iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	20357004

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	8.50e-09	36.1	222	284

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf.....................kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           Ca+C  ++                     ++ ++ l+CgHvfh+ C+  w     +  k ++CP+C+
   Q: 222  CAVCGGRLddsehvhdadavvttkmvedeDEKLYKLSCGHVFHEFCIRGW----VVVGKLQTCPYCK 284
           9***8888555555555555555555444334778***************....99999*******7 PP

Organism

Caenorhabditis elegans

Protein Sequence
(Fasta)

MGQHGAIRLQ NEVQEGMPPP HELTEEEQWA EEHRKMHEKH KGHEAMHMEM MVIFMISVIV 60
GQIFLVTWKR KHFKSYQMCT LIGMLTIPVY VCFNRSWYRF LATWLVFCIF SAFIWLKASA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGCCAAC ATGGGGCAAT TAGGCTGCAG AATGAAGTTC AGGAAGGAAT GGTAAGTATT 60
TATTGATTTT AAAATAGTTT AATTAAAAGT AAAATGATTT CTATTATAAA TTTTTATTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0033017--C:sarcoplasmic reticulum membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0040039--P:inductive cell migration
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

cel:CELE_C16C10.5

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002350	Ailuropoda melanoleuca	51.90	4.00e-94	336.00
IUUC-Apl-003882	Anas platyrhynchos	45.07	2.00e-73	267.00
IUUC-Aca-004343	Anolis carolinensis	35.48	2.00e-06	42.40
IUUC-Ame-010680	Astyanax mexicanus	51.59	4.00e-92	329.00
IUUC-Bta-013045	Bos taurus	51.63	1.00e-90	324.00
IUUC-Cja-019866	Callithrix jacchus	51.58	4.00e-94	336.00
IUUC-Cfa-021176	Canis familiaris	51.42	2.00e-92	330.00
IUUC-Cpo-022268	Cavia porcellus	51.58	7.00e-93	332.00
IUUC-Cre-022649	Chlamydomonas reinhardtii	34.56	4.00e-43	166.00
IUUC-Csa-023727	Chlorocebus sabaeus	51.58	6.00e-94	335.00
IUUC-Cho-025016	Choloepus hoffmanni	51.90	3.00e-94	337.00
IUUC-Cin-025281	Ciona intestinalis	50.48	1.00e-98	351.00
IUUC-Csv-026338	Ciona savignyi	52.01	7.00e-89	318.00
IUUC-Dre-027836	Danio rerio	51.91	6.00e-87	312.00
IUUC-Dno-029737	Dasypus novemcinctus	50.94	2.00e-92	330.00
IUUC-Dor-031070	Dipodomys ordii	47.76	1.00e-80	291.00
IUUC-Dme-031867	Drosophila melanogaster	52.87	2.00e-95	340.00
IUUC-Ete-032964	Echinops telfairi	48.10	4.00e-86	310.00
IUUC-Eca-034398	Equus caballus	51.58	6.00e-94	335.00
IUUC-Eeu-035318	Erinaceus europaeus	42.46	2.00e-74	271.00
IUUC-Fca-035807	Felis catus	51.42	2.00e-92	330.00
IUUC-Fal-036721	Ficedula albicollis	50.99	1.00e-88	318.00
IUUC-Gmo-039699	Gadus morhua	51.58	6.00e-87	312.00
IUUC-Gga-040840	Gallus gallus	51.63	2.00e-89	320.00
IUUC-Gac-042639	Gasterosteus aculeatus	51.27	1.00e-85	308.00
IUUC-Ggo-045576	Gorilla gorilla	51.58	5.00e-94	336.00
IUUC-Hsa-046468	Homo sapiens	51.58	5.00e-94	336.00
IUUC-Itr-049039	Ictidomys tridecemlineatus	47.77	9.00e-96	341.00
IUUC-Lch-050207	Latimeria chalumnae	45.71	1.00e-78	285.00
IUUC-Loc-052172	Lepisosteus oculatus	50.63	1.00e-91	328.00
IUUC-Laf-053879	Loxodonta africana	51.27	1.00e-93	334.00
IUUC-Mcc-055492	Macaca mulatta	51.58	6.00e-94	335.00
IUUC-Meu-055976	Macropus eugenii	47.28	6.00e-45	172.00
IUUC-Mga-059989	Meleagris gallopavo	49.40	4.00e-91	326.00
IUUC-Mmr-060894	Microcebus murinus	51.58	6.00e-94	335.00
IUUC-Mdo-061826	Monodelphis domestica	50.95	1.00e-90	325.00
IUUC-Mmu-063717	Mus musculus	51.27	2.00e-93	334.00
IUUC-Mpu-066826	Mustela putorius furo	51.58	8.00e-94	335.00
IUUC-Mlu-068081	Myotis lucifugus	50.31	2.00e-89	320.00
IUUC-Nle-069734	Nomascus leucogenys	51.58	6.00e-94	335.00
IUUC-Opr-070379	Ochotona princeps	51.63	3.00e-90	323.00
IUUC-Ont-071855	Oreochromis niloticus	50.96	9.00e-86	308.00
IUUC-Ocu-074363	Oryctolagus cuniculus	51.58	3.00e-93	333.00
IUUC-Ola-086489	Oryzias latipes	51.90	4.00e-86	309.00
IUUC-Oga-088323	Otolemur garnettii	51.42	2.00e-92	330.00
IUUC-Oar-090243	Ovis aries	51.90	3.00e-94	337.00
IUUC-Ptr-091374	Pan troglodytes	51.58	5.00e-94	336.00
IUUC-Pan-092115	Papio anubis	51.58	6.00e-94	335.00
IUUC-Psi-093658	Pelodiscus sinensis	50.48	2.00e-84	304.00
IUUC-Pfo-097261	Poecilia formosa	50.64	8.00e-86	308.00
IUUC-Pab-098579	Pongo abelii	51.58	5.00e-94	336.00
IUUC-Pca-100119	Procavia capensis	49.84	2.00e-84	304.00
IUUC-Pva-102111	Pteropus vampyrus	51.75	1.00e-93	335.00
IUUC-Rno-105364	Rattus norvegicus	51.27	2.00e-93	334.00
IUUC-Sha-107005	Sarcophilus harrisii	51.27	4.00e-93	333.00
IUUC-Sar-113163	Sorex araneus	51.58	8.00e-94	335.00
IUUC-Ssc-115633	Sus scrofa	51.10	4.00e-92	329.00
IUUC-Tgu-116869	Taeniopygia guttata	51.31	2.00e-90	324.00
IUUC-Tru-118217	Takifugu rubripes	49.84	4.00e-89	319.00
IUUC-Tsy-119308	Tarsius syrichta	51.90	6.00e-94	335.00
IUUC-Tni-119882	Tetraodon nigroviridis	48.38	5.00e-89	319.00
IUUC-Tbe-127912	Tupaia belangeri	48.84	7.00e-73	265.00
IUUC-Ttr-129087	Tursiops truncatus	51.27	8.00e-94	335.00
IUUC-Vpa-130785	Vicugna pacos	50.65	2.00e-88	317.00
IUUC-Xtr-132801	Xenopus tropicalis	52.85	1.00e-87	315.00
IUUC-Xma-133372	Xiphophorus maculatus	50.96	6.00e-86	309.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence