iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000006872.3	ENSXETT00000015053.3	ENSXETP00000015053.3
ENSXETG00000006872.3	ENSXETT00000064710.1	ENSXETP00000059526.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.80e-81	273.1	192	820

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkg...........ellkslqklfeelwkskkkavsprellkalk 78
           +G++NlgNtC++N+v+Q L++++ l + l+e k++ ++ + +++++            +l++++  +++++ +  k+  sp+ l+++l+
   Q: 192  KGINNLGNTCFFNAVMQNLAQTHMLSDTLNEMKEKGTKLKINSSEDVhlqshcklipgSLTSAVLLFLHNMKEAGKEPLSPKVLFSQLC 280
           59*****************************55555444443333334555666667799999999999999***************** PP
   S: 79   keaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde......aeekkkkknkslisdlFqgqlksqikclecdn 161
           ++a++f+ ++qqD+qE+l++lld+++ e +k+ ++ + +++++ ++++ de      + + k+  + ++i+++F g+l+s+++c+ec++
   Q: 281  QKAPRFKAFQQQDSQELLHYLLDAMRIEETKRIQSGILKAFNNPTTKTADEetkrkvKAYGKEGVKMNFIDRIFVGELTSTVMCEECEH 369
           **************************99999777777777777777777774444335566666666********************** PP
   S: 162  vssreepfldlslpvpgkeetkke................................................................. 185
           +s  +e f+dlslp+ ++     +                                                                 
   Q: 370  ISAVREAFIDLSLPIIEDIYVRARsttsrratcpltsrggggvrasghmgthahmsrsgdclheqkiskrallknlhktskrnqlnrgk 458
           ****************999766668999************************************************************* PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 459  tksasgdenrnlimqgnddvrtagtrinstyaqesipvnqnlntvsqsdgseqndssqlessgdadseaseyensepqadksisldstl 547
           ***************************************************************************************** PP
   S: 186  ..................................................................................slqdcLe 192
                                                                                             s+q+cL 
   Q: 548  hsshnknitldscqhhdvvgfghdavtgplsklginsseedsgsfgkeqllgfthencvlsqnpqtafqtlshgyitrpkecSVQSCLY 636
           ***************************************************************************************** PP
   S: 193  sftkeeelegenkyycekckkkqe.................aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspf 264
           +ft+ e l g+nk++ce+c++kq                  a+k+l ++  P  LilhLkRf + +++   +kin++v+fpl Ldl+pf
   Q: 637  QFTSVELLMGNNKLQCENCTQKQLafqrkqleekqesvytnARKQLLISAAPANLILHLKRF-Y-QNGLTLRKINRHVDFPLVLDLAPF 723
           ********************999999999999999999999*********************.5.5568889***************** PP
   S: 265  ctspeekqke..kkkYeLiavvvHsGslssGHYvayvkn.........................ekgkWllfdDskVtevkeeevleet 326
           c+ ++++  e  ++ Y+L+++v HsGs+++GHY+ayvk                           k++W++++D++V+ v+e++vl+  
   Q: 724  CSATCKNIVEdkCVLYSLYGIVEHSGSMRGGHYTAYVKIrmpfnvlcdiilkhirfgsclgnekLKNQWVYVSDTHVQMVSESRVLS-- 810
           ***8887655559**************************99999999999999998888888766888*******************.. PP
   S: 327  gstaYvlfYkr 337
            s+aY+lfY++
   Q: 811  -SQAYLLFYEK 820
           .********97 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

FVRLESAGKK GQHQQELSLT CHHVSQAVDV NHVKRAVSQA VWSVCTECMK ERRTQDGELV 60
VPAEVWLCLK CGHQGCGANS ECQHSLKHFE ALHTEPHCIA INLSTWLTWC YKCDEELLTH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCTAATACA GTACGTGCAG AATGCACAAG TTTATTTCAG GGCCGAACTA CTAGGGTTAT 60
TACATTTCTA CTTCGTATTA GCAGCTCTGA GACCTGCGTT TTCCTACAGT ACTGTTGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002331	Ailuropoda melanoleuca	63.13	3.00e-132	465.00
IUUC-Apl-003512	Anas platyrhynchos	56.87	0.00e+00	854.00
IUUC-Aca-004284	Anolis carolinensis	53.80	0.00e+00	803.00
IUUC-Bta-012880	Bos taurus	52.54	0.00e+00	745.00
IUUC-Cja-019144	Callithrix jacchus	52.11	0.00e+00	767.00
IUUC-Cfa-020971	Canis familiaris	62.23	2.00e-136	479.00
IUUC-Csa-023910	Chlorocebus sabaeus	52.28	0.00e+00	722.00
IUUC-Dre-028106	Danio rerio	49.70	0.00e+00	719.00
IUUC-Dno-029456	Dasypus novemcinctus	47.39	1.00e-105	377.00
IUUC-Dor-030438	Dipodomys ordii	42.71	4.00e-147	515.00
IUUC-Dme-031870	Drosophila melanogaster	51.63	9.00e-36	145.00
IUUC-Ete-032736	Echinops telfairi	43.61	5.00e-174	604.00
IUUC-Eca-034211	Equus caballus	52.52	0.00e+00	765.00
IUUC-Eeu-034797	Erinaceus europaeus	73.57	3.00e-61	229.00
IUUC-Fca-035947	Felis catus	62.57	2.00e-129	456.00
IUUC-Fal-037199	Ficedula albicollis	55.92	0.00e+00	743.00
IUUC-Gmo-039228	Gadus morhua	60.37	2.00e-130	459.00
IUUC-Gga-040823	Gallus gallus	51.33	7.00e-126	444.00
IUUC-Gac-042406	Gasterosteus aculeatus	60.22	3.00e-125	442.00
IUUC-Ggo-045402	Gorilla gorilla	51.86	0.00e+00	775.00
IUUC-Hsa-046430	Homo sapiens	51.68	0.00e+00	773.00
IUUC-Itr-048855	Ictidomys tridecemlineatus	49.05	1.00e-110	393.00
IUUC-Lch-049547	Latimeria chalumnae	52.03	0.00e+00	750.00
IUUC-Loc-052842	Lepisosteus oculatus	53.25	0.00e+00	759.00
IUUC-Laf-053988	Loxodonta africana	51.33	0.00e+00	775.00
IUUC-Mcc-055491	Macaca mulatta	64.34	2.00e-143	503.00
IUUC-Meu-056256	Macropus eugenii	58.09	4.00e-82	299.00
IUUC-Mla-059026	Melampsora laricipopulina	32.35	2.00e-17	84.00
IUUC-Mga-059833	Meleagris gallopavo	48.94	9.00e-131	460.00
IUUC-Mmr-060952	Microcebus murinus	52.89	8.00e-141	494.00
IUUC-Mdo-062642	Monodelphis domestica	53.86	0.00e+00	766.00
IUUC-Mmu-063945	Mus musculus	51.22	0.00e+00	749.00
IUUC-Mpu-065944	Mustela putorius furo	62.83	8.00e-135	474.00
IUUC-Mlu-067049	Myotis lucifugus	51.26	0.00e+00	717.00
IUUC-Nle-069828	Nomascus leucogenys	52.63	0.00e+00	785.00
IUUC-Opr-070672	Ochotona princeps	50.42	2.00e-85	310.00
IUUC-Ont-072121	Oreochromis niloticus	61.39	7.00e-125	441.00
IUUC-Oan-073656	Ornithorhynchus anatinus	54.51	0.00e+00	800.00
IUUC-Ocu-074323	Oryctolagus cuniculus	64.69	1.00e-134	473.00
IUUC-Ola-087238	Oryzias latipes	58.87	8.00e-128	451.00
IUUC-Oga-088379	Otolemur garnettii	49.52	0.00e+00	704.00
IUUC-Oar-089718	Ovis aries	52.25	0.00e+00	739.00
IUUC-Ptr-091358	Pan troglodytes	51.92	0.00e+00	776.00
IUUC-Pan-092023	Papio anubis	64.34	2.00e-143	503.00
IUUC-Psi-093256	Pelodiscus sinensis	54.74	0.00e+00	819.00
IUUC-Pfo-097285	Poecilia formosa	46.40	0.00e+00	640.00
IUUC-Pab-098539	Pongo abelii	51.98	0.00e+00	778.00
IUUC-Pca-100610	Procavia capensis	56.51	2.00e-96	346.00
IUUC-Pva-102985	Pteropus vampyrus	63.28	6.00e-132	464.00
IUUC-Rno-105538	Rattus norvegicus	50.97	0.00e+00	752.00
IUUC-Sha-107022	Sarcophilus harrisii	69.00	7.00e-143	501.00
IUUC-Sar-113637	Sorex araneus	61.66	2.00e-133	469.00
IUUC-Ssc-115870	Sus scrofa	51.39	0.00e+00	772.00
IUUC-Tgu-116907	Taeniopygia guttata	55.92	0.00e+00	840.00
IUUC-Tru-117835	Takifugu rubripes	53.44	2.00e-104	373.00
IUUC-Tsy-118869	Tarsius syrichta	51.10	0.00e+00	677.00
IUUC-Tni-119716	Tetraodon nigroviridis	66.81	9.00e-88	317.00
IUUC-Tbe-128041	Tupaia belangeri	69.23	3.00e-86	313.00
IUUC-Ttr-128901	Tursiops truncatus	49.33	0.00e+00	700.00
IUUC-Vpa-130331	Vicugna pacos	51.81	0.00e+00	720.00
IUUC-Xma-133100	Xiphophorus maculatus	59.14	8.00e-122	431.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence