iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000028950.2	ENSMMUT00000038944.2	ENSMMUP00000032032.2
ENSMMUG00000028950.2	ENSMMUT00000055019.1	ENSMMUP00000051304.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	7.40e-43	146.8	16	146

Active Site

Position(s)	Description	Evidence
86	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 5    elkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilk...... 87
           elk l+++p+eg+        dl++wev+i+Gp++t+Yegg+Fk++++fp dYP++PP ++fltk++hPn+ye+G+vC+sil+      
   Q: 16   ELKGLQEEPVEGF-------GDLYNWEVAIFGPPNTYYEGGYFKARLKFPIDYPYSPPAFRFLTKMWHPNIYETGDVCISILHppvddp 97
           5666666666666.......48************************************************************9999999 PP
   S: 88   .....eeekWspalsvesvllsiqsllaepnpesplneeaaellkknre 131
                ++e+W+p+++v+++lls++sll+epn+ sp+n++a+ +++k++e
   Q: 98   qsgelPSERWNPTQNVRTILLSVISLLNEPNTFSPANVDASVMYRKWKE 146
           99*9******************************************998 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MAGPLVPSSQ KALLLELKGL QEEPVEGFGD LYNWEVAIFG PPNTYYEGGY FKARLKFPID 60
YPYSPPAFRF LTKMWHPNIY ETGDVCISIL HPPVDDPQSG ELPSERWNPT QNVRTILLSV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCGGCC CGCTAGTGCC CAGCTCGCAG AAGGCGCTGC TGCTGGAGCT CAAGGGGCTG 60
CAGGAAGAGC CGGTCGAGGG CTTCGCGTGA CCCTGGTGGA CGAGGGCGAC CTGTACAACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0016607--C:nuclear speck
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0035458--P:cellular response to interferon-beta
GO:0043951--P:negative regulation of cAMP-mediated signaling
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001600	Ailuropoda melanoleuca	95.09	1.00e-122	432.00
IUUC-Bta-012516	Bos taurus	95.63	2.00e-113	401.00
IUUC-Cja-018852	Callithrix jacchus	85.96	6.00e-97	346.00
IUUC-Cfa-020203	Canis familiaris	95.09	4.00e-114	403.00
IUUC-Cpo-022139	Cavia porcellus	88.16	4.00e-114	403.00
IUUC-Csa-023371	Chlorocebus sabaeus	96.43	1.00e-115	408.00
IUUC-Dor-030875	Dipodomys ordii	95.56	3.00e-116	410.00
IUUC-Fca-035832	Felis catus	97.59	4.00e-94	336.00
IUUC-Gga-040694	Gallus gallus	92.80	2.00e-116	411.00
IUUC-Ggo-044806	Gorilla gorilla	95.54	9.00e-116	409.00
IUUC-Hsa-046245	Homo sapiens	95.54	1.00e-115	408.00
IUUC-Itr-047928	Ictidomys tridecemlineatus	97.97	2.00e-84	303.00
IUUC-Mga-060075	Meleagris gallopavo	92.37	4.00e-116	410.00
IUUC-Mmr-061165	Microcebus murinus	92.86	2.00e-114	404.00
IUUC-Mdo-061825	Monodelphis domestica	94.20	3.00e-113	400.00
IUUC-Mmu-064168	Mus musculus	96.12	2.00e-113	401.00
IUUC-Mpu-066009	Mustela putorius furo	95.09	1.00e-122	431.00
IUUC-Opr-070826	Ochotona princeps	95.02	3.00e-103	367.00
IUUC-Oan-073287	Ornithorhynchus anatinus	87.71	2.00e-111	395.00
IUUC-Ocu-074902	Oryctolagus cuniculus	91.75	2.00e-109	388.00
IUUC-Oga-088845	Otolemur garnettii	94.20	4.00e-120	423.00
IUUC-Ptr-090916	Pan troglodytes	96.10	1.00e-112	399.00
IUUC-Pan-092577	Papio anubis	96.43	1.00e-115	408.00
IUUC-Psi-093039	Pelodiscus sinensis	93.82	4.00e-88	317.00
IUUC-Pab-098200	Pongo abelii	95.61	3.00e-105	374.00
IUUC-Pca-100169	Procavia capensis	86.43	6.00e-66	243.00
IUUC-Pva-102875	Pteropus vampyrus	98.18	2.00e-85	307.00
IUUC-Rno-106079	Rattus norvegicus	96.12	2.00e-113	401.00
IUUC-Ssc-115699	Sus scrofa	90.37	4.00e-88	317.00
IUUC-Tgu-117466	Taeniopygia guttata	90.68	2.00e-114	404.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence