFISFPLELDMTPFLASTKESRMKegqpsstdcvpnENKYSLFAVINHHGTLESGHYTSFIRQQKDQWFSCDDAIITKATIEDLLY- 617
           ****************9996666555788899999999**************************************************. PP
   S: 326  tgstaYvlfYkrr 338
             s++Y+lfY+++
   Q: 618  --SEGYLLFYHKQ 628
           ..********985 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

NLTWSDIGGD EKVLPSNPPC CHSSSSPVCP RRKPRPRPQP GSRSRGRHGL LAPPPPPPPL 60
PPSRPPTWRR SRRRSRPGSR PQTRRSCSGD LGGSGDQGGL GDWLLEVDFD HGPTGCSHVE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AACTTGACGT GGAGCGACAT TGGCGGCGAC GAGAAGGTGC TCCCTTCAAA CCCCCCTTGC 60
TGTCACAGCA GCTCCTCGCC CGTTTGTCCG CGCCGCAAGC CCCGCCCTCG GCCCCAGCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR033383--USP51
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0003682--F:chromatin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016578--P:histone deubiquitination
GO:2001020--P:regulation of response to DNA damage stimulus
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001480	Ailuropoda melanoleuca	92.99	0.00e+00	983.00
IUUC-Ang-009694	Aspergillus niger	30.37	8.00e-56	211.00
IUUC-Bol-016509	Brassica oleracea	38.48	8.00e-75	274.00
IUUC-Bra-016962	Brassica rapa	36.16	9.00e-73	267.00
IUUC-Csa-023824	Chlorocebus sabaeus	94.51	0.00e+00	999.00
IUUC-Cgl-026457	Colletotrichum gloeosporioides	30.06	3.00e-56	212.00
IUUC-Dse-031415	Dothistroma septosporum	29.42	1.00e-60	226.00
IUUC-Eca-033872	Equus caballus	93.01	0.00e+00	986.00
IUUC-Fca-035534	Felis catus	93.84	0.00e+00	974.00
IUUC-Ggo-045109	Gorilla gorilla	93.30	0.00e+00	966.00
IUUC-Hsa-045765	Homo sapiens	94.93	0.00e+00	1014.00
IUUC-Mcc-055420	Macaca mulatta	94.54	0.00e+00	1006.00
IUUC-Mmr-061690	Microcebus murinus	94.35	0.00e+00	1014.00
IUUC-Mmu-063435	Mus musculus	81.20	0.00e+00	833.00
IUUC-Mpu-065679	Mustela putorius furo	93.37	0.00e+00	967.00
IUUC-Mlu-067084	Myotis lucifugus	92.57	0.00e+00	972.00
IUUC-Nle-069859	Nomascus leucogenys	94.89	0.00e+00	1007.00
IUUC-Ocu-074365	Oryctolagus cuniculus	89.69	0.00e+00	964.00
IUUC-Ptr-091479	Pan troglodytes	89.25	0.00e+00	1026.00
IUUC-Pan-091707	Papio anubis	94.32	0.00e+00	996.00
IUUC-Ppa-095413	Physcomitrella patens	34.08	5.00e-83	301.00
IUUC-Pab-097894	Pongo abelii	94.92	0.00e+00	1012.00
IUUC-Ppe-101583	Prunus persica	36.59	2.00e-80	293.00
IUUC-Pgr-103657	Puccinia graminis	25.52	2.00e-39	157.00
IUUC-Rno-105644	Rattus norvegicus	82.67	0.00e+00	843.00
IUUC-Sar-113426	Sorex araneus	74.45	0.00e+00	817.00
IUUC-Sre-115195	Sporisorium reilianum	26.43	4.00e-50	192.00
IUUC-Ssc-115500	Sus scrofa	86.27	0.00e+00	984.00
IUUC-Tsy-119413	Tarsius syrichta	93.41	0.00e+00	961.00
IUUC-Tca-121154	Theobroma cacao	39.96	2.00e-91	329.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence