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Tag Content
UUCD2 ID IUUC-Mlu-067354
UUCD1 version UUC-MyL-00740
Ensembl Protein ID ENSMLUP00000014811.2
UniProt Accession G1PU65; G1PU65_MYOLU
Genbank Protein ID ENSMLUP00000014811
Protein Name Uncharacterized protein
Genbank Nucleotide ID AAPE02042001
Gene Name HACE1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMLUG00000016249.2 ENSMLUT00000016255.2 ENSMLUP00000014811.2
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 1.10e-118 396.5 576 906
Active Site
Position(s) Description Evidence
877 Glycyl thioester intermediate {ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlp 91
           ++lk+ + v+f gEeg+++ Gv re+++ ls+e+ npd+ lf++s++  +t+qpn++s++ np+hl++F+f+G++lg+al +++l+++ 
   Q: 576  AKLKQGIAVRFHGEEGMGQ-GVVREWFDILSNEIVNPDYALFTQSADVGTTFQPNSNSYV-NPDHLNYFRFAGQILGLALNHRQLVNIY 662
           679999*************.***************************************9.89************************** PP
   S: 92   lsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           +++sfyk++lg +++++d++++dpe++k+l++i++n   di++lgl+ltfsv+++++g ++e+ LkpgG +i Vt++NkeeYv+lv+e+
   Q: 663  FTRSFYKHILGIPVNYQDVASIDPEYAKNLQWILDN---DISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQNNKEEYVQLVTEL 748
           **********************************99...************************************************** PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvT 269
           r+++ i+ q++af +Gf+  ip++l++lF+e elell++G++eidv+d+ k+t+y++gy++++p+iqwFwev+e+++ eer  +LqFvT
   Q: 749  RMTRAIQPQINAFLQGFHMFIPPSLIQLFDEFELELLLSGMPEIDVSDWIKNTEYTSGYERQDPVIQWFWEVVEDITPEERVLLLQFVT 837
           ***************************************************************************************** PP
   S: 270  gssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kg 332
           gssr+P+gGfa+++     + f+i     +++ lP+s+TC+n+LkLPeY+skeilk++Ll+A + +  g
   Q: 838  GSSRVPHGGFANIMggsgLQNFTIAAvPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVALHCGsYG 906
           ******************8888888868888********************************986555 PP
   
Organism Myotis lucifugus
Protein Sequence
(Fasta)
VYSAIETPWP MRRSCFRPGR VYFESDNETA VYTLMPMVMA DQHRSVSELL SNSKFDVNYA 60
FGRVKRSLLH IAANCGSVEC LVLLLKKGAN PNYQDISGCT PLHLAARNGQ KKCMSKLLEY 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mlu-067354|E3,HECT|Myotis lucifugus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTGTACAGTG CGATTGAAAC TCCGTGGCCC ATGCGCAGAA GTTGTTTTCG GCCTGGGCGA 60
GTCTATTTTG AAGAAGTACT GTTGATATTT GGCTCTGTTG ACTAATGAAT TTGCTGACTA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mlu-067354|E3,HECT|Myotis lucifugus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR000569--HECT_dom
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT
Pfam

PF12796--Ank_2
PF00632--HECT
PRINTS

PR01415--ANKYRIN
SMART

SM00248--ANK
SM00119--HECTc
Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0000139--C:Golgi membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007030--P:Golgi organization
GO:0061025--P:membrane fusion
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030334--P:regulation of cell migration
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001490 Ailuropoda melanoleuca 96.70 0.00e+00 1826.00
IUUC-Apl-003400 Anas platyrhynchos 87.26 0.00e+00 1137.00
IUUC-Aca-005375 Anolis carolinensis 88.88 0.00e+00 1672.00
IUUC-Ame-011847 Astyanax mexicanus 83.37 0.00e+00 1589.00
IUUC-Bta-012831 Bos taurus 98.42 0.00e+00 1820.00
IUUC-Cja-019160 Callithrix jacchus 96.80 0.00e+00 1832.00
IUUC-Cfa-020346 Canis familiaris 96.69 0.00e+00 1824.00
IUUC-Cpo-021766 Cavia porcellus 95.37 0.00e+00 1801.00
IUUC-Csa-023768 Chlorocebus sabaeus 96.25 0.00e+00 1821.00
IUUC-Cho-024688 Choloepus hoffmanni 93.37 0.00e+00 1163.00
IUUC-Cin-025417 Ciona intestinalis 50.52 9.00e-138 484.00
IUUC-Csv-025993 Ciona savignyi 42.98 0.00e+00 726.00
IUUC-Dre-027819 Danio rerio 84.66 0.00e+00 1584.00
IUUC-Dno-029027 Dasypus novemcinctus 95.50 0.00e+00 1798.00
IUUC-Dor-030327 Dipodomys ordii 89.82 0.00e+00 1617.00
IUUC-Ete-032966 Echinops telfairi 88.22 0.00e+00 1646.00
IUUC-Eca-034339 Equus caballus 96.58 0.00e+00 1822.00
IUUC-Eeu-034544 Erinaceus europaeus 67.44 0.00e+00 656.00
IUUC-Fca-035617 Felis catus 98.31 0.00e+00 1333.00
IUUC-Fal-036687 Ficedula albicollis 89.04 0.00e+00 1702.00
IUUC-Gmo-039508 Gadus morhua 87.05 0.00e+00 816.00
IUUC-Gga-040845 Gallus gallus 89.26 0.00e+00 1724.00
IUUC-Gac-041894 Gasterosteus aculeatus 84.63 0.00e+00 1556.00
IUUC-Ggo-044465 Gorilla gorilla 92.74 0.00e+00 1751.00
IUUC-Hsa-045731 Homo sapiens 96.47 0.00e+00 1825.00
IUUC-Itr-048716 Ictidomys tridecemlineatus 96.47 0.00e+00 1812.00
IUUC-Lch-050436 Latimeria chalumnae 86.88 0.00e+00 1637.00
IUUC-Loc-052287 Lepisosteus oculatus 83.48 0.00e+00 1606.00
IUUC-Laf-053846 Loxodonta africana 96.59 0.00e+00 1816.00
IUUC-Mcc-055845 Macaca mulatta 96.36 0.00e+00 1823.00
IUUC-Meu-056060 Macropus eugenii 97.98 0.00e+00 706.00
IUUC-Mga-059935 Meleagris gallopavo 91.99 0.00e+00 1727.00
IUUC-Mmr-060960 Microcebus murinus 96.80 0.00e+00 1824.00
IUUC-Mdo-061851 Monodelphis domestica 91.28 0.00e+00 1764.00
IUUC-Mmu-063657 Mus musculus 94.60 0.00e+00 1790.00
IUUC-Mpu-066161 Mustela putorius furo 98.25 0.00e+00 820.00
IUUC-Nle-069112 Nomascus leucogenys 96.36 0.00e+00 1821.00
IUUC-Opr-070686 Ochotona princeps 88.41 0.00e+00 800.00
IUUC-Ont-072398 Oreochromis niloticus 84.02 0.00e+00 1556.00
IUUC-Oan-073194 Ornithorhynchus anatinus 94.75 0.00e+00 1728.00
IUUC-Ocu-074397 Oryctolagus cuniculus 83.88 0.00e+00 1516.00
IUUC-Ola-086777 Oryzias latipes 79.59 0.00e+00 1513.00
IUUC-Oga-088684 Otolemur garnettii 96.69 0.00e+00 1828.00
IUUC-Oar-089428 Ovis aries 95.97 0.00e+00 1779.00
IUUC-Ptr-090529 Pan troglodytes 96.36 0.00e+00 1823.00
IUUC-Pan-091702 Papio anubis 96.25 0.00e+00 1821.00
IUUC-Psi-093969 Pelodiscus sinensis 90.43 0.00e+00 1690.00
IUUC-Pfo-097364 Poecilia formosa 85.04 0.00e+00 1572.00
IUUC-Pab-098574 Pongo abelii 96.47 0.00e+00 1825.00
IUUC-Pca-100525 Procavia capensis 82.25 4.00e-166 578.00
IUUC-Pva-102365 Pteropus vampyrus 85.34 0.00e+00 1561.00
IUUC-Rno-105153 Rattus norvegicus 94.49 0.00e+00 1791.00
IUUC-Sha-107319 Sarcophilus harrisii 91.17 0.00e+00 1758.00
IUUC-Sar-113449 Sorex araneus 81.87 5.00e-177 614.00
IUUC-Ssc-115865 Sus scrofa 96.69 0.00e+00 1823.00
IUUC-Tgu-117225 Taeniopygia guttata 89.04 0.00e+00 1719.00
IUUC-Tru-118026 Takifugu rubripes 82.19 0.00e+00 1535.00
IUUC-Tsy-119407 Tarsius syrichta 83.24 0.00e+00 1516.00
IUUC-Tni-120234 Tetraodon nigroviridis 83.58 0.00e+00 1249.00
IUUC-Tur-126774 Triticum urartu 29.17 6.00e-47 182.00
IUUC-Tbe-127708 Tupaia belangeri 88.87 0.00e+00 882.00
IUUC-Ttr-128667 Tursiops truncatus 96.47 0.00e+00 1822.00
IUUC-Vpa-130200 Vicugna pacos 98.30 0.00e+00 1808.00
IUUC-Xtr-132176 Xenopus tropicalis 85.24 0.00e+00 1643.00
Created Date 25-Jun-2017

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